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Tuning the Antigen Density Requirement for CAR T Cell Activity.

Majzner RG, Rietberg SP, Sotillo E, Dong R, Vachharajani VT, Labanieh L, Myklebust JH, Kadapakkam M, Weber EW, Tousley AM, Richards RM, Heitzeneder S, Nguyen SM, Wiebking V, Theruvath J, Lynn RC, Xu P, Dunn AR, Vale RD, Mackall CL.

Cancer Discov. 2020 Mar 19. pii: CD-19-0945. doi: 10.1158/2159-8290.CD-19-0945. [Epub ahead of print]


Scaling up single-cell mechanics to multicellular tissues - the role of the intermediate filament-desmosome network.

Broussard JA, Jaiganesh A, Zarkoob H, Conway DE, Dunn AR, Espinosa HD, Janmey PA, Green KJ.

J Cell Sci. 2020 Mar 16;133(6). pii: jcs228031. doi: 10.1242/jcs.228031. Review.


Perpendicular alignment of lymphatic endothelial cells in response to spatial gradients in wall shear stress.

Michalaki E, Surya VN, Fuller GG, Dunn AR.

Commun Biol. 2020 Feb 6;3(1):57. doi: 10.1038/s42003-019-0732-8.


Binding partner- and force-promoted changes in αE-catenin conformation probed by native cysteine labeling.

Terekhova K, Pokutta S, Kee YS, Li J, Tajkhorshid E, Fuller G, Dunn AR, Weis WI.

Sci Rep. 2019 Oct 25;9(1):15375. doi: 10.1038/s41598-019-51816-3.


Regulation of intrinsic excitability: Roles for learning and memory, aging and Alzheimer's disease, and genetic diversity.

Dunn AR, Kaczorowski CC.

Neurobiol Learn Mem. 2019 Oct;164:107069. doi: 10.1016/j.nlm.2019.107069. Epub 2019 Aug 20.


Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers.

Ellefsen KL, Holt JR, Chang AC, Nourse JL, Arulmoli J, Mekhdjian AH, Abuwarda H, Tombola F, Flanagan LA, Dunn AR, Parker I, Pathak MM.

Commun Biol. 2019 Aug 7;2:298. doi: 10.1038/s42003-019-0514-3. eCollection 2019.


The Synaptic Vesicle Glycoprotein 2: Structure, Function, and Disease Relevance.

Stout KA, Dunn AR, Hoffman C, Miller GW.

ACS Chem Neurosci. 2019 Sep 18;10(9):3927-3938. doi: 10.1021/acschemneuro.9b00351. Epub 2019 Aug 23.


Genetic background modifies CNS-mediated sensorimotor decline in the AD-BXD mouse model of genetic diversity in Alzheimer's disease.

O'Connell KMS, Ouellette AR, Neuner SM, Dunn AR, Kaczorowski CC.

Genes Brain Behav. 2019 Nov;18(8):e12603. doi: 10.1111/gbb.12603. Epub 2019 Aug 19.


Gene-by-environment interactions in Alzheimer's disease and Parkinson's disease.

Dunn AR, O'Connell KMS, Kaczorowski CC.

Neurosci Biobehav Rev. 2019 Aug;103:73-80. doi: 10.1016/j.neubiorev.2019.06.018. Epub 2019 Jun 14. Review.


Lymphatic endothelial cell calcium pulses are sensitive to spatial gradients in wall shear stress.

Surya VN, Michalaki E, Fuller GG, Dunn AR.

Mol Biol Cell. 2019 Mar 21;30(7):923-931. doi: 10.1091/mbc.E18-10-0618. Epub 2019 Feb 27.


Cell-Type-Specific Changes in Intrinsic Excitability in the Subiculum following Learning and Exposure to Novel Environmental Contexts.

Dunn AR, Neuner SM, Ding S, Hope KA, O'Connell KMS, Kaczorowski CC.

eNeuro. 2019 Jan 4;5(6). pii: ENEURO.0484-18.2018. doi: 10.1523/ENEURO.0484-18.2018. eCollection 2018 Nov-Dec.


Mechanical loading of desmosomes depends on the magnitude and orientation of external stress.

Price AJ, Cost AL, Ungewiß H, Waschke J, Dunn AR, Grashoff C.

Nat Commun. 2018 Dec 11;9(1):5284. doi: 10.1038/s41467-018-07523-0.


Mechanobiology: ubiquitous and useful.

Dunn AR.

Mol Biol Cell. 2018 Aug 8;29(16):1917-1918. doi: 10.1091/mbc.E18-07-0427. No abstract available.


NMDA receptor blockade ameliorates abnormalities of spike firing of subthalamic nucleus neurons in a parkinsonian nonhuman primate.

Bhattacharya S, Ma Y, Dunn AR, Bradner JM, Scimemi A, Miller GW, Traynelis SF, Wichmann T.

J Neurosci Res. 2018 Jul;96(7):1324-1335. doi: 10.1002/jnr.24230. Epub 2018 Mar 25.


Immunochemical analysis of the expression of SV2C in mouse, macaque and human brain.

Dunn AR, Hoffman CA, Stout KA, Ozawa M, Dhamsania RK, Miller GW.

Brain Res. 2019 Jan 1;1702:85-95. doi: 10.1016/j.brainres.2017.12.029. Epub 2017 Dec 21.


Vinculin forms a directionally asymmetric catch bond with F-actin.

Huang DL, Bax NA, Buckley CD, Weis WI, Dunn AR.

Science. 2017 Aug 18;357(6352):703-706. doi: 10.1126/science.aan2556.


DACH1 stimulates shear stress-guided endothelial cell migration and coronary artery growth through the CXCL12-CXCR4 signaling axis.

Chang AH, Raftrey BC, D'Amato G, Surya VN, Poduri A, Chen HI, Goldstone AB, Woo J, Fuller GG, Dunn AR, Red-Horse K.

Genes Dev. 2017 Jul 1;31(13):1308-1324. doi: 10.1101/gad.301549.117. Epub 2017 Aug 4.


A cytoskeletal clutch mediates cellular force transmission in a soft, three-dimensional extracellular matrix.

Owen LM, Adhikari AS, Patel M, Grimmer P, Leijnse N, Kim MC, Notbohm J, Franck C, Dunn AR.

Mol Biol Cell. 2017 Jul 7;28(14):1959-1974. doi: 10.1091/mbc.E17-02-0102. Epub 2017 Jun 7.


Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix.

Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup MW, Lakins JN, Ye X, Davidson MW, Lammerding J, Odde DJ, Dunn AR, Weaver VM.

Mol Biol Cell. 2017 Jun 1;28(11):1467-1488. doi: 10.1091/mbc.E16-09-0654. Epub 2017 Apr 5.


Pillars Article: Molecular Cloning of cDNA Encoding a Murine Haematopoietic Growth Regulator, Granulocyte-Macrophage Colony Stimulating Factor. Nature. 1984. 309: 763-767.

Gough NM, Gough J, Metcalf D, Kelso A, Grail D, Nicola NA, Burgess AW, Dunn AR.

J Immunol. 2017 Apr 1;198(7):2522-2526. No abstract available.


Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.

Dunn AR, Stout KA, Ozawa M, Lohr KM, Hoffman CA, Bernstein AI, Li Y, Wang M, Sgobio C, Sastry N, Cai H, Caudle WM, Miller GW.

Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2253-E2262. doi: 10.1073/pnas.1616892114. Epub 2017 Feb 28.


Genetic defects in β-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling.

Krieg M, Stühmer J, Cueva JG, Fetter R, Spilker K, Cremers D, Shen K, Dunn AR, Goodman MB.

Elife. 2017 Jan 18;6. pii: e20172. doi: 10.7554/eLife.20172.


A semi-interpenetrating network of polyacrylamide and recombinant basement membrane allows pluripotent cell culture in a soft, ligand-rich microenvironment.

Price AJ, Huang EY, Sebastiano V, Dunn AR.

Biomaterials. 2017 Mar;121:179-192. doi: 10.1016/j.biomaterials.2016.12.005. Epub 2016 Dec 9.


Sphingosine 1-phosphate receptor 1 regulates the directional migration of lymphatic endothelial cells in response to fluid shear stress.

Surya VN, Michalaki E, Huang EY, Fuller GG, Dunn AR.

J R Soc Interface. 2016 Dec;13(125). pii: 20160823.


Immunochemical localization of vesicular monoamine transporter 2 (VMAT2) in mouse brain.

Cliburn RA, Dunn AR, Stout KA, Hoffman CA, Lohr KM, Bernstein AI, Winokur EJ, Burkett J, Schmitz Y, Caudle WM, Miller GW.

J Chem Neuroanat. 2017 Oct;83-84:82-90. doi: 10.1016/j.jchemneu.2016.11.003. Epub 2016 Nov 9.


Single Molecule Force Measurements in Living Cells Reveal a Minimally Tensioned Integrin State.

Chang AC, Mekhdjian AH, Morimatsu M, Denisin AK, Pruitt BL, Dunn AR.

ACS Nano. 2016 Dec 27;10(12):10745-10752. doi: 10.1021/acsnano.6b03314. Epub 2016 Nov 28.


Selective Enhancement of Dopamine Release in the Ventral Pallidum of Methamphetamine-Sensitized Mice.

Stout KA, Dunn AR, Lohr KM, Alter SP, Cliburn RA, Guillot TS, Miller GW.

ACS Chem Neurosci. 2016 Oct 19;7(10):1364-1373. Epub 2016 Aug 18.


The tubulin repertoire of C. elegans sensory neurons and its context-dependent role in process outgrowth.

Lockhead D, Schwarz EM, O'Hagan R, Bellotti S, Krieg M, Barr MM, Dunn AR, Sternberg PW, Goodman MB.

Mol Biol Cell. 2016 Sep 21. pii: mbc.E16-06-0473. [Epub ahead of print]


Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation.

Sun Z, Tseng HY, Tan S, Senger F, Kurzawa L, Dedden D, Mizuno N, Wasik AA, Thery M, Dunn AR, Fässler R.

Nat Cell Biol. 2016 Sep;18(9):941-53. doi: 10.1038/ncb3402. Epub 2016 Aug 22.


Vesicular Monoamine Transporter 2 (VMAT2) Level Regulates MPTP Vulnerability and Clearance of Excess Dopamine in Mouse Striatal Terminals.

Lohr KM, Chen M, Hoffman CA, McDaniel MJ, Stout KA, Dunn AR, Wang M, Bernstein AI, Miller GW.

Toxicol Sci. 2016 Sep;153(1):79-88. doi: 10.1093/toxsci/kfw106. Epub 2016 Jun 10.


How Hydra Eats.

Dunn AR.

Biophys J. 2016 Apr 12;110(7):1467-1468. doi: 10.1016/j.bpj.2016.01.036. No abstract available.


Nanoscale Patterning of Extracellular Matrix Alters Endothelial Function under Shear Stress.

Nakayama KH, Surya VN, Gole M, Walker TW, Yang W, Lai ES, Ostrowski MA, Fuller GG, Dunn AR, Huang NF.

Nano Lett. 2016 Jan 13;16(1):410-9. doi: 10.1021/acs.nanolett.5b04028. Epub 2015 Dec 28.


Multiplexed Fluid Flow Device to Study Cellular Response to Tunable Shear Stress Gradients.

Ostrowski MA, Huang EY, Surya VN, Poplawski C, Barakat JM, Lin GL, Fuller GG, Dunn AR.

Ann Biomed Eng. 2016 Jul;44(7):2261-72. doi: 10.1007/s10439-015-1500-7. Epub 2015 Nov 20.


A force balance can explain local and global cell movements during early zebrafish development.

Chai J, Hamilton AL, Krieg M, Buckley CD, Riedel-Kruse IH, Dunn AR.

Biophys J. 2015 Jul 21;109(2):407-14. doi: 10.1016/j.bpj.2015.04.029.


Interactions of Phytophthora capsici with Resistant and Susceptible Pepper Roots and Stems.

Dunn AR, Smart CD.

Phytopathology. 2015 Oct;105(10):1355-61. doi: 10.1094/PHYTO-02-15-0045-R. Epub 2015 Sep 30.


Spatial distribution of cell-cell and cell-ECM adhesions regulates force balance while main-taining E-cadherin molecular tension in cell pairs.

Sim JY, Moeller J, Hart KC, Ramallo D, Vogel V, Dunn AR, Nelson WJ, Pruitt BL.

Mol Biol Cell. 2015 Jul 1;26(13):2456-65. doi: 10.1091/mbc.E14-12-1618. Epub 2015 May 13.


Donald Metcalf (1929-2014).

Hilton DJ, Nicola NA, Alexander WS, Roberts AW, Dunn AR.

Cell. 2015 Jan 29;160(3):361-2. No abstract available.


Increased Vesicular Monoamine Transporter 2 (VMAT2; Slc18a2) Protects against Methamphetamine Toxicity.

Lohr KM, Stout KA, Dunn AR, Wang M, Salahpour A, Guillot TS, Miller GW.

ACS Chem Neurosci. 2015 May 20;6(5):790-9. doi: 10.1021/acschemneuro.5b00010. Epub 2015 Mar 9.


Visualizing the interior architecture of focal adhesions with high-resolution traction maps.

Morimatsu M, Mekhdjian AH, Chang AC, Tan SJ, Dunn AR.

Nano Lett. 2015 Apr 8;15(4):2220-8. doi: 10.1021/nl5047335. Epub 2015 Mar 23.


Mechanical systems biology of C. elegans touch sensation.

Krieg M, Dunn AR, Goodman MB.

Bioessays. 2015 Mar;37(3):335-44. doi: 10.1002/bies.201400154. Epub 2015 Jan 19. Review.


Mechano-transduction: from molecules to tissues.

Pruitt BL, Dunn AR, Weis WI, Nelson WJ.

PLoS Biol. 2014 Nov 18;12(11):e1001996. doi: 10.1371/journal.pbio.1001996. eCollection 2014 Nov.


Cell adhesion. The minimal cadherin-catenin complex binds to actin filaments under force.

Buckley CD, Tan J, Anderson KL, Hanein D, Volkmann N, Weis WI, Nelson WJ, Dunn AR.

Science. 2014 Oct 31;346(6209):1254211. doi: 10.1126/science.1254211.


The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination.

Rolland Y, Marighetti P, Malinverno C, Confalonieri S, Luise C, Ducano N, Palamidessi A, Bisi S, Kajiho H, Troglio F, Shcherbakova OG, Dunn AR, Oldani A, Lanzetti L, Di Fiore PP, Disanza A, Scita G.

Dev Cell. 2014 Sep 8;30(5):553-68. doi: 10.1016/j.devcel.2014.08.006.


Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo.

Lohr KM, Bernstein AI, Stout KA, Dunn AR, Lazo CR, Alter SP, Wang M, Li Y, Fan X, Hess EJ, Yi H, Vecchio LM, Goldstein DS, Guillot TS, Salahpour A, Miller GW.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9977-82. doi: 10.1073/pnas.1402134111. Epub 2014 Jun 16.


Two glycosylase families diffusively scan DNA using a wedge residue to probe for and identify oxidatively damaged bases.

Nelson SR, Dunn AR, Kathe SD, Warshaw DM, Wallace SS.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):E2091-9. doi: 10.1073/pnas.1400386111. Epub 2014 May 5.


Quantification of nanowire penetration into living cells.

Xu AM, Aalipour A, Leal-Ortiz S, Mekhdjian AH, Xie X, Dunn AR, Garner CC, Melosh NA.

Nat Commun. 2014 Apr 7;5:3613. doi: 10.1038/ncomms4613.


Evolution of an Experimental Population of Phytophthora capsici in the Field.

Dunn AR, Bruening SR, Grünwald NJ, Smart CD.

Phytopathology. 2014 Oct;104(10):1107-17. doi: 10.1094/PHYTO-12-13-0346-R.


Mechanical control of the sense of touch by β-spectrin.

Krieg M, Dunn AR, Goodman MB.

Nat Cell Biol. 2014 Mar;16(3):224-33. doi: 10.1038/ncb2915. Epub 2014 Feb 23.


Microvascular endothelial cells migrate upstream and align against the shear stress field created by impinging flow.

Ostrowski MA, Huang NF, Walker TW, Verwijlen T, Poplawski C, Khoo AS, Cooke JP, Fuller GG, Dunn AR.

Biophys J. 2014 Jan 21;106(2):366-74. doi: 10.1016/j.bpj.2013.11.4502.


Molecular tension sensors report forces generated by single integrin molecules in living cells.

Morimatsu M, Mekhdjian AH, Adhikari AS, Dunn AR.

Nano Lett. 2013 Sep 11;13(9):3985-9. doi: 10.1021/nl4005145. Epub 2013 Aug 28.

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