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Items: 1 to 50 of 103

1.

Development of a broad-spectrum antimicrobial combination for the treatment of Staphylococcus aureus and Pseudomonas aeruginosa corneal infections.

Chojnacki M, Philbrick A, Wucher B, Reed JN, Tomaras A, Dunman PM, Wozniak RAF.

Antimicrob Agents Chemother. 2018 Nov 12. pii: AAC.01929-18. doi: 10.1128/AAC.01929-18. [Epub ahead of print]

PMID:
30420484
2.

A High-Throughput Screening Approach To Repurpose FDA-Approved Drugs for Bactericidal Applications against Staphylococcus aureus Small-Colony Variants.

Trombetta RP, Dunman PM, Schwarz EM, Kates SL, Awad HA.

mSphere. 2018 Oct 31;3(5). pii: e00422-18. doi: 10.1128/mSphere.00422-18.

3.

Crystal structure of the ribonuclease-P-protein subunit from Staphylococcus aureus.

Ha L, Colquhoun J, Noinaj N, Das C, Dunman PM, Flaherty DP.

Acta Crystallogr F Struct Biol Commun. 2018 Oct 1;74(Pt 10):632-637. doi: 10.1107/S2053230X18011512. Epub 2018 Sep 19.

PMID:
30279314
4.

Elucidating the inhibition of peptidoglycan biosynthesis in Staphylococcus aureus by albocycline, a macrolactone isolated from Streptomyces maizeus.

Liang H, Zhou G, Ge Y, D'Ambrosio EA, Eidem TM, Blanchard C, Shehatou C, Chatare VK, Dunman PM, Valentine AM, Voelz VA, Grimes CL, Andrade RB.

Bioorg Med Chem. 2018 Jul 23;26(12):3453-3460. doi: 10.1016/j.bmc.2018.05.017. Epub 2018 May 24.

PMID:
29805074
5.

Endoribonuclease YbeY Is Linked to Proper Cellular Morphology and Virulence in Brucella abortus.

Budnick JA, Sheehan LM, Colquhoun JM, Dunman PM, Walker GC, Roop RM 2nd, Caswell CC.

J Bacteriol. 2018 May 24;200(12). pii: e00105-18. doi: 10.1128/JB.00105-18. Print 2018 Jun 15.

6.

Novel inhibitors of Staphylococcus aureus RnpA that synergize with mupirocin.

Lounsbury N, Eidem T, Colquhoun J, Mateo G, Abou-Gharbia M, Dunman PM, Childers WE.

Bioorg Med Chem Lett. 2018 Apr 1;28(6):1127-1131. doi: 10.1016/j.bmcl.2018.01.022. Epub 2018 Jan 31.

PMID:
29463447
7.

Identification of Staphylococcus aureus Cellular Pathways Affected by the Stilbenoid Lead Drug SK-03-92 Using a Microarray.

Schwan WR, Polanowski R, Dunman PM, Medina-Bielski S, Lane M, Rott M, Lipker L, Wescott A, Monte A, Cook JM, Baumann DD, Tiruveedhula VVNPB, Witzigmann CM, Mikel C, Rahman MT.

Antibiotics (Basel). 2017 Sep 11;6(3). pii: E17. doi: 10.3390/antibiotics6030017.

8.

A Small-Molecule Inhibitor of Iron-Sulfur Cluster Assembly Uncovers a Link between Virulence Regulation and Metabolism in Staphylococcus aureus.

Choby JE, Mike LA, Mashruwala AA, Dutter BF, Dunman PM, Sulikowski GA, Boyd JM, Skaar EP.

Cell Chem Biol. 2016 Nov 17;23(11):1351-1361. doi: 10.1016/j.chembiol.2016.09.012. Epub 2016 Oct 20.

9.

Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment.

Blanchard C, Brooks L, Ebsworth-Mojica K, Didione L, Wucher B, Dewhurst S, Krysan D, Dunman PM, Wozniak RA.

mSphere. 2016 Sep 14;1(5). pii: e00194-16. doi: 10.1128/mSphere.00194-16. eCollection 2016 Sep-Oct.

11.

Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection.

Wilde AD, Snyder DJ, Putnam NE, Valentino MD, Hammer ND, Lonergan ZR, Hinger SA, Aysanoa EE, Blanchard C, Dunman PM, Wasserman GA, Chen J, Shopsin B, Gilmore MS, Skaar EP, Cassat JE.

PLoS Pathog. 2015 Dec 18;11(12):e1005341. doi: 10.1371/journal.ppat.1005341. eCollection 2015 Dec.

12.

Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments.

Blanchard C, Brooks L, Beckley A, Colquhoun J, Dewhurst S, Dunman PM.

Antimicrob Agents Chemother. 2015 Nov 23;60(2):862-72. doi: 10.1128/AAC.02083-15. Print 2016 Feb.

13.

Clinically Relevant Growth Conditions Alter Acinetobacter baumannii Antibiotic Susceptibility and Promote Identification of Novel Antibacterial Agents.

Colquhoun JM, Wozniak RA, Dunman PM.

PLoS One. 2015 Nov 11;10(11):e0143033. doi: 10.1371/journal.pone.0143033. eCollection 2015.

14.

Editorial overview: Antimicrobials.

Dunman PM, Tomaras AP.

Curr Opin Microbiol. 2015 Oct;27:v-vii. doi: 10.1016/j.mib.2015.09.001. Epub 2015 Sep 15. No abstract available.

PMID:
26384621
15.

Translational deficiencies in antibacterial discovery and new screening paradigms.

Dunman PM, Tomaras AP.

Curr Opin Microbiol. 2015 Oct;27:108-13. doi: 10.1016/j.mib.2015.08.006. Epub 2015 Sep 8. Review.

16.

In the midst of the antimicrobial discovery conundrum: an overview.

Tomaras AP, Dunman PM.

Curr Opin Microbiol. 2015 Oct;27:103-7. doi: 10.1016/j.mib.2015.08.005. Epub 2015 Sep 8. Review. No abstract available.

PMID:
26356257
17.

A LysR-family transcriptional regulator required for virulence in Brucella abortus is highly conserved among the α-proteobacteria.

Sheehan LM, Budnick JA, Blanchard C, Dunman PM, Caswell CC.

Mol Microbiol. 2015 Oct;98(2):318-28. doi: 10.1111/mmi.13123. Epub 2015 Aug 14.

18.

A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis.

Forbes L, Ebsworth-Mojica K, DiDone L, Li SG, Freundlich JS, Connell N, Dunman PM, Krysan DJ.

PLoS One. 2015 Jun 22;10(6):e0129234. doi: 10.1371/journal.pone.0129234. eCollection 2015.

19.

Rot is a key regulator of Staphylococcus aureus biofilm formation.

Mootz JM, Benson MA, Heim CE, Crosby HA, Kavanaugh JS, Dunman PM, Kielian T, Torres VJ, Horswill AR.

Mol Microbiol. 2015 Apr;96(2):388-404. doi: 10.1111/mmi.12943. Epub 2015 Feb 26.

20.

Small-molecule inhibitors of Staphylococcus aureus RnpA-mediated RNA turnover and tRNA processing.

Eidem TM, Lounsbury N, Emery JF, Bulger J, Smith A, Abou-Gharbia M, Childers W, Dunman PM.

Antimicrob Agents Chemother. 2015 Apr;59(4):2016-28. doi: 10.1128/AAC.04352-14. Epub 2015 Jan 20.

21.

Staphylococcus aureus gene expression in a rat model of infective endocarditis.

Hanses F, Roux C, Dunman PM, Salzberger B, Lee JC.

Genome Med. 2014 Nov 3;6(10):93. doi: 10.1186/s13073-014-0093-3. eCollection 2014.

22.

Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus.

Perlmutter JI, Forbes LT, Krysan DJ, Ebsworth-Mojica K, Colquhoun JM, Wang JL, Dunman PM, Flaherty DP.

J Med Chem. 2014 Oct 23;57(20):8540-62. doi: 10.1021/jm5010682. Epub 2014 Oct 6.

23.

Identification of Acinetobacter baumannii serum-associated antibiotic efflux pump inhibitors.

Blanchard C, Barnett P, Perlmutter J, Dunman PM.

Antimicrob Agents Chemother. 2014 Nov;58(11):6360-70. doi: 10.1128/AAC.03535-14. Epub 2014 Aug 11.

24.

Staphylococcus epidermidis agr quorum-sensing system: signal identification, cross talk, and importance in colonization.

Olson ME, Todd DA, Schaeffer CR, Paharik AE, Van Dyke MJ, Büttner H, Dunman PM, Rohde H, Cech NB, Fey PD, Horswill AR.

J Bacteriol. 2014 Oct;196(19):3482-93. doi: 10.1128/JB.01882-14. Epub 2014 Jul 28.

25.

Arginine deiminase in Staphylococcus epidermidis functions to augment biofilm maturation through pH homeostasis.

Lindgren JK, Thomas VC, Olson ME, Chaudhari SS, Nuxoll AS, Schaeffer CR, Lindgren KE, Jones J, Zimmerman MC, Dunman PM, Bayles KW, Fey PD.

J Bacteriol. 2014 Jun;196(12):2277-89. doi: 10.1128/JB.00051-14. Epub 2014 Apr 11.

26.

An ribonuclease T2 family protein modulates Acinetobacter baumannii abiotic surface colonization.

Jacobs AC, Blanchard CE, Catherman SC, Dunman PM, Murata Y.

PLoS One. 2014 Jan 28;9(1):e85729. doi: 10.1371/journal.pone.0085729. eCollection 2014.

27.

The Staphylococcus aureus SrrAB two-component system promotes resistance to nitrosative stress and hypoxia.

Kinkel TL, Roux CM, Dunman PM, Fang FC.

MBio. 2013 Nov 12;4(6):e00696-13. doi: 10.1128/mBio.00696-13.

28.

Global transcriptome analysis of Staphylococcus aureus biofilms in response to innate immune cells.

Scherr TD, Roux CM, Hanke ML, Angle A, Dunman PM, Kielian T.

Infect Immun. 2013 Dec;81(12):4363-76. doi: 10.1128/IAI.00819-13. Epub 2013 Sep 16.

29.

Drug-eluting cements for hard tissue repair: a comparative study using vancomycin and RNPA1000 to inhibit growth of Staphylococcus aureus.

Eidem TM, Coughlan A, Towler MR, Dunman PM, Wren AW.

J Biomater Appl. 2014 Apr;28(8):1235-46. doi: 10.1177/0885328213503388. Epub 2013 Sep 12.

PMID:
24029489
30.

Transcriptional profiling of Staphylococcus aureus during growth in 2 M NaCl leads to clarification of physiological roles for Kdp and Ktr K+ uptake systems.

Price-Whelan A, Poon CK, Benson MA, Eidem TT, Roux CM, Boyd JM, Dunman PM, Torres VJ, Krulwich TA.

MBio. 2013 Aug 20;4(4). pii: e00407-13. doi: 10.1128/mBio.00407-13.

31.

Semen-derived enhancer of viral infection (SEVI) binds bacteria, enhances bacterial phagocytosis by macrophages, and can protect against vaginal infection by a sexually transmitted bacterial pathogen.

Easterhoff D, Ontiveros F, Brooks LR, Kim Y, Ross B, Silva JN, Olsen JS, Feng C, Hardy DJ, Dunman PM, Dewhurst S.

Antimicrob Agents Chemother. 2013 Jun;57(6):2443-50. doi: 10.1128/AAC.02464-12. Epub 2013 Mar 18.

32.

Diverse genetic regulon of the virulence-associated transcriptional regulator MucR in Brucella abortus 2308.

Caswell CC, Elhassanny AE, Planchin EE, Roux CM, Weeks-Gorospe JN, Ficht TA, Dunman PM, Roop RM 2nd.

Infect Immun. 2013 Apr;81(4):1040-51. doi: 10.1128/IAI.01097-12. Epub 2013 Jan 14.

33.

genetic determinants of intrinsic colistin tolerance in Acinetobacter baumannii.

Hood MI, Becker KW, Roux CM, Dunman PM, Skaar EP.

Infect Immun. 2013 Feb;81(2):542-51. doi: 10.1128/IAI.00704-12. Epub 2012 Dec 10. Erratum in: Infect Immun. 2014 Jan;82(1):469.

34.

Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA.

Annadurai S, Martinez R, Canney DJ, Eidem T, Dunman PM, Abou-Gharbia M.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7719-25. doi: 10.1016/j.bmcl.2012.09.095. Epub 2012 Oct 3.

PMID:
23116888
35.

Characterization of the effects of an rpoC mutation that confers resistance to the Fst peptide toxin-antitoxin system toxin.

Brinkman CL, Bumgarner R, Kittichotirat W, Dunman PM, Kuechenmeister LJ, Weaver KE.

J Bacteriol. 2013 Jan;195(1):156-66. doi: 10.1128/JB.01597-12. Epub 2012 Oct 26.

36.

Adenylate kinase release as a high-throughput-screening-compatible reporter of bacterial lysis for identification of antibacterial agents.

Jacobs AC, Didone L, Jobson J, Sofia MK, Krysan D, Dunman PM.

Antimicrob Agents Chemother. 2013 Jan;57(1):26-36. doi: 10.1128/AAC.01640-12. Epub 2012 Oct 1.

37.

The staphylococcal accessory regulator, SarA, is an RNA-binding protein that modulates the mRNA turnover properties of late-exponential and stationary phase Staphylococcus aureus cells.

Morrison JM, Anderson KL, Beenken KE, Smeltzer MS, Dunman PM.

Front Cell Infect Microbiol. 2012 Mar 8;2:26. doi: 10.3389/fcimb.2012.00026. eCollection 2012.

38.

Identification of two small regulatory RNAs linked to virulence in Brucella abortus 2308.

Caswell CC, Gaines JM, Ciborowski P, Smith D, Borchers CH, Roux CM, Sayood K, Dunman PM, Roop Ii RM.

Mol Microbiol. 2012 Jul;85(2):345-60. doi: 10.1111/j.1365-2958.2012.08117.x. Epub 2012 Jun 12.

39.

Growth phase-dependent modulation of Rgg binding specificity in Streptococcus pyogenes.

Anbalagan S, Dmitriev A, McShan WM, Dunman PM, Chaussee MS.

J Bacteriol. 2012 Aug;194(15):3961-71. doi: 10.1128/JB.06709-11. Epub 2012 May 25.

40.

Characterization of SSR42, a novel virulence factor regulatory RNA that contributes to the pathogenesis of a Staphylococcus aureus USA300 representative.

Morrison JM, Miller EW, Benson MA, Alonzo F 3rd, Yoong P, Torres VJ, Hinrichs SH, Dunman PM.

J Bacteriol. 2012 Jun;194(11):2924-38. doi: 10.1128/JB.06708-11. Epub 2012 Apr 6.

41.

RNA decay: a novel therapeutic target in bacteria.

Eidem TM, Roux CM, Dunman PM.

Wiley Interdiscip Rev RNA. 2012 May-Jun;3(3):443-54. doi: 10.1002/wrna.1110. Epub 2012 Feb 28. Review.

42.

Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300.

Gardete S, Kim C, Hartmann BM, Mwangi M, Roux CM, Dunman PM, Chambers HF, Tomasz A.

PLoS Pathog. 2012 Feb;8(2):e1002505. doi: 10.1371/journal.ppat.1002505. Epub 2012 Feb 2.

43.

Characterization of the Acinetobacter baumannii growth phase-dependent and serum responsive transcriptomes.

Jacobs AC, Sayood K, Olmsted SB, Blanchard CE, Hinrichs S, Russell D, Dunman PM.

FEMS Immunol Med Microbiol. 2012 Apr;64(3):403-12. doi: 10.1111/j.1574-695X.2011.00926.x. Epub 2012 Jan 23.

44.

The modulation of Staphylococcus aureus mRNA turnover.

Morrison JM, Dunman PM.

Future Microbiol. 2011 Oct;6(10):1141-50. doi: 10.2217/fmb.11.102.

45.

Transcriptional profiling analysis of the global regulator NorG, a GntR-like protein of Staphylococcus aureus.

Truong-Bolduc QC, Dunman PM, Eidem T, Hooper DC.

J Bacteriol. 2011 Nov;193(22):6207-14. doi: 10.1128/JB.05847-11. Epub 2011 Sep 9.

46.

Rsp inhibits attachment and biofilm formation by repressing fnbA in Staphylococcus aureus MW2.

Lei MG, Cue D, Roux CM, Dunman PM, Lee CY.

J Bacteriol. 2011 Oct;193(19):5231-41. doi: 10.1128/JB.05454-11. Epub 2011 Jul 29.

47.

Identification of Rgg binding sites in the Streptococcus pyogenes chromosome.

Anbalagan S, McShan WM, Dunman PM, Chaussee MS.

J Bacteriol. 2011 Sep;193(18):4933-42. doi: 10.1128/JB.00429-11. Epub 2011 Jul 15.

48.

Characterization of components of the Staphylococcus aureus mRNA degradosome holoenzyme-like complex.

Roux CM, DeMuth JP, Dunman PM.

J Bacteriol. 2011 Oct;193(19):5520-6. doi: 10.1128/JB.05485-11. Epub 2011 Jul 15.

49.

Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis.

Olson PD, Kuechenmeister LJ, Anderson KL, Daily S, Beenken KE, Roux CM, Reniere ML, Lewis TL, Weiss WJ, Pulse M, Nguyen P, Simecka JW, Morrison JM, Sayood K, Asojo OA, Smeltzer MS, Skaar EP, Dunman PM.

PLoS Pathog. 2011 Feb 10;7(2):e1001287. doi: 10.1371/journal.ppat.1001287.

50.

Staphylococcus aureus ClpC divergently regulates capsule via sae and codY in strain newman but activates capsule via codY in strain UAMS-1 and in strain Newman with repaired saeS.

Luong TT, Sau K, Roux C, Sau S, Dunman PM, Lee CY.

J Bacteriol. 2011 Feb;193(3):686-94. doi: 10.1128/JB.00987-10. Epub 2010 Dec 3.

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