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Items: 24

1.

N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration.

Chen CY, Melo E, Jakob P, Friedlein A, Elsässer B, Goettig P, Kueppers V, Delobel F, Stucki C, Dunkley T, Fauser S, Schilling O, Iacone R.

Matrix Biol. 2018 Sep;70:84-101. doi: 10.1016/j.matbio.2018.03.013. Epub 2018 Mar 20.

2.

HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model.

Melo E, Oertle P, Trepp C, Meistermann H, Burgoyne T, Sborgi L, Cabrera AC, Chen CY, Hoflack JC, Kam-Thong T, Schmucki R, Badi L, Flint N, Ghiani ZE, Delobel F, Stucki C, Gromo G, Einhaus A, Hornsperger B, Golling S, Siebourg-Polster J, Gerber F, Bohrmann B, Futter C, Dunkley T, Hiller S, Schilling O, Enzmann V, Fauser S, Plodinec M, Iacone R.

EBioMedicine. 2018 Jan;27:258-274. doi: 10.1016/j.ebiom.2017.12.011. Epub 2017 Dec 13.

3.

HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication.

Cabrera AC, Melo E, Roth D, Topp A, Delobel F, Stucki C, Chen CY, Jakob P, Banfai B, Dunkley T, Schilling O, Huber S, Iacone R, Petrone P.

Sci Rep. 2017 Nov 1;7(1):14804. doi: 10.1038/s41598-017-14208-z.

4.

mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis.

Costa V, Aigner S, Vukcevic M, Sauter E, Behr K, Ebeling M, Dunkley T, Friedlein A, Zoffmann S, Meyer CA, Knoflach F, Lugert S, Patsch C, Fjeldskaar F, Chicha-Gaudimier L, Kiialainen A, Piraino P, Bedoucha M, Graf M, Jessberger S, Ghosh A, Bischofberger J, Jagasia R.

Cell Rep. 2016 Apr 5;15(1):86-95. doi: 10.1016/j.celrep.2016.02.090. Epub 2016 Mar 24.

5.

Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.

Ashford AL, Dunkley TP, Cockerill M, Rowlinson RA, Baak LM, Gallo R, Balmanno K, Goodwin LM, Ward RA, Lochhead PA, Guichard S, Hudson K, Cook SJ.

Cell Mol Life Sci. 2016 Feb;73(4):883-900. doi: 10.1007/s00018-015-2032-x. Epub 2015 Sep 7.

6.

Characterization of a human pluripotent stem cell-derived model of neuronal development using multiplexed targeted proteomics.

Dunkley T, Costa V, Friedlein A, Lugert S, Aigner S, Ebeling M, Miller MT, Patsch C, Piraino P, Cutler P, Jagasia R.

Proteomics Clin Appl. 2015 Aug;9(7-8):684-94. doi: 10.1002/prca.201400150. Epub 2015 May 26.

PMID:
25684324
7.

Quantitative ADME proteomics - CYP and UGT enzymes in the Beagle dog liver and intestine.

Heikkinen AT, Friedlein A, Matondo M, Hatley OJ, Petsalo A, Juvonen R, Galetin A, Rostami-Hodjegan A, Aebersold R, Lamerz J, Dunkley T, Cutler P, Parrott N.

Pharm Res. 2015 Jan;32(1):74-90. doi: 10.1007/s11095-014-1446-8. Epub 2014 Jul 18.

PMID:
25033762
8.

Targeted profiling of polar intracellular metabolites using ion-pair-high performance liquid chromatography and -ultra high performance liquid chromatography coupled to tandem mass spectrometry: applications to serum, urine and tissue extracts.

Michopoulos F, Whalley N, Theodoridis G, Wilson ID, Dunkley TP, Critchlow SE.

J Chromatogr A. 2014 Jul 4;1349:60-8. doi: 10.1016/j.chroma.2014.05.019. Epub 2014 May 12.

PMID:
24861786
9.

AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo.

Loddick SA, Ross SJ, Thomason AG, Robinson DM, Walker GE, Dunkley TP, Brave SR, Broadbent N, Stratton NC, Trueman D, Mouchet E, Shaheen FS, Jacobs VN, Cumberbatch M, Wilson J, Jones RD, Bradbury RH, Rabow A, Gaughan L, Womack C, Barry ST, Robson CN, Critchlow SE, Wedge SR, Brooks AN.

Mol Cancer Ther. 2013 Sep;12(9):1715-27. doi: 10.1158/1535-7163.MCT-12-1174. Epub 2013 Jul 16.

10.

Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics.

Nikolovski N, Rubtsov D, Segura MP, Miles GP, Stevens TJ, Dunkley TP, Munro S, Lilley KS, Dupree P.

Plant Physiol. 2012 Oct;160(2):1037-51. doi: 10.1104/pp.112.204263. Epub 2012 Aug 24.

11.

Improved sub-cellular resolution via simultaneous analysis of organelle proteomics data across varied experimental conditions.

Trotter MW, Sadowski PG, Dunkley TP, Groen AJ, Lilley KS.

Proteomics. 2010 Dec;10(23):4213-9. doi: 10.1002/pmic.201000359.

PMID:
21058340
12.

A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.

Chiò A, Schymick JC, Restagno G, Scholz SW, Lombardo F, Lai SL, Mora G, Fung HC, Britton A, Arepalli S, Gibbs JR, Nalls M, Berger S, Kwee LC, Oddone EZ, Ding J, Crews C, Rafferty I, Washecka N, Hernandez D, Ferrucci L, Bandinelli S, Guralnik J, Macciardi F, Torri F, Lupoli S, Chanock SJ, Thomas G, Hunter DJ, Gieger C, Wichmann HE, Calvo A, Mutani R, Battistini S, Giannini F, Caponnetto C, Mancardi GL, La Bella V, Valentino F, Monsurrò MR, Tedeschi G, Marinou K, Sabatelli M, Conte A, Mandrioli J, Sola P, Salvi F, Bartolomei I, Siciliano G, Carlesi C, Orrell RW, Talbot K, Simmons Z, Connor J, Pioro EP, Dunkley T, Stephan DA, Kasperaviciute D, Fisher EM, Jabonka S, Sendtner M, Beck M, Bruijn L, Rothstein J, Schmidt S, Singleton A, Hardy J, Traynor BJ.

Hum Mol Genet. 2009 Apr 15;18(8):1524-32. doi: 10.1093/hmg/ddp059. Epub 2009 Feb 4.

13.

Determination of genuine residents of plant endomembrane organelles using isotope tagging and multivariate statistics.

Lilley KS, Dunkley TP.

Methods Mol Biol. 2008;432:373-87. doi: 10.1007/978-1-59745-028-7_25.

PMID:
18370031
14.

Quantitative proteomic approach to study subcellular localization of membrane proteins.

Sadowski PG, Dunkley TP, Shadforth IP, Dupree P, Bessant C, Griffin JL, Lilley KS.

Nat Protoc. 2006;1(4):1778-89.

PMID:
17487160
15.

Growth control of the eukaryote cell: a systems biology study in yeast.

Castrillo JI, Zeef LA, Hoyle DC, Zhang N, Hayes A, Gardner DC, Cornell MJ, Petty J, Hakes L, Wardleworth L, Rash B, Brown M, Dunn WB, Broadhurst D, O'Donoghue K, Hester SS, Dunkley TP, Hart SR, Swainston N, Li P, Gaskell SJ, Paton NW, Lilley KS, Kell DB, Oliver SG.

J Biol. 2007;6(2):4. doi: 10.1186/jbiol54.

16.

Mapping the Arabidopsis organelle proteome.

Dunkley TP, Hester S, Shadforth IP, Runions J, Weimar T, Hanton SL, Griffin JL, Bessant C, Brandizzi F, Hawes C, Watson RB, Dupree P, Lilley KS.

Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6518-23. Epub 2006 Apr 17.

17.

Practice patterns in haemophilia A therapy -- global progress towards optimal care.

Geraghty S, Dunkley T, Harrington C, Lindvall K, Maahs J, Sek J.

Haemophilia. 2006 Jan;12(1):75-81.

PMID:
16409179
18.

i-Tracker: for quantitative proteomics using iTRAQ.

Shadforth IP, Dunkley TP, Lilley KS, Bessant C.

BMC Genomics. 2005 Oct 20;6:145.

19.

Confident protein identification using the average peptide score method coupled with search-specific, ab initio thresholds.

Shadforth I, Dunkley T, Lilley K, Crowther D, Bessant C.

Rapid Commun Mass Spectrom. 2005;19(22):3363-8.

PMID:
16235224
20.

Localization of organelle proteins by isotope tagging (LOPIT).

Dunkley TP, Watson R, Griffin JL, Dupree P, Lilley KS.

Mol Cell Proteomics. 2004 Nov;3(11):1128-34. Epub 2004 Aug 4.

21.

The use of isotope-coded affinity tags (ICAT) to study organelle proteomes in Arabidopsis thaliana.

Dunkley TP, Dupree P, Watson RB, Lilley KS.

Biochem Soc Trans. 2004 Jun;32(Pt3):520-3. Review.

PMID:
15157176
22.

Bioelectrochemical signaling in green plants induced by photosensory systems.

Volkov AG, Dunkley TC, Morgan SA, Ruff D 2nd, Boyce YL, Labady AJ.

Bioelectrochemistry. 2004 Jun;63(1-2):91-4.

PMID:
15110254
23.

A systematic approach to modeling, capturing, and disseminating proteomics experimental data.

Taylor CF, Paton NW, Garwood KL, Kirby PD, Stead DA, Yin Z, Deutsch EW, Selway L, Walker J, Riba-Garcia I, Mohammed S, Deery MJ, Howard JA, Dunkley T, Aebersold R, Kell DB, Lilley KS, Roepstorff P, Yates JR 3rd, Brass A, Brown AJ, Cash P, Gaskell SJ, Hubbard SJ, Oliver SG.

Nat Biotechnol. 2003 Mar;21(3):247-54.

PMID:
12610571
24.

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