Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 25

1.

Toreforant, an orally active histamine H4-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study.

Boyle DL, DePrimo SE, Calderon C, Chen D, Dunford PJ, Barchuk W, Firestein GS, Thurmond RL.

Inflamm Res. 2019 Apr;68(4):261-274. doi: 10.1007/s00011-019-01218-y. Epub 2019 Feb 9.

PMID:
30739130
2.

Clinical Development of Histamine H4 Receptor Antagonists.

Thurmond RL, Venable J, Savall B, La D, Snook S, Dunford PJ, Edwards JP.

Handb Exp Pharmacol. 2017;241:301-320. doi: 10.1007/164_2016_130. Review.

PMID:
28233185
3.

The histamine H₄ receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects.

Kollmeier A, Francke K, Chen B, Dunford PJ, Greenspan AJ, Xia Y, Xu XL, Zhou B, Thurmond RL.

J Pharmacol Exp Ther. 2014 Jul;350(1):181-7. doi: 10.1124/jpet.114.215749. Epub 2014 May 9.

PMID:
24817035
4.

Clinical and preclinical characterization of the histamine H(4) receptor antagonist JNJ-39758979.

Thurmond RL, Chen B, Dunford PJ, Greenspan AJ, Karlsson L, La D, Ward P, Xu XL.

J Pharmacol Exp Ther. 2014 May;349(2):176-84. doi: 10.1124/jpet.113.211714. Epub 2014 Feb 18.

PMID:
24549371
5.

Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists.

Savall BM, Chavez F, Tays K, Dunford PJ, Cowden JM, Hack MD, Wolin RL, Thurmond RL, Edwards JP.

J Med Chem. 2014 Mar 27;57(6):2429-39. doi: 10.1021/jm401727m. Epub 2014 Feb 21.

PMID:
24495018
6.

The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis.

Cowden JM, Yu F, Banie H, Farahani M, Ling P, Nguyen S, Riley JP, Zhang M, Zhu J, Dunford PJ, Thurmond RL.

Ann Rheum Dis. 2014 Mar;73(3):600-8. doi: 10.1136/annrheumdis-2013-203832. Epub 2013 Oct 14.

7.

Antagonism of the histamine H4 receptor reduces LPS-induced TNF production in vivo.

Cowden JM, Yu F, Challapalli M, Huang JF, Kim S, Fung-Leung WP, Ma JY, Riley JP, Zhang M, Dunford PJ, Thurmond RL.

Inflamm Res. 2013 Jun;62(6):599-607. doi: 10.1007/s00011-013-0612-5. Epub 2013 Mar 27.

8.

Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines.

Cowden JM, Riley JP, Ma JY, Thurmond RL, Dunford PJ.

Respir Res. 2010 Jun 24;11:86. doi: 10.1186/1465-9921-11-86.

9.

Leukotriene A(4) hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness.

Rao NL, Riley JP, Banie H, Xue X, Sun B, Crawford S, Lundeen KA, Yu F, Karlsson L, Fourie AM, Dunford PJ.

Am J Respir Crit Care Med. 2010 May 1;181(9):899-907. doi: 10.1164/rccm.200807-1158OC. Epub 2010 Jan 28.

PMID:
20110560
10.

The role of histamine in asthma.

Dunford PJ, Holgate ST.

Adv Exp Med Biol. 2010;709:53-66. Review.

PMID:
21618887
11.

The histamine H4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation.

Cowden JM, Zhang M, Dunford PJ, Thurmond RL.

J Invest Dermatol. 2010 Apr;130(4):1023-33. doi: 10.1038/jid.2009.358. Epub 2009 Nov 12.

12.

Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.

Grice CA, Tays KL, Savall BM, Wei J, Butler CR, Axe FU, Bembenek SD, Fourie AM, Dunford PJ, Lundeen K, Coles F, Xue X, Riley JP, Williams KN, Karlsson L, Edwards JP.

J Med Chem. 2008 Jul 24;51(14):4150-69. doi: 10.1021/jm701575k. Epub 2008 Jun 28.

PMID:
18588282
13.

A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker.

Crawford S, Belajic D, Wei J, Riley JP, Dunford PJ, Bembenek S, Fourie A, Edwards JP, Karlsson L, Brunmark A, Wolin RL, Blevitt JM.

Mol Cancer Ther. 2008 Mar;7(3):492-9. doi: 10.1158/1535-7163.MCT-07-0307.

14.

The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines.

Thurmond RL, Gelfand EW, Dunford PJ.

Nat Rev Drug Discov. 2008 Jan;7(1):41-53. doi: 10.1038/nrd2465. Review.

PMID:
18172439
15.

Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase.

Whittle BJ, Varga C, Berko A, Horvath K, Posa A, Riley JP, Lundeen KA, Fourie AM, Dunford PJ.

Br J Pharmacol. 2008 Mar;153(5):983-91. Epub 2007 Dec 24.

16.

Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton.

Rao NL, Dunford PJ, Xue X, Jiang X, Lundeen KA, Coles F, Riley JP, Williams KN, Grice CA, Edwards JP, Karlsson L, Fourie AM.

J Pharmacol Exp Ther. 2007 Jun;321(3):1154-60. Epub 2007 Mar 19.

PMID:
17371808
17.

The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders.

Zhang M, Thurmond RL, Dunford PJ.

Pharmacol Ther. 2007 Mar;113(3):594-606. Epub 2006 Dec 28. Review.

PMID:
17275092
18.

Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus.

Dunford PJ, Williams KN, Desai PJ, Karlsson L, McQueen D, Thurmond RL.

J Allergy Clin Immunol. 2007 Jan;119(1):176-83. Epub 2006 Oct 13.

PMID:
17208599
19.

The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells.

Dunford PJ, O'Donnell N, Riley JP, Williams KN, Karlsson L, Thurmond RL.

J Immunol. 2006 Jun 1;176(11):7062-70.

20.

Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.

Venable JD, Cai H, Chai W, Dvorak CA, Grice CA, Jablonowski JA, Shah CR, Kwok AK, Ly KS, Pio B, Wei J, Desai PJ, Jiang W, Nguyen S, Ling P, Wilson SJ, Dunford PJ, Thurmond RL, Lovenberg TW, Karlsson L, Carruthers NI, Edwards JP.

J Med Chem. 2005 Dec 29;48(26):8289-98.

PMID:
16366610
21.

Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat.

Varga C, Horvath K, Berko A, Thurmond RL, Dunford PJ, Whittle BJ.

Eur J Pharmacol. 2005 Oct 17;522(1-3):130-8. Epub 2005 Oct 6.

PMID:
16213481
22.

A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties.

Thurmond RL, Desai PJ, Dunford PJ, Fung-Leung WP, Hofstra CL, Jiang W, Nguyen S, Riley JP, Sun S, Williams KN, Edwards JP, Karlsson L.

J Pharmacol Exp Ther. 2004 Apr;309(1):404-13. Epub 2004 Jan 13.

PMID:
14722321
23.

Rapid up-regulation of CXC chemokines in the airways after Ag-specific CD4+ T cell activation.

Knott PG, Gater PR, Dunford PJ, Fuentes ME, Bertrand CP.

J Immunol. 2001 Jan 15;166(2):1233-40.

24.

Inhibition of virus-encoded thymidine kinase suppresses herpes simplex virus replication in vitro and in vivo.

Watkins AM, Dunford PJ, Moffatt AM, Wong-Kai-In P, Holland MJ, Pole DS, Thomas GM, Martin J, Roberts NA, Mulqueen MJ.

Antivir Chem Chemother. 1998 Jan;9(1):9-18.

PMID:
9875372
25.

Pseudomonas aeruginosa mastitis due to contamination of an antibiotic preparation used in dry-cow therapy.

Anderson B, Barton M, Corbould A, Dunford PJ, Elliott J, Leis T, Nicholls TJ, Sharman M, Stephenson GM.

Aust Vet J. 1979 Feb;55(2):90-1. No abstract available.

PMID:
444169

Supplemental Content

Loading ...
Support Center