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Items: 43

1.

Genomic Analyses of PMBL Reveal New Drivers and Mechanisms of Sensitivity to PD-1 Blockade.

Chapuy B, Stewart C, Dunford AJ, Kim J, Wienand K, Kamburov A, Griffin GK, Chen PH, Lako A, Redd R, Cote CM, Ducar MD, Thorner AR, Rodig SJ, Getz G, Shipp MA.

Blood. 2019 Oct 28. pii: blood.2019002067. doi: 10.1182/blood.2019002067. [Epub ahead of print]

PMID:
31697821
2.

Vulval Pain in Pediatric and Adolescent Patients.

Dunford A, Rampal D, Kielly M, Grover SR.

J Pediatr Adolesc Gynecol. 2019 Aug;32(4):359-362. doi: 10.1016/j.jpag.2019.03.005. Epub 2019 Mar 26.

PMID:
30923024
3.

A (fire)cloud-based DNA methylation data preprocessing and quality control platform.

Kangeyan D, Dunford A, Iyer S, Stewart C, Hanna M, Getz G, Aryee MJ.

BMC Bioinformatics. 2019 Mar 29;20(1):160. doi: 10.1186/s12859-019-2750-4.

4.

Relationship between regional hepatic glucose metabolism and regional distribution of hepatic fat.

Dunford A, Keramida G, Singh N, Aplin M, Peters AM.

Nucl Med Commun. 2019 Mar;40(3):212-218. doi: 10.1097/MNM.0000000000000968.

PMID:
30628944
5.

Hepato-splenic axis: hepatic and splenic metabolic activities are linked.

Keramida G, Dunford A, Kaya G, Anagnostopoulos CD, Peters AM.

Am J Nucl Med Mol Imaging. 2018 Jun 5;8(3):228-238. eCollection 2018.

6.

Author Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes.

Chapuy B, Stewart C, Dunford AJ, Kim J, Kamburov A, Redd RA, Lawrence MS, Roemer MGM, Li AJ, Ziepert M, Staiger AM, Wala JA, Ducar MD, Leshchiner I, Rheinbay E, Taylor-Weiner A, Coughlin CA, Hess JM, Pedamallu CS, Livitz D, Rosebrock D, Rosenberg M, Tracy AA, Horn H, van Hummelen P, Feldman AL, Link BK, Novak AJ, Cerhan JR, Habermann TM, Siebert R, Rosenwald A, Thorner AR, Meyerson ML, Golub TR, Beroukhim R, Wulf GG, Ott G, Rodig SJ, Monti S, Neuberg DS, Loeffler M, Pfreundschuh M, Trümper L, Getz G, Shipp MA.

Nat Med. 2018 Aug;24(8):1290-1291. doi: 10.1038/s41591-018-0097-4.

PMID:
29955182
7.

Publisher Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes.

Chapuy B, Stewart C, Dunford AJ, Kim J, Kamburov A, Redd RA, Lawrence MS, Roemer MGM, Li AJ, Ziepert M, Staiger AM, Wala JA, Ducar MD, Leshchiner I, Rheinbay E, Taylor-Weiner A, Coughlin CA, Hess JM, Pedamallu CS, Livitz D, Rosebrock D, Rosenberg M, Tracy AA, Horn H, van Hummelen P, Feldman AL, Link BK, Novak AJ, Cerhan JR, Habermann TM, Siebert R, Rosenwald A, Thorner AR, Meyerson ML, Golub TR, Beroukhim R, Wulf GG, Ott G, Rodig SJ, Monti S, Neuberg DS, Loeffler M, Pfreundschuh M, Trümper L, Getz G, Shipp MA.

Nat Med. 2018 Aug;24(8):1292. doi: 10.1038/s41591-018-0098-3.

PMID:
29955181
8.

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes.

Chapuy B, Stewart C, Dunford AJ, Kim J, Kamburov A, Redd RA, Lawrence MS, Roemer MGM, Li AJ, Ziepert M, Staiger AM, Wala JA, Ducar MD, Leshchiner I, Rheinbay E, Taylor-Weiner A, Coughlin CA, Hess JM, Pedamallu CS, Livitz D, Rosebrock D, Rosenberg M, Tracy AA, Horn H, van Hummelen P, Feldman AL, Link BK, Novak AJ, Cerhan JR, Habermann TM, Siebert R, Rosenwald A, Thorner AR, Meyerson ML, Golub TR, Beroukhim R, Wulf GG, Ott G, Rodig SJ, Monti S, Neuberg DS, Loeffler M, Pfreundschuh M, Trümper L, Getz G, Shipp MA.

Nat Med. 2018 May;24(5):679-690. doi: 10.1038/s41591-018-0016-8. Epub 2018 Apr 30. Erratum in: Nat Med. 2018 Aug;24(8):1292. Nat Med. 2018 Aug;24(8):1290-1291.

9.

Spontaneous resolution of labial adhesions in pre-pubertal girls.

Norris JE, Elder CV, Dunford AM, Rampal D, Cheung C, Grover SR.

J Paediatr Child Health. 2018 Jul;54(7):748-753. doi: 10.1111/jpc.13847. Epub 2018 Feb 13.

PMID:
29436045
10.

Combination therapy with mifepristone and misoprostol for the management of first trimester miscarriage: Improved success.

Dunford A, Fyfe R.

Aust N Z J Obstet Gynaecol. 2018 Aug;58(4):438-442. doi: 10.1111/ajo.12747. Epub 2017 Nov 23.

PMID:
29168561
11.

Characterizing reduced coverage regions through comparison of exome and genome sequencing data across 10 centers.

Sanghvi RV, Buhay CJ, Powell BC, Tsai EA, Dorschner MO, Hong CS, Lebo MS, Sasson A, Hanna DS, McGee S, Bowling KM, Cooper GM, Gray DE, Lonigro RJ, Dunford A, Brennan CA, Cibulskis C, Walker K, Carneiro MO, Sailsbery J, Hindorff LA, Robinson DR, Santani A, Sarmady M, Rehm HL, Biesecker LG, Nickerson DA, Hutter CM, Garraway L, Muzny DM, Wagle N; NHGRI Clinical Sequencing Exploratory Research (CSER) Consortium.

Genet Med. 2018 Aug;20(8):855-866. doi: 10.1038/gim.2017.192. Epub 2017 Nov 16.

12.

Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma.

Pectasides E, Stachler MD, Derks S, Liu Y, Maron S, Islam M, Alpert L, Kwak H, Kindler H, Polite B, Sharma MR, Allen K, O'Day E, Lomnicki S, Maranto M, Kanteti R, Fitzpatrick C, Weber C, Setia N, Xiao SY, Hart J, Nagy RJ, Kim KM, Choi MG, Min BH, Nason KS, O'Keefe L, Watanabe M, Baba H, Lanman R, Agoston AT, Oh DJ, Dunford A, Thorner AR, Ducar MD, Wollison BM, Coleman HA, Ji Y, Posner MC, Roggin K, Turaga K, Chang P, Hogarth K, Siddiqui U, Gelrud A, Ha G, Freeman SS, Rhoades J, Reed S, Gydush G, Rotem D, Davison J, Imamura Y, Adalsteinsson V, Lee J, Bass AJ, Catenacci DV.

Cancer Discov. 2018 Jan;8(1):37-48. doi: 10.1158/2159-8290.CD-17-0395. Epub 2017 Oct 4.

13.

Maternal and paternal periconceptional nutrition as an indicator of offspring metabolic syndrome risk in later life through epigenetic imprinting: A systematic review.

Dunford AR, Sangster JM.

Diabetes Metab Syndr. 2017 Dec;11 Suppl 2:S655-S662. doi: 10.1016/j.dsx.2017.04.021. Epub 2017 May 10. Review.

PMID:
28533070
14.

Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers.

Cho SY, Park JW, Liu Y, Park YS, Kim JH, Yang H, Um H, Ko WR, Lee BI, Kwon SY, Ryu SW, Kwon CH, Park DY, Lee JH, Lee SI, Song KS, Hur H, Han SU, Chang H, Kim SJ, Kim BS, Yook JH, Yoo MW, Kim BS, Lee IS, Kook MC, Thiessen N, He A, Stewart C, Dunford A, Kim J, Shih J, Saksena G, Cherniack AD, Schumacher S, Weiner AT, Rosenberg M, Getz G, Yang EG, Ryu MH, Bass AJ, Kim HK.

Gastroenterology. 2017 Aug;153(2):536-549.e26. doi: 10.1053/j.gastro.2017.05.012. Epub 2017 May 15.

15.

The cardiosplenic axis: another obscure pathophysiological function of the spleen and its investigation using molecular imaging.

Dunford A, Keramida G, Anagnostopoulos CD, Michael Peters A.

Nucl Med Commun. 2017 Mar;38(3):205-208. doi: 10.1097/MNM.0000000000000635. Review.

PMID:
28009777
16.

Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias.

Dunford A, Weinstock DM, Savova V, Schumacher SE, Cleary JP, Yoda A, Sullivan TJ, Hess JM, Gimelbrant AA, Beroukhim R, Lawrence MS, Getz G, Lane AA.

Nat Genet. 2017 Jan;49(1):10-16. doi: 10.1038/ng.3726. Epub 2016 Nov 21.

17.

Relationships of body habitus and SUV indices with signal-to-noise ratio of hepatic (18)F-FDG PET.

Keramida G, Dunford A, Siddique M, Cook GJ, Peters AM.

Eur J Radiol. 2016 May;85(5):1012-5. doi: 10.1016/j.ejrad.2016.02.026. Epub 2016 Mar 3.

PMID:
27130064
18.

Targetable genetic features of primary testicular and primary central nervous system lymphomas.

Chapuy B, Roemer MG, Stewart C, Tan Y, Abo RP, Zhang L, Dunford AJ, Meredith DM, Thorner AR, Jordanova ES, Liu G, Feuerhake F, Ducar MD, Illerhaus G, Gusenleitner D, Linden EA, Sun HH, Homer H, Aono M, Pinkus GS, Ligon AH, Ligon KL, Ferry JA, Freeman GJ, van Hummelen P, Golub TR, Getz G, Rodig SJ, de Jong D, Monti S, Shipp MA.

Blood. 2016 Feb 18;127(7):869-81. doi: 10.1182/blood-2015-10-673236. Epub 2015 Dec 23.

19.

What makes a P450 tick?

Munro AW, Girvan HM, Mason AE, Dunford AJ, McLean KJ.

Trends Biochem Sci. 2013 Mar;38(3):140-50. doi: 10.1016/j.tibs.2012.11.006. Epub 2013 Jan 26. Review.

PMID:
23356956
20.

The crystal structure of the FAD/NADPH-binding domain of flavocytochrome P450 BM3.

Joyce MG, Ekanem IS, Roitel O, Dunford AJ, Neeli R, Girvan HM, Baker GJ, Curtis RA, Munro AW, Leys D.

FEBS J. 2012 May;279(9):1694-706. doi: 10.1111/j.1742-4658.2012.08544.x. Epub 2012 Mar 16.

21.

Seasonal variation of phenolic constituents and medicinal activities of Northern Labrador tea, Rhododendron tomentosum ssp. subarcticum, an Inuit and cree First Nations traditional medicine.

Black P, Saleem A, Dunford A, Guerrero-Analco J, Walshe-Roussel B, Haddad P, Cuerrier A, Arnason JT.

Planta Med. 2011 Sep;77(14):1655-62. doi: 10.1055/s-0030-1270968. Epub 2011 Apr 6.

PMID:
21472650
22.

Analysis of the oxidation of short chain alkynes by flavocytochrome P450 BM3.

Waltham TN, Girvan HM, Butler CF, Rigby SR, Dunford AJ, Holt RA, Munro AW.

Metallomics. 2011 Apr;3(4):369-78. doi: 10.1039/c1mt00004g. Epub 2011 Mar 23.

PMID:
21431175
23.

Flavocytochrome P450 BM3 mutant W1046A is a NADH-dependent fatty acid hydroxylase: implications for the mechanism of electron transfer in the P450 BM3 dimer.

Girvan HM, Dunford AJ, Neeli R, Ekanem IS, Waltham TN, Joyce MG, Leys D, Curtis RA, Williams P, Fisher K, Voice MW, Munro AW.

Arch Biochem Biophys. 2011 Mar 1;507(1):75-85. doi: 10.1016/j.abb.2010.09.014. Epub 2010 Sep 22.

PMID:
20868649
24.

Probing the molecular determinants of coenzyme selectivity in the P450 BM3 FAD/NADPH domain.

Dunford AJ, Girvan HM, Scrutton NS, Munro AW.

Biochim Biophys Acta. 2009 Aug;1794(8):1181-9. doi: 10.1016/j.bbapap.2009.03.014. Epub 2009 Apr 1.

PMID:
19344791
25.

Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv.

McLean KJ, Carroll P, Lewis DG, Dunford AJ, Seward HE, Neeli R, Cheesman MR, Marsollier L, Douglas P, Smith WE, Rosenkrands I, Cole ST, Leys D, Parish T, Munro AW.

J Biol Chem. 2008 Nov 28;283(48):33406-16. doi: 10.1074/jbc.M802115200. Epub 2008 Sep 24.

26.

Characterization of coenzyme binding and selectivity determinants in Mycobacterium tuberculosis flavoprotein reductase A: analysis of Arg(199) and Arg(200) mutants at the NADP(H) 2'-phosphate binding site.

Sabri M, Dunford AJ, McLean KJ, Neeli R, Scrutton NS, Leys D, Munro AW.

Biochem J. 2009 Jan 1;417(1):103-12. doi: 10.1042/BJ20080466.

PMID:
18767989
27.

Trp(359) regulates flavin thermodynamics and coenzyme selectivity in Mycobacterium tuberculosis FprA.

Neeli R, Sabri M, McLean KJ, Dunford AJ, Scrutton NS, Leys D, Munro AW.

Biochem J. 2008 May 1;411(3):563-70. doi: 10.1042/bj20071298.

PMID:
18237273
28.

Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1. Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium.

Dunford AJ, McLean KJ, Sabri M, Seward HE, Heyes DJ, Scrutton NS, Munro AW.

J Biol Chem. 2007 Aug 24;282(34):24816-24. Epub 2007 Jun 6.

29.

Structure, function and drug targeting in Mycobacterium tuberculosis cytochrome P450 systems.

McLean KJ, Dunford AJ, Neeli R, Driscoll MD, Munro AW.

Arch Biochem Biophys. 2007 Aug 15;464(2):228-40. Epub 2007 Apr 10. Review.

PMID:
17482138
30.

Conformational and thermodynamic control of electron transfer in neuronal nitric oxide synthase.

Dunford AJ, Rigby SE, Hay S, Munro AW, Scrutton NS.

Biochemistry. 2007 May 1;46(17):5018-29. Epub 2007 Apr 6.

PMID:
17411075
31.

CYP121, CYP51 and associated redox systems in Mycobacterium tuberculosis: towards deconvoluting enzymology of P450 systems in a human pathogen.

McLean KJ, Dunford AJ, Sabri M, Neeli R, Girvan HM, Balding PR, Leys D, Seward HE, Marshall KR, Munro AW.

Biochem Soc Trans. 2006 Dec;34(Pt 6):1178-82. Review.

PMID:
17073780
32.

Biodiversity of cytochrome P450 redox systems.

McLean KJ, Sabri M, Marshall KR, Lawson RJ, Lewis DG, Clift D, Balding PR, Dunford AJ, Warman AJ, McVey JP, Quinn AM, Sutcliffe MJ, Scrutton NS, Munro AW.

Biochem Soc Trans. 2005 Aug;33(Pt 4):796-801. Review.

PMID:
16042601
33.
34.

Binding sites of nitrogenase: kinetic and theoretical studies of cyanide binding to extracted FeMo-cofactor derivatives.

Cui Z, Dunford AJ, Durrant MC, Henderson RA, Smith BE.

Inorg Chem. 2003 Oct 6;42(20):6252-64.

PMID:
14514300
35.

The role of Mo atoms in nitrogen fixation: balancing substrate reduction and dihydrogen production.

Bell J, Dunford AJ, Hollis E, Henderson RA.

Angew Chem Int Ed Engl. 2003 Mar 10;42(10):1149-52. No abstract available.

PMID:
12640646
36.
37.

Ligand movement modulates the rate of proton transfer in reactions of [Fe4S4Cl4]2-.

Dunford AJ, Henderson RA.

Chem Commun (Camb). 2002 Feb 21;(4):360-1.

PMID:
12120074
38.
39.

A bridge across the no-man's land.

Dunford AP.

Br J Gen Pract. 1999 Apr;49(441):315. No abstract available.

40.

The role of the GP in the care of people with HIV and AIDS.

Dunford A.

Br J Gen Pract. 1998 Aug;48(433):1526-7. No abstract available.

41.

Useful plants.

Dunford A, Eldin S.

J R Soc Med. 1997 Mar;90(3):178-9. No abstract available.

42.

The ethics of NHS prescribing for private patients.

Dunford A.

Practitioner. 1989 Feb 22;233(1463):197. No abstract available.

PMID:
2587478
43.

The management of HIV symptomatic patients in general practice.

Dunford A.

Practitioner. 1988 Apr 22;232(1447):445-51. No abstract available.

PMID:
3249725

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