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The learning curve effect on outcomes with frozen elephant trunk technique for extensive thoracic aorta disease.

Dinato FJ, Dias RR, Duncan JA, Fernandes F, Ramires FJA, Mady C, Jatene FB.

J Card Surg. 2019 Sep;34(9):796-802. doi: 10.1111/jocs.14139. Epub 2019 Jul 3.


Experimental Human Infection with Neisseria gonorrhoeae.

Hobbs MM, Duncan JA.

Methods Mol Biol. 2019;1997:431-452. doi: 10.1007/978-1-4939-9496-0_25.


The potential of memory enhancement through modulation of perineuronal nets.

Duncan JA, Foster R, Kwok JCF.

Br J Pharmacol. 2019 Sep;176(18):3611-3621. doi: 10.1111/bph.14672. Epub 2019 May 20. Review.


Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon.

Li X, Deng M, Petrucelli AS, Zhu C, Mo J, Zhang L, Tam JW, Ariel P, Zhao B, Zhang S, Ke H, Li P, Dokholyan NV, Duncan JA, Ting JP.

Immunity. 2019 Mar 19;50(3):591-599.e6. doi: 10.1016/j.immuni.2019.02.009.


Human Immune Responses and the Natural History of Neisseria gonorrhoeae Infection.

Lovett A, Duncan JA.

Front Immunol. 2019 Feb 19;9:3187. doi: 10.3389/fimmu.2018.03187. eCollection 2018. Review.


RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner.

Zhang Y, Dittmer DP, Mieczkowski PA, Host KM, Fusco WG, Duncan JA, Damania B.

MBio. 2018 Jul 3;9(4). pii: e00823-18. doi: 10.1128/mBio.00823-18.


Properly folded and functional PorB from Neisseria gonorrhoeae inhibits dendritic cell stimulation of CD4+ T cell proliferation.

Zhu W, Tomberg J, Knilans KJ, Anderson JE, McKinnon KP, Sempowski GD, Nicholas RA, Duncan JA.

J Biol Chem. 2018 Jul 13;293(28):11218-11229. doi: 10.1074/jbc.RA117.001209. Epub 2018 May 11.


Novel aspects of the assembly and activation of inflammasomes with focus on the NLRC4 inflammasome.

Fusco WG, Duncan JA.

Int Immunol. 2018 Apr 25;30(5):183-193. doi: 10.1093/intimm/dxy009. Review.


A novel mesial temporal stereotactic coordinate system.

Miller KJ, Halpern CH, Sedrak MF, Duncan JA, Grant GA.

J Neurosurg. 2018 Jan 26;130(1):67-75. doi: 10.3171/2017.7.JNS162267.


CASSCF Calculations Reveal Competitive Chair (Pericyclic) and Boat (Pseudopericyclic) Transition States for the [3,3] Sigmatropic Rearrangement of Allyl Esters.

Kreiman HW, Batali ME, Jamieson CS, Lyon MA, Duncan JA.

J Org Chem. 2018 Feb 16;83(4):1717-1726. doi: 10.1021/acs.joc.7b02316. Epub 2018 Feb 2.


The NLRC4 Inflammasome.

Duncan JA, Canna SW.

Immunol Rev. 2018 Jan;281(1):115-123. doi: 10.1111/imr.12607. Review.


Hybrid Approach of Aortic Diseases: Zone 1 Delivery and Volumetric Analysis on the Descending Aorta.

Duncan JA, Dias RR, Dinato FJ, Fernandes F, Ramirez FJÁ, Mady C, Jatene FB.

Braz J Cardiovasc Surg. 2017 Sep-Oct;32(5):361-366. doi: 10.21470/1678-9741-2017-0040.


NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR.

Feng H, Lenarcic EM, Yamane D, Wauthier E, Mo J, Guo H, McGivern DR, González-López O, Misumi I, Reid LM, Whitmire JK, Ting JP, Duncan JA, Moorman NJ, Lemon SM.

Nat Immunol. 2017 Dec;18(12):1299-1309. doi: 10.1038/ni.3853. Epub 2017 Oct 2.


Two cases of the variant RHD*DAU5 allele associated with maternal alloanti-D.

Duncan JA, Nahirniak S, Onell R, Clarke G.

Immunohematology. 2017 Jun;33(2):60-63.


Neisseria gonorrhoeae Lytic Transglycosylases LtgA and LtgD Reduce Host Innate Immune Signaling through TLR2 and NOD2.

Knilans KJ, Hackett KT, Anderson JE, Weng C, Dillard JP, Duncan JA.

ACS Infect Dis. 2017 Sep 8;3(9):624-633. doi: 10.1021/acsinfecdis.6b00088. Epub 2017 Jun 21.


Does aortic valve repair in valve-sparing aortic root reconstruction compromise the longevity of the procedure?

Dias RR, Duncan JA, de Souza Dinato FJ, Araújo LL, Issa HMN, Fernandes F, Mady C, Jatene FB.

Clinics (Sao Paulo). 2017 Apr;72(4):207-212. doi: 10.6061/clinics/2017(04)03.


The impact of co-morbidity in childhood cystic fibrosis.

Duncan JA, Brown SMN.

Paediatr Respir Rev. 2018 Mar;26:13-15. doi: 10.1016/j.prrv.2017.03.009. Epub 2017 Mar 14. Review.


Inflammasome Activation Can Mediate Tissue-Specific Pathogenesis or Protection in Staphylococcus aureus Infection.

Melehani JH, Duncan JA.

Curr Top Microbiol Immunol. 2016;397:257-82. doi: 10.1007/978-3-319-41171-2_13. Review.


Answer to "Key points of reducing neurologic complications in frozen elephant trunk technique".

Dias RR, Duncan JA.

Rev Bras Cir Cardiovasc. 2015 Jul-Aug;30(4):506. doi: 10.5935/1678-9741.20150057. No abstract available.


NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.

Guo H, König R, Deng M, Riess M, Mo J, Zhang L, Petrucelli A, Yoh SM, Barefoot B, Samo M, Sempowski GD, Zhang A, Colberg-Poley AM, Feng H, Lemon SM, Liu Y, Zhang Y, Wen H, Zhang Z, Damania B, Tsao LC, Wang Q, Su L, Duncan JA, Chanda SK, Ting JP.

Cell Host Microbe. 2016 Apr 13;19(4):515-528. doi: 10.1016/j.chom.2016.03.001.


Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse.

Zhang Y, Sloan SA, Clarke LE, Caneda C, Plaza CA, Blumenthal PD, Vogel H, Steinberg GK, Edwards MS, Li G, Duncan JA 3rd, Cheshier SH, Shuer LM, Chang EF, Grant GA, Gephart MG, Barres BA.

Neuron. 2016 Jan 6;89(1):37-53. doi: 10.1016/j.neuron.2015.11.013. Epub 2015 Dec 10.


CASSCF Computational Study of Pseudopericyclic Character in Electrocyclic Rearrangements Involving Heteroatoms.

Bierzynski IR, Settle CA, Kreiman HW, Duncan JA.

J Org Chem. 2016 Jan 15;81(2):442-9. doi: 10.1021/acs.joc.5b02223. Epub 2015 Dec 24.


Surgery of the aortic root: should we go for the valve-sparing root reconstruction or the composite graft-valve replacement is still the first choice of treatment for these patients?

Lamana Fde A, Dias RR, Duncan JA, Faria LB, Malbouisson LM, Borges Lde F, Mady C, Jatene FB.

Rev Bras Cir Cardiovasc. 2015 Jul-Sep;30(3):343-52. doi: 10.5935/1678-9741.20150028.


Surgical treatment of complex aneurysms and thoracic aortic dissections with the Frozen Elephant Trunk technique.

Dias RR, Duncan JA, Vianna DS, de Faria LB, Fernandes F, Ramirez FJ, Mady C, Jatene FB.

Rev Bras Cir Cardiovasc. 2015 Mar-Apr;30(2):205-10. doi: 10.5935/1678-9741.20140119.


Development of Volunteer International Craniofacial Surgery Missions: The Komedyplast Protocol.

Taub PJ, Lin AY, Cladis FP, Baker SB, Gooden CK, Kumar A, Losee JE, Menard R, Starks R, Duncan JA, De Pawlikowski W, Cecchi AW, Weinzweig J.

J Craniofac Surg. 2015 Jun;26(4):1151-5. doi: 10.1097/SCS.0000000000001404. Review.


Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular.

Melehani JH, James DB, DuMont AL, Torres VJ, Duncan JA.

PLoS Pathog. 2015 Jun 12;11(6):e1004970. doi: 10.1371/journal.ppat.1004970. eCollection 2015 Jun.


A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury.

Whidbey C, Vornhagen J, Gendrin C, Boldenow E, Samson JM, Doering K, Ngo L, Ezekwe EA Jr, Gundlach JH, Elovitz MA, Liggitt D, Duncan JA, Adams Waldorf KM, Rajagopal L.

EMBO Mol Med. 2015 Apr;7(4):488-505. doi: 10.15252/emmm.201404883.


G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3.

Giguère PM, Gall BJ, Ezekwe EA Jr, Laroche G, Buckley BK, Kebaier C, Wilson JE, Ting JP, Siderovski DP, Duncan JA.

J Biol Chem. 2014 Nov 28;289(48):33245-57. doi: 10.1074/jbc.M114.578393. Epub 2014 Sep 30.


An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.

Canna SW, de Jesus AA, Gouni S, Brooks SR, Marrero B, Liu Y, DiMattia MA, Zaal KJ, Sanchez GA, Kim H, Chapelle D, Plass N, Huang Y, Villarino AV, Biancotto A, Fleisher TA, Duncan JA, O'Shea JJ, Benseler S, Grom A, Deng Z, Laxer RM, Goldbach-Mansky R.

Nat Genet. 2014 Oct;46(10):1140-6. doi: 10.1038/ng.3089. Epub 2014 Sep 14.


The 3M complex maintains microtubule and genome integrity.

Yan J, Yan F, Li Z, Sinnott B, Cappell KM, Yu Y, Mo J, Duncan JA, Chen X, Cormier-Daire V, Whitehurst AW, Xiong Y.

Mol Cell. 2014 Jun 5;54(5):791-804. doi: 10.1016/j.molcel.2014.03.047. Epub 2014 May 1.


NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.

Zhang L, Mo J, Swanson KV, Wen H, Petrucelli A, Gregory SM, Zhang Z, Schneider M, Jiang Y, Fitzgerald KA, Ouyang S, Liu ZJ, Damania B, Shu HB, Duncan JA, Ting JP.

Immunity. 2014 Mar 20;40(3):329-41. doi: 10.1016/j.immuni.2014.01.010. Epub 2014 Feb 20. Review.


Lipid A's structure mediates Neisseria gonorrhoeae fitness during experimental infection of mice and men.

Hobbs MM, Anderson JE, Balthazar JT, Kandler JL, Carlson RW, Ganguly J, Begum AA, Duncan JA, Lin JT, Sparling PF, Jerse AE, Shafer WM.

MBio. 2013 Nov 19;4(6):e00892-13. doi: 10.1128/mBio.00892-13.


Hexa-acylated lipid A is required for host inflammatory response to Neisseria gonorrhoeae in experimental gonorrhea.

Zhou X, Gao X, Broglie PM, Kebaier C, Anderson JE, Thom N, Apicella MA, Sempowski GD, Duncan JA.

Infect Immun. 2014 Jan;82(1):184-92. doi: 10.1128/IAI.00890-13. Epub 2013 Oct 14.


Assessing ATP binding and hydrolysis by NLR proteins.

Mo J, Duncan JA.

Methods Mol Biol. 2013;1040:153-68. doi: 10.1007/978-1-62703-523-1_12.


Act now against new NHS competition regulations: an open letter to the BMA and the Academy of Medical Royal Colleges calls on them to make a joint public statement of opposition to the amended section 75 regulations.

Davis J, Banks I, Wrigley D, Peedell C, Pollock A, McPherson K, McKee M, Irving WL, Crome P, Greenhalgh T, Holland W, Evans D, Maryon-Davis A, Smyth A, Fleming P, Coleman M, Sharp DJ, Whincup P, Logan S, Cook D, Moore R, Rawaf S, McEewen J, West R, Yudkin JS, Clarke A, Finer N, Domizio P, Bambra C, Jones A, Feder G, Scott-Samuel A, Irvine L, Sharma A, Fitchett M, Boomla K, Folb J, Paul A, McCoy D, Tallis R, Burgess-Allen J, Edwards M, Tomlinson J, Colvin D, Gore J, Brown K, Mitchel S, Lau A, Sayer M, Clark L, Silverman R, Marmot S, Rainbow D, Carter L, Mann N, Fielding R, Logan J, Tebboth L, Arnold N, Stobbart K, Cabot K, Finer S, Edwards M, Davies D, Buttivant H, Kraemer S, Newell J, Griffiths A, Fitzgerald R, Macgibbon R, Lee A, Macklon AF, Hobson E, Jenner D, Jacobson B, Timmis A, Salim A, Evans-Jones J, Caan W, Awsare N, Pride N, Suckling R, Bratty C, Rossiter B, Hawkins D, Currie J, Camilleri-Ferrante C, Fluxman J, Bhatti O, Anson J, Etherington R, Lawrence D, Fell H, Clarke E, Ormerod J, Ormerod O, Ireland M, Duncan JA, Chandy R, Mindell J, Mullen P, Bennett-Richards P, Hirst J, Murphy E, Martin P, Lowes S, Fleming P, Grunewald R, Reeve J, Schweiger M, Coates J, Farrelly G, Chamberlain MA, Lewis G, Young J, Scott B, Gibbs J, Landers A, Deveson P, Ingrams G, Leigh M, Gawler J, Ford A, Nixon J, McCartney M, Bareford D, Singh S, Lockwood K, Cripwell M, Ehrhardt P, Bell D, Wortley P, Tomlinson L, Hotchkiss J, Ford S, Turner G, Reissman G, Lewis D, Johnstone C, Tomson M, Torabi P, Bell D, Tomson D, Tulloch A, Johnston S, Dickinson J, McElderry E, Ross W, Holt K, Logan M, Klonin H, Jenner D, Danby J, Goodger V, Puntis J, Dickson H, Gould DA, Livingstone A, Lefevre D, Kendall B, Singh G, Hall P, Darling J, Hamlyn AN, Patel A, Erskine J, Fisher B, Hughes R, Highton C, Venning H, Singer R, Brearey S, Sikorski J, Paintin D, Feehally J, Savage W, Freud KM, Holt VJ, Gill A, Waterston T, Souza Rd, Hopkinson N, Beadsworth M, Franks A, Daley H, Cullinan P, Basarab A, Folb J, Gurling H, Zinkin P, Kirwin S, Buhrs E, Brown R, West A, Marlowe G, Fellows G, Main J, Applebee J, Koperski M, Jones P, Macfarlane A, Beer N, Mason R, West R, Eisner M, Smailes A, Timms P, Knight D, Jones C, Wesby B, Lyttelton L, Morrison R, Bossano D, Walker J, Davies G, Godfrey P, Wolfe I, Nsutebu E, Stevenson N, Cheeroth S, Miller J, Johnson G, Noor R, Hall A, Bostock D, Michael B, Sharvill J, Macpherson J, Lewis D, Ma R, Middleton J, Jeffreys A, Cole J, Boswell JP, Bury B, Mitchison S, Kinmonth AL, Young G, Maclennan I, Munday P.

BMJ. 2013 Mar 20;346:f1819. doi: 10.1136/bmj.f1819. No abstract available.


Staphylococcus aureus Panton-Valentine leukocidin induces an inflammatory response in human phagocytes via the NLRP3 inflammasome.

Holzinger D, Gieldon L, Mysore V, Nippe N, Taxman DJ, Duncan JA, Broglie PM, Marketon K, Austermann J, Vogl T, Foell D, Niemann S, Peters G, Roth J, Löffler B.

J Leukoc Biol. 2012 Nov;92(5):1069-81. doi: 10.1189/jlb.0112014. Epub 2012 Aug 14.


Neisseria gonorrhoeae suppresses dendritic cell-induced, antigen-dependent CD4 T cell proliferation.

Zhu W, Ventevogel MS, Knilans KJ, Anderson JE, Oldach LM, McKinnon KP, Hobbs MM, Sempowski GD, Duncan JA.

PLoS One. 2012;7(7):e41260. doi: 10.1371/journal.pone.0041260. Epub 2012 Jul 23.


Porphyromonas gingivalis mediates inflammasome repression in polymicrobial cultures through a novel mechanism involving reduced endocytosis.

Taxman DJ, Swanson KV, Broglie PM, Wen H, Holley-Guthrie E, Huang MT, Callaway JB, Eitas TK, Duncan JA, Ting JP.

J Biol Chem. 2012 Sep 21;287(39):32791-9. Epub 2012 Jul 26.


Regulation of the subcellular localization of the G-protein subunit regulator GPSM3 through direct association with 14-3-3 protein.

Giguère PM, Laroche G, Oestreich EA, Duncan JA, Siderovski DP.

J Biol Chem. 2012 Sep 7;287(37):31270-9. doi: 10.1074/jbc.M112.394379. Epub 2012 Jul 26.


Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP.

Mo J, Boyle JP, Howard CB, Monie TP, Davis BK, Duncan JA.

J Biol Chem. 2012 Jun 29;287(27):23057-67. doi: 10.1074/jbc.M112.344283. Epub 2012 May 1.


Staphylococcus aureus α-hemolysin mediates virulence in a murine model of severe pneumonia through activation of the NLRP3 inflammasome.

Kebaier C, Chamberland RR, Allen IC, Gao X, Broglie PM, Hall JD, Jania C, Doerschuk CM, Tilley SL, Duncan JA.

J Infect Dis. 2012 Mar 1;205(5):807-17. doi: 10.1093/infdis/jir846. Epub 2012 Jan 25.


Cutting edge: NLRC5-dependent activation of the inflammasome.

Davis BK, Roberts RA, Huang MT, Willingham SB, Conti BJ, Brickey WJ, Barker BR, Kwan M, Taxman DJ, Accavitti-Loper MA, Duncan JA, Ting JP.

J Immunol. 2011 Feb 1;186(3):1333-7. doi: 10.4049/jimmunol.1003111. Epub 2010 Dec 29.


Scar-improving efficacy of avotermin administered into the wound margins of skin incisions as evaluated by a randomized, double-blind, placebo-controlled, phase II clinical trial.

Bush J, Duncan JA, Bond JS, Durani P, So K, Mason T, O'Kane S, Ferguson MW.

Plast Reconstr Surg. 2010 Nov;126(5):1604-15. doi: 10.1097/PRS.0b013e3181ef8e66.


CASSCF molecular orbital calculations reveal a purely pseudopericyclic mechanism for a [3,3] sigmatropic rearrangement.

Forte L, Lafortune MC, Bierzynski IR, Duncan JA.

J Am Chem Soc. 2010 Feb 24;132(7):2196-201. doi: 10.1021/ja906679g.


How the noninflammasome NLRs function in the innate immune system.

Ting JP, Duncan JA, Lei Y.

Science. 2010 Jan 15;327(5963):286-90. doi: 10.1126/science.1184004. Review.


Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells.

Craven RR, Gao X, Allen IC, Gris D, Bubeck Wardenburg J, McElvania-Tekippe E, Ting JP, Duncan JA.

PLoS One. 2009 Oct 14;4(10):e7446. doi: 10.1371/journal.pone.0007446.


NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways.

Willingham SB, Allen IC, Bergstralh DT, Brickey WJ, Huang MT, Taxman DJ, Duncan JA, Ting JP.

J Immunol. 2009 Aug 1;183(3):2008-15. doi: 10.4049/jimmunol.0900138. Epub 2009 Jul 8.


Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome.

Duncan JA, Gao X, Huang MT, O'Connor BP, Thomas CE, Willingham SB, Bergstralh DT, Jarvis GA, Sparling PF, Ting JP.

J Immunol. 2009 May 15;182(10):6460-9. doi: 10.4049/jimmunol.0802696.


The Vermedx Diabetes Information System reduces healthcare utilization.

Littenberg B, MacLean CD, Zygarowski K, Drapola BH, Duncan JA, Frank CR.

Am J Manag Care. 2009 Mar;15(3):166-70.

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