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Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function.

Kurniawan H, Franchina DG, Guerra L, Bonetti L, -Baguet LS, Grusdat M, Schlicker L, Hunewald O, Dostert C, Merz MP, Binsfeld C, Duncan GS, Farinelle S, Nonnenmacher Y, Haight J, Das Gupta D, Ewen A, Taskesen R, Halder R, Chen Y, Jäger C, Ollert M, Wilmes P, Vasiliou V, Harris IS, Knobbe-Thomsen CB, Turner JD, Mak TW, Lohoff M, Meiser J, Hiller K, Brenner D.

Cell Metab. 2020 Mar 16. pii: S1550-4131(20)30119-4. doi: 10.1016/j.cmet.2020.03.004. [Epub ahead of print]


Choline acetyltransferase-expressing T cells are required to control chronic viral infection.

Cox MA, Duncan GS, Lin GHY, Steinberg BE, Yu LX, Brenner D, Buckler LN, Elia AJ, Wakeham AC, Nieman B, Dominguez-Brauer C, Elford AR, Gill KT, Kubli SP, Haight J, Berger T, Ohashi PS, Tracey KJ, Olofsson PS, Mak TW.

Science. 2019 Feb 8;363(6427):639-644. doi: 10.1126/science.aau9072.


Glutathione Primes T Cell Metabolism for Inflammation.

Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D.

Immunity. 2017 Jun 20;46(6):1089-1090. doi: 10.1016/j.immuni.2017.06.009. No abstract available.


Glutathione Primes T Cell Metabolism for Inflammation.

Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D.

Immunity. 2017 Apr 18;46(4):675-689. doi: 10.1016/j.immuni.2017.03.019. Erratum in: Immunity. 2017 Jun 20;46(6):1089-1090.


K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression.

Hao Z, Sheng Y, Duncan GS, Li WY, Dominguez C, Sylvester J, Su YW, Lin GH, Snow BE, Brenner D, You-Ten A, Haight J, Inoue S, Wakeham A, Elford A, Hamilton S, Liang Y, Zúñiga-Pflücker JC, He HH, Ohashi PS, Mak TW.

Nat Commun. 2017 Jan 13;8:14003. doi: 10.1038/ncomms14003.


Lay members in the Royal Colleges: stricter guidelines needed to clarify public representation.

Bath MF, Duncan GS, Gokani VJ.

J Health Serv Res Policy. 2017 Jan;22(1):1-2. doi: 10.1177/1355819616671764. Epub 2016 Oct 14. No abstract available.


Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A.

Li Y, Shi Y, McCaw L, Li YJ, Zhu F, Gorczynski R, Duncan GS, Yang B, Ben-David Y, Spaner DE.

Blood. 2015 Aug 6;126(6):766-78. doi: 10.1182/blood-2014-12-618678. Epub 2015 Jun 3.


Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.

Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio II, Afzal S, Cairns RA, Cescon DW, Elford AR, Ye J, Lang PA, Li WY, Wakeham A, Duncan GS, Haight J, You-Ten A, Snow B, Yamamoto K, Ohashi PS, Mak TW.

Cell Death Differ. 2015 Nov;22(11):1837-45. doi: 10.1038/cdd.2015.38. Epub 2015 Apr 17.


Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection.

Lang PA, Meryk A, Pandyra AA, Brenner D, Brüstle A, Xu HC, Merches K, Lang F, Khairnar V, Sharma P, Funkner P, Recher M, Shaabani N, Duncan GS, Duhan V, Homey B, Ohashi PS, Häussinger D, Knolle PA, Honke N, Mak TW, Lang KS.

Cell Death Differ. 2015 Jan;22(1):164-73. doi: 10.1038/cdd.2014.138. Epub 2014 Sep 26.


Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells.

Brenner D, Brüstle A, Lin GH, Lang PA, Duncan GS, Knobbe-Thomsen CB, St Paul M, Reardon C, Tusche MW, Snow B, Hamilton SR, Pfefferle A, Gilani SO, Ohashi PS, Lang KS, Mak TW.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1060-5. doi: 10.1073/pnas.1323166111. Epub 2014 Jan 7.


Lymphocyte-derived ACh regulates local innate but not adaptive immunity.

Reardon C, Duncan GS, Brüstle A, Brenner D, Tusche MW, Olofsson PS, Rosas-Ballina M, Tracey KJ, Mak TW.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1410-5. doi: 10.1073/pnas.1221655110. Epub 2013 Jan 7. Erratum in: Proc Natl Acad Sci U S A.. Olofsson, Peder [corrected to Olofsson, Peder S].


2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation.

Duncan GS, Brenner D, Tusche MW, Brüstle A, Knobbe CB, Elia AJ, Mock T, Bray MR, Krammer PH, Mak TW.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21034-9. doi: 10.1073/pnas.1215558110. Epub 2012 Dec 3.


The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.

Hao Z, Duncan GS, Su YW, Li WY, Silvester J, Hong C, You H, Brenner D, Gorrini C, Haight J, Wakeham A, You-Ten A, McCracken S, Elia A, Li Q, Detmar J, Jurisicova A, Hobeika E, Reth M, Sheng Y, Lang PA, Ohashi PS, Zhong Q, Wang X, Mak TW.

J Exp Med. 2012 Jan 16;209(1):173-86. doi: 10.1084/jem.20111363. Epub 2012 Jan 2.


Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription.

Hayashi H, Kohno T, Yasui K, Murota H, Kimura T, Duncan GS, Nakashima T, Yamamoto K, Katayama I, Ma Y, Chua KJ, Suematsu T, Shimokawa I, Akira S, Kubo Y, Mak TW, Matsuyama T.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18766-71. doi: 10.1073/pnas.1116273108. Epub 2011 Oct 31.


14-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1.

Su YW, Hao Z, Hirao A, Yamamoto K, Lin WJ, Young A, Duncan GS, Yoshida H, Wakeham A, Lang PA, Murakami K, Hermeking H, Vogelstein B, Ohashi P, Mak TW.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1555-60. doi: 10.1073/pnas.1017729108. Epub 2011 Jan 4. Erratum in: Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6689. Hermeking, Heiko [added]; Vogelstein, Bert [added]. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15849.


Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo.

Kamizono S, Duncan GS, Seidel MG, Morimoto A, Hamada K, Grosveld G, Akashi K, Lind EF, Haight JP, Ohashi PS, Look AT, Mak TW.

J Exp Med. 2009 Dec 21;206(13):2977-86. doi: 10.1084/jem.20092176. Epub 2009 Dec 7.


Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis.

Hao Z, Duncan GS, Seagal J, Su YW, Hong C, Haight J, Chen NJ, Elia A, Wakeham A, Li WY, Liepa J, Wood GA, Casola S, Rajewsky K, Mak TW.

Immunity. 2008 Oct 17;29(4):615-27. doi: 10.1016/j.immuni.2008.07.016. Epub 2008 Oct 2.


CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation.

Dufner A, Duncan GS, Wakeham A, Elford AR, Hall HT, Ohashi PS, Mak TW.

Mol Cell Biol. 2008 Mar;28(5):1541-52. Epub 2007 Dec 26.


Generation and characterization of B7-H4/B7S1/B7x-deficient mice.

Suh WK, Wang S, Duncan GS, Miyazaki Y, Cates E, Walker T, Gajewska BU, Deenick E, Dawicki W, Okada H, Wakeham A, Itie A, Watts TH, Ohashi PS, Jordana M, Yoshida H, Mak TW.

Mol Cell Biol. 2006 Sep;26(17):6403-11.


Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury.

Berger T, Togawa A, Duncan GS, Elia AJ, You-Ten A, Wakeham A, Fong HE, Cheung CC, Mak TW.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1834-9. Epub 2006 Jan 30.


Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation.

Smookler DS, Mohammed FF, Kassiri Z, Duncan GS, Mak TW, Khokha R.

J Immunol. 2006 Jan 15;176(2):721-5.


Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis.

Hao Z, Duncan GS, Chang CC, Elia A, Fang M, Wakeham A, Okada H, Calzascia T, Jang Y, You-Ten A, Yeh WC, Ohashi P, Wang X, Mak TW.

Cell. 2005 May 20;121(4):579-591. doi: 10.1016/j.cell.2005.03.016.


Enhanced TCR-induced apoptosis in interferon regulatory factor 4-deficient CD4(+) Th cells.

Lohoff M, Mittrücker HW, Brüstle A, Sommer F, Casper B, Huber M, Ferrick DA, Duncan GS, Mak TW.

J Exp Med. 2004 Jul 19;200(2):247-53. Epub 2004 Jul 12.


The inducible costimulator plays the major costimulatory role in humoral immune responses in the absence of CD28.

Suh WK, Tafuri A, Berg-Brown NN, Shahinian A, Plyte S, Duncan GS, Okada H, Wakeham A, Odermatt B, Ohashi PS, Mak TW.

J Immunol. 2004 May 15;172(10):5917-23.


Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death.

Okada H, Bakal C, Shahinian A, Elia A, Wakeham A, Suh WK, Duncan GS, Ciofani M, Rottapel R, Zúñiga-Pflücker JC, Mak TW.

J Exp Med. 2004 Feb 2;199(3):399-410.


Differential requirement for Malt1 in T and B cell antigen receptor signaling.

Ruland J, Duncan GS, Wakeham A, Mak TW.

Immunity. 2003 Nov;19(5):749-58.


Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity.

Woo M, Hakem R, Furlonger C, Hakem A, Duncan GS, Sasaki T, Bouchard D, Lu L, Wu GE, Paige CJ, Mak TW.

Nat Immunol. 2003 Oct;4(10):1016-22. Epub 2003 Sep 14.


The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses.

Suh WK, Gajewska BU, Okada H, Gronski MA, Bertram EM, Dawicki W, Duncan GS, Bukczynski J, Plyte S, Elia A, Wakeham A, Itie A, Chung S, Da Costa J, Arya S, Horan T, Campbell P, Gaida K, Ohashi PS, Watts TH, Yoshinaga SK, Bray MR, Jordana M, Mak TW.

Nat Immunol. 2003 Sep;4(9):899-906. Epub 2003 Aug 17.


Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4.

Lohoff M, Mittrücker HW, Prechtl S, Bischof S, Sommer F, Kock S, Ferrick DA, Duncan GS, Gessner A, Mak TW.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11808-12. Epub 2002 Aug 20.


Generation and characterization of Smac/DIABLO-deficient mice.

Okada H, Suh WK, Jin J, Woo M, Du C, Elia A, Duncan GS, Wakeham A, Itie A, Lowe SW, Wang X, Mak TW.

Mol Cell Biol. 2002 May;22(10):3509-17.


Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.

Suzuki N, Suzuki S, Duncan GS, Millar DG, Wada T, Mirtsos C, Takada H, Wakeham A, Itie A, Li S, Penninger JM, Wesche H, Ohashi PS, Mak TW, Yeh WC.

Nature. 2002 Apr 18;416(6882):750-6. Epub 2002 Mar 31.


Brca1 required for T cell lineage development but not TCR loci rearrangement.

Mak TW, Hakem A, McPherson JP, Shehabeldin A, Zablocki E, Migon E, Duncan GS, Bouchard D, Wakeham A, Cheung A, Karaskova J, Sarosi I, Squire J, Marth J, Hakem R.

Nat Immunol. 2000 Jul;1(1):77-82.


Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure.

Ruland J, Duncan GS, Elia A, del Barco Barrantes I, Nguyen L, Plyte S, Millar DG, Bouchard D, Wakeham A, Ohashi PS, Mak TW.

Cell. 2001 Jan 12;104(1):33-42.


Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells.

Lohoff M, Duncan GS, Ferrick D, Mittrücker HW, Bischof S, Prechtl S, Röllinghoff M, Schmitt E, Pahl A, Mak TW.

J Exp Med. 2000 Aug 7;192(3):325-36.


In vivo evidence that caspase-3 is required for Fas-mediated apoptosis of hepatocytes.

Woo M, Hakem A, Elia AJ, Hakem R, Duncan GS, Patterson BJ, Mak TW.

J Immunol. 1999 Nov 1;163(9):4909-16.


TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses.

Nguyen LT, Duncan GS, Mirtsos C, Ng M, Speiser DE, Shahinian A, Marino MW, Mak TW, Ohashi PS, Yeh WC.

Immunity. 1999 Sep;11(3):379-89.


TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.

Lomaga MA, Yeh WC, Sarosi I, Duncan GS, Furlonger C, Ho A, Morony S, Capparelli C, Van G, Kaufman S, van der Heiden A, Itie A, Wakeham A, Khoo W, Sasaki T, Cao Z, Penninger JM, Paige CJ, Lacey DL, Dunstan CR, Boyle WJ, Goeddel DV, Mak TW.

Genes Dev. 1999 Apr 15;13(8):1015-24.


Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions.

Duncan GS, Andrew DP, Takimoto H, Kaufman SA, Yoshida H, Spellberg J, de la Pompa JL, Elia A, Wakeham A, Karan-Tamir B, Muller WA, Senaldi G, Zukowski MM, Mak TW.

J Immunol. 1999 Mar 1;162(5):3022-30.


Differential requirement for caspase 9 in apoptotic pathways in vivo.

Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, Soengas MS, Elia A, de la Pompa JL, Kagi D, Khoo W, Potter J, Yoshida R, Kaufman SA, Lowe SW, Penninger JM, Mak TW.

Cell. 1998 Aug 7;94(3):339-52.


Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes.

Woo M, Hakem R, Soengas MS, Duncan GS, Shahinian A, Kägi D, Hakem A, McCurrach M, Khoo W, Kaufman SA, Senaldi G, Howard T, Lowe SW, Mak TW.

Genes Dev. 1998 Mar 15;12(6):806-19.


iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1.

Bachmaier K, Neu N, Pummerer C, Duncan GS, Mak TW, Matsuyama T, Penninger JM.

Circulation. 1997 Jul 15;96(2):585-91.


Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo.

Lohoff M, Ferrick D, Mittrucker HW, Duncan GS, Bischof S, Rollinghoff M, Mak TW.

Immunity. 1997 Jun;6(6):681-9.


The transcription factor interferon regulatory factor-1 is essential for natural killer cell function in vivo.

Duncan GS, Mittrücker HW, Kägi D, Matsuyama T, Mak TW.

J Exp Med. 1996 Nov 1;184(5):2043-8.


Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4.

Marengère LE, Waterhouse P, Duncan GS, Mittrücker HW, Feng GS, Mak TW.

Science. 1996 May 24;272(5265):1170-3. Erratum in: Science 1996 Dec 6;274(5293)1597. Science 1997 Apr 4;276(5309):21.


Imaging inflammation with 99Tcm-labeled chemotactic peptides: analogues with reduced neutropenia.

Pollak A, Goodbody AE, Ballinger JR, Duncan GS, Tran LL, Dunn-Dufault R, Meghji K, Lau F, Andrey TW, Boxen I, Sumner-Smith M.

Nucl Med Commun. 1996 Feb;17(2):132-9.


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