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Items: 1 to 50 of 223

1.

Clonal expansion and compartmentalized maintenance of rhesus macaque NK cell subsets.

Wu C, Espinoza DA, Koelle SJ, Yang D, Truitt L, Schlums H, Lafont BA, Davidson-Moncada JK, Lu R, Kaur A, Hammer Q, Li B, Panch S, Allan DA, Donahue RE, Childs RW, Romagnani C, Bryceson YT, Dunbar CE.

Sci Immunol. 2018 Nov 2;3(29). pii: eaat9781. doi: 10.1126/sciimmunol.aat9781.

PMID:
30389798
2.

An Introduction to the Analysis of Single-Cell RNA-Sequencing Data.

AlJanahi AA, Danielsen M, Dunbar CE.

Mol Ther Methods Clin Dev. 2018 Aug 2;10:189-196. doi: 10.1016/j.omtm.2018.07.003. eCollection 2018 Sep 21. Review.

3.

Bone Marrow as a Source of Cells for Paroxysmal Nocturnal Hemoglobinuria Detection.

Dulau-Florea AE, Young NS, Maric I, Calvo KR, Dunbar CE, Townsley DM, Winkler T, Monreal M, Jiang C, Jordan EK, Braylan RC.

Am J Clin Pathol. 2018 Jul 5. doi: 10.1093/ajcp/aqy053. [Epub ahead of print]

PMID:
29982419
4.

Genotoxic Lemons Become Epigenomic Lemonade.

Cordes SF, Dunbar CE.

Cell Stem Cell. 2018 Jul 5;23(1):9-10. doi: 10.1016/j.stem.2018.06.007.

PMID:
29979994
5.

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.

Kim MY, Yu KR, Kenderian SS, Ruella M, Chen S, Shin TH, Aljanahi AA, Schreeder D, Klichinsky M, Shestova O, Kozlowski MS, Cummins KD, Shan X, Shestov M, Bagg A, Morrissette JJD, Sekhri P, Lazzarotto CR, Calvo KR, Kuhns DB, Donahue RE, Behbehani GK, Tsai SQ, Dunbar CE, Gill S.

Cell. 2018 May 31;173(6):1439-1453.e19. doi: 10.1016/j.cell.2018.05.013. Epub 2018 May 31.

PMID:
29856956
6.

Dexpramipexole as an oral steroid-sparing agent in hypereosinophilic syndromes.

Panch SR, Bozik ME, Brown T, Makiya M, Prussin C, Archibald DG, Hebrank GT, Sullivan M, Sun X, Wetzler L, Ware J, Fay MP, Dunbar CE, Dworetzky SI, Khoury P, Maric I, Klion AD.

Blood. 2018 Aug 2;132(5):501-509. doi: 10.1182/blood-2018-02-835330. Epub 2018 May 8. Erratum in: Blood. 2018 Sep 27;132(13):1461.

PMID:
29739754
7.

Efficient differentiation of cardiomyocytes and generation of calcium-sensor reporter lines from nonhuman primate iPSCs.

Lin Y, Liu H, Klein M, Ostrominski J, Hong SG, Yada RC, Chen G, Navarengom K, Schwartzbeck R, San H, Yu ZX, Liu C, Linask K, Beers J, Qiu L, Dunbar CE, Boehm M, Zou J.

Sci Rep. 2018 Apr 12;8(1):5907. doi: 10.1038/s41598-018-24074-y.

8.

Eltrombopag mobilizes iron in patients with aplastic anemia.

Zhao Z, Sun Q, Sokoll LJ, Streiff M, Cheng Z, Grasmeder S, Townsley DM, Young NS, Dunbar CE, Winkler T.

Blood. 2018 May 24;131(21):2399-2402. doi: 10.1182/blood-2018-01-826784. Epub 2018 Apr 9. No abstract available. Erratum in: Blood. 2018 Jul 26;132(4):459.

PMID:
29632023
9.

Gene therapy comes of age.

Dunbar CE, High KA, Joung JK, Kohn DB, Ozawa K, Sadelain M.

Science. 2018 Jan 12;359(6372). pii: eaan4672. doi: 10.1126/science.aan4672. Review.

PMID:
29326244
10.

The impact of aging on primate hematopoiesis as interrogated by clonal tracking.

Yu KR, Espinoza DA, Wu C, Truitt L, Shin TH, Chen S, Fan X, Yabe IM, Panch S, Hong SG, Koelle S, Lu R, Bonifacino A, Krouse A, Metzger M, Donahue RE, Dunbar CE.

Blood. 2018 Mar 15;131(11):1195-1205. doi: 10.1182/blood-2017-08-802033. Epub 2018 Jan 2.

PMID:
29295845
11.

Geographic clonal tracking in macaques provides insights into HSPC migration and differentiation.

Wu C, Espinoza DA, Koelle SJ, Potter EL, Lu R, Li B, Yang D, Fan X, Donahue RE, Roederer M, Dunbar CE.

J Exp Med. 2018 Jan 2;215(1):217-232. doi: 10.1084/jem.20171341. Epub 2017 Nov 15.

12.

CRISPR/Cas9-Based Safe-Harbor Gene Editing in Rhesus iPSCs.

Yada RC, Ostrominski JW, Tunc I, Hong SG, Zou J, Dunbar CE.

Curr Protoc Stem Cell Biol. 2017 Nov 15;43:5A.11.1-5A.11.14. doi: 10.1002/cpsc.37.

13.

Persistent elevation of plasma thrombopoietin levels after treatment in severe aplastic anemia.

Zhao X, Feng X, Wu Z, Winkler T, Desmond R, Olnes M, Dumitriu B, Townsley DM, Dunbar CE, Young NS.

Exp Hematol. 2018 Feb;58:39-43. doi: 10.1016/j.exphem.2017.09.006. Epub 2017 Sep 20.

14.

Transcriptome analysis reveals similarities between human blood CD3- CD56bright cells and mouse CD127+ innate lymphoid cells.

Allan DSJ, Cerdeira AS, Ranjan A, Kirkham CL, Aguilar OA, Tanaka M, Childs RW, Dunbar CE, Strominger JL, Kopcow HD, Carlyle JR.

Sci Rep. 2017 Jun 14;7(1):3501. doi: 10.1038/s41598-017-03256-0.

15.

Rhesus Macaque iPSC Generation and Maintenance.

Yada RC, Hong SG, Lin Y, Winkler T, Dunbar CE.

Curr Protoc Stem Cell Biol. 2017 May 16;41:4A.11.1-4A.11.13. doi: 10.1002/cpsc.25.

16.

Two Decades of ASGCT: Dreams Become Reality.

Dunbar CE.

Mol Ther. 2017 May 3;25(5):1057-1058. doi: 10.1016/j.ymthe.2017.04.011. Epub 2017 Apr 20. No abstract available.

17.

Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia.

Townsley DM, Scheinberg P, Winkler T, Desmond R, Dumitriu B, Rios O, Weinstein B, Valdez J, Lotter J, Feng X, Desierto M, Leuva H, Bevans M, Wu C, Larochelle A, Calvo KR, Dunbar CE, Young NS.

N Engl J Med. 2017 Apr 20;376(16):1540-1550. doi: 10.1056/NEJMoa1613878.

18.

Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.

Schlums H, Jung M, Han H, Theorell J, Bigley V, Chiang SC, Allan DS, Davidson-Moncada JK, Dickinson RE, Holmes TD, Hsu AP, Townsley D, Winkler T, Wang W, Aukrust P, Nordøy I, Calvo KR, Holland SM, Collin M, Dunbar CE, Bryceson YT.

Blood. 2017 Apr 6;129(14):1927-1939. doi: 10.1182/blood-2016-08-734236. Epub 2017 Feb 16.

19.

iPSCs and fibroblast subclones from the same fibroblast population contain comparable levels of sequence variations.

Kwon EM, Connelly JP, Hansen NF, Donovan FX, Winkler T, Davis BW, Alkadi H, Chandrasekharappa SC, Dunbar CE, Mullikin JC, Liu P.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1964-1969. doi: 10.1073/pnas.1616035114. Epub 2017 Feb 6.

20.

Rhesus iPSC Safe Harbor Gene-Editing Platform for Stable Expression of Transgenes in Differentiated Cells of All Germ Layers.

Hong SG, Yada RC, Choi K, Carpentier A, Liang TJ, Merling RK, Sweeney CL, Malech HL, Jung M, Corat MAF, AlJanahi AA, Lin Y, Liu H, Tunc I, Wang X, Palisoc M, Pittaluga S, Boehm M, Winkler T, Zou J, Dunbar CE.

Mol Ther. 2017 Jan 4;25(1):44-53. doi: 10.1016/j.ymthe.2016.10.007. Epub 2017 Jan 4.

21.

Quantitative stability of hematopoietic stem and progenitor cell clonal output in rhesus macaques receiving transplants.

Koelle SJ, Espinoza DA, Wu C, Xu J, Lu R, Li B, Donahue RE, Dunbar CE.

Blood. 2017 Mar 16;129(11):1448-1457. doi: 10.1182/blood-2016-07-728691. Epub 2017 Jan 13.

22.

Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs.

Corat MA, Schlums H, Wu C, Theorell J, Espinoza DA, Sellers SE, Townsley DM, Young NS, Bryceson YT, Dunbar CE, Winkler T.

Blood. 2017 Apr 6;129(14):1940-1946. doi: 10.1182/blood-2016-08-734285. Epub 2016 Nov 30.

23.

Gene and Cell Therapies in Expansion Mode: ASGCT 2016.

Dunbar CE.

Mol Ther. 2016 Aug;24(8):1333-4. doi: 10.1038/mt.2016.154. No abstract available.

24.

The Role of Nonhuman Primate Animal Models in the Clinical Development of Pluripotent Stem Cell Therapies.

Hong SG, Lin Y, Dunbar CE, Zou J.

Mol Ther. 2016 Aug;24(7):1165-9. doi: 10.1038/mt.2016.131. No abstract available.

25.

Gene Editing of Human Hematopoietic Stem and Progenitor Cells: Promise and Potential Hurdles.

Yu KR, Natanson H, Dunbar CE.

Hum Gene Ther. 2016 Oct;27(10):729-740. doi: 10.1089/hum.2016.107. Epub 2016 Aug 2. Review.

26.

Blood's 70th anniversary: CARs on the Blood highway.

Dunbar CE.

Blood. 2016 Jul 7;128(1):1-3. doi: 10.1182/blood-2015-10-635334. No abstract available.

27.

Thrombopoietic status of patients on haemodialysis.

Bat T, Bat BE, El-Moghraby A, Patel S, Feng X, Dunbar CE, Sarac E.

Br J Haematol. 2016 Mar;172(6):954-7. doi: 10.1111/bjh.13918. Epub 2016 Feb 16.

28.

Modeling Human Bone Marrow Failure Syndromes Using Pluripotent Stem Cells and Genome Engineering.

Jung M, Dunbar CE, Winkler T.

Mol Ther. 2015 Dec;23(12):1832-42. doi: 10.1038/mt.2015.180. Epub 2015 Oct 5. Review.

29.

Human hematopoietic stem cells from mobilized peripheral blood can be purified based on CD49f integrin expression.

Huntsman HD, Bat T, Cheng H, Cash A, Cheruku PS, Fu JF, Keyvanfar K, Childs RW, Dunbar CE, Larochelle A.

Blood. 2015 Sep 24;126(13):1631-3. doi: 10.1182/blood-2015-07-660670. No abstract available.

30.

Functional Niche Competition Between Normal Hematopoietic Stem and Progenitor Cells and Myeloid Leukemia Cells.

Glait-Santar C, Desmond R, Feng X, Bat T, Chen J, Heuston E, Mizukawa B, Mulloy JC, Bodine DM, Larochelle A, Dunbar CE.

Stem Cells. 2015 Dec;33(12):3635-42. doi: 10.1002/stem.2208. Epub 2015 Oct 5.

31.

Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders.

Balakumaran A, Mishra PJ, Pawelczyk E, Yoshizawa S, Sworder BJ, Cherman N, Kuznetsov SA, Bianco P, Giri N, Savage SA, Merlino G, Dumitriu B, Dunbar CE, Young NS, Alter BP, Robey PG.

Blood. 2015 Jan 29;125(5):793-802. doi: 10.1182/blood-2014-06-566810. Epub 2014 Dec 12.

32.

Regulated apoptosis of genetically modified hematopoietic stem and progenitor cells via an inducible caspase-9 suicide gene in rhesus macaques.

Barese CN, Felizardo TC, Sellers SE, Keyvanfar K, Di Stasi A, Metzger ME, Krouse AE, Donahue RE, Spencer DM, Dunbar CE.

Stem Cells. 2015 Jan;33(1):91-100. doi: 10.1002/stem.1869.

33.

An AAVS1-targeted minigene platform for correction of iPSCs from all five types of chronic granulomatous disease.

Merling RK, Sweeney CL, Chu J, Bodansky A, Choi U, Priel DL, Kuhns DB, Wang H, Vasilevsky S, De Ravin SS, Winkler T, Dunbar CE, Zou J, Zarember KA, Gallin JI, Holland SM, Malech HL.

Mol Ther. 2015 Jan;23(1):147-57. doi: 10.1038/mt.2014.195. Epub 2014 Oct 7.

34.
35.

Angioedema in patients treated with sirolimus and ACE inhibitor post hematopoietic SCT.

Jung M, Ranpura VN, Dunbar CE, Tisdale JF, Fitzhugh CD, Hsieh MM.

Bone Marrow Transplant. 2014 Nov;49(11):1448-9. doi: 10.1038/bmt.2014.162. Epub 2014 Jul 28. No abstract available.

36.

Path to the clinic: assessment of iPSC-based cell therapies in vivo in a nonhuman primate model.

Hong SG, Winkler T, Wu C, Guo V, Pittaluga S, Nicolae A, Donahue RE, Metzger ME, Price SD, Uchida N, Kuznetsov SA, Kilts T, Li L, Robey PG, Dunbar CE.

Cell Rep. 2014 May 22;7(4):1298-1309. doi: 10.1016/j.celrep.2014.04.019. Epub 2014 May 15.

37.

IFN-γ regulates survival and function of tumor-induced CD11b+ Gr-1high myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1.

Medina-Echeverz J, Haile LA, Zhao F, Gamrekelashvili J, Ma C, Métais JY, Dunbar CE, Kapoor V, Manns MP, Korangy F, Greten TF.

Eur J Immunol. 2014 Aug;44(8):2457-67. doi: 10.1002/eji.201444497. Epub 2014 Jun 16.

38.

Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells.

Wu C, Li B, Lu R, Koelle SJ, Yang Y, Jares A, Krouse AE, Metzger M, Liang F, Loré K, Wu CO, Donahue RE, Chen ISY, Weissman I, Dunbar CE.

Cell Stem Cell. 2014 Apr 3;14(4):486-499. doi: 10.1016/j.stem.2014.01.020.

39.

Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study.

Kim S, Kim N, Presson AP, Metzger ME, Bonifacino AC, Sehl M, Chow SA, Crooks GM, Dunbar CE, An DS, Donahue RE, Chen IS.

Cell Stem Cell. 2014 Apr 3;14(4):473-85. doi: 10.1016/j.stem.2013.12.012.

40.

Patients with myeloid malignancies bearing PDGFRB fusion genes achieve durable long-term remissions with imatinib.

Cheah CY, Burbury K, Apperley JF, Huguet F, Pitini V, Gardembas M, Ross DM, Forrest D, Genet P, Rousselot P, Patton N, Smith G, Dunbar CE, Ito S, Aguiar RC, Odenike O, Gimelfarb A, Cross NC, Seymour JF.

Blood. 2014 Jun 5;123(23):3574-7. doi: 10.1182/blood-2014-02-555607. Epub 2014 Mar 31.

41.

Development of an inducible caspase-9 safety switch for pluripotent stem cell-based therapies.

Wu C, Hong SG, Winkler T, Spencer DM, Jares A, Ichwan B, Nicolae A, Guo V, Larochelle A, Dunbar CE.

Mol Ther Methods Clin Dev. 2014 Nov 12;1:14053. doi: 10.1038/mtm.2014.53. eCollection 2014.

42.

Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug.

Desmond R, Townsley DM, Dumitriu B, Olnes MJ, Scheinberg P, Bevans M, Parikh AR, Broder K, Calvo KR, Wu CO, Young NS, Dunbar CE.

Blood. 2014 Mar 20;123(12):1818-25. doi: 10.1182/blood-2013-10-534743. Epub 2013 Dec 17.

43.

Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34(+) Cells Correlates With In Vivo Vector Copy Number.

Uchida N, Evans ME, Hsieh MM, Bonifacino AC, Krouse AE, Metzger ME, Sellers SE, Dunbar CE, Donahue RE, Tisdale JF.

Mol Ther Nucleic Acids. 2013 Sep 17;2:e122. doi: 10.1038/mtna.2013.49.

44.

Hematopoietic stem cell gene therapy:assessing the relevance of preclinical models.

Larochelle A, Dunbar CE.

Semin Hematol. 2013 Apr;50(2):101-30. Review. No abstract available.

45.

No impact of lentiviral transduction on hematopoietic stem/progenitor cell telomere length or gene expression in the rhesus macaque model.

Sellers SE, Dumitriu B, Morgan MJ, Hughes WM, Wu CO, Raghavarchari N, Yang Y, Uchida N, Tisdale JF, An DS, Chen IS, Hematti P, Donahue RE, Larochelle A, Young NS, Calado RT, Dunbar CE.

Mol Ther. 2014 Jan;22(1):52-8. doi: 10.1038/mt.2013.168. Epub 2013 Jul 18.

46.

Active thrombopoiesis is associated with worse severity and activity of chronic GVHD.

Bat T, Steinberg SM, Childs R, Calvo KR, Barrett AJ, Battiwalla M, Baird K, Zhang D, Pulanic D, Dunbar CE, Pavletic SZ.

Bone Marrow Transplant. 2013 Nov;48(12):1569-73. doi: 10.1038/bmt.2013.95. Epub 2013 Jul 8.

47.

Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromes.

Townsley DM, Desmond R, Dunbar CE, Young NS.

Int J Hematol. 2013 Jul;98(1):48-55. doi: 10.1007/s12185-013-1352-6. Epub 2013 May 21. Review.

48.

Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs.

Winkler T, Hong SG, Decker JE, Morgan MJ, Wu C, Hughes WM 5th, Yang Y, Wangsa D, Padilla-Nash HM, Ried T, Young NS, Dunbar CE, Calado RT.

J Clin Invest. 2013 May;123(5):1952-63. doi: 10.1172/JCI67146. Epub 2013 Apr 15.

49.

Assessing the risks of genotoxicity in the therapeutic development of induced pluripotent stem cells.

Hong SG, Dunbar CE, Winkler T.

Mol Ther. 2013 Feb;21(2):272-81. doi: 10.1038/mt.2012.255. Epub 2012 Dec 4. Review.

50.

An educational infusion: more synergy between Blood and the American Society of Hematology.

Dunbar CE.

Blood. 2012 Nov 29;120(23):4449. doi: 10.1182/blood-2012-10-461673. No abstract available.

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