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Items: 1 to 50 of 233

1.

Impact of CMV Infection on Natural Killer Cell Clonal Repertoire in CMV-Naïve Rhesus Macaques.

Truitt LL, Yang D, Espinoza DA, Fan X, Ram DR, Moström MJ, Tran D, Sprehe LM, Reeves RK, Donahue RE, Kaur A, Dunbar CE, Wu C.

Front Immunol. 2019 Oct 9;10:2381. doi: 10.3389/fimmu.2019.02381. eCollection 2019.

2.

Clonal tracking of erythropoiesis in rhesus macaques.

Fan X, Wu C, Truitt LL, Espinoza DA, Sellers S, Bonifacino A, Zhou Y, Cordes SF, Krouse A, Metzger M, Donahue RE, Lu R, Dunbar CE.

Haematologica. 2019 Oct 3. pii: haematol.2019.231811. doi: 10.3324/haematol.2019.231811. [Epub ahead of print]

3.

Telomere dynamics and hematopoietic differentiation of human DKC1-mutant induced pluripotent stem cells.

Donaires FS, Alves-Paiva RM, Gutierrez-Rodrigues F, da Silva FB, Tellechea MF, Moreira LF, Santana BA, Traina F, Dunbar CE, Winkler T, Calado RT.

Stem Cell Res. 2019 Oct;40:101540. doi: 10.1016/j.scr.2019.101540. Epub 2019 Aug 20.

4.

Busulfan Combined with Immunosuppression Allows Efficient Engraftment of Gene-Modified Cells in a Rhesus Macaque Model.

Uchida N, Nassehi T, Drysdale CM, Gamer J, Yapundich M, Bonifacino AC, Krouse AE, Linde N, Hsieh MM, Donahue RE, Dunbar CE, Kean LS, Tisdale JF.

Mol Ther. 2019 Sep 4;27(9):1586-1596. doi: 10.1016/j.ymthe.2019.05.022. Epub 2019 Jun 5.

PMID:
31253582
5.

Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque.

Espinoza DA, Fan X, Yang D, Cordes SF, Truitt LL, Calvo KR, Yabe IM, Demirci S, Hope KJ, Hong SG, Krouse A, Metzger M, Bonifacino A, Lu R, Uchida N, Tisdale JF, Wu X, DeRavin SS, Malech HL, Donahue RE, Wu C, Dunbar CE.

Mol Ther. 2019 Jun 5;27(6):1074-1086. doi: 10.1016/j.ymthe.2019.04.003. Epub 2019 Apr 9.

PMID:
31023523
6.

CRISPR/Cas9 PIG -A gene editing in nonhuman primate model demonstrates no intrinsic clonal expansion of PNH HSPCs.

Shin TH, Baek EJ, Corat MAF, Chen S, Metais JY, AlJanahi AA, Zhou Y, Donahue RE, Yu KR, Dunbar CE.

Blood. 2019 Jun 6;133(23):2542-2545. doi: 10.1182/blood.2019000800. Epub 2019 Apr 19. No abstract available.

PMID:
31003997
7.

Treatment optimization and genomic outcomes in refractory severe aplastic anemia treated with eltrombopag.

Winkler T, Fan X, Cooper J, Desmond R, Young DJ, Townsley DM, Scheinberg P, Grasmeder S, Larochelle A, Desierto M, Valdez J, Lotter J, Wu C, Shalhoub RN, Calvo KR, Young NS, Dunbar CE.

Blood. 2019 Jun 13;133(24):2575-2585. doi: 10.1182/blood.2019000478. Epub 2019 Apr 16.

PMID:
30992268
8.

Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ.

Alvarado LJ, Huntsman HD, Cheng H, Townsley DM, Winkler T, Feng X, Dunbar CE, Young NS, Larochelle A.

Blood. 2019 May 9;133(19):2043-2055. doi: 10.1182/blood-2018-11-884486. Epub 2019 Feb 25.

PMID:
30803992
9.

Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity.

Yabe IM, Truitt LL, Espinoza DA, Wu C, Koelle S, Panch S, Corat MAF, Winkler T, Yu KR, Hong SG, Bonifacino A, Krouse A, Metzger M, Donahue RE, Dunbar CE.

Mol Ther Methods Clin Dev. 2018 Oct 25;11:143-154. doi: 10.1016/j.omtm.2018.10.009. eCollection 2018 Dec 14.

10.

GATA2 deficiency and human hematopoietic development modeled using induced pluripotent stem cells.

Jung M, Cordes S, Zou J, Yu SJ, Guitart X, Hong SG, Dang V, Kang E, Donaires FS, Hassan SA, Albitar M, Hsu AP, Holland SM, Hickstein DD, Townsley D, Dunbar CE, Winkler T.

Blood Adv. 2018 Dec 11;2(23):3553-3565. doi: 10.1182/bloodadvances.2018017137.

11.

Clonal expansion and compartmentalized maintenance of rhesus macaque NK cell subsets.

Wu C, Espinoza DA, Koelle SJ, Yang D, Truitt L, Schlums H, Lafont BA, Davidson-Moncada JK, Lu R, Kaur A, Hammer Q, Li B, Panch S, Allan DA, Donahue RE, Childs RW, Romagnani C, Bryceson YT, Dunbar CE.

Sci Immunol. 2018 Nov 2;3(29). pii: eaat9781. doi: 10.1126/sciimmunol.aat9781.

PMID:
30389798
12.

An Introduction to the Analysis of Single-Cell RNA-Sequencing Data.

AlJanahi AA, Danielsen M, Dunbar CE.

Mol Ther Methods Clin Dev. 2018 Aug 2;10:189-196. doi: 10.1016/j.omtm.2018.07.003. eCollection 2018 Sep 21. Review.

13.

Bone Marrow as a Source of Cells for Paroxysmal Nocturnal Hemoglobinuria Detection.

Dulau-Florea AE, Young NS, Maric I, Calvo KR, Dunbar CE, Townsley DM, Winkler T, Monreal M, Jiang C, Jordan EK, Braylan RC.

Am J Clin Pathol. 2018 Jul 5. doi: 10.1093/ajcp/aqy053. [Epub ahead of print]

PMID:
29982419
14.

Genotoxic Lemons Become Epigenomic Lemonade.

Cordes SF, Dunbar CE.

Cell Stem Cell. 2018 Jul 5;23(1):9-10. doi: 10.1016/j.stem.2018.06.007.

15.

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.

Kim MY, Yu KR, Kenderian SS, Ruella M, Chen S, Shin TH, Aljanahi AA, Schreeder D, Klichinsky M, Shestova O, Kozlowski MS, Cummins KD, Shan X, Shestov M, Bagg A, Morrissette JJD, Sekhri P, Lazzarotto CR, Calvo KR, Kuhns DB, Donahue RE, Behbehani GK, Tsai SQ, Dunbar CE, Gill S.

Cell. 2018 May 31;173(6):1439-1453.e19. doi: 10.1016/j.cell.2018.05.013. Epub 2018 May 31.

16.

Dexpramipexole as an oral steroid-sparing agent in hypereosinophilic syndromes.

Panch SR, Bozik ME, Brown T, Makiya M, Prussin C, Archibald DG, Hebrank GT, Sullivan M, Sun X, Wetzler L, Ware J, Fay MP, Dunbar CE, Dworetzky SI, Khoury P, Maric I, Klion AD.

Blood. 2018 Aug 2;132(5):501-509. doi: 10.1182/blood-2018-02-835330. Epub 2018 May 8. Erratum in: Blood. 2018 Sep 27;132(13):1461.

17.

Efficient differentiation of cardiomyocytes and generation of calcium-sensor reporter lines from nonhuman primate iPSCs.

Lin Y, Liu H, Klein M, Ostrominski J, Hong SG, Yada RC, Chen G, Navarengom K, Schwartzbeck R, San H, Yu ZX, Liu C, Linask K, Beers J, Qiu L, Dunbar CE, Boehm M, Zou J.

Sci Rep. 2018 Apr 12;8(1):5907. doi: 10.1038/s41598-018-24074-y.

18.

Eltrombopag mobilizes iron in patients with aplastic anemia.

Zhao Z, Sun Q, Sokoll LJ, Streiff M, Cheng Z, Grasmeder S, Townsley DM, Young NS, Dunbar CE, Winkler T.

Blood. 2018 May 24;131(21):2399-2402. doi: 10.1182/blood-2018-01-826784. Epub 2018 Apr 9. No abstract available. Erratum in: Blood. 2018 Jul 26;132(4):459.

19.

Gene therapy comes of age.

Dunbar CE, High KA, Joung JK, Kohn DB, Ozawa K, Sadelain M.

Science. 2018 Jan 12;359(6372). pii: eaan4672. doi: 10.1126/science.aan4672. Review.

PMID:
29326244
20.

The impact of aging on primate hematopoiesis as interrogated by clonal tracking.

Yu KR, Espinoza DA, Wu C, Truitt L, Shin TH, Chen S, Fan X, Yabe IM, Panch S, Hong SG, Koelle S, Lu R, Bonifacino A, Krouse A, Metzger M, Donahue RE, Dunbar CE.

Blood. 2018 Mar 15;131(11):1195-1205. doi: 10.1182/blood-2017-08-802033. Epub 2018 Jan 2.

21.

Geographic clonal tracking in macaques provides insights into HSPC migration and differentiation.

Wu C, Espinoza DA, Koelle SJ, Potter EL, Lu R, Li B, Yang D, Fan X, Donahue RE, Roederer M, Dunbar CE.

J Exp Med. 2018 Jan 2;215(1):217-232. doi: 10.1084/jem.20171341. Epub 2017 Nov 15.

22.

CRISPR/Cas9-Based Safe-Harbor Gene Editing in Rhesus iPSCs.

Yada RC, Ostrominski JW, Tunc I, Hong SG, Zou J, Dunbar CE.

Curr Protoc Stem Cell Biol. 2017 Nov 15;43:5A.11.1-5A.11.14. doi: 10.1002/cpsc.37.

23.

Persistent elevation of plasma thrombopoietin levels after treatment in severe aplastic anemia.

Zhao X, Feng X, Wu Z, Winkler T, Desmond R, Olnes M, Dumitriu B, Townsley DM, Dunbar CE, Young NS.

Exp Hematol. 2018 Feb;58:39-43. doi: 10.1016/j.exphem.2017.09.006. Epub 2017 Sep 20.

24.

Transcriptome analysis reveals similarities between human blood CD3- CD56bright cells and mouse CD127+ innate lymphoid cells.

Allan DSJ, Cerdeira AS, Ranjan A, Kirkham CL, Aguilar OA, Tanaka M, Childs RW, Dunbar CE, Strominger JL, Kopcow HD, Carlyle JR.

Sci Rep. 2017 Jun 14;7(1):3501. doi: 10.1038/s41598-017-03256-0.

25.

Rhesus Macaque iPSC Generation and Maintenance.

Yada RC, Hong SG, Lin Y, Winkler T, Dunbar CE.

Curr Protoc Stem Cell Biol. 2017 May 16;41:4A.11.1-4A.11.13. doi: 10.1002/cpsc.25.

26.

Two Decades of ASGCT: Dreams Become Reality.

Dunbar CE.

Mol Ther. 2017 May 3;25(5):1057-1058. doi: 10.1016/j.ymthe.2017.04.011. Epub 2017 Apr 20. No abstract available.

27.

Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia.

Townsley DM, Scheinberg P, Winkler T, Desmond R, Dumitriu B, Rios O, Weinstein B, Valdez J, Lotter J, Feng X, Desierto M, Leuva H, Bevans M, Wu C, Larochelle A, Calvo KR, Dunbar CE, Young NS.

N Engl J Med. 2017 Apr 20;376(16):1540-1550. doi: 10.1056/NEJMoa1613878.

28.

Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.

Schlums H, Jung M, Han H, Theorell J, Bigley V, Chiang SC, Allan DS, Davidson-Moncada JK, Dickinson RE, Holmes TD, Hsu AP, Townsley D, Winkler T, Wang W, Aukrust P, Nordøy I, Calvo KR, Holland SM, Collin M, Dunbar CE, Bryceson YT.

Blood. 2017 Apr 6;129(14):1927-1939. doi: 10.1182/blood-2016-08-734236. Epub 2017 Feb 16.

29.

iPSCs and fibroblast subclones from the same fibroblast population contain comparable levels of sequence variations.

Kwon EM, Connelly JP, Hansen NF, Donovan FX, Winkler T, Davis BW, Alkadi H, Chandrasekharappa SC, Dunbar CE, Mullikin JC, Liu P.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1964-1969. doi: 10.1073/pnas.1616035114. Epub 2017 Feb 6.

30.

Rhesus iPSC Safe Harbor Gene-Editing Platform for Stable Expression of Transgenes in Differentiated Cells of All Germ Layers.

Hong SG, Yada RC, Choi K, Carpentier A, Liang TJ, Merling RK, Sweeney CL, Malech HL, Jung M, Corat MAF, AlJanahi AA, Lin Y, Liu H, Tunc I, Wang X, Palisoc M, Pittaluga S, Boehm M, Winkler T, Zou J, Dunbar CE.

Mol Ther. 2017 Jan 4;25(1):44-53. doi: 10.1016/j.ymthe.2016.10.007. Epub 2017 Jan 4.

31.

Quantitative stability of hematopoietic stem and progenitor cell clonal output in rhesus macaques receiving transplants.

Koelle SJ, Espinoza DA, Wu C, Xu J, Lu R, Li B, Donahue RE, Dunbar CE.

Blood. 2017 Mar 16;129(11):1448-1457. doi: 10.1182/blood-2016-07-728691. Epub 2017 Jan 13.

32.

Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs.

Corat MA, Schlums H, Wu C, Theorell J, Espinoza DA, Sellers SE, Townsley DM, Young NS, Bryceson YT, Dunbar CE, Winkler T.

Blood. 2017 Apr 6;129(14):1940-1946. doi: 10.1182/blood-2016-08-734285. Epub 2016 Nov 30.

33.

Gene and Cell Therapies in Expansion Mode: ASGCT 2016.

Dunbar CE.

Mol Ther. 2016 Aug;24(8):1333-4. doi: 10.1038/mt.2016.154. No abstract available.

34.

The Role of Nonhuman Primate Animal Models in the Clinical Development of Pluripotent Stem Cell Therapies.

Hong SG, Lin Y, Dunbar CE, Zou J.

Mol Ther. 2016 Aug;24(7):1165-9. doi: 10.1038/mt.2016.131. No abstract available.

35.

Gene Editing of Human Hematopoietic Stem and Progenitor Cells: Promise and Potential Hurdles.

Yu KR, Natanson H, Dunbar CE.

Hum Gene Ther. 2016 Oct;27(10):729-740. doi: 10.1089/hum.2016.107. Epub 2016 Aug 2. Review.

36.

Blood's 70th anniversary: CARs on the Blood highway.

Dunbar CE.

Blood. 2016 Jul 7;128(1):1-3. doi: 10.1182/blood-2015-10-635334. No abstract available.

37.

Thrombopoietic status of patients on haemodialysis.

Bat T, Bat BE, El-Moghraby A, Patel S, Feng X, Dunbar CE, Sarac E.

Br J Haematol. 2016 Mar;172(6):954-7. doi: 10.1111/bjh.13918. Epub 2016 Feb 16.

38.

Modeling Human Bone Marrow Failure Syndromes Using Pluripotent Stem Cells and Genome Engineering.

Jung M, Dunbar CE, Winkler T.

Mol Ther. 2015 Dec;23(12):1832-42. doi: 10.1038/mt.2015.180. Epub 2015 Oct 5. Review.

39.

Human hematopoietic stem cells from mobilized peripheral blood can be purified based on CD49f integrin expression.

Huntsman HD, Bat T, Cheng H, Cash A, Cheruku PS, Fu JF, Keyvanfar K, Childs RW, Dunbar CE, Larochelle A.

Blood. 2015 Sep 24;126(13):1631-3. doi: 10.1182/blood-2015-07-660670. No abstract available.

40.

Functional Niche Competition Between Normal Hematopoietic Stem and Progenitor Cells and Myeloid Leukemia Cells.

Glait-Santar C, Desmond R, Feng X, Bat T, Chen J, Heuston E, Mizukawa B, Mulloy JC, Bodine DM, Larochelle A, Dunbar CE.

Stem Cells. 2015 Dec;33(12):3635-42. doi: 10.1002/stem.2208. Epub 2015 Oct 5.

41.

Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders.

Balakumaran A, Mishra PJ, Pawelczyk E, Yoshizawa S, Sworder BJ, Cherman N, Kuznetsov SA, Bianco P, Giri N, Savage SA, Merlino G, Dumitriu B, Dunbar CE, Young NS, Alter BP, Robey PG.

Blood. 2015 Jan 29;125(5):793-802. doi: 10.1182/blood-2014-06-566810. Epub 2014 Dec 12.

42.

Regulated apoptosis of genetically modified hematopoietic stem and progenitor cells via an inducible caspase-9 suicide gene in rhesus macaques.

Barese CN, Felizardo TC, Sellers SE, Keyvanfar K, Di Stasi A, Metzger ME, Krouse AE, Donahue RE, Spencer DM, Dunbar CE.

Stem Cells. 2015 Jan;33(1):91-100. doi: 10.1002/stem.1869.

43.

An AAVS1-targeted minigene platform for correction of iPSCs from all five types of chronic granulomatous disease.

Merling RK, Sweeney CL, Chu J, Bodansky A, Choi U, Priel DL, Kuhns DB, Wang H, Vasilevsky S, De Ravin SS, Winkler T, Dunbar CE, Zou J, Zarember KA, Gallin JI, Holland SM, Malech HL.

Mol Ther. 2015 Jan;23(1):147-57. doi: 10.1038/mt.2014.195. Epub 2014 Oct 7.

44.
45.

Angioedema in patients treated with sirolimus and ACE inhibitor post hematopoietic SCT.

Jung M, Ranpura VN, Dunbar CE, Tisdale JF, Fitzhugh CD, Hsieh MM.

Bone Marrow Transplant. 2014 Nov;49(11):1448-9. doi: 10.1038/bmt.2014.162. Epub 2014 Jul 28. No abstract available.

46.

Path to the clinic: assessment of iPSC-based cell therapies in vivo in a nonhuman primate model.

Hong SG, Winkler T, Wu C, Guo V, Pittaluga S, Nicolae A, Donahue RE, Metzger ME, Price SD, Uchida N, Kuznetsov SA, Kilts T, Li L, Robey PG, Dunbar CE.

Cell Rep. 2014 May 22;7(4):1298-1309. doi: 10.1016/j.celrep.2014.04.019. Epub 2014 May 15.

47.

IFN-γ regulates survival and function of tumor-induced CD11b+ Gr-1high myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1.

Medina-Echeverz J, Haile LA, Zhao F, Gamrekelashvili J, Ma C, Métais JY, Dunbar CE, Kapoor V, Manns MP, Korangy F, Greten TF.

Eur J Immunol. 2014 Aug;44(8):2457-67. doi: 10.1002/eji.201444497. Epub 2014 Jun 16.

48.

Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells.

Wu C, Li B, Lu R, Koelle SJ, Yang Y, Jares A, Krouse AE, Metzger M, Liang F, Loré K, Wu CO, Donahue RE, Chen ISY, Weissman I, Dunbar CE.

Cell Stem Cell. 2014 Apr 3;14(4):486-499. doi: 10.1016/j.stem.2014.01.020.

49.

Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study.

Kim S, Kim N, Presson AP, Metzger ME, Bonifacino AC, Sehl M, Chow SA, Crooks GM, Dunbar CE, An DS, Donahue RE, Chen IS.

Cell Stem Cell. 2014 Apr 3;14(4):473-85. doi: 10.1016/j.stem.2013.12.012.

50.

Patients with myeloid malignancies bearing PDGFRB fusion genes achieve durable long-term remissions with imatinib.

Cheah CY, Burbury K, Apperley JF, Huguet F, Pitini V, Gardembas M, Ross DM, Forrest D, Genet P, Rousselot P, Patton N, Smith G, Dunbar CE, Ito S, Aguiar RC, Odenike O, Gimelfarb A, Cross NC, Seymour JF.

Blood. 2014 Jun 5;123(23):3574-7. doi: 10.1182/blood-2014-02-555607. Epub 2014 Mar 31.

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