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Items: 1 to 50 of 108

1.

Iron Accumulates in Retinal Vascular Endothelial Cells But Has Minimal Retinal Penetration After IP Iron Dextran Injection in Mice.

Shu W, Baumann BH, Song Y, Liu Y, Wu X, Dunaief JL.

Invest Ophthalmol Vis Sci. 2019 Oct 1;60(13):4378-4387. doi: 10.1167/iovs.19-28250.

2.

Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis.

Khan RS, Baumann B, Dine K, Song Y, Dunaief JL, Kim SF, Shindler KS.

Sci Rep. 2019 Aug 12;9(1):11664. doi: 10.1038/s41598-019-48087-3.

3.

Ferroportin-mediated iron export from vascular endothelial cells in retina and brain.

Baumann BH, Shu W, Song Y, Simpson EM, Lakhal-Littleton S, Dunaief JL.

Exp Eye Res. 2019 Oct;187:107728. doi: 10.1016/j.exer.2019.107728. Epub 2019 Jul 16.

PMID:
31323276
4.

Liver-Specific, but Not Retina-Specific, Hepcidin Knockout Causes Retinal Iron Accumulation and Degeneration.

Baumann BH, Shu W, Song Y, Sterling J, Kozmik Z, Lakhal-Littleton S, Dunaief JL.

Am J Pathol. 2019 Sep;189(9):1814-1830. doi: 10.1016/j.ajpath.2019.05.022. Epub 2019 Jul 6.

PMID:
31287995
5.

Multi-copper ferroxidase deficiency leads to iron accumulation and oxidative damage in astrocytes and oligodendrocytes.

Chen Z, Jiang R, Chen M, Zheng J, Chen M, Braidy N, Liu S, Liu G, Maimaitiming Z, Shen T, Dunaief JL, Vulpe CD, Anderson GJ, Chen H.

Sci Rep. 2019 Jul 1;9(1):9437. doi: 10.1038/s41598-019-46019-9.

6.

Increased serum proteins in non-exudative AMD retinas.

Schultz H, Song Y, Baumann BH, Kapphahn RJ, Montezuma SR, Ferrington DA, Dunaief JL.

Exp Eye Res. 2019 Sep;186:107686. doi: 10.1016/j.exer.2019.05.026. Epub 2019 May 31.

PMID:
31158383
7.

Persistent and Progressive Outer Retina Thinning in Frontotemporal Degeneration.

Kim BJ, Grossman M, Song D, Saludades S, Pan W, Dominguez-Perez S, Dunaief JL, Aleman TS, Ying GS, Irwin DJ.

Front Neurosci. 2019 Apr 4;13:298. doi: 10.3389/fnins.2019.00298. eCollection 2019.

8.

Differential contribution of C5aR and C5b-9 pathways to renal thrombic microangiopathy and macrovascular thrombosis in mice carrying an atypical hemolytic syndrome-related factor H mutation.

Ueda Y, Miwa T, Ito D, Kim H, Sato S, Gullipalli D, Zhou L, Golla M, Song D, Dunaief JL, Palmer MB, Song WC.

Kidney Int. 2019 Jul;96(1):67-79. doi: 10.1016/j.kint.2019.01.009. Epub 2019 Feb 27.

PMID:
30910380
9.

Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration.

Storti F, Klee K, Todorova V, Steiner R, Othman A, van der Velde-Visser S, Samardzija M, Meneau I, Barben M, Karademir D, Pauzuolyte V, Boye SL, Blaser F, Ullmer C, Dunaief JL, Hornemann T, Rohrer L, den Hollander A, von Eckardstein A, Fingerle J, Maugeais C, Grimm C.

Elife. 2019 Mar 13;8. pii: e45100. doi: 10.7554/eLife.45100.

10.

Complement Factor H Mutation W1206R Causes Retinal Thrombosis and Ischemic Retinopathy in Mice.

Song D, Ueda Y, Bhuyan R, Mohammed I, Miwa T, Gullipali D, Kim H, Zhou L, Song Y, Schultz H, Bargoud A, Dunaief JL, Song WC.

Am J Pathol. 2019 Apr;189(4):826-838. doi: 10.1016/j.ajpath.2019.01.009. Epub 2019 Feb 1.

PMID:
30711487
11.

Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration.

Storm T, Burgoyne T, Dunaief JL, Christensen EI, Futter C, Nielsen R.

Invest Ophthalmol Vis Sci. 2019 Jan 2;60(1):322-330. doi: 10.1167/iovs.18-25667.

12.

Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina.

Badiei A, Sudharsan R, Santana E, Dunaief JL, Aguirre GD.

Exp Eye Res. 2019 Apr;181:72-84. doi: 10.1016/j.exer.2019.01.007. Epub 2019 Jan 14.

PMID:
30653965
13.

Five-Year Follow-up of Nonfibrotic Scars in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Daniel E, Ying GS, Kim BJ, Toth CA, Ferris F 3rd, Martin DF, Grunwald JE, Jaffe GJ, Dunaief JL, Pan W, Maguire MG; Comparison of Age-Related Macular Degeneration Treatments Trials.

Ophthalmology. 2019 May;126(5):743-751. doi: 10.1016/j.ophtha.2018.11.020. Epub 2018 Nov 23.

PMID:
30476517
14.

Potential Treatment of Retinal Diseases with Iron Chelators.

Shu W, Dunaief JL.

Pharmaceuticals (Basel). 2018 Oct 22;11(4). pii: E112. doi: 10.3390/ph11040112. Review.

15.

SPECKLED HYPOAUTOFLUORESCENCE AS A SIGN OF RESOLVED SUBRETINAL HEMORRHAGE IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.

Hussnain SA, Dolz-Marco R, Dunaief JL, Curcio CA, Freund KB.

Retina. 2019 Oct;39(10):1925-1935. doi: 10.1097/IAE.0000000000002367.

PMID:
30355956
16.

Mechanisms that minimize retinal impact of apolipoprotein E absence.

Saadane A, Petrov A, Mast N, El-Darzi N, Dao T, Alnemri A, Song Y, Dunaief JL, Pikuleva IA.

J Lipid Res. 2018 Dec;59(12):2368-2382. doi: 10.1194/jlr.M090043. Epub 2018 Oct 17.

17.

Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin.

Fuqua BK, Lu Y, Frazer DM, Darshan D, Wilkins SJ, Dunn L, Loguinov AV, Kogan SC, Matak P, Chen H, Dunaief JL, Vulpe CD, Anderson GJ.

Cell Mol Gastroenterol Hepatol. 2018 Jun 23;6(4):405-427. doi: 10.1016/j.jcmgh.2018.06.006. eCollection 2018.

18.

ASSOCIATION BETWEEN ORAL IRON SUPPLEMENTATION AND RETINAL OR SUBRETINAL HEMORRHAGE IN THE COMPARISON OF AGE-RELATED MACULAR DEGENERATION TREATMENT TRIALS.

Song D, Ying GS, Dunaief JL, Bhuyan R, Li Y, Maguire MG, Grunwald JE, Daniel E, Hagstrom S, Martin DF; Comparison of Age-Related Macular Degeneration Treatment Trial Research Group.

Retina. 2019 Oct;39(10):1965-1972. doi: 10.1097/IAE.0000000000002295.

PMID:
30157115
19.

Retinal Basal Laminar Deposits in Complement fH/fP Mouse Model of Dense Deposit Disease.

Song D, Mohammed I, Bhuyan R, Miwa T, Williams AL, Gullipalli D, Sato S, Song Y, Dunaief JL, Song WC.

Invest Ophthalmol Vis Sci. 2018 Jul 2;59(8):3405-3415. doi: 10.1167/iovs.18-24133.

20.

Iron promotes oxidative cell death caused by bisretinoids of retina.

Ueda K, Kim HJ, Zhao J, Song Y, Dunaief JL, Sparrow JR.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):4963-4968. doi: 10.1073/pnas.1722601115. Epub 2018 Apr 23.

21.

Multi-Copper Ferroxidase-Deficient Mice Have Increased Brain Iron Concentrations and Learning and Memory Deficits.

Zheng J, Jiang R, Chen M, Maimaitiming Z, Wang J, Anderson GJ, Vulpe CD, Dunaief JL, Chen H.

J Nutr. 2018 Apr 1;148(4):643-649. doi: 10.1093/jn/nxy012.

PMID:
29659961
22.

Optical coherence tomography identifies outer retina thinning in frontotemporal degeneration.

Kim BJ, Irwin DJ, Song D, Daniel E, Leveque JD, Raquib AR, Pan W, Ying GS, Aleman TS, Dunaief JL, Grossman M.

Neurology. 2017 Oct 10;89(15):1604-1611. doi: 10.1212/WNL.0000000000004500. Epub 2017 Sep 8.

23.

Conditional Müller Cell Ablation Leads to Retinal Iron Accumulation.

Baumann B, Sterling J, Song Y, Song D, Fruttiger M, Gillies M, Shen W, Dunaief JL.

Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4223-4234. doi: 10.1167/iovs.17-21743.

24.
25.

Complement C5a receptor knockout has diminished light-induced microglia/macrophage retinal migration.

Song D, Sulewski ME Jr, Wang C, Song J, Bhuyan R, Sterling J, Clark E, Song WC, Dunaief JL.

Mol Vis. 2017 Apr 10;23:210-218. eCollection 2017.

26.

Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels.

Sterling J, Guttha S, Song Y, Song D, Hadziahmetovic M, Dunaief JL.

Exp Eye Res. 2017 Feb;155:15-23. doi: 10.1016/j.exer.2016.12.008. Epub 2017 Jan 3.

27.

Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.

Jiang B, Liu G, Zheng J, Chen M, Maimaitiming Z, Chen M, Liu S, Jiang R, Fuqua BK, Dunaief JL, Vulpe CD, Anderson GJ, Wang H, Chen H.

Sci Rep. 2016 Dec 19;6:39470. doi: 10.1038/srep39470.

28.

Retinal Pre-Conditioning by CD59a Knockout Protects against Light-Induced Photoreceptor Degeneration.

Song D, Wilson B, Zhao L, Bhuyan R, Bandyopadhyay M, Lyubarsky A, Yu C, Li Y, Kanu L, Miwa T, Song WC, Finnemann SC, Rohrer B, Dunaief JL.

PLoS One. 2016 Nov 28;11(11):e0166348. doi: 10.1371/journal.pone.0166348. eCollection 2016.

29.

Tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye.

Sarezky D, Raquib AR, Dunaief JL, Kim BJ.

Clin Ophthalmol. 2016 Sep 29;10:1899-1903. eCollection 2016.

30.

AMD-like retinopathy associated with intravenous iron.

Song D, Kanu LN, Li Y, Kelly KL, Bhuyan RK, Aleman T, Morgan JI, Dunaief JL.

Exp Eye Res. 2016 Oct;151:122-33. doi: 10.1016/j.exer.2016.08.008. Epub 2016 Aug 23.

31.

RACking Up Retinal Oxidative Stress.

Dunaief JL.

Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2876. doi: 10.1167/iovs.16-19764. No abstract available.

PMID:
27233036
32.

Mice with hepcidin-resistant ferroportin accumulate iron in the retina.

Theurl M, Song D, Clark E, Sterling J, Grieco S, Altamura S, Galy B, Hentze M, Muckenthaler MU, Dunaief JL.

FASEB J. 2016 Feb;30(2):813-23. doi: 10.1096/fj.15-276758. Epub 2015 Oct 27.

33.

Berberine protects against light-induced photoreceptor degeneration in the mouse retina.

Song D, Song J, Wang C, Li Y, Dunaief JL.

Exp Eye Res. 2016 Apr;145:1-9. doi: 10.1016/j.exer.2015.10.005. Epub 2015 Oct 22.

34.

Retinal abnormalities in β-thalassemia major.

Bhoiwala DL, Dunaief JL.

Surv Ophthalmol. 2016 Jan-Feb;61(1):33-50. doi: 10.1016/j.survophthal.2015.08.005. Epub 2015 Aug 29. Review.

35.

Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.

Zhao L, Hadziahmetovic M, Wang C, Xu X, Song Y, Jinnah HA, Wodzinska J, Iacovelli J, Wolkow N, Krajacic P, Weissberger AC, Connelly J, Spino M, Lee MK, Connor J, Giasson B, Harris ZL, Dunaief JL.

J Neurochem. 2015 Dec;135(5):958-74. doi: 10.1111/jnc.13292. Epub 2015 Sep 29.

36.

CD1 Mouse Retina Is Shielded From Iron Overload Caused by a High Iron Diet.

Bhoiwala DL, Song Y, Cwanger A, Clark E, Zhao LL, Wang C, Li Y, Song D, Dunaief JL.

Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5344-52. doi: 10.1167/iovs.15-17026.

37.

Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.

Yao J, Jia L, Khan N, Lin C, Mitter SK, Boulton ME, Dunaief JL, Klionsky DJ, Guan JL, Thompson DA, Zacks DN.

Autophagy. 2015;11(6):939-53. doi: 10.1080/15548627.2015.1041699.

38.

Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome.

Gelfand BD, Wright CB, Kim Y, Yasuma T, Yasuma R, Li S, Fowler BJ, Bastos-Carvalho A, Kerur N, Uittenbogaard A, Han YS, Lou D, Kleinman ME, McDonald WH, Núñez G, Georgel P, Dunaief JL, Ambati J.

Cell Rep. 2015 Jun 23;11(11):1686-93. doi: 10.1016/j.celrep.2015.05.023. Epub 2015 Jun 11.

39.

Cdc42 and sec10 Are Required for Normal Retinal Development in Zebrafish.

Choi SY, Baek JI, Zuo X, Kim SH, Dunaief JL, Lipschutz JH.

Invest Ophthalmol Vis Sci. 2015 May;56(5):3361-70. doi: 10.1167/iovs.14-15692.

40.

GSTM1 and GSTM5 Genetic Polymorphisms and Expression in Age-Related Macular Degeneration.

Hunter AA 3rd, Smit-McBride Z, Anderson R, Bordbari MH, Ying GS, Kim ES, Park SS, Telander DG, Dunaief JL, Hjelmeland LM, Morse LS.

Curr Eye Res. 2016;41(3):410-6. doi: 10.3109/02713683.2015.1016179. Epub 2015 Apr 21.

41.

Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-β Signaling in the Retinal Pigment Epithelium.

Li Y, Song D, Song Y, Zhao L, Wolkow N, Tobias JW, Song W, Dunaief JL.

J Biol Chem. 2015 May 8;290(19):11918-34. doi: 10.1074/jbc.M115.645903. Epub 2015 Mar 23.

42.

Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain.

Jiang R, Hua C, Wan Y, Jiang B, Hu H, Zheng J, Fuqua BK, Dunaief JL, Anderson GJ, David S, Vulpe CD, Chen H.

J Nutr. 2015 May;145(5):1003-9. doi: 10.3945/jn.114.207316. Epub 2015 Mar 18.

PMID:
25788583
43.

Iron increases APP translation and amyloid-beta production in the retina.

Guo LY, Alekseev O, Li Y, Song Y, Dunaief JL.

Exp Eye Res. 2014 Dec;129:31-7. doi: 10.1016/j.exer.2014.10.012. Epub 2014 Oct 16.

44.

Iron upregulates melanogenesis in cultured retinal pigment epithelial cells.

Wolkow N, Li Y, Maminishkis A, Song Y, Alekseev O, Iacovelli J, Song D, Lee JC, Dunaief JL.

Exp Eye Res. 2014 Nov;128:92-101. doi: 10.1016/j.exer.2014.09.010. Epub 2014 Sep 30.

45.

A high serum iron level causes mouse retinal iron accumulation despite an intact blood-retinal barrier.

Zhao L, Li Y, Song D, Song Y, Theurl M, Wang C, Cwanger A, Su G, Dunaief JL.

Am J Pathol. 2014 Nov;184(11):2862-7. doi: 10.1016/j.ajpath.2014.07.008. Epub 2014 Aug 28.

46.

Systemic administration of the antioxidant/iron chelator α-lipoic acid protects against light-induced photoreceptor degeneration in the mouse retina.

Zhao L, Wang C, Song D, Li Y, Song Y, Su G, Dunaief JL.

Invest Ophthalmol Vis Sci. 2014 Aug 21;55(9):5979-88. doi: 10.1167/iovs.14-15025.

47.

A murine RP1 missense mutation causes protein mislocalization and slowly progressive photoreceptor degeneration.

Song D, Grieco S, Li Y, Hunter A, Chu S, Zhao L, Song Y, DeAngelis RA, Shi LY, Liu Q, Pierce EA, Nishina PM, Lambris JD, Dunaief JL.

Am J Pathol. 2014 Oct;184(10):2721-9. doi: 10.1016/j.ajpath.2014.06.010. Epub 2014 Aug 1.

48.

The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice.

Song D, Zhao L, Li Y, Hadziahmetovic M, Song Y, Connelly J, Spino M, Dunaief JL.

Invest Ophthalmol Vis Sci. 2014 Jun 26;55(7):4525-32. doi: 10.1167/iovs.14-14568.

49.

The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice.

Fuqua BK, Lu Y, Darshan D, Frazer DM, Wilkins SJ, Wolkow N, Bell AG, Hsu J, Yu CC, Chen H, Dunaief JL, Anderson GJ, Vulpe CD.

PLoS One. 2014 Jun 4;9(6):e98792. doi: 10.1371/journal.pone.0098792. eCollection 2014.

50.

Age- and gene-dosage-dependent cre-induced abnormalities in the retinal pigment epithelium.

He L, Marioutina M, Dunaief JL, Marneros AG.

Am J Pathol. 2014 Jun;184(6):1660-7. doi: 10.1016/j.ajpath.2014.02.007.

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