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Items: 1 to 50 of 93

1.

5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10.

Cochet M, Donneger R, Cassier E, Gaven F, Lichtenthaler SF, Marin P, Bockaert J, Dumuis A, Claeysen S.

ACS Chem Neurosci. 2013 Jan 16;4(1):130-40. doi: 10.1021/cn300095t. Epub 2012 Oct 13.

2.

Pharmacological profile of engineered 5-HT₄ receptors and identification of 5-HT₄ receptor-biased ligands.

Gaven F, Pellissier LP, Queffeulou E, Cochet M, Bockaert J, Dumuis A, Claeysen S.

Brain Res. 2013 May 20;1511:65-72. doi: 10.1016/j.brainres.2012.11.005. Epub 2012 Nov 10. Review.

PMID:
23148949
3.

Alzheimer culprits: cellular crossroads and interplay.

Claeysen S, Cochet M, Donneger R, Dumuis A, Bockaert J, Giannoni P.

Cell Signal. 2012 Sep;24(9):1831-40. doi: 10.1016/j.cellsig.2012.05.008. Epub 2012 May 22. Review.

PMID:
22627093
4.

5-HT receptor-associated protein networks: new targets for drug discovery in psychiatric disorders?

Marin P, Becamel C, Dumuis A, Bockaert J.

Curr Drug Targets. 2012 Jan;13(1):28-52. Review.

PMID:
21777185
5.

Enhancement of reference memory in aged rats by specific activation of 5-HT(4) receptors using an olfactory associative discrimination task.

Marchetti E, Jacquet M, Escoffier G, Miglioratti M, Dumuis A, Bockaert J, Roman FS.

Brain Res. 2011 Aug 8;1405:49-56. doi: 10.1016/j.brainres.2011.06.020. Epub 2011 Jun 17.

PMID:
21745655
6.

5-HT(4) receptors, a place in the sun: act two.

Bockaert J, Claeysen S, Compan V, Dumuis A.

Curr Opin Pharmacol. 2011 Feb;11(1):87-93. doi: 10.1016/j.coph.2011.01.012. Epub 2011 Feb 20. Review.

PMID:
21342787
7.

G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient.

Pellissier LP, Barthet G, Gaven F, Cassier E, Trinquet E, Pin JP, Marin P, Dumuis A, Bockaert J, Banères JL, Claeysen S.

J Biol Chem. 2011 Mar 25;286(12):9985-97. doi: 10.1074/jbc.M110.201939. Epub 2011 Jan 19.

8.

Hyperfunction of muscarinic receptor maintains long-term memory in 5-HT4 receptor knock-out mice.

Segu L, Lecomte MJ, Wolff M, Santamaria J, Hen R, Dumuis A, Berrard S, Bockaert J, Buhot MC, Compan V.

PLoS One. 2010 Mar 4;5(3):e9529. doi: 10.1371/journal.pone.0009529.

9.

Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.

de la Fuente T, Martín-Fontecha M, Sallander J, Benhamú B, Campillo M, Medina RA, Pellissier LP, Claeysen S, Dumuis A, Pardo L, López-Rodríguez ML.

J Med Chem. 2010 Feb 11;53(3):1357-69. doi: 10.1021/jm901672k.

PMID:
20078106
10.

Constitutive Gs-mediated, but not G12-mediated, activity of the 5-hydroxytryptamine 5-HT7(a) receptor is modulated by the palmitoylation of its C-terminal domain.

Kvachnina E, Dumuis A, Wlodarczyk J, Renner U, Cochet M, Richter DW, Ponimaskin E.

Biochim Biophys Acta. 2009 Nov;1793(11):1646-55. doi: 10.1016/j.bbamcr.2009.08.008. Epub 2009 Aug 26.

11.

Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.

Barthet G, Carrat G, Cassier E, Barker B, Gaven F, Pillot M, Framery B, Pellissier LP, Augier J, Kang DS, Claeysen S, Reiter E, Banères JL, Benovic JL, Marin P, Bockaert J, Dumuis A.

EMBO J. 2009 Sep 16;28(18):2706-18. doi: 10.1038/emboj.2009.215. Epub 2009 Aug 6.

12.

Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines.

Lemaître S, Lepailleur A, Bureau R, Butt-Gueulle S, Lelong-Boulouard V, Duchatelle P, Boulouard M, Dumuis A, Daveu C, Lezoualc'h F, Pfeiffer B, Dauphin F, Rault S.

Bioorg Med Chem. 2009 Mar 15;17(6):2607-22. doi: 10.1016/j.bmc.2008.11.045. Epub 2008 Nov 24.

PMID:
19261477
13.

Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors.

Pellissier LP, Sallander J, Campillo M, Gaven F, Queffeulou E, Pillot M, Dumuis A, Claeysen S, Bockaert J, Pardo L.

Mol Pharmacol. 2009 Apr;75(4):982-90. doi: 10.1124/mol.108.053686. Epub 2009 Jan 23.

PMID:
19168624
14.

Engineering GPCR signaling pathways with RASSLs.

Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL.

Nat Methods. 2008 Aug;5(8):673-8. doi: 10.1038/nmeth.1232. Review.

15.

5-HT(4) receptors: history, molecular pharmacology and brain functions.

Bockaert J, Claeysen S, Compan V, Dumuis A.

Neuropharmacology. 2008 Nov;55(6):922-31. doi: 10.1016/j.neuropharm.2008.05.013. Epub 2008 May 23. Review.

PMID:
18603269
16.

The promnesic effect of G-protein-coupled 5-HT4 receptors activation is mediated by a potentiation of learning-induced spine growth in the mouse hippocampus.

Restivo L, Roman F, Dumuis A, Bockaert J, Marchetti E, Ammassari-Teule M.

Neuropsychopharmacology. 2008 Sep;33(10):2427-34. Epub 2007 Dec 12.

17.

VRX-03011, a novel 5-HT4 agonist, enhances memory and hippocampal acetylcholine efflux.

Mohler EG, Shacham S, Noiman S, Lezoualc'h F, Robert S, Gastineau M, Rutkowski J, Marantz Y, Dumuis A, Bockaert J, Gold PE, Ragozzino ME.

Neuropharmacology. 2007 Sep;53(4):563-73. Epub 2007 Jun 30.

PMID:
17692343
18.

5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling.

Barthet G, Framery B, Gaven F, Pellissier L, Reiter E, Claeysen S, Bockaert J, Dumuis A.

Mol Biol Cell. 2007 Jun;18(6):1979-91. Epub 2007 Mar 21.

19.

Adaptive changes in serotonin neurons of the raphe nuclei in 5-HT(4) receptor knock-out mouse.

Conductier G, Dusticier N, Lucas G, Côté F, Debonnel G, Daszuta A, Dumuis A, Nieoullon A, Hen R, Bockaert J, Compan V.

Eur J Neurosci. 2006 Aug;24(4):1053-62.

PMID:
16930432
20.

Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.

Bockaert J, Claeysen S, Bécamel C, Dumuis A, Marin P.

Cell Tissue Res. 2006 Nov;326(2):553-72. Epub 2006 Aug 1. Review.

PMID:
16896947
21.

5-HT7 receptor is coupled to G alpha subunits of heterotrimeric G12-protein to regulate gene transcription and neuronal morphology.

Kvachnina E, Liu G, Dityatev A, Renner U, Dumuis A, Richter DW, Dityateva G, Schachner M, Voyno-Yasenetskaya TA, Ponimaskin EG.

J Neurosci. 2005 Aug 24;25(34):7821-30.

22.

Uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors. Distinct molecular events with different GRK2 requirements.

Barthet G, Gaven F, Framery B, Shinjo K, Nakamura T, Claeysen S, Bockaert J, Dumuis A.

J Biol Chem. 2005 Jul 29;280(30):27924-34. Epub 2005 May 26.

23.

Molecular characterization of a purified 5-HT4 receptor: a structural basis for drug efficacy.

Banères JL, Mesnier D, Martin A, Joubert L, Dumuis A, Bockaert J.

J Biol Chem. 2005 May 27;280(21):20253-60. Epub 2005 Mar 17.

24.

Palmitoylation of the 5-hydroxytryptamine4a receptor regulates receptor phosphorylation, desensitization, and beta-arrestin-mediated endocytosis.

Ponimaskin E, Dumuis A, Gaven F, Barthet G, Heine M, Glebov K, Richter DW, Oppermann M.

Mol Pharmacol. 2005 May;67(5):1434-43. Epub 2005 Feb 2.

PMID:
15689570
25.

Modulation of memory processes and cellular excitability in the dentate gyrus of freely moving rats by a 5-HT4 receptors partial agonist, and an antagonist.

Marchetti E, Chaillan FA, Dumuis A, Bockaert J, Soumireu-Mourat B, Roman FS.

Neuropharmacology. 2004 Dec;47(7):1021-35.

PMID:
15555636
26.

GPCR-GIP networks: a first step in the discovery of new therapeutic drugs?

Bockaert J, Dumuis A, Fagni L, Marin P.

Curr Opin Drug Discov Devel. 2004 Sep;7(5):649-57. Review.

PMID:
15503867
27.

GPCR-interacting proteins (GIPs): nature and functions.

Bockaert J, Roussignol G, Bécamel C, Gavarini S, Joubert L, Dumuis A, Fagni L, Marin P.

Biochem Soc Trans. 2004 Nov;32(Pt 5):851-5. Review.

PMID:
15494032
28.

New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting.

Joubert L, Hanson B, Barthet G, Sebben M, Claeysen S, Hong W, Marin P, Dumuis A, Bockaert J.

J Cell Sci. 2004 Oct 15;117(Pt 22):5367-79. Epub 2004 Oct 5.

29.

GPCR interacting proteins (GIP).

Bockaert J, Fagni L, Dumuis A, Marin P.

Pharmacol Ther. 2004 Sep;103(3):203-21. Review.

PMID:
15464590
30.

The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins.

Bécamel C, Gavarini S, Chanrion B, Alonso G, Galéotti N, Dumuis A, Bockaert J, Marin P.

J Biol Chem. 2004 May 7;279(19):20257-66. Epub 2004 Feb 26.

31.

5-HT4 receptors.

Bockaert J, Claeysen S, Compan V, Dumuis A.

Curr Drug Targets CNS Neurol Disord. 2004 Feb;3(1):39-51. Review.

PMID:
14965243
32.

Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice.

Compan V, Zhou M, Grailhe R, Gazzara RA, Martin R, Gingrich J, Dumuis A, Brunner D, Bockaert J, Hen R.

J Neurosci. 2004 Jan 14;24(2):412-9.

33.

The 5-hydroxytryptamine(1A) receptor is stably palmitoylated, and acylation is critical for communication of receptor with Gi protein.

Papoucheva E, Dumuis A, Sebben M, Richter DW, Ponimaskin EG.

J Biol Chem. 2004 Jan 30;279(5):3280-91. Epub 2003 Nov 6.

34.

The 'magic tail' of G protein-coupled receptors: an anchorage for functional protein networks.

Bockaert J, Marin P, Dumuis A, Fagni L.

FEBS Lett. 2003 Jul 3;546(1):65-72. Review.

35.
36.

New benzo[h][1,6]naphthyridine and azepino[3,2-c]quinoline derivatives as selective antagonists of 5-HT4 receptors: binding profile and pharmacological characterization.

Hinschberger A, Butt S, Lelong V, Boulouard M, Dumuis A, Dauphin F, Bureau R, Pfeiffer B, Renard P, Rault S.

J Med Chem. 2003 Jan 2;46(1):138-47.

PMID:
12502367
37.

A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL).

Claeysen S, Joubert L, Sebben M, Bockaert J, Dumuis A.

J Biol Chem. 2003 Jan 10;278(2):699-702. Epub 2002 Nov 18.

38.

SL65.0155, a novel 5-hydroxytryptamine(4) receptor partial agonist with potent cognition-enhancing properties.

Moser PC, Bergis OE, Jegham S, Lochead A, Duconseille E, Terranova JP, Caille D, Berque-Bestel I, Lezoualc'h F, Fischmeister R, Dumuis A, Bockaert J, George P, Soubrié P, Scatton B.

J Pharmacol Exp Ther. 2002 Aug;302(2):731-41.

PMID:
12130738
39.

Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach.

Bécamel C, Alonso G, Galéotti N, Demey E, Jouin P, Ullmer C, Dumuis A, Bockaert J, Marin P.

EMBO J. 2002 May 15;21(10):2332-42.

40.

A 5-HT4 receptor transmembrane network implicated in the activity of inverse agonists but not agonists.

Joubert L, Claeysen S, Sebben M, Bessis AS, Clark RD, Martin RS, Bockaert J, Dumuis A.

J Biol Chem. 2002 Jul 12;277(28):25502-11. Epub 2002 Apr 25. Erratum in: J Biol Chem 2002 Oct 18;277(42):40167.

41.

G protein-coupled receptors: dominant players in cell-cell communication.

Bockaert J, Claeysen S, Bécamel C, Pinloche S, Dumuis A.

Int Rev Cytol. 2002;212:63-132. Review.

PMID:
11804040
42.

The 5-hydroxytryptamine(4a) receptor is palmitoylated at two different sites, and acylation is critically involved in regulation of receptor constitutive activity.

Ponimaskin EG, Heine M, Joubert L, Sebben M, Bickmeyer U, Richter DW, Dumuis A.

J Biol Chem. 2002 Jan 25;277(4):2534-46. Epub 2001 Nov 12.

43.

Constitutively active mutants of 5-HT4 receptors are they in unique active states?

Claeysen S, Sebben M, Bécamel C, Parmentier ML, Dumuis A, Bockaert J.

EMBO Rep. 2001 Jan;2(1):61-7.

44.

Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1.

Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C.

J Biol Chem. 2001 Apr 20;276(16):12974-82. Epub 2001 Jan 9.

45.

Differential modulation of the 5-HT(4) receptor agonists and antagonist on rat learning and memory.

Marchetti E, Dumuis A, Bockaert J, Soumireu-Mourat B, Roman FS.

Neuropharmacology. 2000 Aug 23;39(11):2017-27.

PMID:
10963745
46.

Pharmacological properties of 5-Hydroxytryptamine(4) receptor antagonists on constitutively active wild-type and mutated receptors.

Claeysen S, Sebben M, Bécamel C, Eglen RM, Clark RD, Bockaert J, Dumuis A.

Mol Pharmacol. 2000 Jul;58(1):136-44.

PMID:
10860935
47.

Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain.

Claeysen S, Sebben M, Becamel C, Bockaert J, Dumuis A.

Mol Pharmacol. 1999 May;55(5):910-20.

PMID:
10220570
48.

5-HT4 receptors: cloning and expression of new splice variants.

Claeysen S, Faye P, Sebben M, Taviaux S, Bockaert J, Dumuis A.

Ann N Y Acad Sci. 1998 Dec 15;861:49-56. Review.

PMID:
9928238
49.

5-HT4 receptors: gene, transduction and effects on olfactory memory.

Bockaert J, Claeysen S, Sebben M, Dumuis A.

Ann N Y Acad Sci. 1998 Dec 15;861:1-15. Review.

PMID:
9928233
50.

5-HT4 receptors: long-term blockade of K+ channels and effects on olfactory memory.

Bockaert J, Ansanay H, Letty S, Marchetti-Gauthier E, Roman F, Rondouin G, Fagni L, Soumireu-Mourat B, Dumuis A.

C R Acad Sci III. 1998 Feb-Mar;321(2-3):217-21. Review. No abstract available.

PMID:
9759344

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