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Items: 6


Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases.

Konicek BW, Stephens JR, McNulty AM, Robichaud N, Peery RB, Dumstorf CA, Dowless MS, Iversen PW, Parsons S, Ellis KE, McCann DJ, Pelletier J, Furic L, Yingling JM, Stancato LF, Sonenberg N, Graff JR.

Cancer Res. 2011 Mar 1;71(5):1849-57. doi: 10.1158/0008-5472.CAN-10-3298. Epub 2011 Jan 13.


Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis.

Dumstorf CA, Konicek BW, McNulty AM, Parsons SH, Furic L, Sonenberg N, Graff JR.

Mol Cancer Ther. 2010 Dec;9(12):3158-63. doi: 10.1158/1535-7163.MCT-10-0413. Epub 2010 Oct 22.


eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival.

Graff JR, Konicek BW, Lynch RL, Dumstorf CA, Dowless MS, McNulty AM, Parsons SH, Brail LH, Colligan BM, Koop JW, Hurst BM, Deddens JA, Neubauer BL, Stancato LF, Carter HW, Douglass LE, Carter JH.

Cancer Res. 2009 May 1;69(9):3866-73. doi: 10.1158/0008-5472.CAN-08-3472. Epub 2009 Apr 21.


REV1 is implicated in the development of carcinogen-induced lung cancer.

Dumstorf CA, Mukhopadhyay S, Krishnan E, Haribabu B, McGregor WG.

Mol Cancer Res. 2009 Feb;7(2):247-54. doi: 10.1158/1541-7786.MCR-08-0399. Epub 2009 Jan 27.


Targeting the eIF4F translation initiation complex for cancer therapy.

Konicek BW, Dumstorf CA, Graff JR.

Cell Cycle. 2008 Aug 15;7(16):2466-71. Epub 2008 Aug 18.


Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer.

Dumstorf CA, Clark AB, Lin Q, Kissling GE, Yuan T, Kucherlapati R, McGregor WG, Kunkel TA.

Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18083-8. Epub 2006 Nov 17.

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