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Items: 24

1.

Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β 2-Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies.

Koziczak-Holbro M, Rigel DF, Dumotier B, Sykes DA, Tsao J, Nguyen NH, Bösch J, Jourdain M, Flotte L, Adachi Y, Kiffe M, Azria M, Fairhurst RA, Charlton SJ, Richardson BP, Lach-Trifilieff E, Glass DJ, Ullrich T, Hatakeyama S.

J Pharmacol Exp Ther. 2019 May;369(2):188-199. doi: 10.1124/jpet.118.255307. Epub 2019 Feb 28.

PMID:
30819762
2.

Xenobiotic CAR Activators Induce Dlk1-Dio3 Locus Noncoding RNA Expression in Mouse Liver.

Pouché L, Vitobello A, Römer M, Glogovac M, MacLeod AK, Ellinger-Ziegelbauer H, Westphal M, Dubost V, Stiehl DP, Dumotier B, Fekete A, Moulin P, Zell A, Schwarz M, Moreno R, Huang JTJ, Elcombe CR, Henderson CJ, Roland Wolf C, Moggs JG, Terranova R.

Toxicol Sci. 2017 Aug 1;158(2):367-378. doi: 10.1093/toxsci/kfx104.

PMID:
28541575
3.

Blinded Contractility Analysis in hiPSC-Cardiomyocytes in Engineered Heart Tissue Format: Comparison With Human Atrial Trabeculae.

Mannhardt I, Eder A, Dumotier B, Prondzynski M, Krämer E, Traebert M, Söhren KD, Flenner F, Stathopoulou K, Lemoine MD, Carrier L, Christ T, Eschenhagen T, Hansen A.

Toxicol Sci. 2017 Jul 1;158(1):164-175. doi: 10.1093/toxsci/kfx081.

4.

Secondary pharmacology: screening and interpretation of off-target activities - focus on translation.

Whitebread S, Dumotier B, Armstrong D, Fekete A, Chen S, Hartmann A, Muller PY, Urban L.

Drug Discov Today. 2016 Aug;21(8):1232-42. doi: 10.1016/j.drudis.2016.04.021. Epub 2016 Apr 29. Review.

PMID:
27140035
5.

Republished: A straightforward guide to the basic science behind arrhythmogenesis.

Dumotier BM.

Postgrad Med J. 2015 Apr;91(1074):221-9. doi: 10.1136/postgradmedj-2014-305647rep. Review.

PMID:
25862707
6.

A straightforward guide to the basic science behind arrhythmogenesis.

Dumotier BM.

Heart. 2014 Dec;100(24):1907-15. doi: 10.1136/heartjnl-2014-305647. Epub 2014 Sep 2. Review.

PMID:
25184825
7.

Analysis of unipolar electrograms in rabbit heart demonstrated the key role of ventricular apicobasal dispersion in arrhythmogenicity.

Guérard N, Jordaan P, Dumotier B.

Cardiovasc Toxicol. 2014 Dec;14(4):316-28. doi: 10.1007/s12012-014-9254-2.

PMID:
24740433
8.

Drug-induced QTC prolongation dangerously underestimates proarrhythmic potential: lessons from terfenadine.

Hondeghem LM, Dujardin K, Hoffmann P, Dumotier B, De Clerck F.

J Cardiovasc Pharmacol. 2011 May;57(5):589-97. doi: 10.1097/FJC.0b013e3182135e91.

PMID:
21346598
9.

Oscillations of cardiac wave length and proarrhythmia.

Hondeghem LM, Dumotier B, Traebert M.

Naunyn Schmiedebergs Arch Pharmacol. 2010 Oct;382(4):367-76. doi: 10.1007/s00210-010-0549-y. Epub 2010 Aug 29.

PMID:
20803191
10.

Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).

Cho YS, Whitehead L, Li J, Chen CH, Jiang L, Vögtle M, Francotte E, Richert P, Wagner T, Traebert M, Lu Q, Cao X, Dumotier B, Fejzo J, Rajan S, Wang P, Yan-Neale Y, Shao W, Atadja P, Shultz M.

J Med Chem. 2010 Apr 8;53(7):2952-63. doi: 10.1021/jm100007m.

PMID:
20205394
11.

Report and recommendations of the workshop of the European Centre for the Validation of Alternative Methods for Drug-Induced Cardiotoxicity.

Stummann TC, Beilmann M, Duker G, Dumotier B, Fredriksson JM, Jones RL, Hasiwa M, Kang YJ, Mandenius CF, Meyer T, Minotti G, Valentin YJ, Zünkler BJ, Bremer S.

Cardiovasc Toxicol. 2009 Sep;9(3):107-25. doi: 10.1007/s12012-009-9045-3. Epub 2009 Jul 2.

PMID:
19572114
12.

Modeling and simulation of preclinical cardiac safety: towards an integrative framework.

Soubret A, Helmlinger G, Dumotier B, Bibas R, Georgieva A.

Drug Metab Pharmacokinet. 2009;24(1):76-90. Review.

13.

Ultrafast sodium channel block by dietary fish oil prevents dofetilide-induced ventricular arrhythmias in rabbit hearts.

Dujardin KS, Dumotier B, David M, Guizy M, Valenzuela C, Hondeghem LM.

Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1414-21. doi: 10.1152/ajpheart.01219.2007. Epub 2008 Aug 1.

14.

Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart.

Guérard NC, Traebert M, Suter W, Dumotier BM.

J Pharmacol Toxicol Methods. 2008 Jul-Aug;58(1):32-40. doi: 10.1016/j.vascn.2008.05.129. Epub 2008 Jun 8.

PMID:
18582585
15.

Relevance of in vitro SCREENIT results for drug-induced QT interval prolongation in vivo: a database review and analysis.

Dumotier BM, Deurinck M, Yang Y, Traebert M, Suter W.

Pharmacol Ther. 2008 Aug;119(2):152-9. doi: 10.1016/j.pharmthera.2008.03.001. Epub 2008 Mar 26.

PMID:
18462801
16.

Preclinical cardio-safety assessment of torsadogenic risk and alternative methods to animal experimentation: the inseparable twins.

Dumotier BM, Georgieva AV.

Cell Biol Toxicol. 2007 Jul;23(4):293-302. Epub 2007 Jan 10. Review.

PMID:
17216548
17.

Preclinical cardiac safety assessment of pharmaceutical compounds using an integrated systems-based computer model of the heart.

Bottino D, Penland RC, stamps A, Traebert M, Dumotier B, Georgiva A, Helmlinger G, Lett GS.

Prog Biophys Mol Biol. 2006 Jan-Apr;90(1-3):414-43.

PMID:
16321428
18.

Antimalarial drugs: QT prolongation and cardiac arrhythmias.

Traebert M, Dumotier B.

Expert Opin Drug Saf. 2005 May;4(3):421-31. Review.

PMID:
15934850
19.

Inhibition of hERG K+ currents by antimalarial drugs in stably transfected HEK293 cells.

Traebert M, Dumotier B, Meister L, Hoffmann P, Dominguez-Estevez M, Suter W.

Eur J Pharmacol. 2004 Jan 19;484(1):41-8.

PMID:
14729380
20.

"Use-dependent" effects of cisapride on postrest action potentials in rabbit ventricular myocardium.

Dumotier BM, Bastide M, Adamantidis MM.

Eur J Pharmacol. 2001 Jun 22;422(1-3):137-48.

PMID:
11430924
21.

Chronic amiodarone effects on epicardial conduction and repolarization in the isolated porcine heart.

Lacroix D, Sautière K, Adamantidis M, Dumotier B, Grandmougin D, Extramiana F, Kacet S, Dupuis B.

Pacing Clin Electrophysiol. 2000 Jul;23(7):1133-43.

PMID:
10914370
22.
23.

Sparfloxacin but not levofloxacin or ofloxacin prolongs cardiac repolarization in rabbit Purkinje fibers.

Adamantidis MM, Dumotier BM, Caron JF, Bordet R.

Fundam Clin Pharmacol. 1998;12(1):70-6.

PMID:
9523187
24.

Cisapride-induced prolongation of cardiac action potential and early afterdepolarizations in rabbit Purkinje fibres.

Puisieux FL, Adamantidis MM, Dumotier BM, Dupuis BA.

Br J Pharmacol. 1996 Apr;117(7):1377-9.

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