Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 558


Dissecting the Role of Thyrotropin in the DNA Damage Response in Human Thyrocytes after 131I, γ Radiation and H2O2.

Kyrilli A, Gacquer D, Detours V, Lefort A, Libert F, Twyffels L, Van Den Eeckhaute L, Strickaert A, Maenhaut C, De Deken X, Dumont JE, Miot F, Corvilain B.

J Clin Endocrinol Metab. 2020 Mar 1;105(3). pii: dgz185. doi: 10.1210/clinem/dgz185.


Inhibition of the thyroid hormonogenic H2O2 production by Duox/DuoxA in zebrafish reveals VAS2870 as a new goitrogenic compound.

Giusti N, Gillotay P, Trubiroha A, Opitz R, Dumont JE, Costagliola S, De Deken X.

Mol Cell Endocrinol. 2020 Jan 15;500:110635. doi: 10.1016/j.mce.2019.110635. Epub 2019 Oct 31.


The Dual Oxidase Duox2 stabilized with DuoxA2 in an enzymatic complex at the surface of the cell produces extracellular H2O2 able to induce DNA damage in an inducible cellular model.

Poncelet L, Dumont JE, Miot F, De Deken X.

Exp Cell Res. 2019 Nov 1;384(1):111620. doi: 10.1016/j.yexcr.2019.111620. Epub 2019 Sep 9.


Reprogramming of Energy Metabolism: Increased Expression and Roles of Pyruvate Carboxylase in Papillary Thyroid Cancer.

Strickaert A, Corbet C, Spinette SA, Craciun L, Dom G, Andry G, Larsimont D, Wattiez R, Dumont JE, Feron O, Maenhaut C.

Thyroid. 2019 Jun;29(6):845-857. doi: 10.1089/thy.2018.0435.


Expression, Localization, and Regulation of the Sodium Bicarbonate Cotransporter NBCe1 in the Thyroid.

Virreira M, Jin L, Djerbib S, De Deken X, Miot F, Massart C, Svoboda M, Van Sande J, Beauwens R, Dumont JE, Boom A.

Thyroid. 2019 Feb;29(2):290-301. doi: 10.1089/thy.2017.0576. Epub 2019 Jan 23.


Factors contributing to the resistance of the thyrocyte to hydrogen peroxide.

Ghaddhab C, Kyrilli A, Driessens N, Van Den Eeckhaute E, Hancisse O, De Deken X, Dumont JE, Detours V, Miot F, Corvilain B.

Mol Cell Endocrinol. 2019 Feb 5;481:62-70. doi: 10.1016/j.mce.2018.11.010. Epub 2018 Nov 23.


Thyroid follicular adenomas and carcinomas: molecular profiling provides evidence for a continuous evolution.

Dom G, Frank S, Floor S, Kehagias P, Libert F, Hoang C, Andry G, Spinette A, Craciun L, de Saint Aubin N, Tresallet C, Tissier F, Savagner F, Majjaj S, Gutierrez-Roelens I, Marbaix E, Dumont JE, Maenhaut C.

Oncotarget. 2017 Dec 8;9(12):10343-10359. doi: 10.18632/oncotarget.23130. eCollection 2018 Feb 13.


Distinctive Desmoplastic 3D Morphology Associated With BRAFV600E in Papillary Thyroid Cancers.

Tarabichi M, Antoniou A, Le Pennec S, Gacquer D, de Saint Aubain N, Craciun L, Cielen T, Laios I, Larsimont D, Andry G, Dumont JE, Maenhaut C, Detours V.

J Clin Endocrinol Metab. 2018 Mar 1;103(3):1102-1111. doi: 10.1210/jc.2017-02279.


The human bitter taste receptor T2R38 is broadly tuned for bacterial compounds.

Verbeurgt C, Veithen A, Carlot S, Tarabichi M, Dumont JE, Hassid S, Chatelain P.

PLoS One. 2017 Sep 13;12(9):e0181302. doi: 10.1371/journal.pone.0181302. eCollection 2017.


Commentary: Thyrotropin Stimulates Differentiation Not Proliferation of Normal Human Thyrocytes in Culture.

Kyrilli A, Paternot S, Miot F, Corvilain B, Vassart G, Roger PP, Dumont JE.

Front Endocrinol (Lausanne). 2017 Aug 25;8:214. doi: 10.3389/fendo.2017.00214. eCollection 2017. No abstract available.


Cancer heterogeneity is not compatible with one unique cancer cell metabolic map.

Strickaert A, Saiselet M, Dom G, De Deken X, Dumont JE, Feron O, Sonveaux P, Maenhaut C.

Oncogene. 2017 May 11;36(19):2637-2642. doi: 10.1038/onc.2016.411. Epub 2016 Oct 31. Review.


Overexpression of Interleukin-4 in the Thyroid of Transgenic Mice Upregulates the Expression of Duox1 and the Anion Transporter Pendrin.

Eskalli Z, Achouri Y, Hahn S, Many MC, Craps J, Refetoff S, Liao XH, Dumont JE, Van Sande J, Corvilain B, Miot F, De Deken X.

Thyroid. 2016 Oct;26(10):1499-1512.


miRNA expression and function in thyroid carcinomas: a comparative and critical analysis and a model for other cancers.

Saiselet M, Pita JM, Augenlicht A, Dom G, Tarabichi M, Fimereli D, Dumont JE, Detours V, Maenhaut C.

Oncotarget. 2016 Aug 9;7(32):52475-52492. doi: 10.18632/oncotarget.9655. Review.


AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B.

Johanns M, Lai YC, Hsu MF, Jacobs R, Vertommen D, Van Sande J, Dumont JE, Woods A, Carling D, Hue L, Viollet B, Foretz M, Rider MH.

Nat Commun. 2016 Mar 8;7:10856. doi: 10.1038/ncomms10856.


John B. Stanbury (May 15, 1915-July 6, 2015).

De Groot LJ, Dumont JE, Braverman L, Fierro Benitez R, Medeiros-Neto G, Dow E, Dumont JE, Jameson JL.

Thyroid. 2015 Nov;25(11):1177-80. doi: 10.1089/thy.2015.29008.mem. No abstract available.


MiRNA expression may account for chronic but not for acute regulation of mRNA expression in human thyroid tumor models.

Floor SL, Hebrant A, Pita JM, Saiselet M, Trésallet C, Libert F, Andry G, Dumont JE, van Staveren WC, Maenhaut C.

PLoS One. 2014 Nov 6;9(11):e111581. doi: 10.1371/journal.pone.0111581. eCollection 2014.


Anoctamin-1/TMEM16A is the major apical iodide channel of the thyrocyte.

Twyffels L, Strickaert A, Virreira M, Massart C, Van Sande J, Wauquier C, Beauwens R, Dumont JE, Galietta LJ, Boom A, Kruys V.

Am J Physiol Cell Physiol. 2014 Dec 15;307(12):C1102-12. doi: 10.1152/ajpcell.00126.2014. Epub 2014 Oct 8.


Profiling of olfactory receptor gene expression in whole human olfactory mucosa.

Verbeurgt C, Wilkin F, Tarabichi M, Gregoire F, Dumont JE, Chatelain P.

PLoS One. 2014 May 6;9(5):e96333. doi: 10.1371/journal.pone.0096333. eCollection 2014.


Diphenyleneiodonium, an inhibitor of NOXes and DUOXes, is also an iodide-specific transporter.

Massart C, Giusti N, Beauwens R, Dumont JE, Miot F, Sande JV.

FEBS Open Bio. 2013 Dec 7;4:55-9. doi: 10.1016/j.fob.2013.11.007. eCollection 2013.


Cancer stem cells, a fuzzy evolving concept: a cell population or a cell property?

Antoniou A, Hébrant A, Dom G, Dumont JE, Maenhaut C.

Cell Cycle. 2013 Dec 15;12(24):3743-8. doi: 10.4161/cc.27305. Epub 2013 Nov 22. Review.


Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signaling.

De Deken X, Corvilain B, Dumont JE, Miot F.

Antioxid Redox Signal. 2014 Jun 10;20(17):2776-93. doi: 10.1089/ars.2013.5602. Epub 2013 Oct 25. Review.


Comparative analysis of the thyrocytes and T cells: responses to H2O2 and radiation reveals an H2O2-induced antioxidant transcriptional program in thyrocytes.

Versteyhe S, Driessens N, Ghaddhab C, Tarabichi M, Hoste C, Dumont JE, Miot F, Corvilain B, Detours V.

J Clin Endocrinol Metab. 2013 Oct;98(10):E1645-54. doi: 10.1210/jc.2013-1266. Epub 2013 May 10.


Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and "swarm intelligence".

Tarabichi M, Antoniou A, Saiselet M, Pita JM, Andry G, Dumont JE, Detours V, Maenhaut C.

Cancer Metastasis Rev. 2013 Dec;32(3-4):403-21. doi: 10.1007/s10555-013-9431-y. Review.


Thyroid-specific inactivation of KIF3A alters the TSH signaling pathway and leads to hypothyroidism.

D'Amico E, Gayral S, Massart C, Van Sande J, Reiter JF, Dumont JE, Robaye B, Schurmans S.

J Mol Endocrinol. 2013 Apr 23;50(3):375-87. doi: 10.1530/JME-12-0219. Print 2013 Jun.


5-aza-2'-deoxycytidine has minor effects on differentiation in human thyroid cancer cell lines, but modulates genes that are involved in adaptation in vitro.

Dom G, Galdo VC, Tarabichi M, Tomás G, Hébrant A, Andry G, De Martelar V, Libert F, Leteurtre E, Dumont JE, Maenhaut C, van Staveren WC.

Thyroid. 2013 Mar;23(3):317-28. doi: 10.1089/thy.2012.0388.


mRNA expression in papillary and anaplastic thyroid carcinoma: molecular anatomy of a killing switch.

Hébrant A, Dom G, Dewaele M, Andry G, Trésallet C, Leteurtre E, Dumont JE, Maenhaut C.

PLoS One. 2012;7(10):e37807. doi: 10.1371/journal.pone.0037807. Epub 2012 Oct 24.


A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas.

Dom G, Tarabichi M, Unger K, Thomas G, Oczko-Wojciechowska M, Bogdanova T, Jarzab B, Dumont JE, Detours V, Maenhaut C.

Br J Cancer. 2012 Sep 4;107(6):994-1000. doi: 10.1038/bjc.2012.302. Epub 2012 Jul 24.


The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA.

Hoste C, Dumont JE, Miot F, De Deken X.

Exp Cell Res. 2012 Nov 1;318(18):2353-64. doi: 10.1016/j.yexcr.2012.07.007. Epub 2012 Jul 16.


Hallmarks of cancer: of all cancer cells, all the time?

Floor SL, Dumont JE, Maenhaut C, Raspe E.

Trends Mol Med. 2012 Sep;18(9):509-15. doi: 10.1016/j.molmed.2012.06.005. Epub 2012 Jul 13.


A general method to derive robust organ-specific gene expression-based differentiation indices: application to thyroid cancer diagnostic.

Tomás G, Tarabichi M, Gacquer D, Hébrant A, Dom G, Dumont JE, Keutgen X, Fahey TJ 3rd, Maenhaut C, Detours V.

Oncogene. 2012 Oct 11;31(41):4490-8. doi: 10.1038/onc.2011.626. Epub 2012 Jan 23.


Role of Epac and protein kinase A in thyrotropin-induced gene expression in primary thyrocytes.

van Staveren WC, Beeckman S, Tomás G, Dom G, Hébrant A, Delys L, Vliem MJ, Trésallet C, Andry G, Franc B, Libert F, Dumont JE, Maenhaut C.

Exp Cell Res. 2012 Mar 10;318(5):444-52. doi: 10.1016/j.yexcr.2011.12.022. Epub 2012 Jan 4.


Metabolic reprogramming of the tumor.

Ferreira LM, Hebrant A, Dumont JE.

Oncogene. 2012 Sep 6;31(36):3999-4011. doi: 10.1038/onc.2011.576. Epub 2012 Jan 9. Review.


Pendrin: the thyrocyte apical membrane iodide transporter?

Twyffels L, Massart C, Golstein PE, Raspe E, Van Sande J, Dumont JE, Beauwens R, Kruys V.

Cell Physiol Biochem. 2011;28(3):491-6. doi: 10.1159/000335110. Epub 2011 Nov 18. Review.


Most random gene expression signatures are significantly associated with breast cancer outcome.

Venet D, Dumont JE, Detours V.

PLoS Comput Biol. 2011 Oct;7(10):e1002240. doi: 10.1371/journal.pcbi.1002240. Epub 2011 Oct 20.


Cell biology of H2O2 generation in the thyroid: investigation of the control of dual oxidases (DUOX) activity in intact ex vivo thyroid tissue and cell lines.

Massart C, Hoste C, Virion A, Ruf J, Dumont JE, Van Sande J.

Mol Cell Endocrinol. 2011 Aug 22;343(1-2):32-44. doi: 10.1016/j.mce.2011.05.047. Epub 2011 Jun 6.


Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating-cancer stem cells: distinct, overlapping or same populations.

Floor S, van Staveren WC, Larsimont D, Dumont JE, Maenhaut C.

Oncogene. 2011 Nov 17;30(46):4609-21. doi: 10.1038/onc.2011.184. Epub 2011 Jun 6. Review.


Genetic hyperthyroidism: hyperthyroidism due to activating TSHR mutations.

Hébrant A, van Staveren WC, Maenhaut C, Dumont JE, Leclère J.

Eur J Endocrinol. 2011 Jan;164(1):1-9. doi: 10.1530/EJE-10-0775. Epub 2010 Oct 6. Review.


Extracellular superoxide dismutase is a thyroid differentiation marker down-regulated in cancer.

Laatikainen LE, Castellone MD, Hebrant A, Hoste C, Cantisani MC, Laurila JP, Salvatore G, Salerno P, Basolo F, Näsman J, Dumont JE, Santoro M, Laukkanen MO.

Endocr Relat Cancer. 2010 Aug 16;17(3):785-96. doi: 10.1677/ERC-10-0021. Print 2010 Sep.


A coherent organization of differentiation proteins is required to maintain an appropriate thyroid function in the Pendred thyroid.

Senou M, Khalifa C, Thimmesch M, Jouret F, Devuyst O, Col V, Audinot JN, Lipnik P, Moreno JC, Van Sande J, Dumont JE, Many MC, Colin IM, Gérard AC.

J Clin Endocrinol Metab. 2010 Aug;95(8):4021-30. doi: 10.1210/jc.2010-0228. Epub 2010 May 25.


cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.

Blancquaert S, Wang L, Paternot S, Coulonval K, Dumont JE, Harris TE, Roger PP.

Mol Endocrinol. 2010 Jul;24(7):1453-68. doi: 10.1210/me.2010-0087. Epub 2010 May 19.


Species specific thyroid signal transduction: conserved physiology, divergent mechanisms.

Song Y, Massart C, Chico-Galdo V, Jin L, De Maertelaer V, Decoster C, Dumont JE, Van Sande J.

Mol Cell Endocrinol. 2010 May 5;319(1-2):56-62. doi: 10.1016/j.mce.2010.01.024. Epub 2010 Jan 28.


H2O2, signal, substrate, mutagen and chemorepellent from physiology to biochemistry and disease.

Dumont JE, De Deken X, Miot F, Corvilain V, Contempré B, Goyens R, Massart C, Van Sande J, Allaoui A, Botteaux A.

Bull Mem Acad R Med Belg. 2010;165(5-6):231-4; discussion 235.


Signal transduction in the human thyrocyte and its perversion in thyroid tumors.

Roger PP, van Staveren WC, Coulonval K, Dumont JE, Maenhaut C.

Mol Cell Endocrinol. 2010 May 28;321(1):3-19. doi: 10.1016/j.mce.2009.11.015. Epub 2009 Dec 3. Review.


Association of duoxes with thyroid peroxidase and its regulation in thyrocytes.

Song Y, Ruf J, Lothaire P, Dequanter D, Andry G, Willemse E, Dumont JE, Van Sande J, De Deken X.

J Clin Endocrinol Metab. 2010 Jan;95(1):375-82. doi: 10.1210/jc.2009-1727. Epub 2009 Dec 1.


Dual oxidases and hydrogen peroxide in a complex dialogue between host mucosae and bacteria.

Allaoui A, Botteaux A, Dumont JE, Hoste C, De Deken X.

Trends Mol Med. 2009 Dec;15(12):571-9. doi: 10.1016/j.molmed.2009.10.003. Epub 2009 Nov 11.


Cancer stem cells: a reality, a myth, a fuzzy concept or a misnomer? An analysis.

Maenhaut C, Dumont JE, Roger PP, van Staveren WC.

Carcinogenesis. 2010 Feb;31(2):149-58. doi: 10.1093/carcin/bgp259. Epub 2009 Oct 25. Review.


Hydrogen peroxide induces DNA single- and double-strand breaks in thyroid cells and is therefore a potential mutagen for this organ.

Driessens N, Versteyhe S, Ghaddhab C, Burniat A, De Deken X, Van Sande J, Dumont JE, Miot F, Corvilain B.

Endocr Relat Cancer. 2009 Sep;16(3):845-56. doi: 10.1677/ERC-09-0020. Epub 2009 Jun 9.


Role of caveolin-1 in thyroid phenotype, cell homeostasis, and hormone synthesis: in vivo study of caveolin-1 knockout mice.

Senou M, Costa MJ, Massart C, Thimmesch M, Khalifa C, Poncin S, Boucquey M, Gérard AC, Audinot JN, Dessy C, Ruf J, Feron O, Devuyst O, Guiot Y, Dumont JE, Van Sande J, Many MC.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E438-51. doi: 10.1152/ajpendo.90784.2008. Epub 2009 May 12.


Thyroid gene expression in familial nonautoimmune hyperthyroidism shows common characteristics with hyperfunctioning autonomous adenomas.

Hébrant A, Van Sande J, Roger PP, Patey M, Klein M, Bournaud C, Savagner F, Leclère J, Dumont JE, van Staveren WC, Maenhaut C.

J Clin Endocrinol Metab. 2009 Jul;94(7):2602-9. doi: 10.1210/jc.2008-2191. Epub 2009 Apr 21.


Potential role of Noxes in the protection of mucosae: H(2)O(2) as a bacterial repellent.

Botteaux A, Hoste C, Dumont JE, Van Sande J, Allaoui A.

Microbes Infect. 2009 Apr;11(5):537-44. doi: 10.1016/j.micinf.2009.02.009. Epub 2009 Mar 17.


Supplemental Content

Loading ...
Support Center