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Items: 35


Auspicious Management of a Acute Obstructive Left Colon Tumor in a 93-year-old Patient - Case Report and Literature Review.

Andrei GN, Constantinescu G, Nedelcu C, Dumitriu BC, Valcea S, Beuran M.

Chirurgia (Bucur). 2017 Nov-Dec;112(6):734-746. doi: 10.21614/chirurgia.112.6.734. Review.


Persistent elevation of plasma thrombopoietin levels after treatment in severe aplastic anemia.

Zhao X, Feng X, Wu Z, Winkler T, Desmond R, Olnes M, Dumitriu B, Townsley DM, Dunbar CE, Young NS.

Exp Hematol. 2018 Feb;58:39-43. doi: 10.1016/j.exphem.2017.09.006. Epub 2017 Sep 20.


Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia.

Townsley DM, Scheinberg P, Winkler T, Desmond R, Dumitriu B, Rios O, Weinstein B, Valdez J, Lotter J, Feng X, Desierto M, Leuva H, Bevans M, Wu C, Larochelle A, Calvo KR, Dunbar CE, Young NS.

N Engl J Med. 2017 Apr 20;376(16):1540-1550. doi: 10.1056/NEJMoa1613878.


Epigenetic landscape of the TERT promoter: a potential biomarker for high risk AML/MDS.

Zhao X, Tian X, Kajigaya S, Cantilena CR, Strickland S, Savani BN, Mohan S, Feng X, Keyvanfar K, Dunavin N, Townsley DM, Dumitriu B, Battiwalla M, Rezvani K, Young NS, Barrett AJ, Ito S.

Br J Haematol. 2016 Nov;175(3):427-439. doi: 10.1111/bjh.14244. Epub 2016 Jul 19.


Telomere content measurement in human hematopoietic cells: Comparative analysis of qPCR and Flow-FISH techniques.

Wand T, Fang M, Chen C, Hardy N, McCoy JP Jr, Dumitriu B, Young NS, Biancotto A.

Cytometry A. 2016 Oct;89(10):914-921. doi: 10.1002/cyto.a.22982. Epub 2016 Sep 22.


Telomere Length Recovery: A Strong Predictor of Overall Survival in Acute Promyelocytic Leukemia.

Baljevic M, Dumitriu B, Lee JW, Paietta EM, Wiernik PH, Racevskis J, Chen C, Stein EM, Gallagher RE, Rowe JM, Appelbaum FR, Powell BL, Larson RA, Coutré SE, Lancet J, Litzow MR, Luger SM, Young NS, Tallman MS.

Acta Haematol. 2016;136(4):210-218. Epub 2016 Sep 16.


Danazol Treatment for Telomere Diseases.

Townsley DM, Dumitriu B, Young NS.

N Engl J Med. 2016 Sep 15;375(11):1095-6. doi: 10.1056/NEJMc1607752. No abstract available.


Telomere length and associations with somatic mutations and clinical outcomes in acute myeloid leukemia.

Watts JM, Dumitriu B, Hilden P, Kishtagari A, Rapaport F, Chen C, Ahn J, Devlin SM, Stein EM, Rampal R, Levine RL, Young N, Tallman MS.

Leuk Res. 2016 Oct;49:62-5. doi: 10.1016/j.leukres.2016.07.013. Epub 2016 Jul 25.


Danazol Treatment for Telomere Diseases.

Townsley DM, Dumitriu B, Liu D, Biancotto A, Weinstein B, Chen C, Hardy N, Mihalek AD, Lingala S, Kim YJ, Yao J, Jones E, Gochuico BR, Heller T, Wu CO, Calado RT, Scheinberg P, Young NS.

N Engl J Med. 2016 May 19;374(20):1922-31. doi: 10.1056/NEJMoa1515319.


Alemtuzumab in T-cell large granular lymphocytic leukaemia: interim results from a single-arm, open-label, phase 2 study.

Dumitriu B, Ito S, Feng X, Stephens N, Yunce M, Kajigaya S, Melenhorst JJ, Rios O, Scheinberg P, Chinian F, Keyvanfar K, Battiwalla M, Wu CO, Maric I, Xi L, Raffeld M, Muranski P, Townsley DM, Young NS, Barrett AJ, Scheinberg P.

Lancet Haematol. 2016 Jan;3(1):e22-9. doi: 10.1016/S2352-3026(15)00227-6. Epub 2015 Dec 17.


Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia.

Hosokawa K, Muranski P, Feng X, Townsley DM, Liu B, Knickelbein J, Keyvanfar K, Dumitriu B, Ito S, Kajigaya S, Taylor JG 6th, Kaplan MJ, Nussenblatt RB, Barrett AJ, O'Shea J, Young NS.

J Immunol. 2016 Feb 15;196(4):1568-78. doi: 10.4049/jimmunol.1501739. Epub 2016 Jan 13.


Identification of novel microRNA signatures linked to acquired aplastic anemia.

Hosokawa K, Muranski P, Feng X, Keyvanfar K, Townsley DM, Dumitriu B, Chen J, Kajigaya S, Taylor JG, Hourigan CS, Barrett AJ, Young NS.

Haematologica. 2015 Dec;100(12):1534-45. doi: 10.3324/haematol.2015.126128. Epub 2015 Sep 9.


Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.

Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S.

N Engl J Med. 2015 Jul 2;373(1):35-47. doi: 10.1056/NEJMoa1414799.


Cloning and molecular characterization of telomerase reverse transcriptase (TERT) and telomere length analysis of Peromyscus leucopus.

Zhao X, Ueda Y, Kajigaya S, Alaks G, Desierto MJ, Townsley DM, Dumitriu B, Chen J, Lacy RC, Young NS.

Gene. 2015 Aug 15;568(1):8-18. doi: 10.1016/j.gene.2015.05.013. Epub 2015 May 9.


Conservative management of neurocysticercosis in a patient with hematopoietic stem cell transplantation: a case report and review.

Purvey S, Lu K, Mukkamalla SK, Anandi P, Dumitriu B, Kranick S, Hammoud DA, O'Connell E, Oh AL, Barrett J, Mahanty S, Battiwalla M.

Transpl Infect Dis. 2015 Jun;17(3):456-62. doi: 10.1111/tid.12392. Epub 2015 Jun 1. Review.


Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders.

Balakumaran A, Mishra PJ, Pawelczyk E, Yoshizawa S, Sworder BJ, Cherman N, Kuznetsov SA, Bianco P, Giri N, Savage SA, Merlino G, Dumitriu B, Dunbar CE, Young NS, Alter BP, Robey PG.

Blood. 2015 Jan 29;125(5):793-802. doi: 10.1182/blood-2014-06-566810. Epub 2014 Dec 12.


Telomere attrition and candidate gene mutations preceding monosomy 7 in aplastic anemia.

Dumitriu B, Feng X, Townsley DM, Ueda Y, Yoshizato T, Calado RT, Yang Y, Wakabayashi Y, Kajigaya S, Ogawa S, Zhu J, Young NS.

Blood. 2015 Jan 22;125(4):706-9. doi: 10.1182/blood-2014-10-607572. Epub 2014 Nov 18.


Bone marrow failure and the telomeropathies.

Townsley DM, Dumitriu B, Young NS.

Blood. 2014 Oct 30;124(18):2775-83. doi: 10.1182/blood-2014-05-526285. Epub 2014 Sep 18. Review.


Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4.

Kuehn HS, Ouyang W, Lo B, Deenick EK, Niemela JE, Avery DT, Schickel JN, Tran DQ, Stoddard J, Zhang Y, Frucht DM, Dumitriu B, Scheinberg P, Folio LR, Frein CA, Price S, Koh C, Heller T, Seroogy CM, Huttenlocher A, Rao VK, Su HC, Kleiner D, Notarangelo LD, Rampertaap Y, Olivier KN, McElwee J, Hughes J, Pittaluga S, Oliveira JB, Meffre E, Fleisher TA, Holland SM, Lenardo MJ, Tangye SG, Uzel G.

Science. 2014 Sep 26;345(6204):1623-1627. doi: 10.1126/science.1255904. Epub 2014 Sep 11.


Moderate-dose cyclophosphamide for severe aplastic anemia has significant toxicity and does not prevent relapse and clonal evolution.

Scheinberg P, Townsley D, Dumitriu B, Scheinberg P, Weinstein B, Daphtary M, Rios O, Wu CO, Young NS.

Blood. 2014 Oct 30;124(18):2820-3. doi: 10.1182/blood-2014-05-573642. Epub 2014 Sep 3.


Translocation (8;21) acute myeloid leukemia presenting as severe aplastic anemia.

Purev E, Dumitriu B, Hourigan CS, Young NS, Townsley DM.

Leuk Res Rep. 2014 Jun 11;3(2):46-8. doi: 10.1016/j.lrr.2014.04.002. eCollection 2014.


Telomerase variant A279T induces telomere dysfunction and inhibits non-canonical telomerase activity in esophageal carcinomas.

Zhang Y, Calado R, Rao M, Hong JA, Meeker AK, Dumitriu B, Atay S, McCormick PJ, Garfield SH, Wangsa D, Padilla-Nash HM, Burkett S, Zhang M, Kunst TF, Peterson NR, Xi S, Inchauste S, Altorki NK, Casson AG, Beer DG, Harris CC, Ried T, Young NS, Schrump DS.

PLoS One. 2014 Jul 1;9(7):e101010. doi: 10.1371/journal.pone.0101010. eCollection 2014.


Horse antithymocyte globulin as salvage therapy after rabbit antithymocyte globulin for severe aplastic anemia.

Scheinberg P, Townsley D, Dumitriu B, Scheinberg P, Weinstein B, Rios O, Wu CO, Young NS.

Am J Hematol. 2014 May;89(5):467-9. doi: 10.1002/ajh.23669. Epub 2014 Mar 7.


Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug.

Desmond R, Townsley DM, Dumitriu B, Olnes MJ, Scheinberg P, Bevans M, Parikh AR, Broder K, Calvo KR, Wu CO, Young NS, Dunbar CE.

Blood. 2014 Mar 20;123(12):1818-25. doi: 10.1182/blood-2013-10-534743. Epub 2013 Dec 17.


Telomere dynamics in mice and humans.

Calado RT, Dumitriu B.

Semin Hematol. 2013 Apr;50(2):165-74. Review.


No impact of lentiviral transduction on hematopoietic stem/progenitor cell telomere length or gene expression in the rhesus macaque model.

Sellers SE, Dumitriu B, Morgan MJ, Hughes WM, Wu CO, Raghavarchari N, Yang Y, Uchida N, Tisdale JF, An DS, Chen IS, Hematti P, Donahue RE, Larochelle A, Young NS, Calado RT, Dunbar CE.

Mol Ther. 2014 Jan;22(1):52-8. doi: 10.1038/mt.2013.168. Epub 2013 Jul 18.


Damage control and its costs: BM failure in Fanconi anemia stems from overactive p53/p21.

Dumitriu B, Young NS.

Cell Stem Cell. 2012 Jul 6;11(1):7-8. doi: 10.1016/j.stem.2012.06.013.


Eltrombopag and improved hematopoiesis in refractory aplastic anemia.

Olnes MJ, Scheinberg P, Calvo KR, Desmond R, Tang Y, Dumitriu B, Parikh AR, Soto S, Biancotto A, Feng X, Lozier J, Wu CO, Young NS, Dunbar CE.

N Engl J Med. 2012 Jul 5;367(1):11-9. doi: 10.1056/NEJMoa1200931. Erratum in: N Engl J Med. 2012 Jul 19;367(3):284.


Sox6 is necessary for efficient erythropoiesis in adult mice under physiological and anemia-induced stress conditions.

Dumitriu B, Bhattaram P, Dy P, Huang Y, Quayum N, Jensen J, Lefebvre V.

PLoS One. 2010 Aug 9;5(8):e12088. doi: 10.1371/journal.pone.0012088.


Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage.

Dy P, Smits P, Silvester A, Penzo-Méndez A, Dumitriu B, Han Y, de la Motte CA, Kingsley DM, Lefebvre V.

Dev Biol. 2010 May 15;341(2):346-59. doi: 10.1016/j.ydbio.2010.02.024. Epub 2010 Mar 4.


Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors.

Lefebvre V, Dumitriu B, Penzo-Méndez A, Han Y, Pallavi B.

Int J Biochem Cell Biol. 2007;39(12):2195-214. Epub 2007 Jun 6. Review.


Generation of mice harboring a Sox6 conditional null allele.

Dumitriu B, Dy P, Smits P, Lefebvre V.

Genesis. 2006 May;44(5):219-24.


Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development.

Dumitriu B, Patrick MR, Petschek JP, Cherukuri S, Klingmuller U, Fox PL, Lefebvre V.

Blood. 2006 Aug 15;108(4):1198-207. Epub 2006 Apr 20.


Serotonin receptor antagonists discriminate between PKA- and PKC-mediated plasticity in aplysia sensory neurons.

Dumitriu B, Cohen JE, Wan Q, Negroiu AM, Abrams TW.

J Neurophysiol. 2006 Apr;95(4):2713-20. Epub 2005 Oct 19.


Flow cytometry measurements of intracellular Ca2+ in K 562 cells.

Olariu L, Dumitriu B, Neagu M, Manda G.

Rom J Intern Med. 1999 Jan-Mar;37(1):81-9.


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