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A medial prefrontal cortex cell type necessary and sufficient for a rapid antidepressant response.

Hare BD, Duman RS.

Chronic Stress (Thousand Oaks). 2019 Jan-Dec;3. doi: 10.1177/2470547019841358. Epub 2019 Apr 15. No abstract available.


Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation.

Kato T, Pothula S, Liu RJ, Duman CH, Terwilliger R, Vlasuk GP, Saiah E, Hahm S, Duman RS.

J Clin Invest. 2019 Apr 16;130:2542-2554. doi: 10.1172/JCI126859.


Lower synaptic density is associated with depression severity and network alterations.

Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I.

Nat Commun. 2019 Apr 4;10(1):1529. doi: 10.1038/s41467-019-09562-7.


Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments.

Duman RS, Sanacora G, Krystal JH.

Neuron. 2019 Apr 3;102(1):75-90. doi: 10.1016/j.neuron.2019.03.013. Review.


Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions.

Fogaça MV, Duman RS.

Front Cell Neurosci. 2019 Mar 12;13:87. doi: 10.3389/fncel.2019.00087. eCollection 2019. Review.


Neurobiology of rapid-acting antidepressants: convergent effects on GluA1-synaptic function.

Duman RS, Shinohara R, Fogaça MV, Hare B.

Mol Psychiatry. 2019 Mar 20. doi: 10.1038/s41380-019-0400-x. [Epub ahead of print] Review.


Ketamine: A Paradigm Shift for Depression Research and Treatment.

Krystal JH, Abdallah CG, Sanacora G, Charney DS, Duman RS.

Neuron. 2019 Mar 6;101(5):774-778. doi: 10.1016/j.neuron.2019.02.005.


The Dazzling Promise of Ketamine.

Duman RS.

Cerebrum. 2018 Apr 1;2018. pii: cer-04-18. eCollection 2018 Mar-Apr.


Neurotrophic and Antidepressant Actions of Brain-Derived Neurotrophic Factor Require Vascular Endothelial Growth Factor.

Deyama S, Bang E, Kato T, Li XY, Duman RS.

Biol Psychiatry. 2018 Dec 27. pii: S0006-3223(18)32099-7. doi: 10.1016/j.biopsych.2018.12.014. [Epub ahead of print]


Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects.

Hare BD, Shinohara R, Liu RJ, Pothula S, DiLeone RJ, Duman RS.

Nat Commun. 2019 Jan 15;10(1):223. doi: 10.1038/s41467-018-08168-9.


Role of Neuronal VEGF Signaling in the Prefrontal Cortex in the Rapid Antidepressant Effects of Ketamine.

Deyama S, Bang E, Wohleb ES, Li XY, Kato T, Gerhard DM, Dutheil S, Dwyer JM, Taylor SR, Picciotto MR, Duman RS.

Am J Psychiatry. 2019 May 1;176(5):388-400. doi: 10.1176/appi.ajp.2018.17121368. Epub 2019 Jan 4.


Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine.

Fukumoto K, Fogaça MV, Liu RJ, Duman C, Kato T, Li XY, Duman RS.

Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):297-302. doi: 10.1073/pnas.1814709116. Epub 2018 Dec 17.


Analysis of Bulk Tissue Transcriptome Data Reveals Convergence of Cell Types Altered in Schizophrenia and Bipolar Disorder.

Girgenti MJ, Duman RS.

Biol Psychiatry. 2018 Dec 1;84(11):772-774. doi: 10.1016/j.biopsych.2018.09.014. No abstract available.


BDNF Val66Met polymorphism and posttraumatic stress symptoms in U.S. military veterans: Protective effect of physical exercise.

Pitts BL, Whealin JM, Harpaz-Rotem I, Duman RS, Krystal JH, Southwick SM, Pietrzak RH.

Psychoneuroendocrinology. 2019 Feb;100:198-202. doi: 10.1016/j.psyneuen.2018.10.011. Epub 2018 Oct 17.


Fibroblast growth factor 2 is necessary for the antidepressant effects of fluoxetine.

Simard S, Shail P, MacGregor J, El Sayed M, Duman RS, Vaccarino FM, Salmaso N.

PLoS One. 2018 Oct 1;13(10):e0204980. doi: 10.1371/journal.pone.0204980. eCollection 2018.


Molecular and cellular studies of PTSD: Postmortem transcriptome analysis and novel therapeutic targets.

Duman RS, Girgenti MJ.

J Neurosci Res. 2019 Mar;97(3):292-299. doi: 10.1002/jnr.24306. Epub 2018 Aug 23. Review.


Rapid-Acting Antidepressants: Mechanistic Insights and Future Directions.

Gerhard DM, Duman RS.

Curr Behav Neurosci Rep. 2018 Mar;5(1):36-47. Epub 2018 Feb 5.


Novel rapid-acting antidepressants: molecular and cellular signaling mechanisms.

Thomas AM, Duman RS.

Neuronal Signal. 2017 Dec;1(4). pii: NS20170010. doi: 10.1042/NS20170010. Epub 2017 Sep 5.


Sex-Specific Molecular Changes in Depression.

Gerhard DM, Duman RS.

Biol Psychiatry. 2018 Jul 1;84(1):2-4. doi: 10.1016/j.biopsych.2018.05.005. No abstract available.


Ketamine and rapid-acting antidepressants: a new era in the battle against depression and suicide.

Duman RS.

F1000Res. 2018 May 24;7. pii: F1000 Faculty Rev-659. doi: 10.12688/f1000research.14344.1. eCollection 2018. Review.


The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?

Abdallah CG, Sanacora G, Duman RS, Krystal JH.

Pharmacol Ther. 2018 Oct;190:148-158. doi: 10.1016/j.pharmthera.2018.05.010. Epub 2018 May 25. Review.


Convergent Mechanisms Underlying Rapid Antidepressant Action.

Zanos P, Thompson SM, Duman RS, Zarate CA Jr, Gould TD.

CNS Drugs. 2018 Mar;32(3):197-227. doi: 10.1007/s40263-018-0492-x. Review.


The anxiolytic effects of cannabidiol in chronically stressed mice are mediated by the endocannabinoid system: Role of neurogenesis and dendritic remodeling.

Fogaça MV, Campos AC, Coelho LD, Duman RS, Guimarães FS.

Neuropharmacology. 2018 Jun;135:22-33. doi: 10.1016/j.neuropharm.2018.03.001. Epub 2018 Mar 3.


The Stress-Induced Transcription Factor NR4A1 Adjusts Mitochondrial Function and Synapse Number in Prefrontal Cortex.

Jeanneteau F, Barrère C, Vos M, De Vries CJM, Rouillard C, Levesque D, Dromard Y, Moisan MP, Duric V, Franklin TC, Duman RS, Lewis DA, Ginsberg SD, Arango-Lievano M.

J Neurosci. 2018 Feb 7;38(6):1335-1350. doi: 10.1523/JNEUROSCI.2793-17.2017. Epub 2018 Jan 2.


Circuit and synaptic mechanisms of repeated stress: Perspectives from differing contexts, duration, and development.

Bath KG, Russo SJ, Pleil KE, Wohleb ES, Duman RS, Radley JJ.

Neurobiol Stress. 2017 May 6;7:137-151. doi: 10.1016/j.ynstr.2017.05.001. eCollection 2017 Dec. Review.


BDNF release and signaling are required for the antidepressant actions of GLYX-13.

Kato T, Fogaça MV, Deyama S, Li XY, Fukumoto K, Duman RS.

Mol Psychiatry. 2018 Oct;23(10):2007-2017. doi: 10.1038/mp.2017.220. Epub 2017 Dec 5.


BDNF, 5-HT, and Anxiety: Identification of a Critical Periadolescent Developmental Period.

Duman RS.

Am J Psychiatry. 2017 Dec 1;174(12):1137-1139. doi: 10.1176/appi.ajp.2017.17101084. No abstract available.


Transcriptome Alterations in Posttraumatic Stress Disorder.

Girgenti MJ, Duman RS.

Biol Psychiatry. 2018 May 15;83(10):840-848. doi: 10.1016/j.biopsych.2017.09.023. Epub 2017 Oct 4. Review.


Depression and sterile inflammation: Essential role of danger associated molecular patterns.

Franklin TC, Xu C, Duman RS.

Brain Behav Immun. 2018 Aug;72:2-13. doi: 10.1016/j.bbi.2017.10.025. Epub 2017 Nov 2.


Molecular and Cellular Effects of Traumatic Stress: Implications for PTSD.

Girgenti MJ, Hare BD, Ghosal S, Duman RS.

Curr Psychiatry Rep. 2017 Sep 25;19(11):85. doi: 10.1007/s11920-017-0841-3. Review.


Sex-specific disease-associated modules for depression.

Duman RS.

Nat Med. 2017 Sep 8;23(9):1015-1017. doi: 10.1038/nm.4391. No abstract available.


Persistent Increase in Microglial RAGE Contributes to Chronic Stress-Induced Priming of Depressive-like Behavior.

Franklin TC, Wohleb ES, Zhang Y, Fogaça M, Hare B, Duman RS.

Biol Psychiatry. 2018 Jan 1;83(1):50-60. doi: 10.1016/j.biopsych.2017.06.034. Epub 2017 Jul 21.


Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic.

Krystal JH, Abdallah CG, Averill LA, Kelmendi B, Harpaz-Rotem I, Sanacora G, Southwick SM, Duman RS.

Curr Psychiatry Rep. 2017 Aug 26;19(10):74. doi: 10.1007/s11920-017-0829-z. Review.


Characterization of GABAergic marker expression in the chronic unpredictable stress model of depression.

Banasr M, Lepack A, Fee C, Duric V, Maldonado-Aviles J, DiLeone R, Sibille E, Duman RS, Sanacora G.

Chronic Stress (Thousand Oaks). 2017 Feb;1. doi: 10.1177/2470547017720459. Epub 2017 Aug 3.


Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses.

Yamanashi T, Iwata M, Kamiya N, Tsunetomi K, Kajitani N, Wada N, Iitsuka T, Yamauchi T, Miura A, Pu S, Shirayama Y, Watanabe K, Duman RS, Kaneko K.

Sci Rep. 2017 Aug 9;7(1):7677. doi: 10.1038/s41598-017-08055-1.


Activity-Dependent Brain-Derived Neurotrophic Factor Release Is Required for the Rapid Antidepressant Actions of Scopolamine.

Ghosal S, Bang E, Yue W, Hare BD, Lepack AE, Girgenti MJ, Duman RS.

Biol Psychiatry. 2018 Jan 1;83(1):29-37. doi: 10.1016/j.biopsych.2017.06.017. Epub 2017 Jun 23.


Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence.

Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I; Traumatic Stress Brain Study Group.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8390-8395. doi: 10.1073/pnas.1701749114. Epub 2017 Jul 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Sep 5;:.


Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior.

Wohleb ES, Terwilliger R, Duman CH, Duman RS.

Biol Psychiatry. 2018 Jan 1;83(1):38-49. doi: 10.1016/j.biopsych.2017.05.026. Epub 2017 Jun 12.


Rapid Acting Antidepressants in Chronic Stress Models: Molecular and Cellular Mechanisms.

Hare BD, Ghosal S, Duman RS.

Chronic Stress (Thousand Oaks). 2017 Feb;1. doi: 10.1177/2470547017697317. Epub 2017 Apr 10.


Cariprazine Exhibits Anxiolytic and Dopamine D3 Receptor-Dependent Antidepressant Effects in the Chronic Stress Model.

Duric V, Banasr M, Franklin T, Lepack A, Adham N, Kiss B, Gyertyán I, Duman RS.

Int J Neuropsychopharmacol. 2017 Oct 1;20(10):788-796. doi: 10.1093/ijnp/pyx038.


Phosphodiesterase-1b (Pde1b) knockout mice are resistant to forced swim and tail suspension induced immobility and show upregulation of Pde10a.

Hufgard JR, Williams MT, Skelton MR, Grubisha O, Ferreira FM, Sanger H, Wright ME, Reed-Kessler TM, Rasmussen K, Duman RS, Vorhees CV.

Psychopharmacology (Berl). 2017 Jun;234(12):1803-1813. doi: 10.1007/s00213-017-4587-8. Epub 2017 Mar 23.


How do antidepressants work? New perspectives for refining future treatment approaches.

Harmer CJ, Duman RS, Cowen PJ.

Lancet Psychiatry. 2017 May;4(5):409-418. doi: 10.1016/S2215-0366(17)30015-9. Epub 2017 Jan 31. Review.


Ketamine accelerates fear extinction via mTORC1 signaling.

Girgenti MJ, Ghosal S, LoPresto D, Taylor JR, Duman RS.

Neurobiol Dis. 2017 Apr;100:1-8. doi: 10.1016/j.nbd.2016.12.026. Epub 2016 Dec 30.


Stress induces equivalent remodeling of hippocampal spine synapses in a simulated postpartum environment and in a female rat model of major depression.

Baka J, Csakvari E, Huzian O, Dobos N, Siklos L, Leranth C, MacLusky NJ, Duman RS, Hajszan T.

Neuroscience. 2017 Feb 20;343:384-397. doi: 10.1016/j.neuroscience.2016.12.021. Epub 2016 Dec 22.


Cacna1c in the Prefrontal Cortex Regulates Depression-Related Behaviors via REDD1.

Kabir ZD, Lee AS, Burgdorf CE, Fischer DK, Rajadhyaksha AM, Mok E, Rizzo B, Rice RC, Singh K, Ota KT, Gerhard DM, Schierberl KC, Glass MJ, Duman RS, Rajadhyaksha AM.

Neuropsychopharmacology. 2017 Sep;42(10):2032-2042. doi: 10.1038/npp.2016.271. Epub 2016 Dec 6.


GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine.

Liu RJ, Duman C, Kato T, Hare B, Lopresto D, Bang E, Burgdorf J, Moskal J, Taylor J, Aghajanian G, Duman RS.

Neuropsychopharmacology. 2017 May;42(6):1231-1242. doi: 10.1038/npp.2016.202. Epub 2016 Sep 16.


The Connecticut Mental Health Center: Celebrating 50 Years of a Successful Partnership Between the State and Yale University.

Steiner JL, Anez-Nava L, Baranoski M, Cole R, Davidson L, Delphin-Rittmon M, Dike C, DiLeo PJ, Duman RS, Kirk T Jr, Krystal J, Malison RT, Rohrbaugh RM, Sernyak MJ, Srihari V, Styron T, Tebes JK, Woods S, Zonana H, Jacobs SC.

Psychiatr Serv. 2016 Dec 1;67(12):1286-1289. Epub 2016 Oct 3.


Fast-acting antidepressants rapidly stimulate ERK signaling and BDNF release in primary neuronal cultures.

Lepack AE, Bang E, Lee B, Dwyer JM, Duman RS.

Neuropharmacology. 2016 Dec;111:242-252. doi: 10.1016/j.neuropharm.2016.09.011. Epub 2016 Sep 12.


Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.

Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AFT, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA Jr, Carter CS, Cook EH Jr, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA Jr, Zubieta JK.

Biol Psychiatry. 2016 Jul 15;80(2):84-86. doi: 10.1016/j.biopsych.2016.05.004. No abstract available.

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