Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 63


Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs.

Grall E, Gourain V, Naïr A, Martin E, Birling MC, Freund JN, Duluc I.

Cell Death Dis. 2019 Oct 24;10(11):812. doi: 10.1038/s41419-019-2040-0.


Chromatin de-condensation by switching substrate elasticity.

Rabineau M, Flick F, Ehlinger C, Mathieu E, Duluc I, Jung M, Senger B, Kocgozlu L, Schaaf P, Lavalle P, Freund JN, Haikel Y, Vautier D.

Sci Rep. 2018 Aug 23;8(1):12655. doi: 10.1038/s41598-018-31023-2.


The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms.

Balbinot C, Armant O, Elarouci N, Marisa L, Martin E, De Clara E, Onea A, Deschamps J, Beck F, Freund JN, Duluc I.

J Exp Med. 2018 Mar 5;215(3):911-926. doi: 10.1084/jem.20170934. Epub 2018 Feb 8.


Fine-tuning and autoregulation of the intestinal determinant and tumor suppressor homeobox gene CDX2 by alternative splicing.

Balbinot C, Vanier M, Armant O, Nair A, Penichon J, Soret C, Martin E, Saandi T, Reimund JM, Deschamps J, Beck F, Domon-Dell C, Gross I, Duluc I, Freund JN.

Cell Death Differ. 2017 Dec;24(12):2173-2186. doi: 10.1038/cdd.2017.140. Epub 2017 Sep 1.


Estimation of subject coregistration errors during multimodal preclinical imaging using separate instruments: origins and avoidance of artifacts.

Dillenseger JP, Goetz C, Sayeh A, Healy C, Duluc I, Freund JN, Constantinesco A, Aubertin-Kirch G, Choquet P.

J Med Imaging (Bellingham). 2017 Jul;4(3):035503. doi: 10.1117/1.JMI.4.3.035503. Epub 2017 Aug 22.


Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration.

Romain B, Benbrika-Nehmar R, Marisa L, Legrain M, Lobstein V, Oravecz A, Poidevin L, Bour C, Freund JN, Duluc I, Guenot D, Pencreach E.

Oncotarget. 2017 Jun 13;8(24):38351-38366. doi: 10.18632/oncotarget.16323.


Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells.

Soret C, Martin E, Duluc I, Dantzer F, Vanier M, Gross I, Freund JN, Domon-Dell C.

Cancer Lett. 2016 May 1;374(2):208-15. doi: 10.1016/j.canlet.2016.02.026. Epub 2016 Feb 19.


Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities.

Freund JN, Duluc I, Reimund JM, Gross I, Domon-Dell C.

World J Gastroenterol. 2015 Feb 7;21(5):1436-43. doi: 10.3748/wjg.v21.i5.1436. Review.


Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage.

Pertuy F, Aguilar A, Strassel C, Eckly A, Freund JN, Duluc I, Gachet C, Lanza F, Léon C.

J Thromb Haemost. 2015 Jan;13(1):115-25. doi: 10.1111/jth.12784. Epub 2014 Dec 17.


TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3.

Martianov I, Cler E, Duluc I, Vicaire S, Philipps M, Freund JN, Davidson I.

PLoS One. 2014 Feb 3;9(2):e87365. doi: 10.1371/journal.pone.0087365. eCollection 2014.


Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2.

Derbal-Wolfrom L, Pencreach E, Saandi T, Aprahamian M, Martin E, Greferath R, Tufa E, Choquet P, Lehn JM, Nicolau C, Duluc I, Freund JN.

Oncogene. 2013 Sep 5;32(36):4313-8. doi: 10.1038/onc.2012.445. Epub 2012 Oct 8.


Regulation of the tumor suppressor homeogene Cdx2 by HNF4α in intestinal cancer.

Saandi T, Baraille F, Derbal-Wolfrom L, Cattin AL, Benahmed F, Martin E, Cardot P, Duclos B, Ribeiro A, Freund JN, Duluc I.

Oncogene. 2013 Aug 8;32(32):3782-8. doi: 10.1038/onc.2012.401. Epub 2012 Sep 17.


The tumor suppressor Apc controls planar cell polarities central to gut homeostasis.

Bellis J, Duluc I, Romagnolo B, Perret C, Faux MC, Dujardin D, Formstone C, Lightowler S, Ramsay RG, Freund JN, De Mey JR.

J Cell Biol. 2012 Aug 6;198(3):331-41. doi: 10.1083/jcb.201204086. Epub 2012 Jul 30.


Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells.

Hinkel I, Duluc I, Martin E, Guenot D, Freund JN, Gross I.

Gastroenterology. 2012 Apr;142(4):875-885.e3. doi: 10.1053/j.gastro.2011.12.037. Epub 2011 Dec 24.


Cdx2 determines the fate of postnatal intestinal endoderm.

Stringer EJ, Duluc I, Saandi T, Davidson I, Bialecka M, Sato T, Barker N, Clevers H, Pritchard CA, Winton DJ, Wright NA, Freund JN, Deschamps J, Beck F.

Development. 2012 Feb;139(3):465-74. doi: 10.1242/dev.070722. Epub 2011 Dec 21.


Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells.

Renouf B, Soret C, Saandi T, Delalande F, Martin E, Vanier M, Duluc I, Gross I, Freund JN, Domon-Dell C.

Nucleic Acids Res. 2012 Apr;40(8):3456-69. doi: 10.1093/nar/gkr1242. Epub 2011 Dec 20.


CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype.

Barros R, da Costa LT, Pinto-de-Sousa J, Duluc I, Freund JN, David L, Almeida R.

Gut. 2011 Mar;60(3):290-8. doi: 10.1136/gut.2010.222323. Epub 2010 Dec 9.


CDX2 in congenital gut gastric-type heteroplasia and intestinal-type Meckel diverticula.

Martin E, Vanier M, Tavian M, Guerin E, Domon-Dell C, Duluc I, Gross I, Rowland J, Kim S, Freund JN.

Pediatrics. 2010 Sep;126(3):e723-7. doi: 10.1542/peds.2009-3512. Epub 2010 Aug 2.


Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos.

Young T, Rowland JE, van de Ven C, Bialecka M, Novoa A, Carapuco M, van Nes J, de Graaff W, Duluc I, Freund JN, Beck F, Mallo M, Deschamps J.

Dev Cell. 2009 Oct;17(4):516-26. doi: 10.1016/j.devcel.2009.08.010.


Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2.

Modica S, Morgano A, Salvatore L, Petruzzelli M, Vanier MT, Valanzano R, Esposito DL, Palasciano G, Duluc I, Freund JN, Mariani-Costantini R, Moschetta A.

Gut. 2009 Sep;58(9):1250-9. doi: 10.1136/gut.2008.158386. Epub 2009 Feb 15.


Multiple regulatory regions control the complex expression pattern of the mouse Cdx2 homeobox gene.

Benahmed F, Gross I, Gaunt SJ, Beck F, Jehan F, Domon-Dell C, Martin E, Kedinger M, Freund JN, Duluc I.

Gastroenterology. 2008 Oct;135(4):1238-1247, 1247.e1-3. doi: 10.1053/j.gastro.2008.06.045. Epub 2008 Jun 25.


Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines.

Barros R, Pereira B, Duluc I, Azevedo M, Mendes N, Camilo V, Jacobs RJ, Paulo P, Santos-Silva F, van Seuningen I, van den Brink GR, David L, Freund JN, Almeida R.

J Pathol. 2008 Aug;215(4):411-20. doi: 10.1002/path.2369.


Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer.

Bonhomme C, Calon A, Martin E, Robine S, Neuville A, Kedinger M, Domon-Dell C, Duluc I, Freund JN.

Oncogene. 2008 Jul 24;27(32):4497-502. doi: 10.1038/onc.2008.78. Epub 2008 Mar 31.


The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells.

Gross I, Duluc I, Benameur T, Calon A, Martin E, Brabletz T, Kedinger M, Domon-Dell C, Freund JN.

Oncogene. 2008 Jan 3;27(1):107-15. Epub 2007 Jun 25.


Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation.

Calon A, Gross I, Lhermitte B, Martin E, Beck F, Duclos B, Kedinger M, Duluc I, Domon-Dell C, Freund JN.

Gut. 2007 Dec;56(12):1688-95. Epub 2007 Jun 26.


The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells.

Benahmed F, Gross I, Guenot D, Jehan F, Martin E, Domon-Dell C, Brabletz T, Kedinger M, Freund JN, Duluc I.

Am J Pathol. 2007 Feb;170(2):733-44.


Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein.

Calon A, Gross I, Davidson I, Kedinger M, Duluc I, Domon-Dell C, Freund JN.

Nucleic Acids Res. 2007;35(1):175-85. Epub 2006 Dec 7.


Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability.

Subtil C, Guérin E, Schneider A, Chenard MP, Martin E, Domon-Dell C, Duluc I, Brabletz T, Kedinger M, Duclos B, Gaub MP, Freund JN.

Cancer Lett. 2007 Mar 18;247(2):197-203. Epub 2006 May 30.


Primary tumour genetic alterations and intra-tumoral heterogeneity are maintained in xenografts of human colon cancers showing chromosome instability.

Guenot D, Guérin E, Aguillon-Romain S, Pencreach E, Schneider A, Neuville A, Chenard MP, Duluc I, Du Manoir S, Brigand C, Oudet P, Kedinger M, Gaub MP.

J Pathol. 2006 Apr;208(5):643-52.


Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.

Gross I, Lhermitte B, Domon-Dell C, Duluc I, Martin E, Gaiddon C, Kedinger M, Freund JN.

Oncogene. 2005 Dec 1;24(54):7955-63.


Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression.

Brabletz T, Spaderna S, Kolb J, Hlubek F, Faller G, Bruns CJ, Jung A, Nentwich J, Duluc I, Domon-Dell C, Kirchner T, Freund JN.

Cancer Res. 2004 Oct 1;64(19):6973-7.


SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes.

Blache P, van de Wetering M, Duluc I, Domon C, Berta P, Freund JN, Clevers H, Jay P.

J Cell Biol. 2004 Jul 5;166(1):37-47.


Cdx1 homeobox gene during human colon cancer progression.

Domon-Dell C, Schneider A, Moucadel V, Guerin E, Guenot D, Aguillon S, Duluc I, Martin E, Iovanna J, Launay JF, Duclos B, Chenard MP, Meyer C, Oudet P, Kedinger M, Gaub MP, Freund JN.

Oncogene. 2003 Sep 11;22(39):7913-21.


The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development.

Bonhomme C, Duluc I, Martin E, Chawengsaksophak K, Chenard MP, Kedinger M, Beck F, Freund JN, Domon-Dell C.

Gut. 2003 Oct;52(10):1465-71.


Endoderm- and mesenchyme-dependent commitment of the differentiated epithelial cell types in the developing intestine of rat.

Ratineau C, Duluc I, Pourreyron C, Kedinger M, Freund JN, Roche C.

Differentiation. 2003 Mar;71(2):163-9.


Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium.

Jenny M, Uhl C, Roche C, Duluc I, Guillermin V, Guillemot F, Jensen J, Kedinger M, Gradwohl G.

EMBO J. 2002 Dec 2;21(23):6338-47.


Differentially expressed endoderm and mesenchyme genes along the fetal rat intestine.

Duluc I, Hoff C, Kedinger M, Freund JN.

Genesis. 2001 Feb;29(2):55-9.


Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine.

Lickert H, Domon C, Huls G, Wehrle C, Duluc I, Clevers H, Meyer BI, Freund JN, Kemler R.

Development. 2000 Sep;127(17):3805-13.


The Cdx-1 and Cdx-2 homeobox genes in the intestine.

Freund JN, Domon-Dell C, Kedinger M, Duluc I.

Biochem Cell Biol. 1998;76(6):957-69. Review.


Production of low-lactose milk by ectopic expression of intestinal lactase in the mouse mammary gland.

Jost B, Vilotte JL, Duluc I, Rodeau JL, Freund JN.

Nat Biotechnol. 1999 Feb;17(2):160-4.


Intestinal epithelial-mesenchymal cell interactions.

Kedinger M, Duluc I, Fritsch C, Lorentz O, Plateroti M, Freund JN.

Ann N Y Acad Sci. 1998 Nov 17;859:1-17. Review.


Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras.

Lorentz O, Cadoret A, Duluc I, Capeau J, Gespach C, Cherqui G, Freund JN.

Oncogene. 1999 Jan 7;18(1):87-92.


Lactase is unchanged in suckling mice fed with lactose-free milk.

Jost B, Duluc I, Vilotte JL, Freund JN.

Gastroenterol Clin Biol. 1998 Nov;22(11):863-7.


Cellular and molecular partners involved in gut morphogenesis and differentiation.

Kedinger M, Lefebvre O, Duluc I, Freund JN, Simon-Assmann P.

Philos Trans R Soc Lond B Biol Sci. 1998 Jun 29;353(1370):847-56. Review.


Subepithelial fibroblast cell lines from different levels of gut axis display regional characteristics.

Plateroti M, Rubin DC, Duluc I, Singh R, Foltzer-Jourdainne C, Freund JN, Kedinger M.

Am J Physiol. 1998 May;274(5):G945-54. doi: 10.1152/ajpgi.1998.274.5.G945.


Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation.

Lorentz O, Duluc I, Arcangelis AD, Simon-Assmann P, Kedinger M, Freund JN.

J Cell Biol. 1997 Dec 15;139(6):1553-65.


Functional diversity and interactions between the repeat domains of rat intestinal lactase.

Jost B, Duluc I, Richardson M, Lathe R, Freund JN.

Biochem J. 1997 Oct 1;327 ( Pt 1):95-103.


Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells.

Duluc I, Lorentz O, Fritsch C, Leberquier C, Kedinger M, Freund JN.

J Cell Sci. 1997 Jun;110 ( Pt 11):1317-24.


Identification of homologues of the mammalian intestinal lactase gene in non-mammals (birds and molluscs).

Freund JN, Jost B, Lorentz O, Duluc I.

Biochem J. 1997 Mar 1;322 ( Pt 2):491-8.


Activity of the rat lactase gene promoter in transfected human colon cancer cells.

Boukamel R, Neuville P, Duluc I, Freund JN.

C R Acad Sci III. 1995 Nov;318(11):1133-40.


Supplemental Content

Support Center