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Items: 38


Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding.

Huerta C, Jiang X, Trevino I, Bender CF, Ferguson DA, Probst B, Swinger KK, Stoll VS, Thomas PJ, Dulubova I, Visnick M, Wigley WC.

Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2537-2552. doi: 10.1016/j.bbagen.2016.07.026. Epub 2016 Jul 27.


RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity.

Probst BL, Trevino I, McCauley L, Bumeister R, Dulubova I, Wigley WC, Ferguson DA.

PLoS One. 2015 Apr 21;10(4):e0122942. doi: 10.1371/journal.pone.0122942. eCollection 2015.


Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing.

Matos MF, Xu Y, Dulubova I, Otwinowski Z, Richardson JM, Tomchick DR, Rizo J, Ho A.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3802-7. doi: 10.1073/pnas.1119075109. Epub 2012 Feb 21.


RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction.

Kaeser PS, Deng L, Wang Y, Dulubova I, Liu X, Rizo J, Südhof TC.

Cell. 2011 Jan 21;144(2):282-95. doi: 10.1016/j.cell.2010.12.029.


Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming.

Deák F, Xu Y, Chang WP, Dulubova I, Khvotchev M, Liu X, Südhof TC, Rizo J.

J Cell Biol. 2009 Mar 9;184(5):751-64. doi: 10.1083/jcb.200812026. Epub 2009 Mar 2.


Conformational switch of syntaxin-1 controls synaptic vesicle fusion.

Gerber SH, Rah JC, Min SW, Liu X, de Wit H, Dulubova I, Meyer AC, Rizo J, Arancillo M, Hammer RE, Verhage M, Rosenmund C, Südhof TC.

Science. 2008 Sep 12;321(5895):1507-10. doi: 10.1126/science.1163174. Epub 2008 Aug 14.


NMR analysis of the closed conformation of syntaxin-1.

Chen X, Lu J, Dulubova I, Rizo J.

J Biomol NMR. 2008 May;41(1):43-54. doi: 10.1007/s10858-008-9239-1. Epub 2008 May 6.


Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus.

Khvotchev M, Dulubova I, Sun J, Dai H, Rizo J, Südhof TC.

J Neurosci. 2007 Nov 7;27(45):12147-55.


Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution.

Guan R, Dai H, Tomchick DR, Dulubova I, Machius M, Südhof TC, Rizo J.

Biochemistry. 2007 Aug 7;46(31):8988-98. Epub 2007 Jul 14.


Munc18-1 binds directly to the neuronal SNARE complex.

Dulubova I, Khvotchev M, Liu S, Huryeva I, Südhof TC, Rizo J.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2697-702. Epub 2007 Feb 14.


Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch.

Lu J, Machius M, Dulubova I, Dai H, Südhof TC, Tomchick DR, Rizo J.

PLoS Biol. 2006 Jul;4(7):e192.


A minimal domain responsible for Munc13 activity.

Basu J, Shen N, Dulubova I, Lu J, Guan R, Guryev O, Grishin NV, Rosenmund C, Rizo J.

Nat Struct Mol Biol. 2005 Nov;12(11):1017-8.


A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

Dulubova I, Lou X, Lu J, Huryeva I, Alam A, Schneggenburger R, Südhof TC, Rizo J.

EMBO J. 2005 Aug 17;24(16):2839-50. Epub 2005 Jul 28.


Three-dimensional structure of the rSly1 N-terminal domain reveals a conformational change induced by binding to syntaxin 5.

Araç D, Dulubova I, Pei J, Huryeva I, Grishin NV, Rizo J.

J Mol Biol. 2005 Feb 18;346(2):589-601. Epub 2004 Dec 24.


Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein.

Dulubova I, Ho A, Huryeva I, Südhof TC, Rizo J.

Biochemistry. 2004 Aug 3;43(30):9583-8.


Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins.

Dulubova I, Yamaguchi T, Arac D, Li H, Huryeva I, Min SW, Rizo J, Sudhof TC.

Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):32-7. Epub 2002 Dec 27.


The N-terminal domains of syntaxin 7 and vti1b form three-helix bundles that differ in their ability to regulate SNARE complex assembly.

Antonin W, Dulubova I, Arac D, Pabst S, Plitzner J, Rizo J, Jahn R.

J Biol Chem. 2002 Sep 27;277(39):36449-56. Epub 2002 Jul 11.


How Tlg2p/syntaxin 16 'snares' Vps45.

Dulubova I, Yamaguchi T, Gao Y, Min SW, Huryeva I, Südhof TC, Rizo J.

EMBO J. 2002 Jul 15;21(14):3620-31.


Solution structure of the Vam7p PX domain.

Lu J, Garcia J, Dulubova I, Südhof TC, Rizo J.

Biochemistry. 2002 May 14;41(19):5956-62.


Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif.

Yamaguchi T, Dulubova I, Min SW, Chen X, Rizo J, Südhof TC.

Dev Cell. 2002 Mar;2(3):295-305.


Functional analysis of conserved structural elements in yeast syntaxin Vam3p.

Wang Y, Dulubova I, Rizo J, Südhof TC.

J Biol Chem. 2001 Jul 27;276(30):28598-605. Epub 2001 May 10.


ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins.

Dulubova I, Horiuchi A, Snyder GL, Girault JA, Czernik AJ, Shao L, Ramabhadran R, Greengard P, Nairn AC.

J Neurochem. 2001 Apr;77(1):229-38.


Vam3p structure reveals conserved and divergent properties of syntaxins.

Dulubova I, Yamaguchi T, Wang Y, Südhof TC, Rizo J.

Nat Struct Biol. 2001 Mar;8(3):258-64.


Regulation of Na+, K+-ATPase isoforms in rat neostriatum by dopamine and protein kinase C.

Nishi A, Fisone G, Snyder GL, Dulubova I, Aperia A, Nairn AC, Greengard P.

J Neurochem. 1999 Oct;73(4):1492-501.


A conformational switch in syntaxin during exocytosis: role of munc18.

Dulubova I, Sugita S, Hill S, Hosaka M, Fernandez I, Südhof TC, Rizo J.

EMBO J. 1999 Aug 16;18(16):4372-82.


Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A.

Fernandez I, Ubach J, Dulubova I, Zhang X, Südhof TC, Rizo J.

Cell. 1998 Sep 18;94(6):841-9.


Mutation of the protein kinase C phosphorylation site on rat alpha1 Na+,K+-ATPase alters regulation of intracellular Na+ and pH and influences cell shape and adhesiveness.

Belusa R, Wang ZM, Matsubara T, Sahlgren B, Dulubova I, Nairn AC, Ruoslahti E, Greengard P, Aperia A.

J Biol Chem. 1997 Aug 8;272(32):20179-84.


Phosphorylation by protein kinase C of serine-23 of the alpha-1 subunit of rat Na+,K(+)-ATPase affects its conformational equilibrium.

Logvinenko NS, Dulubova I, Fedosova N, Larsson SH, Nairn AC, Esmann M, Greengard P, Aperia A.

Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9132-7.


Cloning and structure of delta-latroinsectotoxin, a novel insect-specific member of the latrotoxin family: functional expression requires C-terminal truncation.

Dulubova IE, Krasnoperov VG, Khvotchev MV, Pluzhnikov KA, Volkova TM, Grishin EV, Vais H, Bell DR, Usherwood PN.

J Biol Chem. 1996 Mar 29;271(13):7535-43.


[Primary structure of delta-latroinsectotoxin from venom of the Latrodectus mactans tredecimguttatus spider].

Dulubova IE, Khvoshchev MV, Krasnoperov VG, Galkina TG, Pluzhnikov KA, Volkova TM, Grishin EV.

Bioorg Khim. 1996 Jan;22(1):68-73. Russian.


Cloning and structural analysis of alpha-latroinsectotoxin cDNA. Abundance of ankyrin-like repeats.

Kiyatkin N, Dulubova I, Grishin E.

Eur J Biochem. 1993 Apr 1;213(1):121-7.


Structure of the low molecular weight protein copurified with alpha-latrotoxin.

Kiyatkin N, Dulubova I, Chekhovskaya I, Lipkin A, Grishin E.

Toxicon. 1992 Jul;30(7):771-4.


[Structural analysis of a protein component from black widow spider venom, interacting with alpha-latrotoxin].

Kiiatkin NI, Dulubova IE, Volkova TM, Chekhovskaia IA, Lipkin AV, Grishin EV.

Dokl Akad Nauk. 1992;323(1):178-80. Russian. No abstract available.


Cloning and structure of cDNA encoding alpha-latrotoxin from black widow spider venom.

Kiyatkin NI, Dulubova IE, Chekhovskaya IA, Grishin EV.

FEBS Lett. 1990 Sep 17;270(1-2):127-31.


Family of human Na+, K+-ATPase genes. Structure of the gene for the catalytic subunit (alpha III-form) and its relationship with structural features of the protein.

Ovchinnikov YuA, Monastyrskaya GS, Broude NE, Ushkaryov YuA, Melkov AM, Smirnov YuV, Malyshev IV, Allikmets RL, Kostina MB, Dulubova IE, et al.

FEBS Lett. 1988 Jun 6;233(1):87-94.


The family of human Na+,K+-ATPase genes. A partial nucleotide sequence related to the alpha-subunit.

Ovchinnikov YuA, Monastyrskaya GS, Broude NE, Allikmets RL, Ushkaryov YuA, Melkov AM, Smirnov YuV, Malyshev IV, Dulubova IE, Petrukhin KE, et al.

FEBS Lett. 1987 Mar 9;213(1):73-80. No abstract available. Erratum in: FEBS Lett 1987 Apr 20;214(2):375.


[Complete amino acid sequence of neurotoxin Os-1 from the venom of the Central Asian black scorpion Orthochirus scrobiculosus].

Potapenko NA, Volkova TM, Garsia AF, Galkina TG, Dulubova IE.

Bioorg Khim. 1986 May;12(5):581-90. Russian.


[Toxic components of the venom of the Central Asian scorpion, Orthochirus scrobiculosus].

Volkova TM, Dulubova IE, Telezhinskaia IN, Grishin EV.

Bioorg Khim. 1984 Aug;10(8):1100-8. Russian.


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