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NKG2D/NKG2-Ligand Pathway Offers New Opportunities in Cancer Treatment.

Frazao A, Rethacker L, Messaoudene M, Avril MF, Toubert A, Dulphy N, Caignard A.

Front Immunol. 2019 Mar 29;10:661. doi: 10.3389/fimmu.2019.00661. eCollection 2019. Review.


CD16+NKG2Ahigh Natural Killer Cells Infiltrate Breast Cancer-Draining Lymph Nodes.

Frazao A, Messaoudene M, Nunez N, Dulphy N, Roussin F, Sedlik C, Zitvogel L, Piaggio E, Toubert A, Caignard A.

Cancer Immunol Res. 2019 Feb;7(2):208-218. doi: 10.1158/2326-6066.CIR-18-0085. Epub 2018 Dec 4.


AHR: leukemic countermeasure against NK cells.

Dulphy N.

Blood. 2018 Oct 25;132(17):1733-1734. doi: 10.1182/blood-2018-09-873570. No abstract available.


[NK cells: a major role in the antitumoral immunomodulation in CML].

Toubert A, Turhan A, Guerci-Bresler A, Dulphy N, Réa D.

Med Sci (Paris). 2018 Jun-Jul;34(6-7):540-546. doi: 10.1051/medsci/20183406013. Epub 2018 Jul 31. Review. French.


Expression of CD94 by ex vivo-differentiated NK cells correlates with the in vitro and in vivo acquisition of cytotoxic features.

Hasmim M, Khalife N, Zhang Y, Doldur M, Visentin G, Terry S, Giron-Michel J, Tang R, Delhommeau F, Dulphy N, Bourhis JH, Louache F, Chouaib S.

Oncoimmunology. 2017 Jul 18;6(10):e1346763. doi: 10.1080/2162402X.2017.1346763. eCollection 2017.


Molecular and Functional Characterization of Lymphoid Progenitor Subsets Reveals a Bipartite Architecture of Human Lymphopoiesis.

Alhaj Hussen K, Vu Manh TP, Guimiot F, Nelson E, Chabaane E, Delord M, Barbier M, Berthault C, Dulphy N, Alberdi AJ, Burlen-Defranoux O, Socié G, Bories JC, Larghero J, Vanneaux V, Verhoeyen E, Wirth T, Dalod M, Gluckman JC, Cumano A, Canque B.

Immunity. 2017 Oct 17;47(4):680-696.e8. doi: 10.1016/j.immuni.2017.09.009.


Patient's Natural Killer Cells in the Era of Targeted Therapies: Role for Tumor Killers.

Messaoudene M, Frazao A, Gavlovsky PJ, Toubert A, Dulphy N, Caignard A.

Front Immunol. 2017 Jun 12;8:683. doi: 10.3389/fimmu.2017.00683. eCollection 2017.


Natural killer-cell counts are associated with molecular relapse-free survival after imatinib discontinuation in chronic myeloid leukemia: the IMMUNOSTIM study.

Rea D, Henry G, Khaznadar Z, Etienne G, Guilhot F, Nicolini F, Guilhot J, Rousselot P, Huguet F, Legros L, Gardembas M, Dubruille V, Guerci-Bresler A, Charbonnier A, Maloisel F, Ianotto JC, Villemagne B, Mahon FX, Moins-Teisserenc H, Dulphy N, Toubert A.

Haematologica. 2017 Aug;102(8):1368-1377. doi: 10.3324/haematol.2017.165001. Epub 2017 May 18.


Identification of CD245 as myosin 18A, a receptor for surfactant A: A novel pathway for activating human NK lymphocytes.

De Masson A, Giustiniani J, Marie-Cardine A, Bouaziz JD, Dulphy N, Gossot D, Validire P, Tazi A, Garbar C, Bagot M, Merrouche Y, Bensussan A.

Oncoimmunology. 2016 Jan 13;5(5):e1127493. doi: 10.1080/2162402X.2015.1127493. eCollection 2016 May.


Underground Adaptation to a Hostile Environment: Acute Myeloid Leukemia vs. Natural Killer Cells.

Dulphy N, Chrétien AS, Khaznadar Z, Fauriat C, Nanbakhsh A, Caignard A, Chouaib S, Olive D, Toubert A.

Front Immunol. 2016 Mar 9;7:94. doi: 10.3389/fimmu.2016.00094. eCollection 2016. Review.


Natural killer cell licensing after double cord blood transplantation is driven by the self-HLA class I molecules from the dominant cord blood.

Guillaume N, Loiseau P, Gagne K, Teissserenc HM, Cayuela JM, Henry G, Robin M, Peffault de Latour R, Gluckman E, Socié G, Retiere C, Dulphy N, Toubert A.

Haematologica. 2016 May;101(5):e209-12. doi: 10.3324/haematol.2015.138883. Epub 2016 Jan 27. No abstract available.


Natural Killer Lymphocytes Are Dysfunctional in Kidney Transplant Recipients on Diagnosis of Cancer.

Peraldi MN, Berrou J, Venot M, Chardiny V, Durrbach A, Vieillard V, Debré P, Charron D, Suberbielle C, Chevret S, Glotz D, Dulphy N, Toubert A.

Transplantation. 2015 Nov;99(11):2422-30.


Phenotypic analysis of T cells infiltrating colon cancers: Correlations with oncogenetic status.

Chirica M, Le Bourhis L, Lehmann-Che J, Chardiny V, Bouhidel F, Foulboeuf L, Gornet JM, Lourenco N, Dulphy N, Toubert A, Allez M.

Oncoimmunology. 2015 Apr 1;4(8):e1016698. eCollection 2015 Aug.


Defective NK Cells in Acute Myeloid Leukemia Patients at Diagnosis Are Associated with Blast Transcriptional Signatures of Immune Evasion.

Khaznadar Z, Boissel N, Agaugué S, Henry G, Cheok M, Vignon M, Geromin D, Cayuela JM, Castaigne S, Pautas C, Raffoux E, Lachuer J, Sigaux F, Preudhomme C, Dombret H, Dulphy N, Toubert A.

J Immunol. 2015 Sep 15;195(6):2580-90. doi: 10.4049/jimmunol.1500262. Epub 2015 Aug 5.


Polymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility.

Ben Chaaben A, Mariaselvam C, Salah S, Busson M, Dulphy N, Douik H, Ghanem A, Boukaouci W, Al Daccak R, Mamoghli T, Harzallah L, Bouassida J, Fortier C, Gritli S, Ben Hamida J, Charron D, Krishnamoorthy R, Guemira F, Tamouza R.

Immunobiology. 2015 Jan;220(1):20-5.


Favorable impact of natural killer cell reconstitution on chronic graft-versus-host disease and cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation.

Kheav VD, Busson M, Scieux C, Peffault de Latour R, Maki G, Haas P, Mazeron MC, Carmagnat M, Masson E, Xhaard A, Robin M, Ribaud P, Dulphy N, Loiseau P, Charron D, Socié G, Toubert A, Moins-Teisserenc H.

Haematologica. 2014 Dec;99(12):1860-7. doi: 10.3324/haematol.2014.108407. Epub 2014 Aug 1.


Acute myeloid leukemia impairs natural killer cells through the formation of a deficient cytotoxic immunological synapse.

Khaznadar Z, Henry G, Setterblad N, Agaugue S, Raffoux E, Boissel N, Dombret H, Toubert A, Dulphy N.

Eur J Immunol. 2014 Oct;44(10):3068-80. doi: 10.1002/eji.201444500. Epub 2014 Sep 4.


Contribution of CD39 to the immunosuppressive microenvironment of acute myeloid leukaemia at diagnosis.

Dulphy N, Henry G, Hemon P, Khaznadar Z, Dombret H, Boissel N, Bensussan A, Toubert A.

Br J Haematol. 2014 Jun;165(5):722-5. doi: 10.1111/bjh.12774. Epub 2014 Feb 12. No abstract available.


Soluble MICA-NKG2D interaction upregulates IFN-γ production by activated CD3-CD56+ NK cells: potential impact on chronic graft versus host disease.

Boukouaci W, Al-Daccak R, Dulphy N, Lauden L, Amokrane K, Fortier C, Marzais F, Bennabi M, Peffault de Latour R, Socie G, Toubert A, Charron D, Krishnamoorthy R, Tamouza R.

Hum Immunol. 2013 Dec;74(12):1536-41. doi: 10.1016/j.humimm.2013.08.281. Epub 2013 Aug 29.


Natural killer cell function, an important target for infection and tumor protection, is impaired in type 2 diabetes.

Berrou J, Fougeray S, Venot M, Chardiny V, Gautier JF, Dulphy N, Toubert A, Peraldi MN.

PLoS One. 2013 Apr 25;8(4):e62418. doi: 10.1371/journal.pone.0062418. Print 2013.


At diagnosis, diffuse large B-cell lymphoma patients show impaired rituximab-mediated NK-cell cytotoxicity.

Danielou-Lazareth A, Henry G, Geromin D, Khaznadar Z, Briere J, Tamouza R, Cayuela JM, Thieblemont C, Toubert A, Dulphy N.

Eur J Immunol. 2013 May;43(5):1383-8. doi: 10.1002/eji.201242733. Epub 2013 Mar 11.


Activation of the receptor NKG2D leads to production of Th17 cytokines in CD4+ T cells of patients with Crohn's disease.

Pariente B, Mocan I, Camus M, Dutertre CA, Ettersperger J, Cattan P, Gornet JM, Dulphy N, Charron D, Lémann M, Toubert A, Allez M.

Gastroenterology. 2011 Jul;141(1):217-26, 226.e1-2. doi: 10.1053/j.gastro.2011.03.061. Epub 2011 Apr 7.


Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants.

Roux AL, Ray A, Pawlik A, Medjahed H, Etienne G, Rottman M, Catherinot E, Coppée JY, Chaoui K, Monsarrat B, Toubert A, Daffé M, Puzo G, Gaillard JL, Brosch R, Dulphy N, Nigou J, Herrmann JL.

Cell Microbiol. 2011 May;13(5):692-704. doi: 10.1111/j.1462-5822.2010.01565.x. Epub 2011 Jan 5.


NK-cell education is shaped by donor HLA genotype after unrelated allogeneic hematopoietic stem cell transplantation.

Haas P, Loiseau P, Tamouza R, Cayuela JM, Moins-Teisserenc H, Busson M, Henry G, Falk CS, Charron D, Socié G, Toubert A, Dulphy N.

Blood. 2011 Jan 20;117(3):1021-9. doi: 10.1182/blood-2010-02-269381. Epub 2010 Nov 2.


MICA-129 genotype, soluble MICA, and anti-MICA antibodies as biomarkers of chronic graft-versus-host disease.

Boukouaci W, Busson M, Peffault de Latour R, Rocha V, Suberbielle C, Bengoufa D, Dulphy N, Haas P, Scieux C, Amroun H, Gluckman E, Krishnamoorthy R, Toubert A, Charron D, Socié G, Tamouza R.

Blood. 2009 Dec 10;114(25):5216-24. doi: 10.1182/blood-2009-04-217430.


Oxidative stress mediates a reduced expression of the activating receptor NKG2D in NK cells from end-stage renal disease patients.

Peraldi MN, Berrou J, Dulphy N, Seidowsky A, Haas P, Boissel N, Metivier F, Randoux C, Kossari N, Guérin A, Geffroy S, Delavaud G, Marin-Esteban V, Glotz D, Charron D, Toubert A.

J Immunol. 2009 Feb 1;182(3):1696-705.


NKG2D ligands expression and NKG2D-mediated NK activity in Sezary patients.

Dulphy N, Berrou J, Campillo JA, Bagot M, Bensussan A, Toubert A.

J Invest Dermatol. 2009 Feb;129(2):359-64. doi: 10.1038/jid.2008.256. Epub 2008 Aug 28.


An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation.

Dulphy N, Haas P, Busson M, Belhadj S, Peffault de Latour R, Robin M, Carmagnat M, Loiseau P, Tamouza R, Scieux C, Rabian C, Di Santo JP, Charron D, Janin A, Socié G, Toubert A.

J Immunol. 2008 Aug 1;181(3):2227-37.


CD4+NKG2D+ T cells in Crohn's disease mediate inflammatory and cytotoxic responses through MICA interactions.

Allez M, Tieng V, Nakazawa A, Treton X, Pacault V, Dulphy N, Caillat-Zucman S, Paul P, Gornet JM, Douay C, Ravet S, Tamouza R, Charron D, Lémann M, Mayer L, Toubert A.

Gastroenterology. 2007 Jun;132(7):2346-58. Epub 2007 Mar 16.


Modulation of CD103 expression on human colon carcinoma-specific CTL.

Ling KL, Dulphy N, Bahl P, Salio M, Maskell K, Piris J, Warren BF, George BD, Mortensen NJ, Cerundolo V.

J Immunol. 2007 Mar 1;178(5):2908-15.


Intermediate maturation of Mycobacterium tuberculosis LAM-activated human dendritic cells.

Dulphy N, Herrmann JL, Nigou J, Réa D, Boissel N, Puzo G, Charron D, Lagrange PH, Toubert A.

Cell Microbiol. 2007 Jun;9(6):1412-25. Epub 2007 Jan 23.


Activating KIR genes are associated with CMV reactivation and survival after non-T-cell depleted HLA-identical sibling bone marrow transplantation for malignant disorders.

Chen C, Busson M, Rocha V, Appert ML, Lepage V, Dulphy N, Haas P, Socié G, Toubert A, Charron D, Loiseau P.

Bone Marrow Transplant. 2006 Sep;38(6):437-44. Epub 2006 Aug 7.


BCR/ABL oncogene directly controls MHC class I chain-related molecule A expression in chronic myelogenous leukemia.

Boissel N, Rea D, Tieng V, Dulphy N, Brun M, Cayuela JM, Rousselot P, Tamouza R, Le Bouteiller P, Mahon FX, Steinle A, Charron D, Dombret H, Toubert A.

J Immunol. 2006 Apr 15;176(8):5108-16.


Early-onset ankylosing spondylitis is associated with a functional MICA polymorphism.

Amroun H, Djoudi H, Busson M, Allat R, El Sherbini SM, Sloma I, Ramasawmy R, Brun M, Dulphy N, Krishnamoorthy R, Toubert A, Charron D, Abbadi MC, Tamouza R.

Hum Immunol. 2005 Oct;66(10):1057-61. Epub 2005 Nov 2.


Association of HLA-E polymorphism with severe bacterial infection and early transplant-related mortality in matched unrelated bone marrow transplantation.

Tamouza R, Rocha V, Busson M, Fortier C, El Sherbini SM, Esperou H, Filion A, Socié G, Dulphy N, Krishnamoorthy R, Toubert A, Gluckman E, Charron D.

Transplantation. 2005 Jul 15;80(1):140-4.


Efficient priming of antigen-specific cytotoxic T lymphocytes by human cord blood dendritic cells.

Salio M, Dulphy N, Renneson J, Herbert M, McMichael A, Marchant A, Cerundolo V.

Int Immunol. 2003 Oct;15(10):1265-73.


Generation of CD1 tetramers as a tool to monitor glycolipid-specific T cells.

Gadola SD, Karadimitris A, Zaccai NR, Salio M, Dulphy N, Shepherd D, Jones EY, Cerundolo V.

Philos Trans R Soc Lond B Biol Sci. 2003 May 29;358(1433):875-7. Review.


[Natural killer lymphocyte activation in response to stress].

Toubert A, Dulphy N, Tieng V, Tamouza R, Charron D.

Transfus Clin Biol. 2003 Jun;10(3):109-12. Review. French.


Mature CD8(+) T lymphocyte response to viral infection during fetal life.

Marchant A, Appay V, Van Der Sande M, Dulphy N, Liesnard C, Kidd M, Kaye S, Ojuola O, Gillespie GM, Vargas Cuero AL, Cerundolo V, Callan M, McAdam KP, Rowland-Jones SL, Donner C, McMichael AJ, Whittle H.

J Clin Invest. 2003 Jun;111(11):1747-55.


Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen.

May E, Dulphy N, Frauendorf E, Duchmann R, Bowness P, Lopez de Castro JA, Toubert A, Märker-Hermann E.

Tissue Antigens. 2002 Oct;60(4):299-308.


Immunotherapy of colorectal cancer.

Smith CL, Dulphy N, Salio M, Cerundolo V.

Br Med Bull. 2002;64:181-200. Review.


Functional modulation of expanded CD8+ synovial fluid T cells by NK cell receptor expression in HLA-B27-associated reactive arthritis.

Dulphy N, Rabian C, Douay C, Flinois O, Laoussadi S, Kuipers J, Tamouza R, Charron D, Toubert A.

Int Immunol. 2002 May;14(5):471-9.


A new HLA-B*27 allele (B*2719) identified in a Lebanese patient affected with ankylosing spondylitis.

Tamouza R, Mansour I, Bouguacha N, Klayme S, Djouadi K, Laoussadi S, Azoury M, Dulphy N, Ramasawmy R, Krishnamoorthy R, Toubert A, Naman R, Charron D.

Tissue Antigens. 2001 Jul;58(1):30-3.


[Subtypes of the HLA-B27 molecule and association with spondylarthropathies].

Toubert A, Tieng V, Boisgérault F, Dulphy N, Tamouza R, Charron D.

Ann Med Interne (Paris). 1998 Apr;149(3):145-8. French.


Genomic diversity of natural killer cell receptor genes in three populations.

Toneva M, Lepage V, Lafay G, Dulphy N, Busson M, Lester S, Vu-Trien A, Michaylova A, Naumova E, McCluskey J, Charron D.

Tissue Antigens. 2001 Apr;57(4):358-62.


Heart-directed autoimmunity: the case of rheumatic fever.

Guilherme L, Cunha-Neto E, Tanaka AC, Dulphy N, Toubert A, Kalil J.

J Autoimmun. 2001 May;16(3):363-7.


Molecular evidence for antigen-driven immune responses in cardiac lesions of rheumatic heart disease patients.

Guilherme L, Dulphy N, Douay C, Coelho V, Cunha-Neto E, Oshiro SE, Assis RV, Tanaka AC, Pomerantzeff PM, Charron D, Toubert A, Kalil J.

Int Immunol. 2000 Jul;12(7):1063-74.


Common intra-articular T cell expansions in patients with reactive arthritis: identical beta-chain junctional sequences and cytotoxicity toward HLA-B27.

Dulphy N, Peyrat MA, Tieng V, Douay C, Rabian C, Tamouza R, Laoussadi S, Berenbaum F, Chabot A, Bonneville M, Charron D, Toubert A.

J Immunol. 1999 Apr 1;162(7):3830-9.


Frequent enrichment for CD8 T cells reactive against common herpes viruses in chronic inflammatory lesions: towards a reassessment of the physiopathological significance of T cell clonal expansions found in autoimmune inflammatory processes.

Scotet E, Peyrat MA, Saulquin X, Retiere C, Couedel C, Davodeau F, Dulphy N, Toubert A, Bignon JD, Lim A, Vie H, Hallet MM, Liblau R, Weber M, Berthelot JM, Houssaint E, Bonneville M.

Eur J Immunol. 1999 Mar;29(3):973-85.

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