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Items: 1 to 50 of 182

1.

Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse.

Salvage SC, Gallant EM, Beard NA, Ahmad S, Valli H, Fraser JA, Huang CL, Dulhunty AF.

J Cell Sci. 2019 May 21;132(10). pii: jcs229039. doi: 10.1242/jcs.229039.

2.

Activation of RyR2 by class I kinase inhibitors.

Chakraborty AD, Gonano LA, Munro ML, Smith LJ, Thekkedam C, Staudacher V, Gamble AB, Macquaide N, Dulhunty AF, Jones PP.

Br J Pharmacol. 2019 Mar;176(6):773-786. doi: 10.1111/bph.14562. Epub 2019 Jan 30.

PMID:
30588601
3.

Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.

Dulhunty AF, Beard NA, Casarotto MG.

F1000Res. 2018 Nov 27;7. pii: F1000 Faculty Rev-1851. doi: 10.12688/f1000research.16434.1. eCollection 2018. Review.

4.

Exploiting Peptidomimetics to Synthesize Compounds That Activate Ryanodine Receptor Calcium Release Channels.

Robinson K, Easton CJ, Dulhunty AF, Casarotto MG.

ChemMedChem. 2018 Sep 19;13(18):1957-1971. doi: 10.1002/cmdc.201800366. Epub 2018 Aug 28.

PMID:
30058107
5.

Ryanodine receptor Ca2+ release channel post-translational modification: Central player in cardiac and skeletal muscle disease.

Denniss A, Dulhunty AF, Beard NA.

Int J Biochem Cell Biol. 2018 Aug;101:49-53. doi: 10.1016/j.biocel.2018.05.004. Epub 2018 May 15. Review.

PMID:
29775742
6.

Functional and structural characterization of a novel malignant hyperthermia-susceptible variant of DHPR-β1a subunit (CACNB1).

Perez CF, Eltit JM, Lopez JR, Bodnár D, Dulhunty AF, Aditya S, Casarotto MG.

Am J Physiol Cell Physiol. 2018 Mar 1;314(3):C323-C333. doi: 10.1152/ajpcell.00187.2017. Epub 2017 Dec 6.

7.

Publisher's Note: Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding. J. Cell Sci. doi: 10.1242/jcs.204461.

Richardson SJ, Steele GA, Gallant EM, Lam A, Schwartz CE, Board PG, Casarotto MG, Beard NA, Dulhunty AF.

J Cell Sci. 2017 Oct 5. pii: jcs.211243. doi: 10.1242/jcs.211243. [Epub ahead of print] No abstract available.

PMID:
28982713
8.

The Anthracycline Metabolite Doxorubicinol Abolishes RyR2 Sensitivity to Physiological Changes in Luminal Ca2+ through an Interaction with Calsequestrin.

Hanna AD, Lam A, Thekkedam C, Willemse H, Dulhunty AF, Beard NA.

Mol Pharmacol. 2017 Nov;92(5):576-587. doi: 10.1124/mol.117.108183. Epub 2017 Sep 15.

PMID:
28916620
9.

Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding.

Richardson SJ, Steele GA, Gallant EM, Lam A, Schwartz CE, Board PG, Casarotto MG, Beard NA, Dulhunty AF.

J Cell Sci. 2017 Oct 15;130(20):3588-3600. doi: 10.1242/jcs.204461. Epub 2017 Aug 29. Erratum in: J Cell Sci. 2017 Oct 5;:.

10.

Physiology and Pharmacology of Ryanodine Receptor Calcium Release Channels.

Dulhunty AF, Board PG, Beard NA, Casarotto MG.

Adv Pharmacol. 2017;79:287-324. doi: 10.1016/bs.apha.2016.12.001. Epub 2017 Feb 22.

PMID:
28528672
11.

Multiple targets for flecainide action: implications for cardiac arrhythmogenesis.

Salvage SC, Chandrasekharan KH, Jeevaratnam K, Dulhunty AF, Thompson AJ, Jackson AP, Huang CL.

Br J Pharmacol. 2018 Apr;175(8):1260-1278. doi: 10.1111/bph.13807. Epub 2017 May 12. Review.

12.

Structural and biophysical analyses of the skeletal dihydropyridine receptor β subunit β1a reveal critical roles of domain interactions for stability.

Norris NC, Joseph S, Aditya S, Karunasekara Y, Board PG, Dulhunty AF, Oakley AJ, Casarotto MG.

J Biol Chem. 2017 May 19;292(20):8401-8411. doi: 10.1074/jbc.M116.763896. Epub 2017 Mar 28.

13.

Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts.

Walweel K, Molenaar P, Imtiaz MS, Denniss A, Dos Remedios C, van Helden DF, Dulhunty AF, Laver DR, Beard NA.

J Mol Cell Cardiol. 2017 Mar;104:53-62. doi: 10.1016/j.yjmcc.2017.01.016. Epub 2017 Jan 26.

PMID:
28131631
14.

Correction: Cardiac ryanodine receptor activation by a high Ca2+ store load is reversed in a reducing cytoplasmic redox environment.

Hanna AD, Lam A, Thekkedam C, Gallant EM, Beard NA, Dulhunty AF.

J Cell Sci. 2016 Nov 15;129(22):4317. No abstract available.

15.

Core skeletal muscle ryanodine receptor calcium release complex.

Dulhunty AF, Wei-LaPierre L, Casarotto MG, Beard NA.

Clin Exp Pharmacol Physiol. 2017 Jan;44(1):3-12. doi: 10.1111/1440-1681.12676. Review.

PMID:
27696487
16.

The GSTM2 C-Terminal Domain Depresses Contractility and Ca2+ Transients in Neonatal Rat Ventricular Cardiomyocytes.

Hewawasam RP, Liu D, Casarotto MG, Board PG, Dulhunty AF.

PLoS One. 2016 Sep 9;11(9):e0162415. doi: 10.1371/journal.pone.0162415. eCollection 2016.

17.

Three residues in the luminal domain of triadin impact on Trisk 95 activation of skeletal muscle ryanodine receptors.

Wium E, Dulhunty AF, Beard NA.

Pflugers Arch. 2016 Nov;468(11-12):1985-1994. Epub 2016 Sep 5.

PMID:
27595738
18.

Unexpected dependence of RyR1 splice variant expression in human lower limb muscles on fiber-type composition.

Willemse H, Theodoratos A, Smith PN, Dulhunty AF.

Pflugers Arch. 2016 Feb;468(2):269-78. doi: 10.1007/s00424-015-1738-9. Epub 2015 Oct 6.

PMID:
26438192
19.

Glutathione transferase M2 variants inhibit ryanodine receptor function in adult mouse cardiomyocytes.

Samarasinghe K, Liu D, Tummala P, Cappello J, Pace SM, Arnolda L, Casarotto MG, Dulhunty AF, Board PG.

Biochem Pharmacol. 2015 Oct 1;97(3):269-80. doi: 10.1016/j.bcp.2015.08.004. Epub 2015 Aug 7.

PMID:
26256076
20.

Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit.

Rebbeck RT, Willemse H, Groom L, Casarotto MG, Board PG, Beard NA, Dirksen RT, Dulhunty AF.

Skelet Muscle. 2015 Jul 22;5:23. doi: 10.1186/s13395-015-0049-3. eCollection 2015.

21.

C-terminal residues of skeletal muscle calsequestrin are essential for calcium binding and for skeletal ryanodine receptor inhibition.

Beard NA, Dulhunty AF.

Skelet Muscle. 2015 Feb 22;5:6. doi: 10.1186/s13395-015-0029-7. eCollection 2015.

22.

A new cytoplasmic interaction between junctin and ryanodine receptor Ca2+ release channels.

Li L, Mirza S, Richardson SJ, Gallant EM, Thekkedam C, Pace SM, Zorzato F, Liu D, Beard NA, Dulhunty AF.

J Cell Sci. 2015 Mar 1;128(5):951-63. doi: 10.1242/jcs.160689. Epub 2015 Jan 20.

23.

Differences in the regulation of RyR2 from human, sheep, and rat by Ca²⁺ and Mg²⁺ in the cytoplasm and in the lumen of the sarcoplasmic reticulum.

Walweel K, Li J, Molenaar P, Imtiaz MS, Quail A, dos Remedios CG, Beard NA, Dulhunty AF, van Helden DF, Laver DR.

J Gen Physiol. 2014 Sep;144(3):263-71. doi: 10.1085/jgp.201311157.

24.

Cardiac ryanodine receptor activation by a high Ca²⁺ store load is reversed in a reducing cytoplasmic redox environment.

Hanna AD, Lam A, Thekkedam C, Gallant EM, Beard NA, Dulhunty AF.

J Cell Sci. 2014 Oct 15;127(Pt 20):4531-41. doi: 10.1242/jcs.156760. Epub 2014 Aug 21. Erratum in: J Cell Sci. 2016 Nov 15;129(22):4317.

25.

Adverse effects of doxorubicin and its metabolic product on cardiac RyR2 and SERCA2A.

Hanna AD, Lam A, Tham S, Dulhunty AF, Beard NA.

Mol Pharmacol. 2014 Oct;86(4):438-49. doi: 10.1124/mol.114.093849. Epub 2014 Aug 8.

26.

β1a490-508, a 19-residue peptide from C-terminal tail of Cav1.1 β1a subunit, potentiates voltage-dependent calcium release in adult skeletal muscle fibers.

Hernández-Ochoa EO, Olojo RO, Rebbeck RT, Dulhunty AF, Schneider MF.

Biophys J. 2014 Feb 4;106(3):535-47. doi: 10.1016/j.bpj.2013.11.4503.

27.

Skeletal muscle excitation-contraction coupling: who are the dancing partners?

Rebbeck RT, Karunasekara Y, Board PG, Beard NA, Casarotto MG, Dulhunty AF.

Int J Biochem Cell Biol. 2014 Mar;48:28-38. doi: 10.1016/j.biocel.2013.12.001. Epub 2013 Dec 24. Review.

PMID:
24374102
28.

Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins.

Smith JJ, Vetter I, Lewis RJ, Peigneur S, Tytgat J, Lam A, Gallant EM, Beard NA, Alewood PF, Dulhunty AF.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):8906-11. doi: 10.1073/pnas.1214062110. Epub 2013 May 13.

29.

ß-Adrenergic stimulation increases RyR2 activity via intracellular Ca2+ and Mg2+ regulation.

Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne R, vanHelden DF, Laver DR.

PLoS One. 2013;8(3):e58334. doi: 10.1371/journal.pone.0058334. Epub 2013 Mar 22.

30.

An α-helical C-terminal tail segment of the skeletal L-type Ca2+ channel β1a subunit activates ryanodine receptor type 1 via a hydrophobic surface.

Karunasekara Y, Rebbeck RT, Weaver LM, Board PG, Dulhunty AF, Casarotto MG.

FASEB J. 2012 Dec;26(12):5049-59. doi: 10.1096/fj.12-211334. Epub 2012 Sep 7.

PMID:
22962299
31.

A skeletal muscle ryanodine receptor interaction domain in triadin.

Wium E, Dulhunty AF, Beard NA.

PLoS One. 2012;7(8):e43817. doi: 10.1371/journal.pone.0043817. Epub 2012 Aug 24.

32.

Regulation and dysregulation of cardiac ryanodine receptor (RyR2) open probability during diastole in health and disease.

Dulhunty AF, Beard NA, Hanna AD.

J Gen Physiol. 2012 Aug;140(2):87-92. doi: 10.1085/jgp.201210862. No abstract available.

33.

An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity.

Takano K, Liu D, Tarpey P, Gallant E, Lam A, Witham S, Alexov E, Chaubey A, Stevenson RE, Schwartz CE, Board PG, Dulhunty AF.

Hum Mol Genet. 2012 Oct 15;21(20):4497-507. Epub 2012 Jul 19.

34.

Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output.

Dulhunty AF, Wium E, Li L, Hanna AD, Mirza S, Talukder S, Ghazali NA, Beard NA.

Clin Exp Pharmacol Physiol. 2012 May;39(5):477-84. doi: 10.1111/j.1440-1681.2012.05704.x. Review.

PMID:
22524859
35.

The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor.

Liu D, Hewawasam R, Karunasekara Y, Casarotto MG, Dulhunty AF, Board PG.

Biochem Pharmacol. 2012 Jun 1;83(11):1523-9. doi: 10.1016/j.bcp.2012.02.020. Epub 2012 Mar 1.

PMID:
22406107
36.

3D Mapping of the SPRY2 domain of ryanodine receptor 1 by single-particle cryo-EM.

Perálvarez-Marín A, Tae H, Board PG, Casarotto MG, Dulhunty AF, Samsó M.

PLoS One. 2011;6(10):e25813. doi: 10.1371/journal.pone.0025813. Epub 2011 Oct 5.

37.

Multiple actions of the anthracycline daunorubicin on cardiac ryanodine receptors.

Hanna AD, Janczura M, Cho E, Dulhunty AF, Beard NA.

Mol Pharmacol. 2011 Sep;80(3):538-49. doi: 10.1124/mol.111.073478. Epub 2011 Jun 22.

PMID:
21697274
38.

Cyclization of the intrinsically disordered α1S dihydropyridine receptor II-III loop enhances secondary structure and in vitro function.

Tae HS, Cui Y, Karunasekara Y, Board PG, Dulhunty AF, Casarotto MG.

J Biol Chem. 2011 Jun 24;286(25):22589-99. doi: 10.1074/jbc.M110.205476. Epub 2011 Apr 27.

39.

Regulation of the cardiac muscle ryanodine receptor by glutathione transferases.

Dulhunty AF, Hewawasam R, Liu D, Casarotto MG, Board PG.

Drug Metab Rev. 2011 May;43(2):236-52. doi: 10.3109/03602532.2010.549134. Epub 2011 Feb 17. Review.

PMID:
21323602
40.

The β(1a) subunit of the skeletal DHPR binds to skeletal RyR1 and activates the channel via its 35-residue C-terminal tail.

Rebbeck RT, Karunasekara Y, Gallant EM, Board PG, Beard NA, Casarotto MG, Dulhunty AF.

Biophys J. 2011 Feb 16;100(4):922-30. doi: 10.1016/j.bpj.2011.01.022.

41.

The ryanodine receptor: a pivotal Ca2+ regulatory protein and potential therapeutic drug target.

Dulhunty AF, Casarotto MG, Beard NA.

Curr Drug Targets. 2011 May;12(5):709-23. Review.

PMID:
21291389
42.

The elusive role of the SPRY2 domain in RyR1.

Tae H, Wei L, Willemse H, Mirza S, Gallant EM, Board PG, Dirksen RT, Casarotto MG, Dulhunty A.

Channels (Austin). 2011 Mar-Apr;5(2):148-60. Epub 2011 Mar 1.

43.

The structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor.

Hewawasam R, Liu D, Casarotto MG, Dulhunty AF, Board PG.

Biochem Pharmacol. 2010 Aug 1;80(3):381-8. doi: 10.1016/j.bcp.2010.04.019. Epub 2010 Apr 22.

PMID:
20417188
44.

Junctin - the quiet achiever.

Dulhunty A, Wei L, Beard N.

J Physiol. 2009 Jul 1;587(Pt 13):3135-7. doi: 10.1113/jphysiol.2009.171959. Review. No abstract available.

45.

Homer and the ryanodine receptor.

Pouliquin P, Dulhunty AF.

Eur Biophys J. 2009 Dec;39(1):91-102. doi: 10.1007/s00249-009-0494-1. Epub 2009 Jun 10. Review.

PMID:
19513708
46.

The voltage-gated calcium-channel beta subunit: more than just an accessory.

Karunasekara Y, Dulhunty AF, Casarotto MG.

Eur Biophys J. 2009 Dec;39(1):75-81. doi: 10.1007/s00249-009-0467-4. Epub 2009 May 20. Review.

PMID:
19455319
47.

Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.

Beard NA, Wei L, Dulhunty AF.

Eur Biophys J. 2009 Dec;39(1):27-36. doi: 10.1007/s00249-009-0449-6. Epub 2009 May 12. Review.

PMID:
19434403
48.

Ubiquitous SPRY domains and their role in the skeletal type ryanodine receptor.

Tae H, Casarotto MG, Dulhunty AF.

Eur Biophys J. 2009 Dec;39(1):51-9. doi: 10.1007/s00249-009-0455-8. Epub 2009 Apr 28. Review.

PMID:
19399493
49.

Junctin and triadin each activate skeletal ryanodine receptors but junctin alone mediates functional interactions with calsequestrin.

Wei L, Gallant EM, Dulhunty AF, Beard NA.

Int J Biochem Cell Biol. 2009 Nov;41(11):2214-24. doi: 10.1016/j.biocel.2009.04.017. Epub 2009 May 4.

50.

Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle.

Wei L, Hanna AD, Beard NA, Dulhunty AF.

Cell Calcium. 2009 May;45(5):474-84. doi: 10.1016/j.ceca.2009.03.006. Epub 2009 Apr 18.

PMID:
19376574

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