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Systematic review and network meta-analysis with individual participant data on cord management at preterm birth (iCOMP): study protocol.

Seidler AL, Duley L, Katheria AC, De Paco Matallana C, Dempsey E, Rabe H, Kattwinkel J, Mercer J, Josephsen J, Fairchild K, Andersson O, Hosono S, Sundaram V, Datta V, El-Naggar W, Tarnow-Mordi W, Debray T, Hooper SB, Kluckow M, Polglase G, Davis PG, Montgomery A, Hunter KE, Barba A, Simes J, Askie L; iCOMP Collaboration.

BMJ Open. 2020 Mar 29;10(3):e034595. doi: 10.1136/bmjopen-2019-034595.


A randomised feasibility trial comparing needle fasciotomy with limited fasciectomy treatment for Dupuytren's contractures.

Davis TRC, Tan W, Harrison EF, Hollingworth W, Karantana A, Mills N, Hepburn T, Sprange K, Duley L, Blazeby JM, Bainbridge CG, Murali SR, Montgomery AA; HAND-1 Study group.

Pilot Feasibility Stud. 2020 Jan 30;6:7. doi: 10.1186/s40814-019-0546-y. eCollection 2020.


Top research priorities for preterm birth: results of a prioritisation partnership between people affected by preterm birth and healthcare professionals.

Oliver S, Uhm S, Duley L, Crowe S, David AL, James CP, Chivers Z, Gyte G, Gale C, Turner M, Chambers B, Dowling I, McNeill J, Alderdice F, Shennan A, Deshpande S.

BMC Pregnancy Childbirth. 2019 Dec 30;19(1):528. doi: 10.1186/s12884-019-2654-3.


Antiplatelet agents for preventing pre-eclampsia and its complications.

Duley L, Meher S, Hunter KE, Seidler AL, Askie LM.

Cochrane Database Syst Rev. 2019 Oct 30;2019(10). doi: 10.1002/14651858.CD004659.pub3.


Gentamicin, azithromycin and ceftriaxone in the treatment of gonorrhoea: the relationship between antibiotic MIC and clinical outcome.

Cole MJ, Tan W, Fifer H, Brittain C, Duley L, Hepburn T, Lawrence T, Montgomery AA, Sprange K, Thandi S, Churchward C, Tripodo F, Woodford N, Ross JDC.

J Antimicrob Chemother. 2020 Feb 1;75(2):449-457. doi: 10.1093/jac/dkz436.


Improving quality of care and outcome at very preterm birth: the Preterm Birth research programme, including the Cord pilot RCT.

Duley L, Dorling J, Ayers S, Oliver S, Yoxall CW, Weeks A, Megone C, Oddie S, Gyte G, Chivers Z, Thornton J, Field D, Sawyer A, McGuire W.

Southampton (UK): NIHR Journals Library; 2019 Sep.


Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes.

Rabe H, Gyte GM, Díaz-Rossello JL, Duley L.

Cochrane Database Syst Rev. 2019 Sep 17;9:CD003248. doi: 10.1002/14651858.CD003248.pub4.


Randomised trial of cord clamping at very preterm birth: outcomes at 2 years.

Armstrong-Buisseret L, Powers K, Dorling J, Bradshaw L, Johnson S, Mitchell E, Duley L.

Arch Dis Child Fetal Neonatal Ed. 2019 Aug 1. pii: fetalneonatal-2019-316912. doi: 10.1136/archdischild-2019-316912. [Epub ahead of print]


Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT.

Sprigg N, Flaherty K, Appleton JP, Al-Shahi Salman R, Bereczki D, Beridze M, Ciccone A, Collins R, Dineen RA, Duley L, Egea-Guerrero JJ, England TJ, Karlinski M, Krishnan K, Laska AC, Law ZK, Ovesen C, Ozturk S, Pocock SJ, Roberts I, Robinson TG, Roffe C, Peters N, Scutt P, Thanabalan J, Werring D, Whynes D, Woodhouse L, Bath PM.

Health Technol Assess. 2019 Jul;23(35):1-48. doi: 10.3310/hta23350.


Alternative Magnesium Sulfate Dosing Regimens for Women With Preeclampsia: A Population Pharmacokinetic Exposure-Response Modeling and Simulation Study.

Du L, Wenning LA, Carvalho B, Duley L, Brookfield KF, Witjes H, de Greef R, Lumbiganon P, Titapant V, Kongwattanakul K, Long Q, Sangkomkamhang US, Gülmezoglu AM, Oladapo OT.

J Clin Pharmacol. 2019 Nov;59(11):1519-1526. doi: 10.1002/jcph.1448. Epub 2019 Jun 3.


Gentamicin as an alternative to ceftriaxone in the treatment of gonorrhoea: the G-TOG non-inferiority RCT.

Ross JD, Harding J, Duley L, Montgomery AA, Hepburn T, Tan W, Brittain C, Meakin G, Sprange K, Thandi S, Jackson L, Roberts T, Wilson J, White J, Dewsnap C, Cole M, Lawrence T.

Health Technol Assess. 2019 May;23(20):1-104. doi: 10.3310/hta23200.


Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG): a randomised non-inferiority trial.

Ross JDC, Brittain C, Cole M, Dewsnap C, Harding J, Hepburn T, Jackson L, Keogh M, Lawrence T, Montgomery AA, Roberts TE, Sprange K, Tan W, Thandi S, White J, Wilson J, Duley L; G-ToG trial team.

Lancet. 2019 Jun 22;393(10190):2511-2520. doi: 10.1016/S0140-6736(18)32817-4. Epub 2019 May 2. Erratum in: Lancet. 2019 Jun 29;393(10191):2590. Lancet. 2019 Jun 20;:. Lancet. 2019 Oct 5;394(10205):1230.


Women's experiences of participating in a randomised trial comparing alternative policies for timing of cord clamping at very preterm birth: a questionnaire study.

Bradshaw L, Sawyer A, Mitchell E, Armstrong-Buisseret L, Ayers S, Duley L.

Trials. 2019 Apr 16;20(1):225. doi: 10.1186/s13063-019-3325-4.


Cord pilot trial, comparing alternative policies for timing of cord clamping before 32 weeks gestation: follow-up for women up to one year.

Bradshaw L, Sawyer A, Armstrong-Buisseret L, Mitchell E, Ayers S, Duley L.

BMC Pregnancy Childbirth. 2019 Feb 21;19(1):78. doi: 10.1186/s12884-019-2223-9.


Temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: FAST.

McKeever T, Mortimer K, Bradshaw L, Haydock R, Pavord I, Higgins B, Walker S, Wilson A, Price D, Thomas M, Devereux G, Brightling C, Renwick C, Parrott S, Mitchell E, Duley L, Harrison T.

Health Technol Assess. 2018 Dec;22(70):1-82. doi: 10.3310/hta22700.


Population Pharmacokinetic Modeling to Evaluate Standard Magnesium Sulfate Treatments and Alternative Dosing Regimens for Women With Preeclampsia.

Du L, Wenning L, Migoya E, Xu Y, Carvalho B, Brookfield K, Witjes H, de Greef R, Lumbiganon P, Sangkomkamhang U, Titapant V, Duley L, Long Q, Oladapo OT.

J Clin Pharmacol. 2019 Mar;59(3):374-385. doi: 10.1002/jcph.1328. Epub 2018 Nov 13.


Efficacy and cost-effectiveness of nurse-led care involving education and engagement of patients and a treat-to-target urate-lowering strategy versus usual care for gout: a randomised controlled trial.

Doherty M, Jenkins W, Richardson H, Sarmanova A, Abhishek A, Ashton D, Barclay C, Doherty S, Duley L, Hatton R, Rees F, Stevenson M, Zhang W.

Lancet. 2018 Oct 20;392(10156):1403-1412. doi: 10.1016/S0140-6736(18)32158-5.


Development of a standardised set of metrics for monitoring site performance in multicentre randomised trials: a Delphi study.

Whitham D, Turzanski J, Bradshaw L, Clarke M, Culliford L, Duley L, Shaw L, Skea Z, Treweek SP, Walker K, Williamson PR, Montgomery AA; Site Performance Metrics for Multicentre Randomised Trials Collaboration.

Trials. 2018 Oct 16;19(1):557. doi: 10.1186/s13063-018-2940-9.


Monitoring performance of sites within multicentre randomised trials: a systematic review of performance metrics.

Walker KF, Turzanski J, Whitham D, Montgomery A, Duley L.

Trials. 2018 Oct 16;19(1):562. doi: 10.1186/s13063-018-2941-8.


Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation.

Churchill D, Duley L, Thornton JG, Moussa M, Ali HS, Walker KF.

Cochrane Database Syst Rev. 2018 Oct 5;10:CD003106. doi: 10.1002/14651858.CD003106.pub3.


Antihypertensive drug therapy for mild to moderate hypertension during pregnancy.

Abalos E, Duley L, Steyn DW, Gialdini C.

Cochrane Database Syst Rev. 2018 Oct 1;10:CD002252. doi: 10.1002/14651858.CD002252.pub4.


Triple versus guideline antiplatelet therapy to prevent recurrence after acute ischaemic stroke or transient ischaemic attack: the TARDIS RCT.

Bath PM, Woodhouse LJ, Appleton JP, Beridze M, Christensen H, Dineen RA, Flaherty K, Duley L, England TJ, Havard D, Heptinstall S, James M, Kasonde C, Krishnan K, Markus HS, Montgomery AA, Pocock S, Randall M, Ranta A, Robinson TG, Scutt P, Venables GS, Sprigg N.

Health Technol Assess. 2018 Aug;22(48):1-76. doi: 10.3310/hta22480.


Associations between the timing and dosing of aspirin prophylaxis and term and preterm pre-eclampsia.

Askie L, Duley L.

BMJ Evid Based Med. 2018 Jun 7. pii: bmjebm-2018-110931. doi: 10.1136/bmjebm-2018-110931. [Epub ahead of print] Review. No abstract available.


Early, specialist vocational rehabilitation to facilitate return to work after traumatic brain injury: the FRESH feasibility RCT.

Radford K, Sutton C, Sach T, Holmes J, Watkins C, Forshaw D, Jones T, Hoffman K, O'Connor R, Tyerman R, Merchán-Baeza JA, Morris R, McManus E, Drummond A, Walker M, Duley L, Shakespeare D, Hammond A, Phillips J.

Health Technol Assess. 2018 May;22(33):1-124. doi: 10.3310/hta22330.


Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial.

Sprigg N, Flaherty K, Appleton JP, Al-Shahi Salman R, Bereczki D, Beridze M, Christensen H, Ciccone A, Collins R, Czlonkowska A, Dineen RA, Duley L, Egea-Guerrero JJ, England TJ, Krishnan K, Laska AC, Law ZK, Ozturk S, Pocock SJ, Roberts I, Robinson TG, Roffe C, Seiffge D, Scutt P, Thanabalan J, Werring D, Whynes D, Bath PM; TICH-2 Investigators.

Lancet. 2018 May 26;391(10135):2107-2115. doi: 10.1016/S0140-6736(18)31033-X. Epub 2018 May 16.


Home interventions and light therapy for the treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomised controlled trial.

Haines RH, Thomas KS, Montgomery AA, Ravenscroft JC, Akram P, Chalmers JR, Whitham D, Duley L, Eleftheriadou V, Meakin G, Mitchell EJ, White J, Rogers A, Sach T, Santer M, Tan W, Hepburn T, Williams HC, Batchelor J.

BMJ Open. 2018 Apr 3;8(4):e018649. doi: 10.1136/bmjopen-2017-018649.


Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations.

McKeever T, Mortimer K, Wilson A, Walker S, Brightling C, Skeggs A, Pavord I, Price D, Duley L, Thomas M, Bradshaw L, Higgins B, Haydock R, Mitchell E, Devereux G, Harrison T.

N Engl J Med. 2018 Mar 8;378(10):902-910. doi: 10.1056/NEJMoa1714257. Epub 2018 Mar 3.


What are the main inefficiencies in trial conduct: a survey of UKCRC registered clinical trials units in the UK.

Duley L, Gillman A, Duggan M, Belson S, Knox J, McDonald A, Rawcliffe C, Simon J, Sprosen T, Watson J, Wood W.

Trials. 2018 Jan 8;19(1):15. doi: 10.1186/s13063-017-2378-5.


Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial.

Bath PM, Woodhouse LJ, Appleton JP, Beridze M, Christensen H, Dineen RA, Duley L, England TJ, Flaherty K, Havard D, Heptinstall S, James M, Krishnan K, Markus HS, Montgomery AA, Pocock SJ, Randall M, Ranta A, Robinson TG, Scutt P, Venables GS, Sprigg N; TARDIS Investigators.

Lancet. 2018 Mar 3;391(10123):850-859. doi: 10.1016/S0140-6736(17)32849-0. Epub 2017 Dec 20.


Evaluating progestogens for prevention of preterm birth international collaborative (EPPPIC) individual participant data (IPD) meta-analysis: protocol.

Stewart LA, Simmonds M, Duley L, Dietz KC, Harden M, Hodkinson A, Llewellyn A, Sharif S, Walker R, Wright K; EPPPIC group.

Syst Rev. 2017 Nov 28;6(1):235. doi: 10.1186/s13643-017-0600-x.


Improving readiness for recruitment through simulated trial activation: the Adjuvant Steroids in Adults with Pandemic influenza (ASAP) trial.

Lim WS, Meakin G, Brittain C, Bewick T, Duley L.

Trials. 2017 Nov 16;18(1):546. doi: 10.1186/s13063-017-2290-z.


Delayed versus Immediate Cord Clamping in Preterm Infants.

Tarnow-Mordi W, Morris J, Kirby A, Robledo K, Askie L, Brown R, Evans N, Finlayson S, Fogarty M, Gebski V, Ghadge A, Hague W, Isaacs D, Jeffery M, Keech A, Kluckow M, Popat H, Sebastian L, Aagaard K, Belfort M, Pammi M, Abdel-Latif M, Reynolds G, Ariff S, Sheikh L, Chen Y, Colditz P, Liley H, Pritchard M, de Luca D, de Waal K, Forder P, Duley L, El-Naggar W, Gill A, Newnham J, Simmer K, Groom K, Weston P, Gullam J, Patel H, Koh G, Lui K, Marlow N, Morris S, Sehgal A, Wallace E, Soll R, Young L, Sweet D, Walker S, Watkins A, Wright I, Osborn D, Simes J; Australian Placental Transfusion Study Collaborative Group.

N Engl J Med. 2017 Dec 21;377(25):2445-2455. doi: 10.1056/NEJMoa1711281. Epub 2017 Oct 29.


Assessing the neuroprotective benefits for babies of antenatal magnesium sulphate: An individual participant data meta-analysis.

Crowther CA, Middleton PF, Voysey M, Askie L, Duley L, Pryde PG, Marret S, Doyle LW; AMICABLE Group.

PLoS Med. 2017 Oct 4;14(10):e1002398. doi: 10.1371/journal.pmed.1002398. eCollection 2017 Oct.


Randomised trial of cord clamping and initial stabilisation at very preterm birth.

Duley L, Dorling J, Pushpa-Rajah A, Oddie SJ, Yoxall CW, Schoonakker B, Bradshaw L, Mitchell EJ, Fawke JA; Cord Pilot Trial Collaborative Group.

Arch Dis Child Fetal Neonatal Ed. 2018 Jan;103(1):F6-F14. doi: 10.1136/archdischild-2016-312567. Epub 2017 Sep 18.


Women's views and experiences of two alternative consent pathways for participation in a preterm intrapartum trial: a qualitative study.

Sawyer A, Chhoa C, Ayers S, Pushpa-Rajah A, Duley L.

Trials. 2017 Sep 9;18(1):422. doi: 10.1186/s13063-017-2149-3.


Different strategies for diagnosing gestational diabetes to improve maternal and infant health.

Farrar D, Duley L, Dowswell T, Lawlor DA.

Cochrane Database Syst Rev. 2017 Aug 23;8:CD007122. doi: 10.1002/14651858.CD007122.pub4. Review.


Fifteen-minute consultation: stabilisation of the high-risk newborn infant beside the mother.

Batey N, Yoxall CW, Fawke JA, Duley L, Dorling J.

Arch Dis Child Educ Pract Ed. 2017 Oct;102(5):235-238. doi: 10.1136/archdischild-2016-312276. Epub 2017 Jul 27.


Clinicians' views and experiences of offering two alternative consent pathways for participation in a preterm intrapartum trial: a qualitative study.

Chhoa CY, Sawyer A, Ayers S, Pushpa-Rajah A, Duley L.

Trials. 2017 Apr 26;18(1):196. doi: 10.1186/s13063-017-1940-5.


Gentamicin versus ceftriaxone for the treatment of gonorrhoea (G-TOG trial): study protocol for a randomised trial.

Brittain C, Childs M, Duley L, Harding J, Hepburn T, Meakin G, Montgomery AA, Tan W, Ross JD.

Trials. 2016 Nov 24;17(1):558.


Baseline characteristics of the 3096 patients recruited into the 'Triple Antiplatelets for Reducing Dependency after Ischemic Stroke' trial.

Bath PM, Appleton JP, Beridze M, Christensen H, Dineen RA, Duley L, England TJ, Heptinstall S, James M, Krishnan K, Markus HS, Pocock S, Ranta A, Robinson TG, Flaherty K, Scutt P, Venables GS, Woodhouse LJ, Sprigg N.

Int J Stroke. 2017 Jul;12(5):524-538. doi: 10.1177/1747493016677988. Epub 2016 Nov 4.


Antiplatelet therapy before or after 16 weeks' gestation for preventing preeclampsia: an individual participant data meta-analysis.

Meher S, Duley L, Hunter K, Askie L.

Am J Obstet Gynecol. 2017 Feb;216(2):121-128.e2. doi: 10.1016/j.ajog.2016.10.016. Epub 2016 Nov 1. Review.


FourFold Asthma Study (FAST): a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations.

Skeggs A, McKeever T, Duley L, Mitchell E, Bradshaw L, Mortimer K, Walker S, Parrott S, Wilson A, Pavord I, Brightling C, Thomas M, Price D, Devereux G, Higgins B, Harrison T, Haydock R.

Trials. 2016 Oct 13;17(1):499.


Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: Protocol for a randomized, placebo-controlled trial.

Sprigg N, Robson K, Bath P, Dineen R, Roberts I, Robinson T, Roffe C, Werring D, Al-Shahi Salman R, Pocock S, Duley L, England T, Whynes D, Ciccone A, Laska AC, Christensen H, Ozturk S, Collins R, Bereczki D, Egea-Guerrero JJ, Law ZK, Czlonkowska A, Seiffge D, Beredzie M; TICH-2 Investigators.

Int J Stroke. 2016 Aug;11(6):683-94. doi: 10.1177/1747493016641960. Epub 2016 Apr 5.


Use of biochemical tests of placental function for improving pregnancy outcome.

Heazell AE, Whitworth M, Duley L, Thornton JG.

Cochrane Database Syst Rev. 2015 Nov 25;(11):CD011202. doi: 10.1002/14651858.CD011202.pub2. Review.


Clinical pharmacokinetic properties of magnesium sulphate in women with pre-eclampsia and eclampsia.

Okusanya BO, Oladapo OT, Long Q, Lumbiganon P, Carroli G, Qureshi Z, Duley L, Souza JP, Gülmezoglu AM.

BJOG. 2016 Feb;123(3):356-66. doi: 10.1111/1471-0528.13753. Epub 2015 Nov 24. Review.


The ethical issues regarding consent to clinical trials with pre-term or sick neonates: a systematic review (framework synthesis) of the empirical research.

Wilman E, Megone C, Oliver S, Duley L, Gyte G, Wright JM.

Trials. 2015 Nov 4;16:502. doi: 10.1186/s13063-015-0957-x. Review.


Providing immediate neonatal care and resuscitation at birth beside the mother: clinicians' views, a qualitative study.

Yoxall CW, Ayers S, Sawyer A, Bertullies S, Thomas M, D Weeks A, Duley L.

BMJ Open. 2015 Sep 30;5(9):e008494. doi: 10.1136/bmjopen-2015-008494.

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