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Items: 28

1.

Preclinical Pharmacological Development of Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.

Rolt A, Le D, Hu Z, Wang AQ, Shah P, Singleton M, Hughes E, Dulcey AE, He S, Imamura M, Uchida T, Chayama K, Xu X, Marugan JJ, Liang TJ.

J Infect Dis. 2018 May 5;217(11):1761-1769. doi: 10.1093/infdis/jiy039.

2.

Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK.

Dai S, Dulcey AE, Hu X, Wassif CA, Porter FD, Austin CP, Ory DS, Marugan J, Zheng W.

Autophagy. 2017 Aug 3;13(8):1435-1451. doi: 10.1080/15548627.2017.1329081. Epub 2017 Jun 14.

3.

SU9516 Increases α7β1 Integrin and Ameliorates Disease Progression in the mdx Mouse Model of Duchenne Muscular Dystrophy.

Sarathy A, Wuebbles RD, Fontelonga TM, Tarchione AR, Mathews Griner LA, Heredia DJ, Nunes AM, Duan S, Brewer PD, Van Ry T, Hennig GW, Gould TW, Dulcey AE, Wang A, Xu X, Chen CZ, Hu X, Zheng W, Southall N, Ferrer M, Marugan J, Burkin DJ.

Mol Ther. 2017 Jun 7;25(6):1395-1407. doi: 10.1016/j.ymthe.2017.03.022. Epub 2017 Apr 5.

4.

Reduction of Blood Amyloid-β Oligomers in Alzheimer's Disease Transgenic Mice by c-Abl Kinase Inhibition.

Estrada LD, Chamorro D, Yañez MJ, Gonzalez M, Leal N, von Bernhardi R, Dulcey AE, Marugan J, Ferrer M, Soto C, Zanlungo S, Inestrosa NC, Alvarez AR.

J Alzheimers Dis. 2016 Oct 4;54(3):1193-1205.

PMID:
27567806
5.

Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus.

Mukhopadhyay R, Roy S, Venkatadri R, Su YP, Ye W, Barnaeva E, Mathews Griner L, Southall N, Hu X, Wang AQ, Xu X, Dulcey AE, Marugan JJ, Ferrer M, Arav-Boger R.

PLoS Pathog. 2016 Jun 23;12(6):e1005717. doi: 10.1371/journal.ppat.1005717. eCollection 2016 Jun.

6.

Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.

He S, Xiao J, Dulcey AE, Lin B, Rolt A, Hu Z, Hu X, Wang AQ, Xu X, Southall N, Ferrer M, Zheng W, Liang TJ, Marugan JJ.

J Med Chem. 2016 Feb 11;59(3):841-53. doi: 10.1021/acs.jmedchem.5b00752. Epub 2016 Feb 1.

7.

In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity.

Lynn GM, Laga R, Darrah PA, Ishizuka AS, Balaci AJ, Dulcey AE, Pechar M, Pola R, Gerner MY, Yamamoto A, Buechler CR, Quinn KM, Smelkinson MG, Vanek O, Cawood R, Hills T, Vasalatiy O, Kastenmüller K, Francica JR, Stutts L, Tom JK, Ryu KA, Esser-Kahn AP, Etrych T, Fisher KD, Seymour LW, Seder RA.

Nat Biotechnol. 2015 Nov;33(11):1201-10. doi: 10.1038/nbt.3371. Epub 2015 Oct 26.

8.

STAQ: A route toward low power, multicolor nanoscopy.

Rosales T, Sackett DL, Xu J, Shi ZD, Xu B, Li H, Kaur G, Frohart E, Shenoy N, Cheal SM, Wu H, Dulcey AE, Hu Y, Li C, Lane K, Griffiths GL, Knutson JR.

Microsc Res Tech. 2015 May;78(5):343-55. doi: 10.1002/jemt.22478. Epub 2015 Mar 12.

PMID:
25762506
9.

Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin.

Hall MD, Marshall TS, Kwit AD, Miller Jenkins LM, Dulcey AE, Madigan JP, Pluchino KM, Goldsborough AS, Brimacombe KR, Griffiths GL, Gottesman MM.

J Biol Chem. 2014 Aug 1;289(31):21473-89. doi: 10.1074/jbc.M114.581702. Epub 2014 Jun 14.

10.

Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor.

Free RB, Chun LS, Moritz AE, Miller BN, Doyle TB, Conroy JL, Padron A, Meade JA, Xiao J, Hu X, Dulcey AE, Han Y, Duan L, Titus S, Bryant-Genevier M, Barnaeva E, Ferrer M, Javitch JA, Beuming T, Shi L, Southall NT, Marugan JJ, Sibley DR.

Mol Pharmacol. 2014 Jul;86(1):96-105. doi: 10.1124/mol.113.090563. Epub 2014 Apr 22.

11.

Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists.

Xiao J, Free RB, Barnaeva E, Conroy JL, Doyle T, Miller B, Bryant-Genevier M, Taylor MK, Hu X, Dulcey AE, Southall N, Ferrer M, Titus S, Zheng W, Sibley DR, Marugan JJ.

J Med Chem. 2014 Apr 24;57(8):3450-63. doi: 10.1021/jm500126s. Epub 2014 Apr 10.

12.

A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice.

Neumann S, Nir EA, Eliseeva E, Huang W, Marugan J, Xiao J, Dulcey AE, Gershengorn MC.

Endocrinology. 2014 Jan;155(1):310-4. doi: 10.1210/en.2013-1835. Epub 2013 Dec 4.

13.

The N-acetyl-binding pocket of N-acetylglucosaminyltransferases also accommodates a sugar analog with a chemical handle at C2.

Pasek M, Ramakrishnan B, Boeggeman E, Mercer N, Dulcey AE, Griffiths GL, Qasba PK.

Glycobiology. 2012 Mar;22(3):379-88. doi: 10.1093/glycob/cwr110. Epub 2011 Aug 25.

14.

Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin.

Goldsborough AS, Handley MD, Dulcey AE, Pluchino KM, Kannan P, Brimacombe KR, Hall MD, Griffiths G, Gottesman MM.

J Med Chem. 2011 Jul 28;54(14):4987-97. doi: 10.1021/jm2001663. Epub 2011 Jun 24.

16.

Programming the supramolecular helical polymerization of dendritic dipeptides via the stereochemical information of the dipeptide.

Rosen BM, Peterca M, Morimitsu K, Dulcey AE, Leowanawat P, Resmerita AM, Imam MR, Percec V.

J Am Chem Soc. 2011 Apr 6;133(13):5135-51. doi: 10.1021/ja200280h. Epub 2011 Mar 10.

PMID:
21391688
17.

Hollow spherical supramolecular dendrimers.

Percec V, Peterca M, Dulcey AE, Imam MR, Hudson SD, Nummelin S, Adelman P, Heiney PA.

J Am Chem Soc. 2008 Oct 1;130(39):13079-94. doi: 10.1021/ja8034703. Epub 2008 Sep 5.

PMID:
18771261
18.

Selective transport of water mediated by porous dendritic dipeptides.

Kaucher MS, Peterca M, Dulcey AE, Kim AJ, Vinogradov SA, Hammer DA, Heiney PA, Percec V.

J Am Chem Soc. 2007 Sep 26;129(38):11698-9. Epub 2007 Sep 5. No abstract available.

PMID:
17784763
19.

Helical pores self-assembled from homochiral dendritic dipeptides based on L-Tyr and nonpolar alpha-amino acids.

Percec V, Dulcey AE, Peterca M, Adelman P, Samant R, Balagurusamy VS, Heiney PA.

J Am Chem Soc. 2007 May 9;129(18):5992-6002. Epub 2007 Apr 13.

PMID:
17429976
20.

Self-assembly of hybrid dendrons with complex primary structure into functional helical pores.

Percec V, Smidrkal J, Peterca M, Mitchell CM, Nummelin S, Dulcey AE, Sienkowska MJ, Heiney PA.

Chemistry. 2007;13(14):3989-4007.

PMID:
17304597
21.

Self-assembly, structural, and retrostructural analysis of dendritic dipeptide pores undergoing reversible circular to elliptical shape change.

Peterca M, Percec V, Dulcey AE, Nummelin S, Korey S, Ilies M, Heiney PA.

J Am Chem Soc. 2006 May 24;128(20):6713-20.

PMID:
16704274
22.

Principles of self-assembly of helical pores from dendritic dipeptides.

Percec V, Dulcey AE, Peterca M, Ilies M, Nummelin S, Sienkowska MJ, Heiney PA.

Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2518-23. Epub 2006 Feb 9.

23.

Solvent controlled self-assembly at the liquid-solid interface revealed by STM.

Mamdouh W, Uji-i H, Ladislaw JS, Dulcey AE, Percec V, De Schryver FC, De Feyter S.

J Am Chem Soc. 2006 Jan 11;128(1):317-25.

PMID:
16390161
24.

Programming the internal structure and stability of helical pores self-assembled from dendritic dipeptides via the protective groups of the peptide.

Percec V, Dulcey AE, Peterca M, Ilies M, Sienkowska MJ, Heiney PA.

J Am Chem Soc. 2005 Dec 21;127(50):17902-9.

PMID:
16351122
25.

The internal structure of helical pores self-assembled from dendritic dipeptides is stereochemically programmed and allosterically regulated.

Percec V, Dulcey AE, Peterca M, Ilies M, Ladislaw J, Rosen BM, Edlund U, Heiney PA.

Angew Chem Int Ed Engl. 2005 Oct 14;44(40):6516-21. No abstract available.

PMID:
16158450
26.

Expression of molecular chirality and two-dimensional supramolecular self-assembly of chiral, racemic, and achiral monodendrons at the liquid-solid interface.

Mamdouh W, Uji-I H, Dulcey AE, Percec V, De Feyter S, De Schryver FC.

Langmuir. 2004 Aug 31;20(18):7678-85.

PMID:
15323519
27.

Self-assembly of amphiphilic dendritic dipeptides into helical pores.

Percec V, Dulcey AE, Balagurusamy VS, Miura Y, Smidrkal J, Peterca M, Nummelin S, Edlund U, Hudson SD, Heiney PA, Duan H, Magonov SN, Vinogradov SA.

Nature. 2004 Aug 12;430(7001):764-8.

PMID:
15306805
28.

Supramolecular dendritic liquid quasicrystals.

Zeng X, Ungar G, Liu Y, Percec V, Dulcey AE, Hobbs JK.

Nature. 2004 Mar 11;428(6979):157-60.

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