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Items: 1 to 50 of 91

1.

A revised pharmacophore model for 5-HT2A receptor antagonists derived from the atypical antipsychotic agent risperidone.

Shah UH, Gaitonde SA, Moreno JL, Glennon RA, Dukat M, González-Maeso J.

ACS Chem Neurosci. 2019 Jan 4. doi: 10.1021/acschemneuro.8b00637. [Epub ahead of print]

PMID:
30609893
2.

"Methylene Bridge" to 5-HT3 Receptor Antagonists: Conformationally Constrained Phenylguanidines.

Abdelkhalek AS, Alley GS, Alwassil OI, Khatri S, Mosier PD, Nyce HL, White MM, Schulte MK, Dukat M.

ACS Chem Neurosci. 2018 Nov 8. doi: 10.1021/acschemneuro.8b00431. [Epub ahead of print]

PMID:
30375852
3.

des-Formylflustrabromine (dFBr): A Structure-Activity Study on Its Ability To Potentiate the Action of Acetylcholine at α4β2 Nicotinic Acetylcholine Receptors.

Dukat M, Jain A, German N, Ferrara-Pontoriero R, Huang Y, Ma Y, Schulte MK, Glennon RA.

ACS Chem Neurosci. 2018 Aug 2. doi: 10.1021/acschemneuro.8b00156. [Epub ahead of print]

PMID:
30028943
4.

A new chemotype inhibitor for the human organic cation transporter 3 (hOCT3).

Pan X, Iyer KA, Liu H, Sweet DH, Dukat M.

Bioorg Med Chem Lett. 2017 Sep 15;27(18):4440-4445. doi: 10.1016/j.bmcl.2017.08.008. Epub 2017 Aug 5.

PMID:
28811134
5.

Reevaluation of fenpropimorph as a σ receptor ligand: Structure-affinity relationship studies at human σ1 receptors.

Sguazzini E, Schmidt HR, Iyer KA, Kruse AC, Dukat M.

Bioorg Med Chem Lett. 2017 Jul 1;27(13):2912-2919. doi: 10.1016/j.bmcl.2017.04.088. Epub 2017 Apr 29.

PMID:
28495085
6.

Synthetic Cathinones: A Brief Overview of Overviews with Applications to the Forensic Sciences.

Glennon RA, Dukat M.

Ann Forensic Res Anal. 2017;4(2). pii: 1040. Epub 2017 Mar 21.

7.

Structure-Activity Relationships of Synthetic Cathinones.

Glennon RA, Dukat M.

Curr Top Behav Neurosci. 2017;32:19-47. doi: 10.1007/7854_2016_41.

8.

Superagonist, Full Agonist, Partial Agonist, and Antagonist Actions of Arylguanidines at 5-Hydroxytryptamine-3 (5-HT3) Subunit A Receptors.

Alix K, Khatri S, Mosier PD, Casterlow S, Yan D, Nyce HL, White MM, Schulte MK, Dukat M.

ACS Chem Neurosci. 2016 Nov 16;7(11):1565-1574. Epub 2016 Sep 6.

PMID:
27533595
9.

Reformulating a Pharmacophore for 5-HT2A Serotonin Receptor Antagonists.

Younkin J, Gaitonde SA, Ellaithy A, Vekariya R, Baki L, Moreno JL, Shah S, Drossopoulos P, Hideshima KS, Eltit JM, González-Maeso J, Logothetis DE, Dukat M, Glennon RA.

ACS Chem Neurosci. 2016 Sep 21;7(9):1292-9. doi: 10.1021/acschemneuro.6b00162. Epub 2016 Jul 19.

10.

Receptor-ligand interaction at 5-HT3 serotonin receptors: a cluster approach.

Rao BK, Samanta D, Joshi S, Basu K, Baldwin SD, Jha A, Dukat M, Glennon RA, Jena P.

J Phys Chem A. 2014 Sep 18;118(37):8471-6. doi: 10.1021/jp5017906. Epub 2014 Jun 10.

PMID:
24878072
11.

2-Amino-6-chloro-3,4-dihydroquinazoline: A novel 5-HT3 receptor antagonist with antidepressant character.

Dukat M, Alix K, Worsham J, Khatri S, Schulte MK.

Bioorg Med Chem Lett. 2013 Nov 1;23(21):5945-8. doi: 10.1016/j.bmcl.2013.08.072. Epub 2013 Aug 24.

PMID:
24035337
12.

Deconstruction of the α4β2 nicotinic acetylcholine receptor positive allosteric modulator desformylflustrabromine.

German N, Kim JS, Jain A, Dukat M, Pandya A, Ma Y, Weltzin M, Schulte MK, Glennon RA.

J Med Chem. 2011 Oct 27;54(20):7259-67. doi: 10.1021/jm200834x. Epub 2011 Oct 3.

13.

Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships.

Klein MT, Dukat M, Glennon RA, Teitler M.

J Pharmacol Exp Ther. 2011 Jun;337(3):860-7. doi: 10.1124/jpet.111.179606. Epub 2011 Mar 21.

14.

MD-354 selectively antagonizes the antinociceptive effects of (-)nicotine in the mouse tail-flick assay.

Dukat M, Wesołowska A, Alley G, Young S, Abdrakhmanova GR, Navarro HA, Young R, Glennon RA.

Psychopharmacology (Berl). 2010 Jul;210(4):547-57. doi: 10.1007/s00213-010-1857-0. Epub 2010 Apr 30.

PMID:
20431995
15.

Antinociceptive synergism of MD-354 and clonidine. Part II. The alpha-adrenoceptor component.

Young S, Vainio M, Scheinin M, Dukat M.

Basic Clin Pharmacol Toxicol. 2010 Aug;107(2):690-7. doi: 10.1111/j.1742-7843.2010.00563.x. Epub 2010 Mar 28.

16.

The medicinal chemistry of 5-HT6 receptor ligands with a focus on arylsulfonyltryptamine analogs.

Glennon RA, Siripurapu U, Roth BL, Kolanos R, Bondarev ML, Sikazwe D, Lee M, Dukat M.

Curr Top Med Chem. 2010;10(5):579-95. Review.

17.

[Therapeutic use of platelet-rich plasma in oral surgery].

Lazić Z, Bubalo M, Petković-Curcin A, Dukat M, Mihajlović B.

Vojnosanit Pregl. 2009 Oct;66(10):821-5. Review. Serbian. No abstract available.

PMID:
19938761
18.

Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies.

Dukat M, Mosier PD, Kolanos R, Roth BL, Glennon RA.

J Med Chem. 2008 Feb 14;51(3):603-11. doi: 10.1021/jm070910s. Epub 2008 Jan 18.

19.

The 5-HT3 receptor partial agonist MD-354 (meta-chlorophenylguanidine) enhances the discriminative stimulus actions of (+)amphetamine in rats.

Dukat M, Wesolowska A, Young R, Glennon RA.

Pharmacol Biochem Behav. 2007 Jun-Jul;87(2):203-7. Epub 2007 Mar 30.

PMID:
17540440
20.

MD-354: what is it good for?

Dukat M, Glennon RA, Young S.

CNS Drug Rev. 2007 Spring;13(1):1-20. Review.

21.

N-Methyl-1-(4-methoxyphenyl)-2-aminopropane (PMMA) and N-Methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) produce non-identical discriminative stimuli in rats.

Glennon RA, Young R, Dukat M, Chang-Fong J, El-Zahabi M.

Pharmacol Biochem Behav. 2007 Mar;86(3):477-84. Epub 2007 Jan 18.

22.

Interaction of N1-unsubstituted and N1-benzenesulfonyltryptamines at h5-HT6 receptors.

Kolanos R, Dukat M, Roth BL, Glennon RA.

Bioorg Med Chem Lett. 2006 Nov 15;16(22):5832-5. Epub 2006 Aug 30.

PMID:
16945532
23.

Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors.

Sikazwe D, Bondarev ML, Dukat M, Rangisetty JB, Roth BL, Glennon RA.

J Med Chem. 2006 Aug 24;49(17):5217-25.

PMID:
16913710
24.

Aryloxyethylamines: binding at alpha7 nicotinic acetylcholine receptors.

Ragab HM, Kim JS, Dukat M, Navarro H, Glennon RA.

Bioorg Med Chem Lett. 2006 Aug 15;16(16):4283-6. Epub 2006 Jun 9.

PMID:
16765047
25.

TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) exhibits anxiolytic-like activity in a marble-burying assay in mice.

Young R, Batkai S, Dukat M, Glennon RA.

Pharmacol Biochem Behav. 2006 May;84(1):62-73. Epub 2006 Jun 5.

PMID:
16750844
26.

TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) inhibits the consumption of "snacks" in mice.

Young R, Rothman RB, Rangisetty JB, Partilla JS, Dukat M, Glennon RA.

Pharmacol Biochem Behav. 2006 May;84(1):74-83. Epub 2006 Jun 5.

PMID:
16750261
27.

Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors.

Siripurapu U, Kolanos R, Dukat M, Roth BL, Glennon RA.

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3793-6. Epub 2006 May 18.

PMID:
16709453
28.

S(+)- and R(-)N-methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) as discriminative stimuli: effect of cocaine.

Bondareva T, Wesołowska A, Dukat M, Lee M, Young R, Glennon RA.

Pharmacol Biochem Behav. 2005 Nov;82(3):531-8. Epub 2005 Dec 7.

PMID:
16337676
29.

Antinociception: mechanistic studies on the action of MD-354 and clonidine. Part 1. The 5-HT3 component.

Dukat M, Wesołowska A.

Eur J Pharmacol. 2005 Dec 28;528(1-3):59-64.

PMID:
16321376
30.

Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors.

Pullagurla M, Siripurapu U, Kolanos R, Bondarev ML, Dukat M, Setola V, Roth BL, Glennon RA.

Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302. Epub 2005 Sep 23.

PMID:
16183286
31.

3-(2-Aminoethyl)pyridine analogs as alpha4beta2 nicotinic cholinergic receptor ligands.

Dukat M, Ramunno A, Banzi R, Damaj MI, Martin B, Glennon RA.

Bioorg Med Chem Lett. 2005 Oct 1;15(19):4308-12.

PMID:
16039854
32.

Interaction of chiral MS-245 analogs at h5-HT6 receptors.

Abate C, Kolanos R, Dukat M, Setola V, Roth BL, Glennon RA.

Bioorg Med Chem Lett. 2005 Aug 1;15(15):3510-3.

PMID:
15990303
33.

6-(2-Phenylethyl)nicotine: a novel nicotinic cholinergic receptor ligand.

Ramunno A, Dukat M, Lee M, Young R, El-Zahabi M, Damaj MI, Martin B, Glennon RA.

Bioorg Med Chem Lett. 2005 Jul 1;15(13):3237-40.

PMID:
15925512
34.

Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor.

Setola V, Dukat M, Glennon RA, Roth BL.

Mol Pharmacol. 2005 Jul;68(1):20-33. Epub 2005 Apr 14.

PMID:
15831837
35.

Binding of isotryptamines and indenes at h5-HT6 serotonin receptors.

Kolanos R, Siripurapu U, Pullagurla M, Riaz M, Setola V, Roth BL, Dukat M, Glennon RA.

Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91.

PMID:
15808453
36.

1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands.

Lee M, Rangisetty JB, Pullagurla MR, Dukat M, Setola V, Roth BL, Glennon RA.

Bioorg Med Chem Lett. 2005 Mar 15;15(6):1707-11.

PMID:
15745826
37.

2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands.

Prisinzano T, Dukat M, Law H, Slassi A, MacLean N, DeLannoy I, Glennon RA.

Bioorg Med Chem Lett. 2004 Sep 20;14(18):4697-9.

PMID:
15324890
38.

Effect of 5-HT3 receptor over-expression on the discriminative stimulus effects of ethanol.

Shelton KL, Dukat M, Allan AM.

Alcohol Clin Exp Res. 2004 Aug;28(8):1161-71.

PMID:
15318114
39.

Stimulus effects of three sulfur-containing psychoactive agents.

Khorana N, Pullagurla MR, Dukat M, Young R, Glennon RA.

Pharmacol Biochem Behav. 2004 Aug;78(4):821-6.

PMID:
15301941
40.

MD-354 potentiates the antinociceptive effect of clonidine in the mouse tail-flick but not hot-plate assay.

Wesolowska A, Young S, Dukat M.

Eur J Pharmacol. 2004 Jul 14;495(2-3):129-36.

PMID:
15249161
41.

(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.

Dukat M, Taroua M, Dahdouh A, Siripurapu U, Damaj MI, Martin BR, Glennon RA.

Bioorg Med Chem Lett. 2004 Jul 16;14(14):3651-4.

PMID:
15203136
42.

Binding of tryptamine analogs at h5-HT1E receptors: a structure-affinity investigation.

Dukat M, Smith C, Herrick-Davis K, Teitler M, Glennon RA.

Bioorg Med Chem. 2004 May 15;12(10):2545-52.

PMID:
15110837
43.

1,2,3,4-tetrahydrocarbazoles as 5-HT6 serotonin receptor ligands.

Chang-Fong J, Rangisetty JB, Dukat M, Setola V, Raffay T, Roth B, Glennon RA.

Bioorg Med Chem Lett. 2004 Apr 19;14(8):1961-4.

PMID:
15050637
44.

alpha4beta2 nACh receptor pharmacophore models.

Glennon RA, Dukat M.

Bioorg Med Chem Lett. 2004 Apr 19;14(8):1841-4.

PMID:
15050612
45.

Musings on alpha4beta2 nicotinic acetylcholine (nACh) receptor pharmacophore models.

Glennon RA, Dukat M, Liao L.

Curr Top Med Chem. 2004;4(6):631-44. Review.

PMID:
14965299
46.

3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors.

Dogruer D, Lee M, Dukat M, Damaj MI, Martin BR, Glennon RA.

Bioorg Med Chem Lett. 2004 Jan 19;14(2):523-6.

PMID:
14698195
47.

Quaternary ammonium 3-(aminoethoxy)pyridines as antinociceptive agents.

Simsek R, Chang-Fong J, Lee M, Dukat M, Imad Damaj M, Martin BR, Glennon RA.

Bioorg Med Chem Lett. 2003 Sep 1;13(17):2917-20.

PMID:
14611857
48.

Arylguanidine and arylbiguanide binding at 5-HT3 serotonin receptors: a QSAR study.

Glennon RA, Daoud MK, Dukat M, Teitler M, Herrick-Davis K, Purohit A, Syed H.

Bioorg Med Chem. 2003 Oct 1;11(20):4449-54.

PMID:
13129581
49.

N1-benzenesulfonylgramine and N1-benzenesulfonylskatole: novel 5-HT6 receptor ligand templates.

Pullagurla MR, Dukat M, Setola V, Roth B, Glennon RA.

Bioorg Med Chem Lett. 2003 Oct 6;13(19):3355-9.

PMID:
12951125
50.

Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors.

Khorana N, Smith C, Herrick-Davis K, Purohit A, Teitler M, Grella B, Dukat M, Glennon RA.

J Med Chem. 2003 Aug 28;46(18):3930-7.

PMID:
12930153

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