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Items: 50

1.

Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation.

Bonaventure P, Dugovic C, Shireman B, Preville C, Yun S, Lord B, Nepomuceno D, Wennerholm M, Lovenberg T, Carruthers N, Fitz SD, Shekhar A, Johnson PL.

Front Pharmacol. 2017 Jun 9;8:357. doi: 10.3389/fphar.2017.00357. eCollection 2017.

2.

Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice.

Yun S, Wennerholm M, Shelton JE, Bonaventure P, Letavic MA, Shireman BT, Lovenberg TW, Dugovic C.

Front Behav Neurosci. 2017 May 8;11:83. doi: 10.3389/fnbeh.2017.00083. eCollection 2017.

3.

Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8.

Maher MP, Wu N, Ravula S, Ameriks MK, Savall BM, Liu C, Lord B, Wyatt RM, Matta JA, Dugovic C, Yun S, Ver Donck L, Steckler T, Wickenden AD, Carruthers NI, Lovenberg TW.

J Pharmacol Exp Ther. 2016 May;357(2):394-414. doi: 10.1124/jpet.115.231712. Epub 2016 Mar 17.

PMID:
26989142
4.

Direct Imaging of Hippocampal Epileptiform Calcium Motifs Following Kainic Acid Administration in Freely Behaving Mice.

Berdyyeva TK, Frady EP, Nassi JJ, Aluisio L, Cherkas Y, Otte S, Wyatt RM, Dugovic C, Ghosh KK, Schnitzer MJ, Lovenberg T, Bonaventure P.

Front Neurosci. 2016 Feb 29;10:53. doi: 10.3389/fnins.2016.00053. eCollection 2016.

5.

GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine.

Liu C, Bonaventure P, Lee G, Nepomuceno D, Kuei C, Wu J, Li Q, Joseph V, Sutton SW, Eckert W, Yao X, Yieh L, Dvorak C, Carruthers N, Coate H, Yun S, Dugovic C, Harrington A, Lovenberg TW.

Mol Pharmacol. 2015 Nov;88(5):911-25. doi: 10.1124/mol.115.100412. Epub 2015 Sep 8.

PMID:
26349500
6.

Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia.

Bonaventure P, Shelton J, Yun S, Nepomuceno D, Sutton S, Aluisio L, Fraser I, Lord B, Shoblock J, Welty N, Chaplan SR, Aguilar Z, Halter R, Ndifor A, Koudriakova T, Rizzolio M, Letavic M, Carruthers NI, Lovenberg T, Dugovic C.

J Pharmacol Exp Ther. 2015 Sep;354(3):471-82. doi: 10.1124/jpet.115.225466. Epub 2015 Jul 15.

PMID:
26177655
7.

Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate.

Letavic MA, Bonaventure P, Carruthers NI, Dugovic C, Koudriakova T, Lord B, Lovenberg TW, Ly KS, Mani NS, Nepomuceno D, Pippel DJ, Rizzolio M, Shelton JE, Shah CR, Shireman BT, Young LK, Yun S.

J Med Chem. 2015 Jul 23;58(14):5620-36. doi: 10.1021/acs.jmedchem.5b00742. Epub 2015 Jul 8.

PMID:
26087021
8.

Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development.

Letavic MA, Aluisio L, Apodaca R, Bajpai M, Barbier AJ, Bonneville A, Bonaventure P, Carruthers NI, Dugovic C, Fraser IC, Kramer ML, Lord B, Lovenberg TW, Li LY, Ly KS, Mcallister H, Mani NS, Morton KL, Ndifor A, Nepomuceno SD, Pandit CR, Sands SB, Shah CR, Shelton JE, Snook SS, Swanson DM, Xiao W.

ACS Med Chem Lett. 2015 Mar 13;6(4):450-4. doi: 10.1021/ml5005156. eCollection 2015 Apr 9.

9.

Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity.

Shelton J, Yun S, Losee Olson S, Turek F, Bonaventure P, Dvorak C, Lovenberg T, Dugovic C.

Front Behav Neurosci. 2015 Jan 15;8:453. doi: 10.3389/fnbeh.2014.00453. eCollection 2014.

10.

A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects.

Bonaventure P, Yun S, Johnson PL, Shekhar A, Fitz SD, Shireman BT, Lebold TP, Nepomuceno D, Lord B, Wennerholm M, Shelton J, Carruthers N, Lovenberg T, Dugovic C.

J Pharmacol Exp Ther. 2015 Mar;352(3):590-601. doi: 10.1124/jpet.114.220392. Epub 2015 Jan 12.

11.

Zolpidem reduces hippocampal neuronal activity in freely behaving mice: a large scale calcium imaging study with miniaturized fluorescence microscope.

Berdyyeva T, Otte S, Aluisio L, Ziv Y, Burns LD, Dugovic C, Yun S, Ghosh KK, Schnitzer MJ, Lovenberg T, Bonaventure P.

PLoS One. 2014 Nov 5;9(11):e112068. doi: 10.1371/journal.pone.0112068. eCollection 2014.

12.

Pharmacological or genetic orexin1 receptor inhibition attenuates MK-801 induced glutamate release in mouse cortex.

Aluisio L, Fraser I, Berdyyeva T, Tryputsen V, Shireman BT, Shoblock J, Lovenberg T, Dugovic C, Bonaventure P.

Front Neurosci. 2014 May 20;8:107. doi: 10.3389/fnins.2014.00107. eCollection 2014.

13.

Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism.

Dugovic C, Shelton JE, Yun S, Bonaventure P, Shireman BT, Lovenberg TW.

Front Neurosci. 2014 Feb 14;8:28. doi: 10.3389/fnins.2014.00028. eCollection 2014.

14.

Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder.

Bonaventure P, Dugovic C, Kramer M, De Boer P, Singh J, Wilson S, Bertelsen K, Di J, Shelton J, Aluisio L, Dvorak L, Fraser I, Lord B, Nepomuceno D, Ahnaou A, Drinkenburg W, Chai W, Dvorak C, Sands S, Carruthers N, Lovenberg TW.

J Pharmacol Exp Ther. 2012 Aug;342(2):429-40. doi: 10.1124/jpet.112.193995. Epub 2012 May 8.

PMID:
22570363
15.

JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats.

Galici R, Rezvani AH, Aluisio L, Lord B, Levin ED, Fraser I, Boggs J, Welty N, Shoblock JR, Motley ST, Letavic MA, Carruthers NI, Dugovic C, Lovenberg TW, Bonaventure P.

Psychopharmacology (Berl). 2011 Apr;214(4):829-41. doi: 10.1007/s00213-010-2092-4. Epub 2010 Nov 18.

PMID:
21086115
16.

Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.

Letavic MA, Aluisio L, Atack JR, Bonaventure P, Carruthers NI, Dugovic C, Everson A, Feinstein MA, Fraser IC, Hoey K, Jiang X, Keith JM, Koudriakova T, Leung P, Lord B, Lovenberg TW, Ly KS, Morton KL, Motley ST, Nepomuceno D, Rizzolio M, Rynberg R, Sepassi K, Shelton J.

Bioorg Med Chem Lett. 2010 Jul 15;20(14):4210-4. doi: 10.1016/j.bmcl.2010.05.041. Epub 2010 May 16.

PMID:
20561786
17.

Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists.

Stocking EM, Aluisio L, Atack JR, Bonaventure P, Carruthers NI, Dugovic C, Everson A, Fraser I, Jiang X, Leung P, Lord B, Ly KS, Morton KL, Nepomuceno D, Shah CR, Shelton J, Soyode-Johnson A, Letavic MA.

Bioorg Med Chem Lett. 2010 May 1;20(9):2755-60. doi: 10.1016/j.bmcl.2010.03.071. Epub 2010 Mar 20.

PMID:
20382018
18.

Diamine-based human histamine H3 receptor antagonists: (4-aminobutyn-1-yl)benzylamines.

Dvorak CA, Apodaca R, Xiao W, Jablonowski JA, Bonaventure P, Dugovic C, Shelton J, Lord B, Miller K, Dvorak LK, Lovenberg TW, Carruthers NI.

Eur J Med Chem. 2009 Oct;44(10):4098-106. doi: 10.1016/j.ejmech.2009.04.049. Epub 2009 May 13.

PMID:
19524331
19.

Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.

Dugovic C, Shelton JE, Aluisio LE, Fraser IC, Jiang X, Sutton SW, Bonaventure P, Yun S, Li X, Lord B, Dvorak CA, Carruthers NI, Lovenberg TW.

J Pharmacol Exp Ther. 2009 Jul;330(1):142-51. doi: 10.1124/jpet.109.152009. Epub 2009 Apr 10.

PMID:
19363060
20.

5-HT7 receptor deletion enhances REM sleep suppression induced by selective serotonin reuptake inhibitors, but not by direct stimulation of 5-HT1A receptor.

Shelton J, Bonaventure P, Li X, Yun S, Lovenberg T, Dugovic C.

Neuropharmacology. 2009 Feb;56(2):448-54. doi: 10.1016/j.neuropharm.2008.09.014. Epub 2008 Oct 7.

PMID:
18948124
21.

Pharmacological characterization of JNJ-28583867, a histamine H(3) receptor antagonist and serotonin reuptake inhibitor.

Barbier AJ, Aluisio L, Lord B, Qu Y, Wilson SJ, Boggs JD, Bonaventure P, Miller K, Fraser I, Dvorak L, Pudiak C, Dugovic C, Shelton J, Mazur C, Letavic MA, Carruthers NI, Lovenberg TW.

Eur J Pharmacol. 2007 Dec 8;576(1-3):43-54. Epub 2007 Aug 14.

PMID:
17765221
22.

Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents.

Bonaventure P, Kelly L, Aluisio L, Shelton J, Lord B, Galici R, Miller K, Atack J, Lovenberg TW, Dugovic C.

J Pharmacol Exp Ther. 2007 May;321(2):690-8. Epub 2007 Feb 21.

PMID:
17314195
23.

Histamine H3 receptor antagonists: from target identification to drug leads.

Bonaventure P, Letavic M, Dugovic C, Wilson S, Aluisio L, Pudiak C, Lord B, Mazur C, Kamme F, Nishino S, Carruthers N, Lovenberg T.

Biochem Pharmacol. 2007 Apr 15;73(8):1084-96. Epub 2006 Nov 3.

PMID:
17129577
24.

Diurnal sex differences in the sleep-wake cycle of mice are dependent on gonadal function.

Paul KN, Dugovic C, Turek FW, Laposky AD.

Sleep. 2006 Sep;29(9):1211-23.

PMID:
17040009
25.

Altered sleep regulation in leptin-deficient mice.

Laposky AD, Shelton J, Bass J, Dugovic C, Perrino N, Turek FW.

Am J Physiol Regul Integr Comp Physiol. 2006 Apr;290(4):R894-903. Epub 2005 Nov 17.

26.

RBD--an emerging clue to neurodegenerative disorders.

Turek FW, Dugovic C.

Sleep. 2005 Aug 1;28(8):920-1. No abstract available.

PMID:
16218074
27.

Deletion of the mammalian circadian clock gene BMAL1/Mop3 alters baseline sleep architecture and the response to sleep deprivation.

Laposky A, Easton A, Dugovic C, Walisser J, Bradfield C, Turek F.

Sleep. 2005 Apr;28(4):395-409.

PMID:
16171284
28.

Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist.

Barbier AJ, Berridge C, Dugovic C, Laposky AD, Wilson SJ, Boggs J, Aluisio L, Lord B, Mazur C, Pudiak CM, Langlois X, Xiao W, Apodaca R, Carruthers NI, Lovenberg TW.

Br J Pharmacol. 2004 Nov;143(5):649-61. Epub 2004 Oct 4. Erratum in: Br J Pharmacol. 2005 Jan;144(1):145.

29.

Behavioral characterization of mice lacking histamine H(3) receptors.

Toyota H, Dugovic C, Koehl M, Laposky AD, Weber C, Ngo K, Wu Y, Lee DH, Yanai K, Sakurai E, Watanabe T, Liu C, Chen J, Barbier AJ, Turek FW, Fung-Leung WP, Lovenberg TW.

Mol Pharmacol. 2002 Aug;62(2):389-97. Erratum in: Mol Pharmacol 2002 Sep;62(3):763.

PMID:
12130692
30.

Role of serotonin in sleep mechanisms.

Dugovic C.

Rev Neurol (Paris). 2001 Nov;157(11 Pt 2):S16-9. Review.

PMID:
11924032
31.

Current understanding of the circadian clock and the clinical implications for neurological disorders.

Turek FW, Dugovic C, Zee PC.

Arch Neurol. 2001 Nov;58(11):1781-7. Review.

PMID:
11708984
32.

Similar genetic mechanisms may underlie sleep-wake states in neonatal and adult rats.

Dugovic C, Turek FW.

Neuroreport. 2001 Oct 8;12(14):3085-9.

PMID:
11568642
33.

The selective neurokinin 1 receptor antagonist R116301 modulates photic responses of the hamster circadian system.

Challet E, Dugovic C, Turek FW, Olivier Van Reeth.

Neuropharmacology. 2001 Mar;40(3):408-15.

PMID:
11166333
34.

Sleep in the Wistar-Kyoto rat, a putative genetic animal model for depression.

Dugovic C, Solberg LC, Redei E, Van Reeth O, Turek FW.

Neuroreport. 2000 Feb 28;11(3):627-31.

PMID:
10718326
35.

High corticosterone levels in prenatally stressed rats predict persistent paradoxical sleep alterations.

Dugovic C, Maccari S, Weibel L, Turek FW, Van Reeth O.

J Neurosci. 1999 Oct 1;19(19):8656-64.

36.

Survey on the pharmacodynamics of the new antipsychotic risperidone.

Megens AA, Awouters FH, Schotte A, Meert TF, Dugovic C, Niemegeers CJ, Leysen JE.

Psychopharmacology (Berl). 1994 Feb;114(1):9-23. Review.

PMID:
7531353
37.
38.

Effects of ritanserin and chlordiazepoxide on sleep-wakefulness alterations in rats following chronic cocaine treatment.

Dugovic C, Meert TF, Ashton D, Clincke GH.

Psychopharmacology (Berl). 1992;108(3):263-70.

PMID:
1523277
39.

Sleep-wakefulness patterns in the helpless rat.

Adrien J, Dugovic C, Martin P.

Physiol Behav. 1991 Feb;49(2):257-62.

PMID:
2062895
40.

Serotonin and sleep-wakefulness.

Wauquier A, Dugovic C.

Ann N Y Acad Sci. 1990;600:447-58; discussion 458-9. Review. No abstract available.

PMID:
2252326
41.

Differential effects of the new antipsychotic risperidone on sleep and wakefulness in the rat.

Dugovic C, Wauquier A, Janssen PA.

Neuropharmacology. 1989 Dec;28(12):1431-3.

PMID:
2482460
42.

The light-dark cycle modulates the effects of ritanserin on sleep-wakefulness patterns in the rat.

Dugovic C, Leysen JE, Janssen PF, Wauquier A.

Pharmacol Biochem Behav. 1989 Nov;34(3):533-7.

PMID:
2516324
43.
44.

Functional role of 5-HT2 receptors in the regulation of sleep and wakefulness in the rat.

Dugovic C, Wauquier A, Leysen JE, Marrannes R, Janssen PA.

Psychopharmacology (Berl). 1989;97(4):436-42.

PMID:
2524856
45.

Time course of night sleep EEG in the first year of life: a description based on automatic analysis.

Bes F, Baroncini P, Dugovic C, Fagioli I, Schulz H, Franc B, Salzarulo P.

Electroencephalogr Clin Neurophysiol. 1988 Jun;69(6):501-7.

PMID:
2453326
46.

Effects of lithium on dopamine behavioural supersensitivity induced by rapid eye movement sleep deprivation.

Arriaga F, Dugovic C, Wauquier A.

Neuropsychobiology. 1988;20(1):23-7.

PMID:
2852779
47.

5-HT2 receptors could be primarily involved in the regulation of slow-wave sleep in the rat.

Dugovic C, Wauquier A.

Eur J Pharmacol. 1987 May 7;137(1):145-6. No abstract available.

PMID:
2956115
48.

Beta 1 and beta 2 adrenergic receptors: their role in the regulation of paradoxical sleep in the rat.

Lanfumey L, Dugovic C, Adrien J.

Electroencephalogr Clin Neurophysiol. 1985 Jun;60(6):558-67.

PMID:
2408856
49.

[Induction of paradoxical sleep (PS) by infusion of cerebrospinal fluid from PS-deprived rats].

Dugovic C, Adrien J.

C R Acad Sci III. 1985;301(10):531-4. French.

PMID:
3937570
50.

Presence of a paradoxical sleep (PS) factor in the cerebrospinal fluid of PS-deprived rats.

Adrien J, Dugovic C.

Eur J Pharmacol. 1984 Apr 20;100(2):223-6.

PMID:
6734718

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