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Design of amidobenzimidazole STING receptor agonists with systemic activity.

Ramanjulu JM, Pesiridis GS, Yang J, Concha N, Singhaus R, Zhang SY, Tran JL, Moore P, Lehmann S, Eberl HC, Muelbaier M, Schneck JL, Clemens J, Adam M, Mehlmann J, Romano J, Morales A, Kang J, Leister L, Graybill TL, Charnley AK, Ye G, Nevins N, Behnia K, Wolf AI, Kasparcova V, Nurse K, Wang L, Li Y, Klein M, Hopson CB, Guss J, Bantscheff M, Bergamini G, Reilly MA, Lian Y, Duffy KJ, Adams J, Foley KP, Gough PJ, Marquis RW, Smothers J, Hoos A, Bertin J.

Nature. 2018 Dec;564(7736):439-443. doi: 10.1038/s41586-018-0705-y. Epub 2018 Nov 7.


High levels of fecundity in small and isolated populations of a self-compatible Aloe pollinated by opportunistic birds and bees.

Patrick KL, Johnson SD, Duffy KJ.

Plant Biol (Stuttg). 2018 Jul;20(4):780-788. doi: 10.1111/plb.12724. Epub 2018 Apr 17.


The relative contribution of diurnal and nocturnal pollinators to plant female fitness in a specialized nursery pollination system.

Scopece G, Campese L, Duffy KJ, Cozzolino S.

AoB Plants. 2018 Jan 17;10(1):ply002. doi: 10.1093/aobpla/ply002. eCollection 2018 Feb.


Specialized mutualisms may constrain the geographical distribution of flowering plants.

Duffy KJ, Johnson SD.

Proc Biol Sci. 2017 Nov 15;284(1866). pii: 20171841. doi: 10.1098/rspb.2017.1841.


Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia.

Ariazi JL, Duffy KJ, Adams DF, Fitch DM, Luo L, Pappalardi M, Biju M, DiFilippo EH, Shaw T, Wiggall K, Erickson-Miller C.

J Pharmacol Exp Ther. 2017 Dec;363(3):336-347. doi: 10.1124/jpet.117.242503. Epub 2017 Sep 19.


Quantitative sensory testing measures individual pain responses in emergency department patients.

Duffy KJ, Flickinger KL, Kristan JT, Repine MJ, Gianforcaro A, Hasley RB, Feroz S, Rupp JM, Al-Baghli J, Pacella ML, Suffoletto BP, Callaway CW.

J Pain Res. 2017 May 24;10:1241-1253. doi: 10.2147/JPR.S132485. eCollection 2017.


Global pattern of plant utilization across different organisms: Does plant apparency or plant phylogeny matter?

Dai X, Zhang W, Xu J, Duffy KJ, Guo Q.

Ecol Evol. 2017 Mar 14;7(8):2535-2545. doi: 10.1002/ece3.2882. eCollection 2017 Apr.


Comparison of two double red cell collection settings on Fenwal Alyx apheresis instrument.

Burgstaler EA, Duffy KJ, Gandhi MJ.

J Clin Apher. 2017 Dec;32(6):392-396. doi: 10.1002/jca.21527. Epub 2017 Feb 9.


Effects of distance from models on the fitness of floral mimics.

Duffy KJ, Johnson SD.

Plant Biol (Stuttg). 2017 May;19(3):438-443. doi: 10.1111/plb.12555. Epub 2017 Feb 26.


Double red blood cell collection: comparison of three apheresis systems.

Burgstaler EA, Duffy KJ, Gandhi MJ.

Transfusion. 2016 Sep;56(9):2362-7. doi: 10.1111/trf.13705. Epub 2016 Jul 13.


Genetic diversity and floral width variation in introduced and native populations of a long-lived woody perennial.

Stout JC, Duffy KJ, Egan PA, Harbourne M, Hodkinson TR.

AoB Plants. 2014 Dec 19;7. pii: plu087. doi: 10.1093/aobpla/plu087.


Male interference with pollination efficiency in a hermaphroditic orchid.

Duffy KJ, Johnson SD.

J Evol Biol. 2014 Aug;27(8):1751-6. doi: 10.1111/jeb.12395. Epub 2014 May 6.


Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury.

Kapitsinou PP, Sano H, Michael M, Kobayashi H, Davidoff O, Bian A, Yao B, Zhang MZ, Harris RC, Duffy KJ, Erickson-Miller CL, Sutton TA, Haase VH.

J Clin Invest. 2014 Jun;124(6):2396-409. doi: 10.1172/JCI69073. Epub 2014 May 1.


A temporal dimension to the influence of pollen rewards on bee behaviour and fecundity in Aloe tenuior.

Duffy KJ, Johnson SD, Peter CI.

PLoS One. 2014 Apr 22;9(4):e94908. doi: 10.1371/journal.pone.0094908. eCollection 2014.


Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

Xie H, Hanai J, Ren JG, Kats L, Burgess K, Bhargava P, Signoretti S, Billiard J, Duffy KJ, Grant A, Wang X, Lorkiewicz PK, Schatzman S, Bousamra M 2nd, Lane AN, Higashi RM, Fan TW, Pandolfi PP, Sukhatme VP, Seth P.

Cell Metab. 2014 May 6;19(5):795-809. doi: 10.1016/j.cmet.2014.03.003. Epub 2014 Apr 10.


Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells.

Billiard J, Dennison JB, Briand J, Annan RS, Chai D, Colón M, Dodson CS, Gilbert SA, Greshock J, Jing J, Lu H, McSurdy-Freed JE, Orband-Miller LA, Mills GB, Quinn CJ, Schneck JL, Scott GF, Shaw AN, Waitt GM, Wooster RF, Duffy KJ.

Cancer Metab. 2013 Sep 6;1(1):19. doi: 10.1186/2049-3002-1-19.


Emasculation increases seed set in the bird-pollinated hermaphrodite Kniphofia linearifolia (Xanthorrhoeaceae): evidence for sexual conflict?

Duffy KJ, Patrick KL, Johnson SD.

Am J Bot. 2013 Mar;100(3):622-7. doi: 10.3732/ajb.1200531. Epub 2013 Feb 27.


Copy number variation analysis in 98 individuals with PHACE syndrome.

Siegel DH, Shieh JTC, Kwon EK, Baselga E, Blei F, Cordisco M, Dobyns WB, Duffy KJ, Garzon MC, Gibbs DL, Grimmer JF, Hayflick SJ, Krol AL, Kwok PY, Lorier R, Matter A, McWeeney S, Metry D, Mitchell S, Pope E, Santoro JL, Stevenson DA, Bayrak-Toydemir P, Wilmot B, Worthey EA, Frieden IJ, Drolet BA, Broeckel U.

J Invest Dermatol. 2013 Mar;133(3):677-684. doi: 10.1038/jid.2012.367. Epub 2012 Oct 25.


Stable isotope series from elephant ivory reveal lifetime histories of a true dietary generalist.

Codron J, Codron D, Sponheimer M, Kirkman K, Duffy KJ, Raubenheimer EJ, Mélice JL, Grant R, Clauss M, Lee-Thorp JA.

Proc Biol Sci. 2012 Jun 22;279(1737):2433-41. doi: 10.1098/rspb.2011.2472. Epub 2012 Feb 15.


Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury.

Kapitsinou PP, Jaffe J, Michael M, Swan CE, Duffy KJ, Erickson-Miller CL, Haase VH.

Am J Physiol Renal Physiol. 2012 May 1;302(9):F1172-9. doi: 10.1152/ajprenal.00667.2011. Epub 2012 Jan 18.


Endoscopic management of gastrointestinal bleeding from multifocal lymphangioendotheliomatosis with thrombocytopenia: limited efficacy and complications.

Noel RJ, Duffy KJ, Kelly ME, Tondravi N, North PE, Drolet BA.

J Pediatr Gastroenterol Nutr. 2012 Jun;54(6):822-4. doi: 10.1097/MPG.0b013e31822aa2db. No abstract available.


Effects of pollen reward removal on fecundity in a self-incompatible hermaphrodite plant.

Duffy KJ, Johnson SD.

Plant Biol (Stuttg). 2011 May;13(3):556-60. doi: 10.1111/j.1438-8677.2011.00445.x. Epub 2011 Feb 11.


Identifying sighting clusters of endangered taxa with historical records.

Duffy KJ.

Conserv Biol. 2011 Apr;25(2):392-9. doi: 10.1111/j.1523-1739.2010.01612.x. Epub 2010 Dec 3.


Landscape-scale feeding patterns of African elephant inferred from carbon isotope analysis of feces.

Codron J, Codron D, Lee-Thorp JA, Sponheimer M, Kirkman K, Duffy KJ, Sealy J.

Oecologia. 2011 Jan;165(1):89-99. doi: 10.1007/s00442-010-1835-6. Epub 2010 Nov 12.


Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat.

Bao W, Qin P, Needle S, Erickson-Miller CL, Duffy KJ, Ariazi JL, Zhao S, Olzinski AR, Behm DJ, Pipes GC, Jucker BM, Hu E, Lepore JJ, Willette RN.

J Cardiovasc Pharmacol. 2010 Aug;56(2):147-55. doi: 10.1097/FJC.0b013e3181e2bfef.


Association of hearing loss with PHACE syndrome.

Duffy KJ, Runge-Samuelson C, Bayer ML, Friedland D, Sulman C, Chun R, Kerschner JE, Metry D, Adams D, Drolet BA.

Arch Dermatol. 2010 Dec;146(12):1391-6. doi: 10.1001/archdermatol.2010.201. Epub 2010 Aug 16.


Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295.

Qian X, McDonald A, Zhou HJ, Adams ND, Parrish CA, Duffy KJ, Fitch DM, Tedesco R, Ashcraft LW, Yao B, Jiang H, Huang JK, Marin MV, Aroyan CE, Wang J, Ahmed S, Burgess JL, Chaudhari AM, Donatelli CA, Darcy MG, Ridgers LH, Newlander KA, Schmidt SJ, Chai D, Colón M, Zimmerman MN, Lad L, Sakowicz R, Schauer S, Belmont L, Baliga R, Pierce DW, Finer JT, Wang Z, Morgan BP, Morgans DJ Jr, Auger KR, Sung CM, Carson JD, Luo L, Hugger ED, Copeland RA, Sutton D, Elliott JD, Jackson JR, Wood KW, Dhanak D, Bergnes G, Knight SD.

ACS Med Chem Lett. 2010 Jan 19;1(1):30-4. doi: 10.1021/ml900018m. eCollection 2010 Apr 8.


A case of ankyloblepharon, ectodermal dysplasia, and cleft lip/palate syndrome with ectrodactyly: are the p63 syndromes distinct after all?

Chiu YE, Drolet BA, Duffy KJ, Holland KE.

Pediatr Dermatol. 2011 Jan-Feb;28(1):15-9. doi: 10.1111/j.1525-1470.2009.00976.x.


Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase.

Shaw AN, Tedesco R, Bambal R, Chai D, Concha NO, Darcy MG, Dhanak D, Duffy KJ, Fitch DM, Gates A, Johnston VK, Keenan RM, Lin-Goerke J, Liu N, Sarisky RT, Wiggall KJ, Zimmerman MN.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4350-3. doi: 10.1016/j.bmcl.2009.05.091. Epub 2009 May 28.


Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors.

Tedesco R, Chai D, Darcy MG, Dhanak D, Fitch DM, Gates A, Johnston VK, Keenan RM, Lin-Goerke J, Sarisky RT, Shaw AN, Valko KL, Wiggall KJ, Zimmerman MN, Duffy KJ.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4354-8. doi: 10.1016/j.bmcl.2009.05.080. Epub 2009 May 27.


Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist.

Erickson-Miller CL, Delorme E, Tian SS, Hopson CB, Landis AJ, Valoret EI, Sellers TS, Rosen J, Miller SG, Luengo JI, Duffy KJ, Jenkins JM.

Stem Cells. 2009 Feb;27(2):424-30. doi: 10.1634/stemcells.2008-0366.


A novel procedure for genotyping of single nucleotide polymorphisms in trisomy with genomic DNA and the invader assay.

Duffy KJ, Littrell J, Locke A, Sherman SL, Olivier M.

Nucleic Acids Res. 2008 Dec;36(22):e145. doi: 10.1093/nar/gkn736. Epub 2008 Oct 21.


Ecology and genetic diversity of the dense-flowered orchid, Neotinea maculata, at the centre and edge of its range.

Duffy KJ, Scopece G, Cozzolino S, Fay MF, Smith RJ, Stout JC.

Ann Bot. 2009 Aug;104(3):507-16. doi: 10.1093/aob/mcn200. Epub 2008 Oct 21.


Inferring national and regional declines of rare orchid species with probabilistic models.

Duffy KJ, Kingston NE, Sayers BA, Roberts DL, Stout JC.

Conserv Biol. 2009 Feb;23(1):184-95. doi: 10.1111/j.1523-1739.2008.01064.x. Epub 2008 Sep 15.


Novel ATP-competitive kinesin spindle protein inhibitors.

Parrish CA, Adams ND, Auger KR, Burgess JL, Carson JD, Chaudhari AM, Copeland RA, Diamond MA, Donatelli CA, Duffy KJ, Faucette LF, Finer JT, Huffman WF, Hugger ED, Jackson JR, Knight SD, Luo L, Moore ML, Newlander KA, Ridgers LH, Sakowicz R, Shaw AN, Sung CM, Sutton D, Wood KW, Zhang SY, Zimmerman MN, Dhanak D.

J Med Chem. 2007 Oct 4;50(20):4939-52. Epub 2007 Aug 29.


Prognosis following acute myocardial infarction: insights from cardiovascular magnetic resonance.

Duffy KJ, Ferrari VA.

Curr Cardiol Rep. 2007 Mar;9(1):57-62. Review.


The role of foraging behaviour in the sexual segregation of the African elephant.

Shannon G, Page BR, Duffy KJ, Slotow R.

Oecologia. 2006 Nov;150(2):344-54. Epub 2006 Aug 23.


3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

Tedesco R, Shaw AN, Bambal R, Chai D, Concha NO, Darcy MG, Dhanak D, Fitch DM, Gates A, Gerhardt WG, Halegoua DL, Han C, Hofmann GA, Johnston VK, Kaura AC, Liu N, Keenan RM, Lin-Goerke J, Sarisky RT, Wiggall KJ, Zimmerman MN, Duffy KJ.

J Med Chem. 2006 Feb 9;49(3):971-83.


Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist.

Erickson-Miller CL, DeLorme E, Tian SS, Hopson CB, Stark K, Giampa L, Valoret EI, Duffy KJ, Luengo JL, Rosen J, Miller SG, Dillon SB, Lamb P.

Exp Hematol. 2005 Jan;33(1):85-93.


Resistance profile of a hepatitis C virus RNA-dependent RNA polymerase benzothiadiazine inhibitor.

Nguyen TT, Gates AT, Gutshall LL, Johnston VK, Gu B, Duffy KJ, Sarisky RT.

Antimicrob Agents Chemother. 2003 Nov;47(11):3525-30.


Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives.

Gu B, Johnston VK, Gutshall LL, Nguyen TT, Gontarek RR, Darcy MG, Tedesco R, Dhanak D, Duffy KJ, Kao CC, Sarisky RT.

J Biol Chem. 2003 May 9;278(19):16602-7. Epub 2003 Jan 27.


Selective binding and oligomerization of the murine granulocyte colony-stimulating factor receptor by a low molecular weight, nonpeptidyl ligand.

Doyle ML, Tian SS, Miller SG, Kessler L, Baker AE, Brigham-Burke MR, Dillon SB, Duffy KJ, Keenan RM, Lehr R, Rosen J, Schneeweis LA, Trill J, Young PR, Luengo JI, Lamb P.

J Biol Chem. 2003 Mar 14;278(11):9426-34. Epub 2003 Jan 10.


Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

Dhanak D, Duffy KJ, Johnston VK, Lin-Goerke J, Darcy M, Shaw AN, Gu B, Silverman C, Gates AT, Nonnemacher MR, Earnshaw DL, Casper DJ, Kaura A, Baker A, Greenwood C, Gutshall LL, Maley D, DelVecchio A, Macarron R, Hofmann GA, Alnoah Z, Cheng HY, Chan G, Khandekar S, Keenan RM, Sarisky RT.

J Biol Chem. 2002 Oct 11;277(41):38322-7. Epub 2002 Aug 6.


Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d]imidazole thrombopoietin mimics.

Duffy KJ, Price AT, Delorme E, Dillon SB, Duquenne C, Erickson-Miller C, Giampa L, Huang Y, Keenan RM, Lamb P, Liu N, Miller SG, Rosen J, Shaw AN, Smith H, Wiggall KJ, Zhang L, Luengo JI.

J Med Chem. 2002 Aug 15;45(17):3576-8.


Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 1. Discovery and optimization of salicylaldehyde thiosemicarbazone thrombopoietin mimics.

Duffy KJ, Shaw AN, Delorme E, Dillon SB, Erickson-Miller C, Giampa L, Huang Y, Keenan RM, Lamb P, Liu N, Miller SG, Price AT, Rosen J, Smith H, Wiggall KJ, Zhang L, Luengo JI.

J Med Chem. 2002 Aug 15;45(17):3573-5.


Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis.

Duffy KJ, Darcy MG, Delorme E, Dillon SB, Eppley DF, Erickson-Miller C, Giampa L, Hopson CB, Huang Y, Keenan RM, Lamb P, Leong L, Liu N, Miller SG, Price AT, Rosen J, Shah R, Shaw TN, Smith H, Stark KC, Tian SS, Tyree C, Wiggall KJ, Zhang L, Luengo JI.

J Med Chem. 2001 Oct 25;44(22):3730-45.


Natural DNA mixtures generated in fraternal twins in utero.

Rubocki RJ, McCue BJ, Duffy KJ, Shepard KL, Shepherd SJ, Wisecarver JL.

J Forensic Sci. 2001 Jan;46(1):120-5.


Loss of heterozygosity detected in a short tandem repeat (STR) locus commonly used for human DNA identification.

Rubocki RJ, Duffy KJ, Shepard KL, McCue BJ, Shepherd SJ, Wisecarver JL.

J Forensic Sci. 2000 Sep;45(5):1087-9.


Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K.

Duffy KJ, Ridgers LH, DesJarlais RL, Tomaszek TA, Bossard MJ, Thompson SK, Keenan RM, Veber DF.

Bioorg Med Chem Lett. 1999 Jul 19;9(14):1907-10.


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