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Items: 48

1.

Role of connexins and pannexins in cardiovascular physiology.

Meens MJ, Kwak BR, Duffy HS.

Cell Mol Life Sci. 2015 Aug;72(15):2779-92. doi: 10.1007/s00018-015-1959-2. Epub 2015 Jun 20. Review.

PMID:
26091747
2.

CR1-mediated ATP release by human red blood cells promotes CR1 clustering and modulates the immune transfer process.

Melhorn MI, Brodsky AS, Estanislau J, Khoory JA, Illigens B, Hamachi I, Kurishita Y, Fraser AD, Nicholson-Weller A, Dolmatova E, Duffy HS, Ghiran IC.

J Biol Chem. 2013 Oct 25;288(43):31139-53. doi: 10.1074/jbc.M113.486035. Epub 2013 Sep 10.

3.

Mitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death.

Sovari AA, Rutledge CA, Jeong EM, Dolmatova E, Arasu D, Liu H, Vahdani N, Gu L, Zandieh S, Xiao L, Bonini MG, Duffy HS, Dudley SC Jr.

Circ Arrhythm Electrophysiol. 2013 Jun;6(3):623-31. doi: 10.1161/CIRCEP.112.976787. Epub 2013 Apr 4.

4.

Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation.

Dolmatova E, Spagnol G, Boassa D, Baum JR, Keith K, Ambrosi C, Kontaridis MI, Sorgen PL, Sosinsky GE, Duffy HS.

Am J Physiol Heart Circ Physiol. 2012 Nov 15;303(10):H1208-18. doi: 10.1152/ajpheart.00251.2012. Epub 2012 Sep 14.

5.

Omega 3 fatty acid inhibition of inflammatory cytokine-mediated Connexin43 regulation in the heart.

Baum JR, Dolmatova E, Tan A, Duffy HS.

Front Physiol. 2012 Jul 12;3:272. doi: 10.3389/fphys.2012.00272. eCollection 2012.

6.

Endothelial cells require related transcription enhancer factor-1 for cell-cell connections through the induction of gap junction proteins.

An X, Jin Y, Philbrick MJ, Wu J, Messmer-Blust A, Song X, Cully BL, He P, Xu M, Duffy HS, Li J.

Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1951-9. doi: 10.1161/ATVBAHA.112.250159. Epub 2012 May 31.

PMID:
22652601
7.

SkM1 and Cx32 improve conduction in canine myocardial infarcts yet only SkM1 is antiarrhythmic.

Boink GJ, Lau DH, Shlapakova IN, Sosunov EA, Anyukhovsky EP, Driessen HE, Dun W, Chen M, Danilo P Jr, Rosen TS, Őzgen N, Duffy HS, Kryukova Y, Boyden PA, Robinson RB, Brink PR, Cohen IS, Rosen MR.

Cardiovasc Res. 2012 Jun 1;94(3):450-9. doi: 10.1093/cvr/cvs107. Epub 2012 Feb 27.

8.

Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death.

Van Norstrand DW, Asimaki A, Rubinos C, Dolmatova E, Srinivas M, Tester DJ, Saffitz JE, Duffy HS, Ackerman MJ.

Circulation. 2012 Jan 24;125(3):474-81. doi: 10.1161/CIRCULATIONAHA.111.057224. Epub 2011 Dec 16.

9.

The molecular mechanisms of gap junction remodeling.

Duffy HS.

Heart Rhythm. 2012 Aug;9(8):1331-4. doi: 10.1016/j.hrthm.2011.11.048. Epub 2011 Nov 28. Review. No abstract available.

10.

Myofibroblasts cause heterogeneous Cx43 reduction and are unlikely to be coupled to myocytes in the healing canine infarct.

Baum JR, Long B, Cabo C, Duffy HS.

Am J Physiol Heart Circ Physiol. 2012 Feb 1;302(3):H790-800. doi: 10.1152/ajpheart.00498.2011. Epub 2011 Nov 18.

11.

Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death.

Sovari AA, Iravanian S, Dolmatova E, Jiao Z, Liu H, Zandieh S, Kumar V, Wang K, Bernstein KE, Bonini MG, Duffy HS, Dudley SC.

J Am Coll Cardiol. 2011 Nov 22;58(22):2332-9. doi: 10.1016/j.jacc.2011.07.048.

12.

Inhibition of renin-angiotensin system (RAS) reduces ventricular tachycardia risk by altering connexin43.

Iravanian S, Sovari AA, Lardin HA, Liu H, Xiao HD, Dolmatova E, Jiao Z, Harris BS, Witham EA, Gourdie RG, Duffy HS, Bernstein KE, Dudley SC Jr.

J Mol Med (Berl). 2011 Jul;89(7):677-87. doi: 10.1007/s00109-011-0761-3. Epub 2011 May 7.

13.

Pannexin channels are not gap junction hemichannels.

Sosinsky GE, Boassa D, Dermietzel R, Duffy HS, Laird DW, MacVicar B, Naus CC, Penuela S, Scemes E, Spray DC, Thompson RJ, Zhao HB, Dahl G.

Channels (Austin). 2011 May-Jun;5(3):193-7. Epub 2011 May 1. Review.

14.

Adult mouse epicardium modulates myocardial injury by secreting paracrine factors.

Zhou B, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, Gise Av, Zhou P, Hu YW, Wang G, Zhang B, Wang L, Hall JL, Moses MA, McGowan FX, Pu WT.

J Clin Invest. 2011 May;121(5):1894-904. doi: 10.1172/JCI45529. Epub 2011 Apr 18.

15.

Characterization of gap junction remodeling in epicardial border zone of healing canine infarcts and electrophysiological effects of partial reversal by rotigaptide.

Macia E, Dolmatova E, Cabo C, Sosinsky AZ, Dun W, Coromilas J, Ciaccio EJ, Boyden PA, Wit AL, Duffy HS.

Circ Arrhythm Electrophysiol. 2011 Jun;4(3):344-51. doi: 10.1161/CIRCEP.110.959312. Epub 2011 Apr 14.

16.

Increased Cell-Cell Coupling Increases Infarct Size and Does not Decrease Incidence of Ventricular Tachycardia in Mice.

Prestia KA, Sosunov EA, Anyukhovsky EP, Dolmatova E, Kelly CW, Brink PR, Robinson RB, Rosen MR, Duffy HS.

Front Physiol. 2011 Jan 31;2:1. doi: 10.3389/fphys.2011.00001. eCollection 2011.

17.

Fibroblasts, myofibroblasts, and fibrosis: fact, fiction, and the future.

Duffy HS.

J Cardiovasc Pharmacol. 2011 Apr;57(4):373-5. doi: 10.1097/FJC.0b013e3182155a38.

PMID:
21346592
18.

Fibroblasts and myofibroblasts: what are we talking about?

Baum J, Duffy HS.

J Cardiovasc Pharmacol. 2011 Apr;57(4):376-9. doi: 10.1097/FJC.0b013e3182116e39. Review.

19.

Inflammatory responses in the atria: should they stay or should they go?

Duffy HS.

Heart Rhythm. 2011 Feb;8(2):286-7. doi: 10.1016/j.hrthm.2010.11.006. Epub 2010 Nov 5. No abstract available.

20.

The Renin-Angiotensin system mediates the effects of stretch on conduction velocity, connexin43 expression, and redistribution in intact ventricle.

Hussain W, Patel PM, Chowdhury RA, Cabo C, Ciaccio EJ, Lab MJ, Duffy HS, Wit AL, Peters NS.

J Cardiovasc Electrophysiol. 2010 Nov;21(11):1276-83. doi: 10.1111/j.1540-8167.2010.01802.x.

21.

The ever-shrinking world of cardiac ion channel remodeling: the role of microRNAs in heart disease.

Duffy HS.

Heart Rhythm. 2009 Dec;6(12):1810-1. doi: 10.1016/j.hrthm.2009.09.021. Epub 2009 Sep 18. No abstract available.

22.

TVP1022 protects neonatal rat ventricular myocytes against doxorubicin-induced functional derangements.

Berdichevski A, Meiry G, Milman F, Reiter I, Sedan O, Eliyahu S, Duffy HS, Youdim MB, Binah O.

J Pharmacol Exp Ther. 2010 Feb;332(2):413-20. doi: 10.1124/jpet.109.161158. Epub 2009 Nov 13.

23.

Structural and molecular mechanisms of gap junction remodeling in epicardial border zone myocytes following myocardial infarction.

Kieken F, Mutsaers N, Dolmatova E, Virgil K, Wit AL, Kellezi A, Hirst-Jensen BJ, Duffy HS, Sorgen PL.

Circ Res. 2009 May 8;104(9):1103-12. doi: 10.1161/CIRCRESAHA.108.190454. Epub 2009 Apr 2.

24.

Epicardial border zone overexpression of skeletal muscle sodium channel SkM1 normalizes activation, preserves conduction, and suppresses ventricular arrhythmia: an in silico, in vivo, in vitro study.

Lau DH, Clausen C, Sosunov EA, Shlapakova IN, Anyukhovsky EP, Danilo P Jr, Rosen TS, Kelly C, Duffy HS, Szabolcs MJ, Chen M, Robinson RB, Lu J, Kumari S, Cohen IS, Rosen MR.

Circulation. 2009 Jan 6;119(1):19-27. doi: 10.1161/CIRCULATIONAHA.108.809301. Epub 2008 Dec 22.

25.

Cardiac connections--the antiarrhythmic solution?

Duffy HS.

N Engl J Med. 2008 Mar 27;358(13):1397-8. doi: 10.1056/NEJMcibr0708922. No abstract available.

PMID:
18367745
26.

Is there a role for remodeled connexins in AF? No simple answers.

Duffy HS, Wit AL.

J Mol Cell Cardiol. 2008 Jan;44(1):4-13. Epub 2007 Sep 4. Review.

27.

Drug development for treatment of cardiac arrhythmias: targeting the gap junctions.

Wit AL, Duffy HS.

Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H16-8. Epub 2007 Sep 21. No abstract available.

28.

Cleft diving: looking in the extracellular matrix for answers to atrial arrhythmias.

Duffy HS.

Heart Rhythm. 2007 Jul;4(7):950-1. Epub 2007 Apr 6. No abstract available.

PMID:
17599683
29.

Early electrical remodeling in rabbit pulmonary vein results from trafficking of intracellular SK2 channels to membrane sites.

Ozgen N, Dun W, Sosunov EA, Anyukhovsky EP, Hirose M, Duffy HS, Boyden PA, Rosen MR.

Cardiovasc Res. 2007 Sep 1;75(4):758-69. Epub 2007 May 10.

30.

Gap junctional complexes: from partners to functions.

Hervé JC, Bourmeyster N, Sarrouilhe D, Duffy HS.

Prog Biophys Mol Biol. 2007 May-Jun;94(1-2):29-65. Epub 2007 Mar 19. Review.

PMID:
17507078
31.

The gap junction protein connexin32 interacts with the Src homology 3/hook domain of discs large homolog 1.

Duffy HS, Iacobas I, Hotchkiss K, Hirst-Jensen BJ, Bosco A, Dandachi N, Dermietzel R, Sorgen PL, Spray DC.

J Biol Chem. 2007 Mar 30;282(13):9789-96. Epub 2007 Feb 5.

32.

How do myocytes tell right from left?

Duffy HS.

Circ Res. 2006 Sep 15;99(6):563-4. Review. No abstract available.

PMID:
16973910
33.

Heterogeneous gap junction remodeling in reentrant circuits in the epicardial border zone of the healing canine infarct.

Cabo C, Yao J, Boyden PA, Chen S, Hussain W, Duffy HS, Ciaccio EJ, Peters NS, Wit AL.

Cardiovasc Res. 2006 Nov 1;72(2):241-9. Epub 2006 Jul 12.

PMID:
16914125
34.

Cardiac connexins: genes to nexus.

Duffy HS, Fort AG, Spray DC.

Adv Cardiol. 2006;42:1-17. doi: 10.1159/000092550. Review.

PMID:
16646581
35.

Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1.

Sorgen PL, Duffy HS, Sahoo P, Coombs W, Delmar M, Spray DC.

J Biol Chem. 2004 Dec 24;279(52):54695-701. Epub 2004 Oct 18.

36.

Modifications in the biophysical properties of connexin43 channels by a peptide of the cytoplasmic loop region.

Seki A, Duffy HS, Coombs W, Spray DC, Taffet SM, Delmar M.

Circ Res. 2004 Aug 20;95(4):e22-8. Epub 2004 Jul 29.

PMID:
15284189
37.

pH-dependent dimerization of the carboxyl terminal domain of Cx43.

Sorgen PL, Duffy HS, Spray DC, Delmar M.

Biophys J. 2004 Jul;87(1):574-81.

38.

Structural bases for the chemical regulation of Connexin43 channels.

Delmar M, Coombs W, Sorgen P, Duffy HS, Taffet SM.

Cardiovasc Res. 2004 May 1;62(2):268-75. Review.

PMID:
15094347
39.

Regulation of connexin43 protein complexes by intracellular acidification.

Duffy HS, Ashton AW, O'Donnell P, Coombs W, Taffet SM, Delmar M, Spray DC.

Circ Res. 2004 Feb 6;94(2):215-22. Epub 2003 Dec 29.

PMID:
14699011
40.

Kinetics of protein-protein interactions of connexins: use of enzyme linked sorbent assays.

Duffy HS, O'Donnell P, Coombs W, Taffet SM, Delmar M, Spray DC.

Cell Commun Adhes. 2003 Jul-Dec;10(4-6):207-10.

PMID:
14681017
41.

Formation of the gap junction nexus: binding partners for connexins.

Duffy HS, Delmar M, Spray DC.

J Physiol Paris. 2002 Apr-Jun;96(3-4):243-9. Review.

PMID:
12445902
42.

Sequence-specific resonance assignment of the carboxyl terminal domain of Connexin43.

Sorgen PL, Duffy HS, Cahill SM, Coombs W, Spray DC, Delmar M, Girvin ME.

J Biomol NMR. 2002 Jul;23(3):245-6. No abstract available.

PMID:
12238598
43.

pH-dependent intramolecular binding and structure involving Cx43 cytoplasmic domains.

Duffy HS, Sorgen PL, Girvin ME, O'Donnell P, Coombs W, Taffet SM, Delmar M, Spray DC.

J Biol Chem. 2002 Sep 27;277(39):36706-14. Epub 2002 Jul 31.

44.

Functional demonstration of connexin-protein binding using surface plasmon resonance.

Duffy HS, Delmar M, Coombs W, Tafftet SM, Hertzberg EL, Spray DC.

Cell Commun Adhes. 2001;8(4-6):225-9.

PMID:
12064593
45.
46.

Gap junctions in glia. Types, roles, and plasticity.

Spray DC, Duffy HS, Scemes E.

Adv Exp Med Biol. 1999;468:339-59. Review. No abstract available.

PMID:
10635041
47.
48.

Mixed synapses discovered and mapped throughout mammalian spinal cord.

Rash JE, Dillman RK, Bilhartz BL, Duffy HS, Whalen LR, Yasumura T.

Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4235-9.

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