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Items: 1 to 50 of 83

1.

Sustained Release of Vascular Endothelial Growth Factor from Poly(ε-caprolactone-PEG-ε-caprolactone)-b-Poly(l-lactide) Multiblock Copolymer Microspheres.

Scheiner KC, Maas-Bakker RF, Nguyen TT, Duarte AM, Hendriks G, Sequeira L, Duffy GP, Steendam R, Hennink WE, Kok RJ.

ACS Omega. 2019 Jul 1;4(7):11481-11492. doi: 10.1021/acsomega.9b01272. eCollection 2019 Jul 31.

2.

A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction.

Dolan EB, Hofmann B, de Vaal MH, Bellavia G, Straino S, Kovarova L, Pravda M, Velebny V, Daro D, Braun N, Monahan DS, Levey RE, O'Neill H, Hinderer S, Greensmith R, Monaghan MG, Schenke-Layland K, Dockery P, Murphy BP, Kelly HM, Wildhirt S, Duffy GP.

Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109751. doi: 10.1016/j.msec.2019.109751. Epub 2019 May 15.

PMID:
31349422
3.

Insulin-like growth factor-1 (IGF-1) poly (lactic-co-glycolic acid) (PLGA) microparticles - development, characterisation, and in vitro assessment of bioactivity for cardiac applications.

Hameed A, Gallagher LB, Dolan E, O'Sullivan J, Ruiz-Hernandez E, Duffy GP, Kelly H.

J Microencapsul. 2019 May;36(3):267-277. doi: 10.1080/02652048.2019.1622605. Epub 2019 Jun 14.

PMID:
31195912
4.

Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir.

Whyte W, Roche ET, Varela CE, Mendez K, Islam S, O'Neill H, Weafer F, Shirazi RN, Weaver JC, Vasilyev NV, McHugh PE, Murphy B, Duffy GP, Walsh CJ, Mooney DJ.

Nat Biomed Eng. 2018 Jun;2(6):416-428. doi: 10.1038/s41551-018-0247-5. Epub 2018 Jun 11.

PMID:
31011199
5.

RGD-decorated cholesterol stabilized polyplexes for targeted siRNA delivery to glioblastoma cells.

Lou B, Connor K, Sweeney K, Miller IS, O'Farrell A, Ruiz-Hernandez E, Murray DM, Duffy GP, Wolfe A, Mastrobattista E, Byrne AT, Hennink WE.

Drug Deliv Transl Res. 2019 Jun;9(3):679-693. doi: 10.1007/s13346-019-00637-y.

PMID:
30972664
6.

An injectable alginate/extra cellular matrix (ECM) hydrogel towards acellular treatment of heart failure.

Curley CJ, Dolan EB, Otten M, Hinderer S, Duffy GP, Murphy BP.

Drug Deliv Transl Res. 2019 Feb;9(1):1-13. doi: 10.1007/s13346-018-00601-2.

PMID:
30511249
7.

Advanced Material Catheter (AMCath), a minimally invasive endocardial catheter for the delivery of fast-gelling covalently cross-linked hyaluronic acid hydrogels.

Dolan EB, Kovarova L, O'Neill H, Pravda M, Sulakova R, Scigalkova I, Velebny V, Daro D, Braun N, Cooney GM, Bellavia G, Straino S, Cavanagh BL, Flanagan A, Kelly HM, Duffy GP, Murphy BP.

J Biomater Appl. 2018 Nov;33(5):681-692. doi: 10.1177/0885328218805878. Epub 2018 Oct 25.

PMID:
30354912
8.

Hydrogels in adipose tissue engineering-Potential application in post-mastectomy breast regeneration.

O'Halloran NA, Dolan EB, Kerin MJ, Lowery AJ, Duffy GP.

J Tissue Eng Regen Med. 2018 Dec;12(12):2234-2247. doi: 10.1002/term.2753. Epub 2018 Nov 8. Review.

PMID:
30334613
9.

Towards Alternative Approaches for Coupling of a Soft Robotic Sleeve to the Heart.

Horvath MA, Varela CE, Dolan EB, Whyte W, Monahan DS, Payne CJ, Wamala IA, Vasilyev NV, Pigula FA, Mooney DJ, Walsh CJ, Duffy GP, Roche ET.

Ann Biomed Eng. 2018 Oct;46(10):1534-1547. doi: 10.1007/s10439-018-2046-2. Epub 2018 May 15.

PMID:
29766347
10.

Harnessing an Inhibitory Role of miR-16 in Osteogenesis by Human Mesenchymal Stem Cells for Advanced Scaffold-Based Bone Tissue Engineering.

Mencía Castaño I, Curtin CM, Duffy GP, O'Brien FJ.

Tissue Eng Part A. 2019 Jan;25(1-2):24-33. doi: 10.1089/ten.TEA.2017.0460. Epub 2018 Apr 10.

PMID:
29490603
11.

Direct UV-Triggered Thiol-ene Cross-Linking of Electrospun Polyester Fibers from Unsaturated Poly(macrolactone)s and Their Drug Loading by Solvent Swelling.

de Oliveira FCS, Olvera D, Sawkins MJ, Cryan SA, Kimmins SD, da Silva TE, Kelly DJ, Duffy GP, Kearney C, Heise A.

Biomacromolecules. 2017 Dec 11;18(12):4292-4298. doi: 10.1021/acs.biomac.7b01335. Epub 2017 Nov 14.

PMID:
29134814
12.

Olfactory Derived Stem Cells Delivered in a Biphasic Conduit Promote Peripheral Nerve Repair In Vivo.

Roche P, Alekseeva T, Widaa A, Ryan A, Matsiko A, Walsh M, Duffy GP, O'Brien FJ.

Stem Cells Transl Med. 2017 Oct;6(10):1894-1904. doi: 10.1002/sctm.16-0420.

13.

Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation.

Ryan AJ, O'Neill HS, Duffy GP, O'Brien FJ.

Curr Opin Pharmacol. 2017 Oct;36:66-71. doi: 10.1016/j.coph.2017.07.013. Epub 2017 Aug 31. Review.

PMID:
28865291
14.

A collagen cardiac patch incorporating alginate microparticles permits the controlled release of hepatocyte growth factor and insulin-like growth factor-1 to enhance cardiac stem cell migration and proliferation.

O'Neill HS, O'Sullivan J, Porteous N, Ruiz-Hernandez E, Kelly HM, O'Brien FJ, Duffy GP.

J Tissue Eng Regen Med. 2018 Jan;12(1):e384-e394. doi: 10.1002/term.2392. Epub 2017 Jun 19.

PMID:
27943590
15.

Tissue Engineered Solutions for Intracardiac Septal Defects: A Large Step Forward in an Unmet Clinical Need.

Hameed A, Duffy GP, Hasan B, Fatimi SH.

Ann Surg. 2017 Feb;265(2):e11-e12. doi: 10.1097/SLA.0000000000002060. No abstract available.

PMID:
27811507
16.

Nanomedicines for advanced cancer treatments: Transitioning towards responsive systems.

van Elk M, Murphy BP, Eufrásio-da-Silva T, O'Reilly DP, Vermonden T, Hennink WE, Duffy GP, Ruiz-Hernández E.

Int J Pharm. 2016 Dec 30;515(1-2):132-164. doi: 10.1016/j.ijpharm.2016.10.013. Epub 2016 Oct 7. Review.

PMID:
27725268
17.

A stimuli responsive liposome loaded hydrogel provides flexible on-demand release of therapeutic agents.

O'Neill HS, Herron CC, Hastings CL, Deckers R, Lopez Noriega A, Kelly HM, Hennink WE, McDonnell CO, O'Brien FJ, Ruiz-Hernández E, Duffy GP.

Acta Biomater. 2017 Jan 15;48:110-119. doi: 10.1016/j.actbio.2016.10.001. Epub 2016 Oct 20.

PMID:
27773752
18.

An in vitro investigation to assess procedure parameters for injecting therapeutic hydrogels into the myocardium.

Curley CJ, Dolan EB, Cavanagh B, O'Sullivan J, Duffy GP, Murphy BP.

J Biomed Mater Res B Appl Biomater. 2017 Nov;105(8):2618-2629. doi: 10.1002/jbm.b.33802. Epub 2016 Oct 20.

PMID:
27764526
19.

Next generation bone tissue engineering: non-viral miR-133a inhibition using collagen-nanohydroxyapatite scaffolds rapidly enhances osteogenesis.

Mencía Castaño I, Curtin CM, Duffy GP, O'Brien FJ.

Sci Rep. 2016 Jun 14;6:27941. doi: 10.1038/srep27941.

20.

Spatiotemporal delivery of small molecule therapeutics using a thermosensitive liposome loaded hydrogel.

O'Neill H, Herron C, Hastings C, Lopez-Noriega A, Kelly HM, O'Brien FJ, Ruiz-Hernandez E, Duffy GP.

J Control Release. 2015 Sep 10;213:e28-9. doi: 10.1016/j.jconrel.2015.05.044. Epub 2015 Aug 19. No abstract available.

PMID:
27005143
21.

Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives.

O'Neill HS, Gallagher LB, O'Sullivan J, Whyte W, Curley C, Dolan E, Hameed A, O'Dwyer J, Payne C, O'Reilly D, Ruiz-Hernandez E, Roche ET, O'Brien FJ, Cryan SA, Kelly H, Murphy B, Duffy GP.

Adv Mater. 2016 Jul;28(27):5648-61. doi: 10.1002/adma.201505349. Epub 2016 Feb 3. Review.

PMID:
26840955
22.

Delivering Nucleic-Acid Based Nanomedicines on Biomaterial Scaffolds for Orthopedic Tissue Repair: Challenges, Progress and Future Perspectives.

Raftery RM, Walsh DP, Castaño IM, Heise A, Duffy GP, Cryan SA, O'Brien FJ.

Adv Mater. 2016 Jul;28(27):5447-69. doi: 10.1002/adma.201505088. Epub 2016 Feb 3. Review.

PMID:
26840618
23.

Form and function in regenerative medicine: introduction.

O'Brien FJ, Duffy GP.

J Anat. 2015 Dec;227(6):705-6. doi: 10.1111/joa.12401. No abstract available.

24.

The effect of bisphosphonate treatment on the biochemical and cellular events during bone remodelling in response to microinjury stimulation.

Mulcahy LE, Curtin CM, McCoy RJ, O'Brien FJ, Taylor D, Lee TC, Duffy GP.

Eur Cell Mater. 2015 Nov 27;30:271-81.

25.

Effect of collagen-glycosaminoglycan scaffold pore size on matrix mineralization and cellular behavior in different cell types.

Murphy CM, Duffy GP, Schindeler A, O'brien FJ.

J Biomed Mater Res A. 2016 Jan;104(1):291-304. doi: 10.1002/jbm.a.35567. Epub 2015 Oct 1.

PMID:
26386362
26.

The pre-vascularisation of a collagen-chondroitin sulphate scaffold using human amniotic fluid-derived stem cells to enhance and stabilise endothelial cell-mediated vessel formation.

Lloyd-Griffith C, McFadden TM, Duffy GP, Unger RE, Kirkpatrick CJ, O'Brien FJ.

Acta Biomater. 2015 Oct;26:263-73. doi: 10.1016/j.actbio.2015.08.030. Epub 2015 Aug 20.

PMID:
26300337
27.

Investigating the effect of hypoxic culture on the endothelial differentiation of human amniotic fluid-derived stem cells.

Lloyd-Griffith C, Duffy GP, O'Brien FJ.

J Anat. 2015 Dec;227(6):767-80. doi: 10.1111/joa.12283. Epub 2015 Mar 31.

28.

A novel collagen-nanohydroxyapatite microRNA-activated scaffold for tissue engineering applications capable of efficient delivery of both miR-mimics and antagomiRs to human mesenchymal stem cells.

Mencía Castaño I, Curtin CM, Shaw G, Murphy JM, Duffy GP, O'Brien FJ.

J Control Release. 2015 Feb 28;200:42-51. doi: 10.1016/j.jconrel.2014.12.034. Epub 2014 Dec 28.

PMID:
25550154
29.

Drug and cell delivery for cardiac regeneration.

Hastings CL, Roche ET, Ruiz-Hernandez E, Schenke-Layland K, Walsh CJ, Duffy GP.

Adv Drug Deliv Rev. 2015 Apr;84:85-106. doi: 10.1016/j.addr.2014.08.006. Epub 2014 Aug 27. Review.

30.

Combinatorial gene therapy accelerates bone regeneration: non-viral dual delivery of VEGF and BMP2 in a collagen-nanohydroxyapatite scaffold.

Curtin CM, Tierney EG, McSorley K, Cryan SA, Duffy GP, O'Brien FJ.

Adv Healthc Mater. 2015 Jan 28;4(2):223-7. doi: 10.1002/adhm.201400397. Epub 2014 Aug 13.

PMID:
25125073
31.

An experimental investigation of the effect of mechanical and biochemical stimuli on cell migration within a decellularized vascular construct.

Sheridan WS, Ryan AJ, Duffy GP, O'Brien FJ, Murphy BP.

Ann Biomed Eng. 2014 Oct;42(10):2029-38. doi: 10.1007/s10439-014-1063-z. Epub 2014 Jul 2.

PMID:
24986334
32.

Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart.

Roche ET, Hastings CL, Lewin SA, Shvartsman D, Brudno Y, Vasilyev NV, O'Brien FJ, Walsh CJ, Duffy GP, Mooney DJ.

Biomaterials. 2014 Aug;35(25):6850-6858. doi: 10.1016/j.biomaterials.2014.04.114. Epub 2014 May 23.

33.

The application of a thermoresponsive chitosan/β-GP gel to enhance cell repopulation of decellularized vascular scaffolds.

Sheridan WS, Grant OB, Duffy GP, Murphy BP.

J Biomed Mater Res B Appl Biomater. 2014 Nov;102(8):1700-10. doi: 10.1002/jbm.b.33138. Epub 2014 Mar 25.

PMID:
24664907
34.

Hyperthermia-induced drug delivery from thermosensitive liposomes encapsulated in an injectable hydrogel for local chemotherapy.

López-Noriega A, Hastings CL, Ozbakir B, O'Donnell KE, O'Brien FJ, Storm G, Hennink WE, Duffy GP, Ruiz-Hernández E.

Adv Healthc Mater. 2014 Jun;3(6):854-9. doi: 10.1002/adhm.201300649. Epub 2014 Jan 16.

PMID:
24436226
35.

Enhanced delivery of microRNA mimics to cardiomyocytes using ultrasound responsive microbubbles reverses hypertrophy in an in-vitro model.

Gill SL, O'Neill H, McCoy RJ, Logeswaran S, O'Brien F, Stanton A, Kelly H, Duffy GP.

Technol Health Care. 2014;22(1):37-51. doi: 10.3233/THC-130772.

PMID:
24398813
37.

The delayed addition of human mesenchymal stem cells to pre-formed endothelial cell networks results in functional vascularization of a collagen-glycosaminoglycan scaffold in vivo.

McFadden TM, Duffy GP, Allen AB, Stevens HY, Schwarzmaier SM, Plesnila N, Murphy JM, Barry FP, Guldberg RE, O'Brien FJ.

Acta Biomater. 2013 Dec;9(12):9303-16. doi: 10.1016/j.actbio.2013.08.014. Epub 2013 Aug 17.

PMID:
23958783
38.

Orchestrating osteogenic differentiation of mesenchymal stem cells--identification of placental growth factor as a mechanosensitive gene with a pro-osteogenic role.

McCoy RJ, Widaa A, Watters KM, Wuerstle M, Stallings RL, Duffy GP, O'Brien FJ.

Stem Cells. 2013 Nov;31(11):2420-31. doi: 10.1002/stem.1482.

39.

Optimum parameters for freeze-drying decellularized arterial scaffolds.

Sheridan WS, Duffy GP, Murphy BP.

Tissue Eng Part C Methods. 2013 Dec;19(12):981-90. doi: 10.1089/ten.TEC.2012.0741. Epub 2013 Jun 25.

40.

Non-viral gene-activated matrices: next generation constructs for bone repair.

Tierney EG, Duffy GP, Cryan SA, Curtin CM, O'Brien FJ.

Organogenesis. 2013 Jan-Mar;9(1):22-8. doi: 10.4161/org.24329. Epub 2013 Jan 1.

41.

A new technique for articulated cement spacers in infected total knee arthroplasty.

Smith CS, Zitzke RC, Duffy GP.

Am J Orthop (Belle Mead NJ). 2012 Dec;41(12):E163-5.

PMID:
23431530
42.

High levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells and promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2 gene-activated matrix.

Tierney EG, McSorley K, Hastings CL, Cryan SA, O'Brien T, Murphy MJ, Barry FP, O'Brien FJ, Duffy GP.

J Control Release. 2013 Feb 10;165(3):173-82. doi: 10.1016/j.jconrel.2012.11.013. Epub 2012 Nov 29.

PMID:
23201622
43.

Supramolecular hydrogels with reverse thermal gelation properties from (oligo)tyrosine containing block copolymers.

Huang J, Hastings CL, Duffy GP, Kelly HM, Raeburn J, Adams DJ, Heise A.

Biomacromolecules. 2013 Jan 14;14(1):200-6. doi: 10.1021/bm301629f. Epub 2012 Dec 7.

PMID:
23190093
44.

Development of a thermoresponsive chitosan gel combined with human mesenchymal stem cells and desferrioxamine as a multimodal pro-angiogenic therapeutic for the treatment of critical limb ischaemia.

Hastings CL, Kelly HM, Murphy MJ, Barry FP, O'Brien FJ, Duffy GP.

J Control Release. 2012 Jul 10;161(1):73-80. doi: 10.1016/j.jconrel.2012.04.033. Epub 2012 Apr 27.

PMID:
22562065
45.

Mechanical characterization of a customized decellularized scaffold for vascular tissue engineering.

Sheridan WS, Duffy GP, Murphy BP.

J Mech Behav Biomed Mater. 2012 Apr;8:58-70. doi: 10.1016/j.jmbbm.2011.12.003. Epub 2011 Dec 27.

PMID:
22402154
46.
47.

Encapsulation of cardiac stem cells in superoxide dismutase-loaded alginate prevents doxorubicin-mediated toxicity.

Liu TC, Ismail S, Brennan O, Hastings C, Duffy GP.

J Tissue Eng Regen Med. 2013 Apr;7(4):302-11. doi: 10.1002/term.523. Epub 2011 Dec 30.

PMID:
22213742
48.

Innovative collagen nano-hydroxyapatite scaffolds offer a highly efficient non-viral gene delivery platform for stem cell-mediated bone formation.

Curtin CM, Cunniffe GM, Lyons FG, Bessho K, Dickson GR, Duffy GP, O'Brien FJ.

Adv Mater. 2012 Feb 7;24(6):749-54. doi: 10.1002/adma.201103828. Epub 2012 Jan 2.

PMID:
22213347
49.

The development of non-viral gene-activated matrices for bone regeneration using polyethyleneimine (PEI) and collagen-based scaffolds.

Tierney EG, Duffy GP, Hibbitts AJ, Cryan SA, O'Brien FJ.

J Control Release. 2012 Mar 10;158(2):304-11. doi: 10.1016/j.jconrel.2011.11.026. Epub 2011 Nov 27.

PMID:
22138069
50.

Temporal and spatial changes in cartilage-matrix-specific gene expression in mesenchymal stem cells in response to dynamic compression.

Haugh MG, Meyer EG, Thorpe SD, Vinardell T, Duffy GP, Kelly DJ.

Tissue Eng Part A. 2011 Dec;17(23-24):3085-93. doi: 10.1089/ten.tea.2011.0198. Epub 2011 Aug 26.

PMID:
21870950

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