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Items: 43


Integrative analysis of prognostic biomarkers derived from multiomics panels helps discrimination of chronic kidney disease trajectories in people with type 2 diabetes.

Kammer M, Heinzel A, Willency JA, Duffin KL, Mayer G, Simons K, Gerl MJ, Klose C, Heinze G, Reindl-Schwaighofer R, Hu K, Perco P, Eder S, Rosivall L, Mark PB, Ju W, Kretzler M, McCarthy MI, Heerspink HL, Wiecek A, Gomez MF, Oberbauer R; BEAt-DKD Consortium.

Kidney Int. 2019 Dec;96(6):1381-1388. doi: 10.1016/j.kint.2019.07.025. Epub 2019 Aug 30.


Associations of osteopontin and NT-proBNP with circulating miRNA levels in acute coronary syndrome.

Kwee LC, Neely ML, Grass E, Gregory SG, Roe MT, Ohman EM, Fox KAA, White HD, Armstrong PW, Bowsman LM, Haas JV, Duffin KL, Chan MY, Shah SH.

Physiol Genomics. 2019 Oct 1;51(10):506-515. doi: 10.1152/physiolgenomics.00033.2019. Epub 2019 Sep 18.


A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.

Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ, Satake E, Simeone CA, Shah H, Qiu C, Looker HC, Fiorina P, Ware CF, Sun JK, Doria A, Kretzler M, Susztak K, Duffin KL, Nelson RG, Krolewski AS.

Nat Med. 2019 May;25(5):805-813. doi: 10.1038/s41591-019-0415-5. Epub 2019 Apr 22.


GDF15 and Growth Control.

Emmerson PJ, Duffin KL, Chintharlapalli S, Wu X.

Front Physiol. 2018 Nov 27;9:1712. doi: 10.3389/fphys.2018.01712. eCollection 2018. Review.


Validation of Plasma Biomarker Candidates for the Prediction of eGFR Decline in Patients With Type 2 Diabetes.

Heinzel A, Kammer M, Mayer G, Reindl-Schwaighofer R, Hu K, Perco P, Eder S, Rosivall L, Mark PB, Ju W, Kretzler M, Gilmour P, Wilson JM, Duffin KL, Abdalla M, McCarthy MI, Heinze G, Heerspink HL, Wiecek A, Gomez MF, Oberbauer R; BEAt-DKD Consortium.

Diabetes Care. 2018 Sep;41(9):1947-1954. doi: 10.2337/dc18-0532. Epub 2018 Jul 6.


JAK1/JAK2 inhibition by baricitinib in diabetic kidney disease: results from a Phase 2 randomized controlled clinical trial.

Tuttle KR, Brosius FC 3rd, Adler SG, Kretzler M, Mehta RL, Tumlin JA, Tanaka Y, Haneda M, Liu J, Silk ME, Cardillo TE, Duffin KL, Haas JV, Macias WL, Nunes FP, Janes JM.

Nephrol Dial Transplant. 2018 Nov 1;33(11):1950-1959. doi: 10.1093/ndt/gfx377.


Markers of early progressive renal decline in type 2 diabetes suggest different implications for etiological studies and prognostic tests development.

Nowak N, Skupien J, Smiles AM, Yamanouchi M, Niewczas MA, Galecki AT, Duffin KL, Breyer MD, Pullen N, Bonventre JV, Krolewski AS.

Kidney Int. 2018 May;93(5):1198-1206. doi: 10.1016/j.kint.2017.11.024. Epub 2018 Feb 2.


Improved clinical trial enrollment criterion to identify patients with diabetes at risk of end-stage renal disease.

Yamanouchi M, Skupien J, Niewczas MA, Smiles AM, Doria A, Stanton RC, Galecki AT, Duffin KL, Pullen N, Breyer MD, Bonventre JV, Warram JH, Krolewski AS.

Kidney Int. 2017 Jul;92(1):258-266. doi: 10.1016/j.kint.2017.02.010. Epub 2017 Apr 7.


A prospective study of multiple protein biomarkers to predict progression in diabetic chronic kidney disease.

Agarwal R, Duffin KL, Laska DA, Voelker JR, Breyer MD, Mitchell PG.

Nephrol Dial Transplant. 2014 Dec;29(12):2293-302. doi: 10.1093/ndt/gfu255. Epub 2014 Aug 1.


An enzyme-generated fragment of tau measured in serum shows an inverse correlation to cognitive function.

Henriksen K, Wang Y, Sørensen MG, Barascuk N, Suhy J, Pedersen JT, Duffin KL, Dean RA, Pajak M, Christiansen C, Zheng Q, Karsdal MA.

PLoS One. 2013 May 22;8(5):e64990. doi: 10.1371/journal.pone.0064990. Print 2013.


Circulating levels of citrullinated and MMP-degraded vimentin (VICM) in liver fibrosis related pathology.

Vassiliadis E, Oliveira CP, Alvares-da-Silva MR, Zhang C, Carrilho FJ, Stefano JT, Rabelo F, Pereira L, Kappel CR, Henriksen K, Veidal SS, Vainer B, Duffin KL, Christiansen C, Leeming DJ, Karsdal M.

Am J Transl Res. 2012;4(4):403-14. Epub 2012 Oct 10.


Clinical evaluation of a matrix metalloproteinase-12 cleaved fragment of titin as a cardiovascular serological biomarker.

Vassiliadis E, Rasmussen LM, Byrjalsen I, Larsen DV, Chaturvedi R, Hosbond S, Saabye L, Diederichsen AC, Genovese F, Duffin KL, Zheng Q, Chen X, Leeming DJ, Christiansen C, Karsdal MA.

J Transl Med. 2012 Jul 6;10:140. doi: 10.1186/1479-5876-10-140.


Development of a novel clinical biomarker assay to detect and quantify aggrecanase-generated aggrecan fragments in human synovial fluid, serum and urine.

Swearingen CA, Carpenter JW, Siegel R, Brittain IJ, Dotzlaf J, Durham TB, Toth JL, Laska DA, Marimuthu J, Liu C, Brown DP, Carter QL, Wiley MR, Duffin KL, Mitchell PG, Thirunavukkarasu K.

Osteoarthritis Cartilage. 2010 Sep;18(9):1150-8. doi: 10.1016/j.joca.2010.06.011. Epub 2010 Jul 13.


A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs.

Swearingen CA, Chambers MG, Lin C, Marimuthu J, Rito CJ, Carter QL, Dotzlaf J, Liu C, Chandrasekhar S, Duffin KL, Mitchell PG, Durham TB, Wiley MR, Thirunavukkarasu K.

Osteoarthritis Cartilage. 2010 Sep;18(9):1159-66. doi: 10.1016/j.joca.2010.02.019. Epub 2010 Jul 13.


Proteomic analysis of demyelinated and remyelinating brain tissue following dietary cuprizone administration.

Werner SR, Saha JK, Broderick CL, Zhen EY, Higgs RE, Duffin KL, Smith RC.

J Mol Neurosci. 2010 Oct;42(2):210-25. doi: 10.1007/s12031-010-9354-9. Epub 2010 Apr 17.


Characterization of metalloprotease cleavage products of human articular cartilage.

Zhen EY, Brittain IJ, Laska DA, Mitchell PG, Sumer EU, Karsdal MA, Duffin KL.

Arthritis Rheum. 2008 Aug;58(8):2420-31. doi: 10.1002/art.23654.


Neural MMP-28 expression precedes myelination during development and peripheral nerve repair.

Werner SR, Mescher AL, Neff AW, King MW, Chaturvedi S, Duffin KL, Harty MW, Smith RC.

Dev Dyn. 2007 Oct;236(10):2852-64.


The role of mass spectrometry in biomarker discovery and measurement.

Ackermann BL, Hale JE, Duffin KL.

Curr Drug Metab. 2006 Jun;7(5):525-39. Review.


Temporal generation of multiple antifungal proteins in primed seeds.

Wang X, Thoma RS, Carroll JA, Duffin KL.

Biochem Biophys Res Commun. 2002 Mar 22;292(1):236-42.


Lipid remodeling in mouse liver and plasma resulting from delta6 fatty acid desaturase inhibition.

Duffin KL, Obukowicz MG, Salsgiver WJ, Welsch DJ, Shieh C, Raz A, Needleman P.

Lipids. 2001 Nov;36(11):1203-8.


Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.

Obukowicz MG, Welsch DJ, Salsgiver WJ, Martin-Berger CL, Chinn KS, Duffin KL, Raz A, Needleman P.

J Pharmacol Exp Ther. 1998 Oct;287(1):157-66.


Generation of hemoglobin peptides in the acidic digestive vacuole of Plasmodium falciparum implicates peptide transport in amino acid production.

Kolakovich KA, Gluzman IY, Duffin KL, Goldberg DE.

Mol Biochem Parasitol. 1997 Aug;87(2):123-35.


Altered arachidonic acid metabolism in urate crystal induced inflammation.

Margalit A, Duffin KL, Shaffer AF, Gregory SA, Isakson PC.

Inflammation. 1997 Apr;21(2):205-22.


Naturally processed peptides from rheumatoid arthritis associated and non-associated HLA-DR alleles.

Kirschmann DA, Duffin KL, Smith CE, Welply JK, Howard SC, Schwartz BD, Woulfe SL.

J Immunol. 1995 Dec 15;155(12):5655-62.


Determination of the disulfide bond pairings in human tissue factor pathway inhibitor purified from Escherichia coli.

Violand BN, Schlittler MR, Duffin KL, Smith CE.

J Protein Chem. 1995 Jul;14(5):341-7.


Proteolytic cleavage of insulin-like growth factor binding protein 4 (IGFBP-4). Localization of cleavage site to non-homologous region of native IGFBP-4.

Chernausek SD, Smith CE, Duffin KL, Busby WH, Wright G, Clemmons DR.

J Biol Chem. 1995 May 12;270(19):11377-82.


Enzymatic synthesis of a 6'-sulphated sialyl-Lewisx which is an inhibitor of L-selectin binding to peripheral addressin.

Scudder PR, Shailubhai K, Duffin KL, Streeter PR, Jacob GS.

Glycobiology. 1994 Dec;4(6):929-32.


Activity of two-chain recombinant human cytomegalovirus protease.

Holwerda BC, Wittwer AJ, Duffin KL, Smith C, Toth MV, Carr LS, Wiegand RC, Bryant ML.

J Biol Chem. 1994 Oct 14;269(41):25911-5.


Heterogeneity of plasma tissue factor pathway inhibitor.

Broze GJ Jr, Lange GW, Duffin KL, MacPhail L.

Blood Coagul Fibrinolysis. 1994 Aug;5(4):551-9.


Isolation of Escherichia coli synthesized recombinant eukaryotic proteins that contain epsilon-N-acetyllysine.

Violand BN, Schlittler MR, Lawson CQ, Kane JF, Siegel NR, Smith CE, Kolodziej EW, Duffin KL.

Protein Sci. 1994 Jul;3(7):1089-97.


Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway.

Gluzman IY, Francis SE, Oksman A, Smith CE, Duffin KL, Goldberg DE.

J Clin Invest. 1994 Apr;93(4):1602-8.


Characterization of human uroguanylin: a member of the guanylin peptide family.

Kita T, Smith CE, Fok KF, Duffin KL, Moore WM, Karabatsos PJ, Kachur JF, Hamra FK, Pidhorodeckyj NV, Forte LR, et al.

Am J Physiol. 1994 Feb;266(2 Pt 2):F342-8.


High-level expression and purification of human leukotriene A4 hydrolase from insect cells infected with a baculovirus vector.

Gierse JK, Luckow VA, Askonas LJ, Duffin KL, Aykent S, Bild GS, Rodi CP, Sullivan PM, Bourner MJ, Kimack NM, et al.

Protein Expr Purif. 1993 Oct;4(5):358-66.


Identification and oligosaccharide structure analysis of rhodopsin glycoforms containing galactose and sialic acid.

Duffin KL, Lange GW, Welply JK, Florman R, O'Brien PJ, Dell A, Reason AJ, Morris HR, Fliesler SJ.

Glycobiology. 1993 Aug;3(4):365-80.


Identification of components in waste streams by electrospray and tandem mass spectrometry.

Hughes BM, McKenzie DE, Duffin KL.

J Am Soc Mass Spectrom. 1993 Jul;4(7):604-10. doi: 10.1016/1044-0305(93)85022-P.


Novel in-frame two codon translational hop during synthesis of bovine placental lactogen in a recombinant strain of Escherichia coli.

Kane JF, Violand BN, Curran DF, Staten NR, Duffin KL, Bogosian G.

Nucleic Acids Res. 1992 Dec 25;20(24):6707-12.


Isolation and characterization of porcine somatotropin containing a succinimide residue in place of aspartate129.

Violand BN, Schlittler MR, Kolodziej EW, Toren PC, Cabonce MA, Siegel NR, Duffin KL, Zobel JF, Smith CE, Tou JS.

Protein Sci. 1992 Dec;1(12):1634-41.


Characterization of N-linked oligosaccharides by electrospray and tandem mass spectrometry.

Duffin KL, Welply JK, Huang E, Henion JD.

Anal Chem. 1992 Jul 1;64(13):1440-8.


Guanylin: an endogenous activator of intestinal guanylate cyclase.

Currie MG, Fok KF, Kato J, Moore RJ, Hamra FK, Duffin KL, Smith CE.

Proc Natl Acad Sci U S A. 1992 Feb 1;89(3):947-51.


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