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Evaluating the impact of national education in pediatric palliative care: the Quality of Care Collaborative Australia.

Slater PJ, Herbert AR, Baggio SJ, Donovan LA, McLarty AM, Duffield JA, Pedersen LC, Duc JK, Delaney AM, Johnson SA, Heywood MG, Burr CA; Quality of Care Collaborative Australia.

Adv Med Educ Pract. 2018 Dec 14;9:927-941. doi: 10.2147/AMEP.S180526. eCollection 2018.


Non-equilibrium x-ray spectroscopy using direct quantum dynamics.

Northey T, Duffield J, Penfold TJ.

J Chem Phys. 2018 Sep 28;149(12):124107. doi: 10.1063/1.5047487.


Deletion of the Mitochondrial Complex-IV Cofactor Heme A:Farnesyltransferase Causes Focal Segmental Glomerulosclerosis and Interferon Response.

Baek JH, Gomez IG, Wada Y, Roach A, Mahad D, Duffield JS.

Am J Pathol. 2018 Dec;188(12):2745-2762. doi: 10.1016/j.ajpath.2018.08.018. Epub 2018 Sep 28.


Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney.

Puranik AS, Leaf IA, Jensen MA, Hedayat AF, Saad A, Kim KW, Saadalla AM, Woollard JR, Kashyap S, Textor SC, Grande JP, Lerman A, Simari RD, Randolph GJ, Duffield JS, Lerman LO.

Sci Rep. 2018 Sep 17;8(1):13948. doi: 10.1038/s41598-018-31887-4.


Intraperitoneal Local Anesthetic Instillation and Postoperative Infusion Improves Functional Recovery Following Colectomy: A Randomized Controlled Trial.

Duffield JA, Thomas ML, Moore JW, Hunter RA, Wood C, Gentili S, Lewis M.

Dis Colon Rectum. 2018 Oct;61(10):1205-1216. doi: 10.1097/DCR.0000000000001177.


Interleukin-1β Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis.

Lemos DR, McMurdo M, Karaca G, Wilflingseder J, Leaf IA, Gupta N, Miyoshi T, Susa K, Johnson BG, Soliman K, Wang G, Morizane R, Bonventre JV, Duffield JS.

J Am Soc Nephrol. 2018 Jun;29(6):1690-1705. doi: 10.1681/ASN.2017121283. Epub 2018 May 8.


Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies.

Lemos DR, Duffield JS.

Sci Transl Med. 2018 Jan 31;10(426). pii: eaan5174. doi: 10.1126/scitranslmed.aan5174. Review.


Life cycle energy and greenhouse gas emission effects of biodiesel in the United States with induced land use change impacts.

Chen R, Qin Z, Han J, Wang M, Taheripour F, Tyner W, O'Connor D, Duffield J.

Bioresour Technol. 2018 Mar;251:249-258. doi: 10.1016/j.biortech.2017.12.031. Epub 2017 Dec 15.


Uromodulin p.Cys147Trp mutation drives kidney disease by activating ER stress and apoptosis.

Johnson BG, Dang LT, Marsh G, Roach AM, Levine ZG, Monti A, Reyon D, Feigenbaum L, Duffield JS.

J Clin Invest. 2017 Nov 1;127(11):3954-3969. doi: 10.1172/JCI93817. Epub 2017 Oct 9.


TIMP3 is Regulated by Pericytes upon Shear Stress Detection Leading to a Modified Endothelial Cell Response.

Schrimpf C, Koppen T, Duffield JS, Böer U, David S, Ziegler W, Haverich A, Teebken OE, Wilhelmi M.

Eur J Vasc Endovasc Surg. 2017 Oct;54(4):524-533. doi: 10.1016/j.ejvs.2017.07.002. Epub 2017 Aug 12.


Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N-cadherin balance in mural cell-endothelial cell-regulated barrier function.

Alimperti S, Mirabella T, Bajaj V, Polacheck W, Pirone DM, Duffield J, Eyckmans J, Assoian RK, Chen CS.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8758-8763. doi: 10.1073/pnas.1618333114. Epub 2017 Aug 1.


Hyperactive FOXO1 results in lack of tip stalk identity and deficient microvascular regeneration during kidney injury.

Dang LTH, Aburatani T, Marsh GA, Johnson BG, Alimperti S, Yoon CJ, Huang A, Szak S, Nakagawa N, Gomez I, Ren S, Read SK, Sparages C, Aplin AC, Nicosia RF, Chen C, Ligresti G, Duffield JS.

Biomaterials. 2017 Oct;141:314-329. doi: 10.1016/j.biomaterials.2017.07.010. Epub 2017 Jul 7.


Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing.

Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V, Kisseleva T, Brenner D, Duffield J, Burkly LC.

Mol Ther Nucleic Acids. 2017 Jun 16;7:314-323. doi: 10.1016/j.omtn.2017.04.014. Epub 2017 Apr 20.


What can target kidney fibrosis?

Leaf IA, Duffield JS.

Nephrol Dial Transplant. 2017 Jan 1;32(suppl_1):i89-i97. doi: 10.1093/ndt/gfw388. Review.


Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial.

Snowdon VK, Lachlan NJ, Hoy AM, Hadoke PW, Semple SI, Patel D, Mungall W, Kendall TJ, Thomson A, Lennen RJ, Jansen MA, Moran CM, Pellicoro A, Ramachandran P, Shaw I, Aucott RL, Severin T, Saini R, Pak J, Yates D, Dongre N, Duffield JS, Webb DJ, Iredale JP, Hayes PC, Fallowfield JA.

PLoS Med. 2017 Feb 28;14(2):e1002248. doi: 10.1371/journal.pmed.1002248. eCollection 2017 Feb.


Lung pericyte-like cells are functional interstitial immune sentinel cells.

Hung CF, Mittelsteadt KL, Brauer R, McKinney BL, Hallstrand TS, Parks WC, Chen P, Schnapp LM, Liles WC, Duffield JS, Altemeier WA.

Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1;312(4):L556-L567. doi: 10.1152/ajplung.00349.2016. Epub 2017 Feb 10.


Connective Tissue Growth Factor Domain 4 Amplifies Fibrotic Kidney Disease through Activation of LDL Receptor-Related Protein 6.

Johnson BG, Ren S, Karaca G, Gomez IG, Fligny C, Smith B, Ergun A, Locke G, Gao B, Hayes S, MacDonnell S, Duffield JS.

J Am Soc Nephrol. 2017 Jun;28(6):1769-1782. doi: 10.1681/ASN.2016080826. Epub 2017 Jan 27.


Inhibition of αvβ5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury.

McCurley A, Alimperti S, Campos-Bilderback SB, Sandoval RM, Calvino JE, Reynolds TL, Quigley C, Mugford JW, Polacheck WJ, Gomez IG, Dovey J, Marsh G, Huang A, Qian F, Weinreb PH, Dolinski BM, Moore S, Duffield JS, Chen CS, Molitoris BA, Violette SM, Crackower MA.

J Am Soc Nephrol. 2017 Jun;28(6):1741-1752. doi: 10.1681/ASN.2016020200. Epub 2017 Jan 6.


Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis.

Xavier S, Sahu RK, Landes SG, Yu J, Taylor RP, Ayyadevara S, Megyesi J, Stallcup WB, Duffield JS, Reis ES, Lambris JD, Portilla D.

Am J Physiol Renal Physiol. 2017 Mar 1;312(3):F516-F532. doi: 10.1152/ajprenal.00604.2016. Epub 2017 Jan 4.


Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease.

Nakagawa N, Barron L, Gomez IG, Johnson BG, Roach AM, Kameoka S, Jack RM, Lupher ML Jr, Gharib SA, Duffield JS.

JCI Insight. 2016 Dec 8;1(20):e87446. doi: 10.1172/jci.insight.87446.


Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.

Sakai N, Chun J, Duffield JS, Lagares D, Wada T, Luster AD, Tager AM.

Kidney Int. 2017 Mar;91(3):628-641. doi: 10.1016/j.kint.2016.09.030. Epub 2016 Dec 4.


Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury.

Leaf IA, Nakagawa S, Johnson BG, Cha JJ, Mittelsteadt K, Guckian KM, Gomez IG, Altemeier WA, Duffield JS.

J Clin Invest. 2017 Jan 3;127(1):321-334. doi: 10.1172/JCI87532. Epub 2016 Nov 21.


PDGFRα signalling promotes fibrogenic responses in collagen-producing cells in Duchenne muscular dystrophy.

Ieronimakis N, Hays A, Prasad A, Janebodin K, Duffield JS, Reyes M.

J Pathol. 2016 Dec;240(4):410-424. doi: 10.1002/path.4801. Epub 2016 Oct 20.


Lung Pericytes and Resident Fibroblasts: Busy Multitaskers.

Barron L, Gharib SA, Duffield JS.

Am J Pathol. 2016 Oct;186(10):2519-31. doi: 10.1016/j.ajpath.2016.07.004. Epub 2016 Aug 21. Review.


Beyond EMT: Epithelial STAT3 as a Central Regulator of Fibrogenesis.

Duffield JS.

J Am Soc Nephrol. 2016 Dec;27(12):3502-3504. Epub 2016 Jul 1. No abstract available.


Maintenance of vascular integrity by pericytes is essential for normal kidney function.

Lemos DR, Marsh G, Huang A, Campanholle G, Aburatani T, Dang L, Gomez I, Fisher K, Ligresti G, Peti-Peterdi J, Duffield JS.

Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1230-F1242. doi: 10.1152/ajprenal.00030.2016. Epub 2016 Jun 22.


Incidence of Achalasia in South Australia Based on Esophageal Manometry Findings.

Duffield JA, Hamer PW, Heddle R, Holloway RH, Myers JC, Thompson SK.

Clin Gastroenterol Hepatol. 2017 Mar;15(3):360-365. doi: 10.1016/j.cgh.2016.05.036. Epub 2016 Jun 4.


TWEAK-Fn14 Signaling Activates Myofibroblasts to Drive Progression of Fibrotic Kidney Disease.

Gomez IG, Roach AM, Nakagawa N, Amatucci A, Johnson BG, Dunn K, Kelly MC, Karaca G, Zheng TS, Szak S, Peppiatt-Wildman CM, Burkly LC, Duffield JS.

J Am Soc Nephrol. 2016 Dec;27(12):3639-3652. Epub 2016 Mar 29.


MicroRNAs as novel therapeutic targets to treat kidney injury and fibrosis.

Gomez IG, Nakagawa N, Duffield JS.

Am J Physiol Renal Physiol. 2016 May 1;310(10):F931-44. doi: 10.1152/ajprenal.00523.2015. Epub 2016 Feb 24. Review.


Nonhematopoietic Peroxisome Proliferator-Activated Receptor-α Protects Against Cardiac Injury and Enhances Survival in Experimental Polymicrobial Sepsis.

Standage SW, Waworuntu RL, Delaney MA, Maskal SM, Bennion BG, Duffield JS, Parks WC, Liles WC, McGuire JK.

Crit Care Med. 2016 Aug;44(8):e594-603. doi: 10.1097/CCM.0000000000001585.


Cells of renin lineage express hypoxia inducible factor 2α following experimental ureteral obstruction.

Stefanska A, Eng D, Kaverina N, Pippin JW, Gross KW, Duffield JS, Shankland SJ.

BMC Nephrol. 2016 Jan 8;17:5. doi: 10.1186/s12882-015-0216-0.


A Novel Three-Dimensional Human Peritubular Microvascular System.

Ligresti G, Nagao RJ, Xue J, Choi YJ, Xu J, Ren S, Aburatani T, Anderson SK, MacDonald JW, Bammler TK, Schwartz SM, Muczynski KA, Duffield JS, Himmelfarb J, Zheng Y.

J Am Soc Nephrol. 2016 Aug;27(8):2370-81. doi: 10.1681/ASN.2015070747. Epub 2015 Dec 11.


The FOXD1 lineage of kidney perivascular cells and myofibroblasts: functions and responses to injury.

Gomez IG, Duffield JS.

Kidney Int Suppl (2011). 2014 Nov;4(1):26-33. Review.


Interstitial pericytes decrease in aged mouse kidneys.

Stefanska A, Eng D, Kaverina N, Duffield JS, Pippin JW, Rabinovitch P, Shankland SJ.

Aging (Albany NY). 2015 Jun;7(6):370-82.


Cells of renin lineage are adult pluripotent progenitors in experimental glomerular disease.

Pippin JW, Kaverina NV, Eng DG, Krofft RD, Glenn ST, Duffield JS, Gross KW, Shankland SJ.

Am J Physiol Renal Physiol. 2015 Aug 15;309(4):F341-58. doi: 10.1152/ajprenal.00438.2014. Epub 2015 Jun 10.


Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion.

Pamir N, Liu NC, Irwin A, Becker L, Peng Y, Ronsein GE, Bornfeldt KE, Duffield JS, Heinecke JW.

J Biol Chem. 2015 Jun 5;290(23):14656-67. doi: 10.1074/jbc.M115.645820. Epub 2015 Apr 30.


CYR61 (CCN1) overexpression induces lung injury in mice.

Grazioli S, Gil S, An D, Kajikawa O, Farnand AW, Hanson JF, Birkland T, Chen P, Duffield J, Schnapp LM, Altemeier WA, Matute-Bello G.

Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8):L759-65. doi: 10.1152/ajplung.00190.2014. Epub 2015 Feb 20.


Dicer1 activity in the stromal compartment regulates nephron differentiation and vascular patterning during mammalian kidney organogenesis.

Nakagawa N, Xin C, Roach AM, Naiman N, Shankland SJ, Ligresti G, Ren S, Szak S, Gomez IG, Duffield JS.

Kidney Int. 2015 Jun;87(6):1125-40. doi: 10.1038/ki.2014.406. Epub 2015 Feb 4.


Low birth weight activates the renin-angiotensin system, but limits cardiac angiogenesis in early postnatal life.

Wang KC, Brooks DA, Summers-Pearce B, Bobrovskaya L, Tosh DN, Duffield JA, Botting KJ, Zhang S, Caroline McMillen I, Morrison JL.

Physiol Rep. 2015 Feb 3;3(2). pii: e12270. doi: 10.14814/phy2.12270. Print 2015 Feb 1.


IGF-2R-Gαq signaling and cardiac hypertrophy in the low-birth-weight lamb.

Wang KC, Tosh DN, Zhang S, McMillen IC, Duffield JA, Brooks DA, Morrison JL.

Am J Physiol Regul Integr Comp Physiol. 2015 Apr 1;308(7):R627-35. doi: 10.1152/ajpregu.00346.2014. Epub 2015 Jan 28.


Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways.

Gomez IG, MacKenna DA, Johnson BG, Kaimal V, Roach AM, Ren S, Nakagawa N, Xin C, Newitt R, Pandya S, Xia TH, Liu X, Borza DB, Grafals M, Shankland SJ, Himmelfarb J, Portilla D, Liu S, Chau BN, Duffield JS.

J Clin Invest. 2015 Jan;125(1):141-56. doi: 10.1172/JCI75852. Epub 2014 Nov 21.


Deficient Autophagy Results in Mitochondrial Dysfunction and FSGS.

Kawakami T, Gomez IG, Ren S, Hudkins K, Roach A, Alpers CE, Shankland SJ, D'Agati VD, Duffield JS.

J Am Soc Nephrol. 2015 May;26(5):1040-52. doi: 10.1681/ASN.2013111202. Epub 2014 Nov 18.


Progenitor cells and podocyte regeneration.

Shankland SJ, Pippin JW, Duffield JS.

Semin Nephrol. 2014 Jul;34(4):418-28. doi: 10.1016/j.semnephrol.2014.06.008. Epub 2014 Jun 13. Review.


The role of pericyte detachment in vascular rarefaction.

Schrimpf C, Teebken OE, Wilhelmi M, Duffield JS.

J Vasc Res. 2014;51(4):247-58. doi: 10.1159/000365149. Epub 2014 Sep 3. Review.


MicroRNAs are potential therapeutic targets in fibrosing kidney disease: lessons from animal models.

Duffield JS, Grafals M, Portilla D.

Drug Discov Today Dis Models. 2013 Fall;10(3):e127-e135.


The effect of placental restriction on insulin signaling and lipogenic pathways in omental adipose tissue in the postnatal lamb.

Lie S, Duffield JA, McMillen IC, Morrison JL, Ozanne SE, Pilgrim C, Muhlhausler BS.

J Dev Orig Health Dis. 2013 Oct;4(5):421-9. doi: 10.1017/S2040174413000202.


Cellular and molecular mechanisms in kidney fibrosis.

Duffield JS.

J Clin Invest. 2014 Jun;124(6):2299-306. doi: 10.1172/JCI72267. Epub 2014 Jun 2. Review.


Lineage tracing reveals distinctive fates for mesothelial cells and submesothelial fibroblasts during peritoneal injury.

Chen YT, Chang YT, Pan SY, Chou YH, Chang FC, Yeh PY, Liu YH, Chiang WC, Chen YM, Wu KD, Tsai TJ, Duffield JS, Lin SL.

J Am Soc Nephrol. 2014 Dec;25(12):2847-58. doi: 10.1681/ASN.2013101079. Epub 2014 May 22.


Translational profiles of medullary myofibroblasts during kidney fibrosis.

Grgic I, Krautzberger AM, Hofmeister A, Lalli M, DiRocco DP, Fleig SV, Liu J, Duffield JS, McMahon AP, Aronow B, Humphreys BD.

J Am Soc Nephrol. 2014 Sep;25(9):1979-90. doi: 10.1681/ASN.2013101143. Epub 2014 Mar 20.


Cells of renin lineage take on a podocyte phenotype in aging nephropathy.

Pippin JW, Glenn ST, Krofft RD, Rusiniak ME, Alpers CE, Hudkins K, Duffield JS, Gross KW, Shankland SJ.

Am J Physiol Renal Physiol. 2014 May 15;306(10):F1198-209. doi: 10.1152/ajprenal.00699.2013. Epub 2014 Mar 19.

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