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Items: 1 to 50 of 90

1.

Comparative Analyses of the 12 Most Abundant PCB Congeners Detected in Human Maternal Serum for Activity at the Thyroid Hormone Receptor and Ryanodine Receptor.

Sethi S, Morgan RK, Feng W, Lin Y, Li X, Luna C, Koch M, Bansal R, Duffel MW, Puschner B, Zoeller RT, Lehmler HJ, Pessah IN, Lein PJ.

Environ Sci Technol. 2019 Apr 2;53(7):3948-3958. doi: 10.1021/acs.est.9b00535. Epub 2019 Mar 19.

PMID:
30821444
2.

Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells.

Rodriguez EA, Vanle BC, Doorn JA, Lehmler HJ, Robertson LW, Duffel MW.

Environ Toxicol Pharmacol. 2018 Sep;62:69-78. doi: 10.1016/j.etap.2018.06.010. Epub 2018 Jun 26.

3.

Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1.

Parker VS, Squirewell EJ, Lehmler HJ, Robertson LW, Duffel MW.

Environ Toxicol Pharmacol. 2018 Mar;58:196-201. doi: 10.1016/j.etap.2018.01.010. Epub 2018 Feb 3.

4.

Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example.

Li X, Holland EB, Feng W, Zheng J, Dong Y, Pessah IN, Duffel MW, Robertson LW, Lehmler HJ.

Environ Sci Pollut Res Int. 2018 Jun;25(17):16508-16521. doi: 10.1007/s11356-017-1162-0. Epub 2018 Jan 10.

5.

Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs).

Dhakal K, Gadupudi GS, Lehmler HJ, Ludewig G, Duffel MW, Robertson LW.

Environ Sci Pollut Res Int. 2018 Jun;25(17):16277-16290. doi: 10.1007/s11356-017-9694-x. Epub 2017 Jul 25.

6.

Identification of a sulfate metabolite of PCB 11 in human serum.

Grimm FA, Lehmler HJ, Koh WX, DeWall J, Teesch LM, Hornbuckle KC, Thorne PS, Robertson LW, Duffel MW.

Environ Int. 2017 Jan;98:120-128. doi: 10.1016/j.envint.2016.10.023. Epub 2016 Nov 3.

7.

Sulfation of Lower Chlorinated Polychlorinated Biphenyls Increases Their Affinity for the Major Drug-Binding Sites of Human Serum Albumin.

Rodriguez EA, Li X, Lehmler HJ, Robertson LW, Duffel MW.

Environ Sci Technol. 2016 May 17;50(10):5320-7. doi: 10.1021/acs.est.6b00484. Epub 2016 May 4.

8.

Mechanistic insights into the specificity of human cytosolic sulfotransferase 2A1 (hSULT2A1) for hydroxylated polychlorinated biphenyls through the use of fluoro-tagged probes.

Ekuase EJ, van 't Erve TJ, Rahaman A, Robertson LW, Duffel MW, Luthe G.

Environ Sci Pollut Res Int. 2016 Feb;23(3):2119-27. doi: 10.1007/s11356-015-4886-8. Epub 2015 Jul 14.

9.

Tissue Distribution, Metabolism, and Excretion of 3,3'-Dichloro-4'-sulfooxy-biphenyl in the Rat.

Grimm FA, He X, Teesch LM, Lehmler HJ, Robertson LW, Duffel MW.

Environ Sci Technol. 2015 Jul 7;49(13):8087-95. doi: 10.1021/acs.est.5b01499. Epub 2015 Jun 18.

10.
11.

Metabolism and metabolites of polychlorinated biphenyls.

Grimm FA, Hu D, Kania-Korwel I, Lehmler HJ, Ludewig G, Hornbuckle KC, Duffel MW, Bergman Å, Robertson LW.

Crit Rev Toxicol. 2015 Mar;45(3):245-72. doi: 10.3109/10408444.2014.999365. Epub 2015 Jan 28. Review.

12.

Modulating inhibitors of transthyretin fibrillogenesis via sulfation: polychlorinated biphenyl sulfates as models.

Grimm FA, Lehmler HJ, He X, Robertson LW, Duffel MW.

Chem Biol Interact. 2015 Feb 25;228:1-8. doi: 10.1016/j.cbi.2015.01.002. Epub 2015 Jan 13.

13.

Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1).

Squirewell EJ, Qin X, Duffel MW.

Drug Metab Dispos. 2014 Nov;42(11):1843-50. doi: 10.1124/dmd.114.059709. Epub 2014 Aug 25.

14.

Binding interactions of hydroxylated polychlorinated biphenyls (OHPCBs) with human hydroxysteroid sulfotransferase hSULT2A1.

Ekuase EJ, Lehmler HJ, Robertson LW, Duffel MW.

Chem Biol Interact. 2014 Apr 5;212:56-64. doi: 10.1016/j.cbi.2014.01.018. Epub 2014 Feb 5.

15.

Chlorinated biphenyl quinones and phenyl-2,5-benzoquinone differentially modify the catalytic activity of human hydroxysteroid sulfotransferase hSULT2A1.

Qin X, Lehmler HJ, Teesch LM, Robertson LW, Duffel MW.

Chem Res Toxicol. 2013 Oct 21;26(10):1474-85. doi: 10.1021/tx400207q. Epub 2013 Oct 4.

16.

Effective synthesis of sulfate metabolites of chlorinated phenols.

Lehmler HJ, He X, Li X, Duffel MW, Parkin S.

Chemosphere. 2013 Nov;93(9):1965-71. doi: 10.1016/j.chemosphere.2013.06.087. Epub 2013 Jul 29.

17.

3,4',5-Trichloro-biphenyl-4-yl 2,2,2-trichloro-ethyl sulfate.

Lehmler HJ, He X, Duffel MW, Parkin S.

Acta Crystallogr Sect E Struct Rep Online. 2013 Mar 28;69(Pt 4):o620. doi: 10.1107/S1600536813007976. Print 2013 Apr 1.

18.

Sulfated metabolites of polychlorinated biphenyls are high-affinity ligands for the thyroid hormone transport protein transthyretin.

Grimm FA, Lehmler HJ, He X, Robertson LW, Duffel MW.

Environ Health Perspect. 2013 Jun;121(6):657-62. doi: 10.1289/ehp.1206198. Epub 2013 Apr 12.

19.

Modification of the catalytic function of human hydroxysteroid sulfotransferase hSULT2A1 by formation of disulfide bonds.

Qin X, Teesch LM, Duffel MW.

Drug Metab Dispos. 2013 May;41(5):1094-103. doi: 10.1124/dmd.112.050534. Epub 2013 Feb 26.

20.

Identification of sulfated metabolites of 4-chlorobiphenyl (PCB3) in the serum and urine of male rats.

Dhakal K, He X, Lehmler HJ, Teesch LM, Duffel MW, Robertson LW.

Chem Res Toxicol. 2012 Dec 17;25(12):2796-804. doi: 10.1021/tx300416v. Epub 2012 Nov 16.

21.

Oxidative modification of rat sulfotransferase 1A1 activity in hepatic tissue slices correlates with effects on the purified enzyme.

Dammanahalli JK, Duffel MW.

Drug Metab Dispos. 2012 Feb;40(2):298-303. doi: 10.1124/dmd.111.042044. Epub 2011 Oct 31.

22.

2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is enantioselectively oxidized to hydroxylated metabolites by rat liver microsomes.

Wu X, Pramanik A, Duffel MW, Hrycay EG, Bandiera SM, Lehmler HJ, Kania-Korwel I.

Chem Res Toxicol. 2011 Dec 19;24(12):2249-57. doi: 10.1021/tx200360m. Epub 2011 Nov 10.

23.

Gas chromatographic analysis with chiral cyclodextrin phases reveals the enantioselective formation of hydroxylated polychlorinated biphenyls by rat liver microsomes.

Kania-Korwel I, Duffel MW, Lehmler HJ.

Environ Sci Technol. 2011 Nov 15;45(22):9590-6. doi: 10.1021/es2014727. Epub 2011 Oct 19.

24.

Regioselective Iodination of Chlorinated Aromatic Compounds Using Silver Salts.

Joshi SN, Vyas SM, Wu H, Duffel MW, Parkin S, Lehmler HJ.

Tetrahedron. 2011 Sep 30;67(39):7461-7469.

25.

Structure-activity relationships for hydroxylated polychlorinated biphenyls as inhibitors of the sulfation of dehydroepiandrosterone catalyzed by human hydroxysteroid sulfotransferase SULT2A1.

Ekuase EJ, Liu Y, Lehmler HJ, Robertson LW, Duffel MW.

Chem Res Toxicol. 2011 Oct 17;24(10):1720-8. doi: 10.1021/tx200260h. Epub 2011 Sep 28.

26.

Synthesis of Sterically Hindered Polychlorinated Biphenyl Derivatives.

Joshi SN, Vyas SM, Duffel MW, Parkin S, Lehmler HJ.

Synthesis (Stuttg). 2011 Jan 1;7:1045-1054.

27.

Substrate inhibition in human hydroxysteroid sulfotransferase SULT2A1: studies on the formation of catalytically non-productive enzyme complexes.

Gulcan HO, Duffel MW.

Arch Biochem Biophys. 2011 Mar 15;507(2):232-40. doi: 10.1016/j.abb.2010.12.027. Epub 2010 Dec 25.

28.

Physicochemical properties of hydroxylated polychlorinated biphenyls aid in predicting their interactions with rat sulfotransferase 1A1 (rSULT1A1).

Liu Y, Lehmler HJ, Robertson LW, Duffel MW.

Chem Biol Interact. 2011 Feb 1;189(3):153-60. doi: 10.1016/j.cbi.2010.11.009. Epub 2010 Dec 3.

29.

4'-Chloro-biphenyl-3-yl 2,2,2-trichloro-ethyl sulfate.

Li X, Parkin S, Duffel MW, Robertson LW, Lehmler HJ.

Acta Crystallogr Sect E Struct Rep Online. 2010 Aug 18;66(Pt 9):o2306. doi: 10.1107/S1600536810031338.

30.

3',4'-Dichloro-biphenyl-4-yl 2,2,2-trichloro-ethyl sulfate.

Li X, Parkin S, Duffel MW, Robertson LW, Lehmler HJ.

Acta Crystallogr Sect E Struct Rep Online. 2010 Jun 9;66(Pt 7):o1615-6. doi: 10.1107/S1600536810020362.

31.

Biphenyl-4-yl 2,2,2-trichloro-ethyl sulfate.

Li X, Parkin S, Duffel MW, Robertson LW, Lehmler HJ.

Acta Crystallogr Sect E Struct Rep Online. 2010 Apr 14;66(Pt 5):o1073. doi: 10.1107/S1600536810012845.

32.

An efficient approach to sulfate metabolites of polychlorinated biphenyls.

Li X, Parkin S, Duffel MW, Robertson LW, Lehmler HJ.

Environ Int. 2010 Nov;36(8):843-8. doi: 10.1016/j.envint.2009.02.005. Epub 2009 Apr 5.

33.

Structure-activity relationships for hydroxylated polychlorinated biphenyls as substrates and inhibitors of rat sulfotransferases and modification of these relationships by changes in thiol status.

Liu Y, Smart JT, Song Y, Lehmler HJ, Robertson LW, Duffel MW.

Drug Metab Dispos. 2009 May;37(5):1065-72. doi: 10.1124/dmd.108.026021. Epub 2009 Feb 5.

34.

Oxidation of 4-chlorobiphenyl metabolites to electrophilic species by prostaglandin H synthase.

Wangpradit O, Teesch LM, Mariappan SV, Duffel MW, Norstrom K, Robertson LW, Luthe G.

Chem Res Toxicol. 2009 Jan;22(1):64-71. doi: 10.1021/tx800300t.

35.

Pentachlorophenol and other chlorinated phenols are substrates for human hydroxysteroid sulfotransferase hSULT2A1.

Gulcan HO, Liu Y, Duffel MW.

Chem Res Toxicol. 2008 Aug;21(8):1503-8. doi: 10.1021/tx800133d. Epub 2008 Jul 26.

36.

Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1.

Liu Y, Apak TI, Lehmler HJ, Robertson LW, Duffel MW.

Chem Res Toxicol. 2006 Nov;19(11):1420-5.

PMID:
17112228
37.
38.

Formation of tamoxifen-DNA adducts via O-sulfonation, not O-acetylation, of alpha-hydroxytamoxifen in rat and human livers.

Kim SY, Laxmi YR, Suzuki N, Ogura K, Watabe T, Duffel MW, Shibutani S.

Drug Metab Dispos. 2005 Nov;33(11):1673-8. Epub 2005 Aug 11.

PMID:
16099924
39.
40.

Influence of phenylalanines 77 and 138 on the stereospecificity of aryl sulfotransferase IV.

Sheng JJ, Saxena A, Duffel MW.

Drug Metab Dispos. 2004 May;32(5):559-65.

PMID:
15100179
41.

Enantioselectivity of human hydroxysteroid sulfotransferase ST2A3 with naphthyl-1-ethanols.

Sheng JJ, Duffel MW.

Drug Metab Dispos. 2003 Jun;31(6):697-700.

PMID:
12756199
43.

Enzymatic aspects of the phenol (aryl) sulfotransferases.

Duffel MW, Marshal AD, McPhie P, Sharma V, Jakoby WB.

Drug Metab Rev. 2001 Aug-Nov;33(3-4):369-95. Review.

PMID:
11768773
44.

Measurement of aryl and alcohol sulfotransferase activity.

Sheng JJ, Sharma V, Duffel MW.

Curr Protoc Toxicol. 2001 Aug;Chapter 4:Unit4.5. doi: 10.1002/0471140856.tx0405s08.

PMID:
20945296
45.

Mechanism of lower genotoxicity of toremifene compared with tamoxifen.

Shibutani S, Ravindernath A, Terashima I, Suzuki N, Laxmi YR, Kanno Y, Suzuki M, Apak TI, Sheng JJ, Duffel MW.

Cancer Res. 2001 May 15;61(10):3925-31.

46.

Bacterial expression, purification, and characterization of rat hydroxysteroid sulfotransferase STa.

Sheng JJ, Duffel MW.

Protein Expr Purif. 2001 Feb;21(1):235-42.

PMID:
11162411
47.

In vitro and ex vivo hydrolysis rates of ethacrynate esters and their relationship to intraocular pressure in the rabbit eye.

Deshpande G, Schoenwald RD, Barfknecht CF, Duffel MW.

J Ocul Pharmacol Ther. 2000 Dec;16(6):539-56.

PMID:
11132901
48.

Structure-function modeling of the interactions of N-alkyl-N-hydroxyanilines with rat hepatic aryl sulfotransferase IV.

King RS, Sharma V, Pedersen LC, Kakuta Y, Negishi M, Duffel MW.

Chem Res Toxicol. 2000 Dec;13(12):1251-8.

PMID:
11123966
49.
50.

Sulfation of alpha-hydroxytamoxifen catalyzed by human hydroxysteroid sulfotransferase results in tamoxifen-DNA adducts.

Shibutani S, Shaw PM, Suzuki N, Dasaradhi L, Duffel MW, Terashima I.

Carcinogenesis. 1998 Nov;19(11):2007-11.

PMID:
9855017

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