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Items: 37

1.

The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo.

Nuriel T, Peng KY, Ashok A, Dillman AA, Figueroa HY, Apuzzo J, Ambat J, Levy E, Cookson MR, Mathews PM, Duff KE.

Front Neurosci. 2017 Dec 12;11:702. doi: 10.3389/fnins.2017.00702. eCollection 2017.

2.

Targeting the 26S Proteasome To Protect Against Proteotoxic Diseases.

Myeku N, Duff KE.

Trends Mol Med. 2018 Jan;24(1):18-29. doi: 10.1016/j.molmed.2017.11.006. Epub 2017 Dec 9. Review.

3.

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology.

Nuriel T, Angulo SL, Khan U, Ashok A, Chen Q, Figueroa HY, Emrani S, Liu L, Herman M, Barrett G, Savage V, Buitrago L, Cepeda-Prado E, Fung C, Goldberg E, Gross SS, Hussaini SA, Moreno H, Small SA, Duff KE.

Nat Commun. 2017 Nov 13;8(1):1464. doi: 10.1038/s41467-017-01444-0.

4.

Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit.

Angulo SL, Orman R, Neymotin SA, Liu L, Buitrago L, Cepeda-Prado E, Stefanov D, Lytton WW, Stewart M, Small SA, Duff KE, Moreno H.

Neurobiol Dis. 2017 Dec;108:261-276. doi: 10.1016/j.nbd.2017.08.015. Epub 2017 Aug 30.

PMID:
28860088
5.

Progressive Pathological Changes in Neurochemical Profile of the Hippocampus and Early Changes in the Olfactory Bulbs of Tau Transgenic Mice (rTg4510).

Kim J, Choi IY, Duff KE, Lee P.

Neurochem Res. 2017 Jun;42(6):1649-1660. doi: 10.1007/s11064-017-2298-5. Epub 2017 May 18.

6.

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.

Fu H, Rodriguez GA, Herman M, Emrani S, Nahmani E, Barrett G, Figueroa HY, Goldberg E, Hussaini SA, Duff KE.

Neuron. 2017 Feb 8;93(3):533-541.e5. doi: 10.1016/j.neuron.2016.12.023. Epub 2017 Jan 19.

7.

3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice.

Fu H, Hussaini SA, Wegmann S, Profaci C, Daniels JD, Herman M, Emrani S, Figueroa HY, Hyman BT, Davies P, Duff KE.

PLoS One. 2016 Jul 28;11(7):e0159463. doi: 10.1371/journal.pone.0159463. eCollection 2016.

8.

Neuronal activity enhances tau propagation and tau pathology in vivo.

Wu JW, Hussaini SA, Bastille IM, Rodriguez GA, Mrejeru A, Rilett K, Sanders DW, Cook C, Fu H, Boonen RA, Herman M, Nahmani E, Emrani S, Figueroa YH, Diamond MI, Clelland CL, Wray S, Duff KE.

Nat Neurosci. 2016 Aug;19(8):1085-92. doi: 10.1038/nn.4328. Epub 2016 Jun 20.

9.

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory.

Fá M, Puzzo D, Piacentini R, Staniszewski A, Zhang H, Baltrons MA, Li Puma DD, Chatterjee I, Li J, Saeed F, Berman HL, Ripoli C, Gulisano W, Gonzalez J, Tian H, Costa JA, Lopez P, Davidowitz E, Yu WH, Haroutunian V, Brown LM, Palmeri A, Sigurdsson EM, Duff KE, Teich AF, Honig LS, Sierks M, Moe JG, D'Adamio L, Grassi C, Kanaan NM, Fraser PE, Arancio O.

Sci Rep. 2016 Jan 20;6:19393. doi: 10.1038/srep19393.

10.

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.

Myeku N, Clelland CL, Emrani S, Kukushkin NV, Yu WH, Goldberg AL, Duff KE.

Nat Med. 2016 Jan;22(1):46-53. doi: 10.1038/nm.4011. Epub 2015 Dec 21.

11.

Vitamin D insufficiency and schizophrenia risk: evaluation of hyperprolinemia as a mediator of association.

Clelland JD, Read LL, Drouet V, Kaon A, Kelly A, Duff KE, Nadrich RH, Rajparia A, Clelland CL.

Schizophr Res. 2014 Jun;156(1):15-22. doi: 10.1016/j.schres.2014.03.017. Epub 2014 Apr 29.

12.

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease.

Khan UA, Liu L, Provenzano FA, Berman DE, Profaci CP, Sloan R, Mayeux R, Duff KE, Small SA.

Nat Neurosci. 2014 Feb;17(2):304-11. doi: 10.1038/nn.3606. Epub 2013 Dec 22.

13.

Mechanisms of protein seeding in neurodegenerative diseases.

Walker LC, Diamond MI, Duff KE, Hyman BT.

JAMA Neurol. 2013 Mar 1;70(3):304-10. Review.

14.

Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons.

Wu JW, Herman M, Liu L, Simoes S, Acker CM, Figueroa H, Steinberg JI, Margittai M, Kayed R, Zurzolo C, Di Paolo G, Duff KE.

J Biol Chem. 2013 Jan 18;288(3):1856-70. doi: 10.1074/jbc.M112.394528. Epub 2012 Nov 27.

15.

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.

Congdon EE, Wu JW, Myeku N, Figueroa YH, Herman M, Marinec PS, Gestwicki JE, Dickey CA, Yu WH, Duff KE.

Autophagy. 2012 Apr;8(4):609-22. doi: 10.4161/auto.19048. Epub 2012 Apr 1.

16.

Comparative lipidomic analysis of mouse and human brain with Alzheimer disease.

Chan RB, Oliveira TG, Cortes EP, Honig LS, Duff KE, Small SA, Wenk MR, Shui G, Di Paolo G.

J Biol Chem. 2012 Jan 20;287(4):2678-88. doi: 10.1074/jbc.M111.274142. Epub 2011 Dec 1.

17.

Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction.

Alldred MJ, Duff KE, Ginsberg SD.

Neurobiol Dis. 2012 Feb;45(2):751-62. doi: 10.1016/j.nbd.2011.10.022. Epub 2011 Nov 7.

18.

Modulation of ABCA1 by an LXR agonist reduces β-amyloid levels and improves outcome after traumatic brain injury.

Loane DJ, Washington PM, Vardanian L, Pocivavsek A, Hoe HS, Duff KE, Cernak I, Rebeck GW, Faden AI, Burns MP.

J Neurotrauma. 2011 Feb;28(2):225-36. doi: 10.1089/neu.2010.1595.

19.

Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits.

Oliveira TG, Chan RB, Tian H, Laredo M, Shui G, Staniszewski A, Zhang H, Wang L, Kim TW, Duff KE, Wenk MR, Arancio O, Di Paolo G.

J Neurosci. 2010 Dec 8;30(49):16419-28. doi: 10.1523/JNEUROSCI.3317-10.2010.

20.

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden.

O'Leary JC 3rd, Li Q, Marinec P, Blair LJ, Congdon EE, Johnson AG, Jinwal UK, Koren J 3rd, Jones JR, Kraft C, Peters M, Abisambra JF, Duff KE, Weeber EJ, Gestwicki JE, Dickey CA.

Mol Neurodegener. 2010 Nov 1;5:45. doi: 10.1186/1750-1326-5-45.

21.

Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria.

Area-Gomez E, de Groof AJ, Boldogh I, Bird TD, Gibson GE, Koehler CM, Yu WH, Duff KE, Yaffe MP, Pon LA, Schon EA.

Am J Pathol. 2009 Nov;175(5):1810-6. doi: 10.2353/ajpath.2009.090219. Epub 2009 Oct 15.

22.

Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.

Yu WH, Dorado B, Figueroa HY, Wang L, Planel E, Cookson MR, Clark LN, Duff KE.

Am J Pathol. 2009 Aug;175(2):736-47. doi: 10.2353/ajpath.2009.080928. Epub 2009 Jul 23.

23.

Inhibition of tau polymerization with a cyanine dye in two distinct model systems.

Congdon EE, Figueroa YH, Wang L, Toneva G, Chang E, Kuret J, Conrad C, Duff KE.

J Biol Chem. 2009 Jul 31;284(31):20830-9. doi: 10.1074/jbc.M109.016089. Epub 2009 May 28.

24.

Structure-activity relationship of cyanine tau aggregation inhibitors.

Chang E, Congdon EE, Honson NS, Duff KE, Kuret J.

J Med Chem. 2009 Jun 11;52(11):3539-47. doi: 10.1021/jm900116d.

25.

Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia.

Planel E, Bretteville A, Liu L, Virag L, Du AL, Yu WH, Dickson DW, Whittington RA, Duff KE.

FASEB J. 2009 Aug;23(8):2595-604. doi: 10.1096/fj.08-122424. Epub 2009 Mar 11.

26.

Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimer's double transgenic mice using focused ultrasound.

Choi JJ, Wang S, Brown TR, Small SA, Duff KE, Konofagou EE.

Ultrason Imaging. 2008 Jul;30(3):189-200.

27.

Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.

Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, Bretteville A, Figueroa HY, Yu WH, Whittington RA, Davies P, Takashima A, Nixon RA, Duff KE.

J Neurosci. 2008 Nov 26;28(48):12798-807. doi: 10.1523/JNEUROSCI.4101-08.2008.

28.

Is tau aggregation toxic or protective?

Congdon EE, Duff KE.

J Alzheimers Dis. 2008 Aug;14(4):453-7. Review.

PMID:
18688098
29.

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.

Hirata-Fukae C, Li HF, Hoe HS, Gray AJ, Minami SS, Hamada K, Niikura T, Hua F, Tsukagoshi-Nagai H, Horikoshi-Sakuraba Y, Mughal M, Rebeck GW, LaFerla FM, Mattson MP, Iwata N, Saido TC, Klein WL, Duff KE, Aisen PS, Matsuoka Y.

Brain Res. 2008 Jun 24;1216:92-103. doi: 10.1016/j.brainres.2008.03.079. Epub 2008 Apr 10.

PMID:
18486110
30.

Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

Wen Y, Planel E, Herman M, Figueroa HY, Wang L, Liu L, Lau LF, Yu WH, Duff KE.

J Neurosci. 2008 Mar 5;28(10):2624-32. doi: 10.1523/JNEUROSCI.5245-07.2008.

31.

Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms.

Planel E, Tatebayashi Y, Miyasaka T, Liu L, Wang L, Herman M, Yu WH, Luchsinger JA, Wadzinski B, Duff KE, Takashima A.

J Neurosci. 2007 Dec 12;27(50):13635-48.

32.

Increased dopaminergic neuron sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in transgenic mice expressing mutant A53T alpha-synuclein.

Yu WH, Matsuoka Y, Sziráki I, Hashim A, Lafrancois J, Sershen H, Duff KE.

Neurochem Res. 2008 May;33(5):902-11. Epub 2007 Nov 13.

PMID:
17999181
33.

Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.

Planel E, Richter KE, Nolan CE, Finley JE, Liu L, Wen Y, Krishnamurthy P, Herman M, Wang L, Schachter JB, Nelson RB, Lau LF, Duff KE.

J Neurosci. 2007 Mar 21;27(12):3090-7.

34.

Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice.

Lemere CA, Spooner ET, LaFrancois J, Malester B, Mori C, Leverone JF, Matsuoka Y, Taylor JW, DeMattos RB, Holtzman DM, Clements JD, Selkoe DJ, Duff KE.

Neurobiol Dis. 2003 Oct;14(1):10-8.

PMID:
13678662
35.

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease.

Refolo LM, Pappolla MA, LaFrancois J, Malester B, Schmidt SD, Thomas-Bryant T, Tint GS, Wang R, Mercken M, Petanceska SS, Duff KE.

Neurobiol Dis. 2001 Oct;8(5):890-9.

PMID:
11592856
36.

Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain.

Wengenack TM, Whelan S, Curran GL, Duff KE, Poduslo JF.

Neuroscience. 2000;101(4):939-44.

PMID:
11113343
37.

Women's environmental health.

Duff KE.

Environ Health Perspect. 2000 Jul;108(7):A298. No abstract available.

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