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Items: 1 to 50 of 196

1.

A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources.

Kernik DC, Morotti S, Wu H, Garg P, Duff HJ, Kurokawa J, Jalife J, Wu JC, Grandi E, Clancy CE.

J Physiol. 2019 Jul 6. doi: 10.1113/JP277724. [Epub ahead of print]

PMID:
31278749
2.

The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.

Perissinotti L, Guo J, Kudaibergenova M, Lees-Miller J, Ol'khovich M, Sharapova A, Perlovich GL, Muruve DA, Gerull B, Noskov SY, Duff HJ.

Mol Pharmacol. 2019 Aug;96(2):259-271. doi: 10.1124/mol.118.115642. Epub 2019 Jun 10.

PMID:
31182542
3.

Characterization of a Unique Form of Arrhythmic Cardiomyopathy Caused by Recessive Mutation in LEMD2.

Abdelfatah N, Chen R, Duff HJ, Seifer CM, Buffo I, Huculak C, Clarke S, Clegg R, Jassal DS, Gordon PMK, Ober C; Care4Rare Canada Consortium, Frosk P, Gerull B.

JACC Basic Transl Sci. 2019 Apr 29;4(2):204-221. doi: 10.1016/j.jacbts.2018.12.001. eCollection 2019 Apr.

4.

Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy.

Brodehl A, Rezazadeh S, Williams T, Munsie NM, Liedtke D, Oh T, Ferrier R, Shen Y, Jones SJM, Stiegler AL, Boggon TJ, Duff HJ, Friedman JM, Gibson WT; FORGE Canada Consortium, Childs SJ, Gerull B.

Transl Res. 2019 Jun;208:15-29. doi: 10.1016/j.trsl.2019.02.004. Epub 2019 Feb 15.

PMID:
30802431
5.

Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study.

Perissinotti LL, De Biase PM, Guo J, Yang PC, Lee MC, Clancy CE, Duff HJ, Noskov SY.

Front Physiol. 2018 Apr 12;9:207. doi: 10.3389/fphys.2018.00207. eCollection 2018.

6.

Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD.

Komada T, Chung H, Lau A, Platnich JM, Beck PL, Benediktsson H, Duff HJ, Jenne CN, Muruve DA.

J Am Soc Nephrol. 2018 Apr;29(4):1165-1181. doi: 10.1681/ASN.2017080863. Epub 2018 Feb 9.

7.

Genetic Determinants of Hereditary Bradyarrhythmias: A Contemporary Review of a Diverse Group of Disorders.

Rezazadeh S, Duff HJ.

Can J Cardiol. 2017 Jun;33(6):758-767. doi: 10.1016/j.cjca.2017.03.010. Epub 2017 Mar 21. Review.

PMID:
28545623
8.

Reversible Dilated Cardiomyopathy Caused by a High Burden of Ventricular Arrhythmias in Andersen-Tawil Syndrome.

Rezazadeh S, Guo J, Duff HJ, Ferrier RA, Gerull B.

Can J Cardiol. 2016 Dec;32(12):1576.e15-1576.e18. doi: 10.1016/j.cjca.2016.07.587. Epub 2016 Jul 27.

PMID:
27789106
9.

Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts.

Zhong X, Sun B, Vallmitjana A, Mi T, Guo W, Ni M, Wang R, Guo A, Duff HJ, Gillis AM, Song LS, Hove-Madsen L, Benitez R, Chen SR.

Biochem J. 2016 Nov 1;473(21):3951-3964. Epub 2016 Aug 31.

10.

Role of the pH in state-dependent blockade of hERG currents.

Wang Y, Guo J, Perissinotti LL, Lees-Miller J, Teng G, Durdagi S, Duff HJ, Noskov SY.

Sci Rep. 2016 Oct 12;6:32536. doi: 10.1038/srep32536.

11.

Dynamic Clamp: Insights From State-of-the-Art Experimentation.

Duff HJ.

Circ Arrhythm Electrophysiol. 2015 Oct;8(5):1012-3. doi: 10.1161/CIRCEP.115.003298. No abstract available.

PMID:
26487621
12.

In response to Melgari et al. "hERG potassium channel inhibition by ivabradine requires channel gating".

Lees-Miller JP, Guo J, Wang Y, Perissinotti LL, Noskov SY, Duff HJ.

J Mol Cell Cardiol. 2015 Oct;87:192-3. doi: 10.1016/j.yjmcc.2015.08.003. Epub 2015 Aug 20. No abstract available.

PMID:
26299838
13.

Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4.

Lees-Miller JP, Guo J, Wang Y, Perissinotti LL, Noskov SY, Duff HJ.

J Mol Cell Cardiol. 2015 Aug;85:71-8. doi: 10.1016/j.yjmcc.2015.05.009. Epub 2015 May 16.

PMID:
25986146
14.

Tetrandrine reverses human cardiac myofibroblast activation and myocardial fibrosis.

Teng G, Svystonyuk D, Mewhort HE, Turnbull JD, Belke DD, Duff HJ, Fedak PW.

Am J Physiol Heart Circ Physiol. 2015 Jun 15;308(12):H1564-74. doi: 10.1152/ajpheart.00126.2015. Epub 2015 Apr 10.

15.

Ketones prevent oxidative impairment of hippocampal synaptic integrity through KATP channels.

Kim DY, Abdelwahab MG, Lee SH, O'Neill D, Thompson RJ, Duff HJ, Sullivan PG, Rho JM.

PLoS One. 2015 Apr 7;10(4):e0119316. doi: 10.1371/journal.pone.0119316. eCollection 2015.

16.

Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel.

Perissinotti LL, Guo J, De Biase PM, Clancy CE, Duff HJ, Noskov SY.

Biophys J. 2015 Mar 24;108(6):1414-1424. doi: 10.1016/j.bpj.2014.12.056.

17.

NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.

Guo J, Cheng YM, Lees-Miller JP, Perissinotti LL, Claydon TW, Hull CM, Thouta S, Roach DE, Durdagi S, Noskov SY, Duff HJ.

Biophys J. 2015 Mar 24;108(6):1400-1413. doi: 10.1016/j.bpj.2014.12.055.

18.

Role of mutation and pharmacologic block of human KCNH2 in vasculogenesis and fetal mortality: partial rescue by transforming growth factor-β.

Teng G, Zhao X, Lees-Miller JP, Belke D, Shi C, Chen Y, O'Brien ER, Fedak PW, Bracey N, Cross JC, Duff HJ.

Circ Arrhythm Electrophysiol. 2015 Apr;8(2):420-8. doi: 10.1161/CIRCEP.114.001837. Epub 2015 Feb 3.

PMID:
25648353
19.

Phenotypic analysis of arrhythmogenic cardiomyopathy in the Hutterite population: role of electrocardiogram in identifying high-risk desmocollin-2 carriers.

Wong JA, Duff HJ, Yuen T, Kolman L, Exner DV, Weeks SG, Gerull B.

J Am Heart Assoc. 2014 Dec 11;3(6):e001407. doi: 10.1161/JAHA.114.001407.

20.

Hierarchical regulation of wound healing by NOD-like receptors in cardiovascular disease.

Bracey NA, Duff HJ, Muruve DA.

Antioxid Redox Signal. 2015 May 1;22(13):1176-87. doi: 10.1089/ars.2014.6125. Epub 2014 Nov 10. Review.

PMID:
25273899
21.

Structure driven design of novel human ether-a-go-go-related-gene channel (hERG1) activators.

Guo J, Durdagi S, Changalov M, Perissinotti LL, Hargreaves JM, Back TG, Noskov SY, Duff HJ.

PLoS One. 2014 Sep 5;9(9):e105553. doi: 10.1371/journal.pone.0105553. eCollection 2014.

22.

The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study.

Ezekowitz JA, Becher H, Belenkie I, Clark AM, Duff HJ, Friedrich MG, Haykowsky MJ, Howlett JG, Kassiri Z, Kaul P, Kim DH, Knudtson ML, Light PE, Lopaschuk GD, McAlister FA, Noga ML, Oudit GY, Paterson DI, Quan H, Schulz R, Thompson RB, Weeks SG, Anderson TJ, Dyck JR.

BMC Cardiovasc Disord. 2014 Jul 25;14:91. doi: 10.1186/1471-2261-14-91.

23.

Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome.

Bracey NA, Gershkovich B, Chun J, Vilaysane A, Meijndert HC, Wright JR Jr, Fedak PW, Beck PL, Muruve DA, Duff HJ.

J Biol Chem. 2014 Jul 11;289(28):19571-84. doi: 10.1074/jbc.M114.550624. Epub 2014 May 19.

24.

Rehabilitating drug-induced long-QT promoters: in-silico design of hERG-neutral cisapride analogues with retained pharmacological activity.

Durdagi S, Randall T, Duff HJ, Chamberlin A, Noskov SY.

BMC Pharmacol Toxicol. 2014 Mar 8;15:14. doi: 10.1186/2050-6511-15-14.

25.

Beyond doctrine and dogma: one gene--multisystem effects.

Duff HJ.

Circ Cardiovasc Genet. 2014 Feb;7(1):4. doi: 10.1161/CIRCGENETICS.114.000508. No abstract available.

PMID:
24550429
26.

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.

Chen W, Wang R, Chen B, Zhong X, Kong H, Bai Y, Zhou Q, Xie C, Zhang J, Guo A, Tian X, Jones PP, O'Mara ML, Liu Y, Mi T, Zhang L, Bolstad J, Semeniuk L, Cheng H, Zhang J, Chen J, Tieleman DP, Gillis AM, Duff HJ, Fill M, Song LS, Chen SR.

Nat Med. 2014 Feb;20(2):184-92. doi: 10.1038/nm.3440. Epub 2014 Jan 19.

27.

Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population.

Gerull B, Kirchner F, Chong JX, Tagoe J, Chandrasekharan K, Strohm O, Waggoner D, Ober C, Duff HJ.

Circ Cardiovasc Genet. 2013 Aug;6(4):327-36. doi: 10.1161/CIRCGENETICS.113.000097. Epub 2013 Jul 17.

PMID:
23863954
28.

Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice.

Bai Y, Jones PP, Guo J, Zhong X, Clark RB, Zhou Q, Wang R, Vallmitjana A, Benitez R, Hove-Madsen L, Semeniuk L, Guo A, Song LS, Duff HJ, Chen SR.

Circ Res. 2013 Aug 16;113(5):517-26. doi: 10.1161/CIRCRESAHA.113.301678. Epub 2013 Jul 15.

29.

Inflammasome-independent NLRP3 augments TGF-β signaling in kidney epithelium.

Wang W, Wang X, Chun J, Vilaysane A, Clark S, French G, Bracey NA, Trpkov K, Bonni S, Duff HJ, Beck PL, Muruve DA.

J Immunol. 2013 Feb 1;190(3):1239-49. doi: 10.4049/jimmunol.1201959. Epub 2012 Dec 21.

30.

Auto-entrainment risk assessment in heart failure.

Roach DE, Morck ML, Sheldon RS, Duff HJ.

Circ Arrhythm Electrophysiol. 2013 Feb;6(1):129-36. doi: 10.1161/CIRCEP.112.971986. Epub 2012 Dec 22.

PMID:
23264372
31.

Modeling of open, closed, and open-inactivated states of the hERG1 channel: structural mechanisms of the state-dependent drug binding.

Durdagi S, Deshpande S, Duff HJ, Noskov SY.

J Chem Inf Model. 2012 Oct 22;52(10):2760-74. doi: 10.1021/ci300353u. Epub 2012 Oct 2.

PMID:
22989185
32.

The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β.

Bracey NA, Beck PL, Muruve DA, Hirota SA, Guo J, Jabagi H, Wright JR Jr, Macdonald JA, Lees-Miller JP, Roach D, Semeniuk LM, Duff HJ.

Exp Physiol. 2013 Feb;98(2):462-72. doi: 10.1113/expphysiol.2012.068338. Epub 2012 Jul 30.

33.

Structure-guided topographic mapping and mutagenesis to elucidate binding sites for the human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator NS1643.

Durdagi S, Guo J, Lees-Miller JP, Noskov SY, Duff HJ.

J Pharmacol Exp Ther. 2012 Aug;342(2):441-52. doi: 10.1124/jpet.111.189159. Epub 2012 May 9.

PMID:
22573844
34.

Cell therapy limits myofibroblast differentiation and structural cardiac remodeling: basic fibroblast growth factor-mediated paracrine mechanism.

Fedak PW, Bai L, Turnbull J, Ngu J, Narine K, Duff HJ.

Circ Heart Fail. 2012 May 1;5(3):349-56. doi: 10.1161/CIRCHEARTFAILURE.111.965889. Epub 2012 Apr 16.

PMID:
22508775
35.

Impact of stirred suspension bioreactor culture on the differentiation of murine embryonic stem cells into cardiomyocytes.

Shafa M, Krawetz R, Zhang Y, Rattner JB, Godollei A, Duff HJ, Rancourt DE.

BMC Cell Biol. 2011 Dec 14;12:53. doi: 10.1186/1471-2121-12-53.

36.

Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release.

Zhou Q, Xiao J, Jiang D, Wang R, Vembaiyan K, Wang A, Smith CD, Xie C, Chen W, Zhang J, Tian X, Jones PP, Zhong X, Guo A, Chen H, Zhang L, Zhu W, Yang D, Li X, Chen J, Gillis AM, Duff HJ, Cheng H, Feldman AM, Song LS, Fill M, Back TG, Chen SR.

Nat Med. 2011 Jul 10;17(8):1003-9. doi: 10.1038/nm.2406.

37.

Combined receptor and ligand-based approach to the universal pharmacophore model development for studies of drug blockade to the hERG1 pore domain.

Durdagi S, Duff HJ, Noskov SY.

J Chem Inf Model. 2011 Feb 28;51(2):463-74. doi: 10.1021/ci100409y. Epub 2011 Jan 11.

PMID:
21241063
38.

Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations.

Subbotina J, Yarov-Yarovoy V, Lees-Miller J, Durdagi S, Guo J, Duff HJ, Noskov SY.

Proteins. 2010 Nov 1;78(14):2922-34. doi: 10.1002/prot.22815.

39.

Insights into the molecular mechanism of hERG1 channel activation and blockade by drugs.

Durdagi S, Subbotina J, Lees-Miller J, Guo J, Duff HJ, Noskov SY.

Curr Med Chem. 2010;17(30):3514-32. Review.

PMID:
20738248
40.

Impact of atrial antitachycardia pacing and atrial pace prevention therapies on atrial fibrillation burden over long-term follow-up.

Gillis AM, Morck M, Exner DV, Sheldon RS, Duff HJ, Mitchell BL, Wyse GD.

Europace. 2009 Aug;11(8):1041-7. doi: 10.1093/europace/eup115. Epub 2009 May 21.

PMID:
19460849
41.

Interactions of H562 in the S5 helix with T618 and S621 in the pore helix are important determinants of hERG1 potassium channel structure and function.

Lees-Miller JP, Subbotina JO, Guo J, Yarov-Yarovoy V, Noskov SY, Duff HJ.

Biophys J. 2009 May 6;96(9):3600-10. doi: 10.1016/j.bpj.2009.01.028.

42.

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans.

Watanabe H, Chopra N, Laver D, Hwang HS, Davies SS, Roach DE, Duff HJ, Roden DM, Wilde AA, Knollmann BC.

Nat Med. 2009 Apr;15(4):380-3. doi: 10.1038/nm.1942. Epub 2009 Mar 29.

43.

Homozygous missense N629D hERG (KCNH2) potassium channel mutation causes developmental defects in the right ventricle and its outflow tract and embryonic lethality.

Teng GQ, Zhao X, Lees-Miller JP, Quinn FR, Li P, Rancourt DE, London B, Cross JC, Duff HJ.

Circ Res. 2008 Dec 5;103(12):1483-91. doi: 10.1161/CIRCRESAHA.108.177055. Epub 2008 Oct 23.

44.

iNOS in cardiac myocytes plays a critical role in death in a murine model of hypertrophy induced by calcineurin.

Somers JR, Beck PL, Lees-Miller JP, Roach D, Li Y, Guo J, Loken S, Zhan S, Semeniuk L, Duff HJ.

Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1122-H1131. doi: 10.1152/ajpheart.00386.2008. Epub 2008 Jul 11.

45.

Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor.

Kong H, Jones PP, Koop A, Zhang L, Duff HJ, Chen SR.

Biochem J. 2008 Sep 15;414(3):441-52. doi: 10.1042/BJ20080489.

46.

Beneficial effects of statin therapy for prevention of atrial fibrillation following DDDR pacemaker implantation.

Gillis AM, Morck M, Exner DV, Soo A, Rose MS, Sheldon RS, Duff HJ, Kavanagh KM, Mitchell LB, Wyse DG.

Eur Heart J. 2008 Aug;29(15):1873-80. doi: 10.1093/eurheartj/ehn192. Epub 2008 May 13.

PMID:
18477727
47.

Polymorphisms in multiple genes are associated with resting heart rate in a stepwise allele-dependent manner.

Wilton SB, Anderson TJ, Parboosingh J, Bridge PJ, Exner DV, Forrest D, Duff HJ.

Heart Rhythm. 2008 May;5(5):694-700. doi: 10.1016/j.hrthm.2008.01.039. Epub 2008 Feb 2.

PMID:
18452871
48.

hERG: the long and short of it.

Duff HJ.

Heart Rhythm. 2008 Apr;5(4):591-2. doi: 10.1016/j.hrthm.2008.02.041. Epub 2008 Mar 6. No abstract available.

PMID:
18362028
49.

Noninvasive risk assessment early after a myocardial infarction the REFINE study.

Exner DV, Kavanagh KM, Slawnych MP, Mitchell LB, Ramadan D, Aggarwal SG, Noullett C, Van Schaik A, Mitchell RT, Shibata MA, Gulamhussein S, McMeekin J, Tymchak W, Schnell G, Gillis AM, Sheldon RS, Fick GH, Duff HJ; REFINE Investigators.

J Am Coll Cardiol. 2007 Dec 11;50(24):2275-84. Epub 2007 Nov 26.

50.

Transmural temporospatial left ventricular activation during pacing from different sites: potential implications for optimal pacing.

Kavanagh KM, Belenkie I, Duff HJ.

Cardiovasc Res. 2008 Jan;77(1):81-8. Epub 2007 Oct 12.

PMID:
18006458

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