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The Pore-Lipid Interface: Role of Amino Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.

Duff HJ, Noskov SY, Muruve D, Perlovic G, Ol Khovich M, Sharapova A, Gerull B, Guo J, Kudaibergenova M, Perissinotti L.

Mol Pharmacol. 2019 Jun 10. pii: mol.118.115642. doi: 10.1124/mol.118.115642. [Epub ahead of print]


Characterization of a Unique Form of Arrhythmic Cardiomyopathy Caused by Recessive Mutation in LEMD2.

Abdelfatah N, Chen R, Duff HJ, Seifer CM, Buffo I, Huculak C, Clarke S, Clegg R, Jassal DS, Gordon PMK, Ober C; Care4Rare Canada Consortium, Frosk P, Gerull B.

JACC Basic Transl Sci. 2019 Apr 29;4(2):204-221. doi: 10.1016/j.jacbts.2018.12.001. eCollection 2019 Apr.


Survivors of institutional abuse in long-term child care in Scotland.

Carr A, Nearchou F, Duff H, Ní Mhaoileoin D, Cullen K, O'Dowd A, Battigelli L.

Child Abuse Negl. 2019 Jul;93:38-54. doi: 10.1016/j.chiabu.2019.04.018. Epub 2019 May 2.


Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy.

Brodehl A, Rezazadeh S, Williams T, Munsie NM, Liedtke D, Oh T, Ferrier R, Shen Y, Jones SJM, Stiegler AL, Boggon TJ, Duff HJ, Friedman JM, Gibson WT; FORGE Canada Consortium, Childs SJ, Gerull B.

Transl Res. 2019 Jun;208:15-29. doi: 10.1016/j.trsl.2019.02.004. Epub 2019 Feb 15.


Early Repolarization Pattern Inheritance in the Cardiac Arrest Survivors With Preserved Ejection Fraction Registry (CASPER).

Malhi N, So PP, Cheung CC, Laksman ZWM, Healey JS, Chauhan VS, Green MS, Champagne J, Steinberg C, Sanatani S, Angaran P, Duff H, Roberts JD, Arbour L, Leather R, Simpson CS, Tadros R, Talajic M, Gardner M, Siefer C, Krahn AD.

JACC Clin Electrophysiol. 2018 Nov;4(11):1473-1479. doi: 10.1016/j.jacep.2018.07.001. Epub 2018 Aug 29.


A Systematic Review of Reviews of the Outcome of Noninstitutional Child Maltreatment.

Carr A, Duff H, Craddock F.

Trauma Violence Abuse. 2018 Sep 24:1524838018801334. doi: 10.1177/1524838018801334. [Epub ahead of print]


A Systematic Review of the Outcome of Child Abuse in Long-Term Care.

Carr A, Duff H, Craddock F.

Trauma Violence Abuse. 2018 Jan 1:1524838018789154. doi: 10.1177/1524838018789154. [Epub ahead of print]


A Systematic Review of Reviews of the Outcome of Severe Neglect in Underresourced Childcare Institutions.

Carr A, Duff H, Craddock F.

Trauma Violence Abuse. 2018 Jan 1:1524838018777788. doi: 10.1177/1524838018777788. [Epub ahead of print]


Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study.

Perissinotti LL, De Biase PM, Guo J, Yang PC, Lee MC, Clancy CE, Duff HJ, Noskov SY.

Front Physiol. 2018 Apr 12;9:207. doi: 10.3389/fphys.2018.00207. eCollection 2018.


Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD.

Komada T, Chung H, Lau A, Platnich JM, Beck PL, Benediktsson H, Duff HJ, Jenne CN, Muruve DA.

J Am Soc Nephrol. 2018 Apr;29(4):1165-1181. doi: 10.1681/ASN.2017080863. Epub 2018 Feb 9.


The impact of social activities, social networks, social support and social relationships on the cognitive functioning of healthy older adults: a systematic review.

Kelly ME, Duff H, Kelly S, McHugh Power JE, Brennan S, Lawlor BA, Loughrey DG.

Syst Rev. 2017 Dec 19;6(1):259. doi: 10.1186/s13643-017-0632-2. Review.


Randomized Crossover Trial of Blood Volume Monitoring-Guided Ultrafiltration Biofeedback to Reduce Intradialytic Hypotensive Episodes with Hemodialysis.

Leung KCW, Quinn RR, Ravani P, Duff H, MacRae JM.

Clin J Am Soc Nephrol. 2017 Nov 7;12(11):1831-1840. doi: 10.2215/CJN.01030117. Epub 2017 Oct 10.


Genetic Determinants of Hereditary Bradyarrhythmias: A Contemporary Review of a Diverse Group of Disorders.

Rezazadeh S, Duff HJ.

Can J Cardiol. 2017 Jun;33(6):758-767. doi: 10.1016/j.cjca.2017.03.010. Epub 2017 Mar 21. Review.


Statin Induced Regression of Cardiomyopathy Trial: A Randomized, Placebo-controlled Double-blind Trial.

Hersi A, Giannoccaro JP, Howarth A, Exner D, Weeks S, Eitel I, Herman RC, Duff H, Ritchie D, Mcrae M, Sheldon R.

Heart Views. 2016 Oct-Dec;17(4):129-135. doi: 10.4103/1995-705X.201784.


Ankyrin-B Defects: Serendipity and Inquisitiveness are the Mothers of Invention.

Duff H, Sheldon RS.

Circ Cardiovasc Genet. 2017 Jan;10(1). pii: e001698. doi: 10.1161/CIRCGENETICS.117.001698. No abstract available.


Reversible Dilated Cardiomyopathy Caused by a High Burden of Ventricular Arrhythmias in Andersen-Tawil Syndrome.

Rezazadeh S, Guo J, Duff HJ, Ferrier RA, Gerull B.

Can J Cardiol. 2016 Dec;32(12):1576.e15-1576.e18. doi: 10.1016/j.cjca.2016.07.587. Epub 2016 Jul 27.


Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts.

Zhong X, Sun B, Vallmitjana A, Mi T, Guo W, Ni M, Wang R, Guo A, Duff HJ, Gillis AM, Song LS, Hove-Madsen L, Benitez R, Chen SR.

Biochem J. 2016 Nov 1;473(21):3951-3964. Epub 2016 Aug 31.


Role of the pH in state-dependent blockade of hERG currents.

Wang Y, Guo J, Perissinotti LL, Lees-Miller J, Teng G, Durdagi S, Duff HJ, Noskov SY.

Sci Rep. 2016 Oct 12;6:32536. doi: 10.1038/srep32536.


Dissociative States: hERG Channel (Kv11.1) Modulators That Enhance Dissociation of Drugs From Their Blocking Receptor: Potential New Therapeutic Drugs.

Rezazadeh S, Duff H.

Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e004003. doi: 10.1161/CIRCEP.116.004003. No abstract available.


Dynamic Clamp: Insights From State-of-the-Art Experimentation.

Duff HJ.

Circ Arrhythm Electrophysiol. 2015 Oct;8(5):1012-3. doi: 10.1161/CIRCEP.115.003298. No abstract available.


In response to Melgari et al. "hERG potassium channel inhibition by ivabradine requires channel gating".

Lees-Miller JP, Guo J, Wang Y, Perissinotti LL, Noskov SY, Duff HJ.

J Mol Cell Cardiol. 2015 Oct;87:192-3. doi: 10.1016/j.yjmcc.2015.08.003. Epub 2015 Aug 20. No abstract available.


Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4.

Lees-Miller JP, Guo J, Wang Y, Perissinotti LL, Noskov SY, Duff HJ.

J Mol Cell Cardiol. 2015 Aug;85:71-8. doi: 10.1016/j.yjmcc.2015.05.009. Epub 2015 May 16.


Tetrandrine reverses human cardiac myofibroblast activation and myocardial fibrosis.

Teng G, Svystonyuk D, Mewhort HE, Turnbull JD, Belke DD, Duff HJ, Fedak PW.

Am J Physiol Heart Circ Physiol. 2015 Jun 15;308(12):H1564-74. doi: 10.1152/ajpheart.00126.2015. Epub 2015 Apr 10.


Ketones prevent oxidative impairment of hippocampal synaptic integrity through KATP channels.

Kim DY, Abdelwahab MG, Lee SH, O'Neill D, Thompson RJ, Duff HJ, Sullivan PG, Rho JM.

PLoS One. 2015 Apr 7;10(4):e0119316. doi: 10.1371/journal.pone.0119316. eCollection 2015.


Early repolarization syndrome: A case report focusing on dynamic electrocardiographic changes before ventricular arrhythmias and genetic analysis.

Tan VH, Duff H, Gerull B, Sumner G.

HeartRhythm Case Rep. 2015 Apr 2;1(4):213-216. doi: 10.1016/j.hrcr.2015.03.001. eCollection 2015 Jul. No abstract available.


Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel.

Perissinotti LL, Guo J, De Biase PM, Clancy CE, Duff HJ, Noskov SY.

Biophys J. 2015 Mar 24;108(6):1414-1424. doi: 10.1016/j.bpj.2014.12.056.


NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.

Guo J, Cheng YM, Lees-Miller JP, Perissinotti LL, Claydon TW, Hull CM, Thouta S, Roach DE, Durdagi S, Noskov SY, Duff HJ.

Biophys J. 2015 Mar 24;108(6):1400-1413. doi: 10.1016/j.bpj.2014.12.055.


Role of mutation and pharmacologic block of human KCNH2 in vasculogenesis and fetal mortality: partial rescue by transforming growth factor-β.

Teng G, Zhao X, Lees-Miller JP, Belke D, Shi C, Chen Y, O'Brien ER, Fedak PW, Bracey N, Cross JC, Duff HJ.

Circ Arrhythm Electrophysiol. 2015 Apr;8(2):420-8. doi: 10.1161/CIRCEP.114.001837. Epub 2015 Feb 3.


Phenotypic analysis of arrhythmogenic cardiomyopathy in the Hutterite population: role of electrocardiogram in identifying high-risk desmocollin-2 carriers.

Wong JA, Duff HJ, Yuen T, Kolman L, Exner DV, Weeks SG, Gerull B.

J Am Heart Assoc. 2014 Dec 11;3(6):e001407. doi: 10.1161/JAHA.114.001407.


Hierarchical regulation of wound healing by NOD-like receptors in cardiovascular disease.

Bracey NA, Duff HJ, Muruve DA.

Antioxid Redox Signal. 2015 May 1;22(13):1176-87. doi: 10.1089/ars.2014.6125. Epub 2014 Nov 10. Review.


Congenital long QT syndrome: severe torsades de pointes provoked by epinephrine in a digenic mutation carrier.

Tan VH, Duff H, Kuriachan V, Gerull B.

Heart Lung. 2014 Nov-Dec;43(6):541-5. doi: 10.1016/j.hrtlng.2014.07.004. Epub 2014 Sep 16.


Structure driven design of novel human ether-a-go-go-related-gene channel (hERG1) activators.

Guo J, Durdagi S, Changalov M, Perissinotti LL, Hargreaves JM, Back TG, Noskov SY, Duff HJ.

PLoS One. 2014 Sep 5;9(9):e105553. doi: 10.1371/journal.pone.0105553. eCollection 2014.


The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study.

Ezekowitz JA, Becher H, Belenkie I, Clark AM, Duff HJ, Friedrich MG, Haykowsky MJ, Howlett JG, Kassiri Z, Kaul P, Kim DH, Knudtson ML, Light PE, Lopaschuk GD, McAlister FA, Noga ML, Oudit GY, Paterson DI, Quan H, Schulz R, Thompson RB, Weeks SG, Anderson TJ, Dyck JR.

BMC Cardiovasc Disord. 2014 Jul 25;14:91. doi: 10.1186/1471-2261-14-91.


Trait impulsivity predicts D-KEFS tower test performance in university students.

Lyvers M, Basch V, Duff H, Edwards MS.

Appl Neuropsychol Adult. 2015;22(2):88-93. doi: 10.1080/23279095.2013.850693. Epub 2014 Jun 13.


Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome.

Bracey NA, Gershkovich B, Chun J, Vilaysane A, Meijndert HC, Wright JR Jr, Fedak PW, Beck PL, Muruve DA, Duff HJ.

J Biol Chem. 2014 Jul 11;289(28):19571-84. doi: 10.1074/jbc.M114.550624. Epub 2014 May 19.


Rehabilitating drug-induced long-QT promoters: in-silico design of hERG-neutral cisapride analogues with retained pharmacological activity.

Durdagi S, Randall T, Duff HJ, Chamberlin A, Noskov SY.

BMC Pharmacol Toxicol. 2014 Mar 8;15:14. doi: 10.1186/2050-6511-15-14.


Beyond doctrine and dogma: one gene--multisystem effects.

Duff HJ.

Circ Cardiovasc Genet. 2014 Feb;7(1):4. doi: 10.1161/CIRCGENETICS.114.000508. No abstract available.


The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.

Chen W, Wang R, Chen B, Zhong X, Kong H, Bai Y, Zhou Q, Xie C, Zhang J, Guo A, Tian X, Jones PP, O'Mara ML, Liu Y, Mi T, Zhang L, Bolstad J, Semeniuk L, Cheng H, Zhang J, Chen J, Tieleman DP, Gillis AM, Duff HJ, Fill M, Song LS, Chen SR.

Nat Med. 2014 Feb;20(2):184-92. doi: 10.1038/nm.3440. Epub 2014 Jan 19.


Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population.

Gerull B, Kirchner F, Chong JX, Tagoe J, Chandrasekharan K, Strohm O, Waggoner D, Ober C, Duff HJ.

Circ Cardiovasc Genet. 2013 Aug;6(4):327-36. doi: 10.1161/CIRCGENETICS.113.000097. Epub 2013 Jul 17.


Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice.

Bai Y, Jones PP, Guo J, Zhong X, Clark RB, Zhou Q, Wang R, Vallmitjana A, Benitez R, Hove-Madsen L, Semeniuk L, Guo A, Song LS, Duff HJ, Chen SR.

Circ Res. 2013 Aug 16;113(5):517-26. doi: 10.1161/CIRCRESAHA.113.301678. Epub 2013 Jul 15.


Inflammasome-independent NLRP3 augments TGF-β signaling in kidney epithelium.

Wang W, Wang X, Chun J, Vilaysane A, Clark S, French G, Bracey NA, Trpkov K, Bonni S, Duff HJ, Beck PL, Muruve DA.

J Immunol. 2013 Feb 1;190(3):1239-49. doi: 10.4049/jimmunol.1201959. Epub 2012 Dec 21.


Auto-entrainment risk assessment in heart failure.

Roach DE, Morck ML, Sheldon RS, Duff HJ.

Circ Arrhythm Electrophysiol. 2013 Feb;6(1):129-36. doi: 10.1161/CIRCEP.112.971986. Epub 2012 Dec 22.


Modeling of open, closed, and open-inactivated states of the hERG1 channel: structural mechanisms of the state-dependent drug binding.

Durdagi S, Deshpande S, Duff HJ, Noskov SY.

J Chem Inf Model. 2012 Oct 22;52(10):2760-74. doi: 10.1021/ci300353u. Epub 2012 Oct 2.


The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β.

Bracey NA, Beck PL, Muruve DA, Hirota SA, Guo J, Jabagi H, Wright JR Jr, Macdonald JA, Lees-Miller JP, Roach D, Semeniuk LM, Duff HJ.

Exp Physiol. 2013 Feb;98(2):462-72. doi: 10.1113/expphysiol.2012.068338. Epub 2012 Jul 30.


Structure-guided topographic mapping and mutagenesis to elucidate binding sites for the human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator NS1643.

Durdagi S, Guo J, Lees-Miller JP, Noskov SY, Duff HJ.

J Pharmacol Exp Ther. 2012 Aug;342(2):441-52. doi: 10.1124/jpet.111.189159. Epub 2012 May 9.


Rash impulsiveness and reward sensitivity in relation to risky drinking by university students: potential roles of frontal systems.

Lyvers M, Duff H, Basch V, Edwards MS.

Addict Behav. 2012 Aug;37(8):940-6. doi: 10.1016/j.addbeh.2012.03.028. Epub 2012 Apr 1.


Cell therapy limits myofibroblast differentiation and structural cardiac remodeling: basic fibroblast growth factor-mediated paracrine mechanism.

Fedak PW, Bai L, Turnbull J, Ngu J, Narine K, Duff HJ.

Circ Heart Fail. 2012 May 1;5(3):349-56. doi: 10.1161/CIRCHEARTFAILURE.111.965889. Epub 2012 Apr 16.


Impact of stirred suspension bioreactor culture on the differentiation of murine embryonic stem cells into cardiomyocytes.

Shafa M, Krawetz R, Zhang Y, Rattner JB, Godollei A, Duff HJ, Rancourt DE.

BMC Cell Biol. 2011 Dec 14;12:53. doi: 10.1186/1471-2121-12-53.


Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release.

Zhou Q, Xiao J, Jiang D, Wang R, Vembaiyan K, Wang A, Smith CD, Xie C, Chen W, Zhang J, Tian X, Jones PP, Zhong X, Guo A, Chen H, Zhang L, Zhu W, Yang D, Li X, Chen J, Gillis AM, Duff HJ, Cheng H, Feldman AM, Song LS, Fill M, Back TG, Chen SR.

Nat Med. 2011 Jul 10;17(8):1003-9. doi: 10.1038/nm.2406.


A review of the literature relating to psychological interventions and people with intellectual disabilities: issues for research, policy, education and clinical practice.

Brown M, Duff H, Karatzias T, Horsburgh D.

J Intellect Disabil. 2011 Mar;15(1):31-45. doi: 10.1177/1744629511401166. Review.


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