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Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations.

Ono K, Keller J, López Ramírez O, González Garrido A, Zobeiri OA, Chang HHV, Vijayakumar S, Ayiotis A, Duester G, Della Santina CC, Jones SM, Cullen KE, Eatock RA, Wu DK.

Nat Commun. 2020 Jan 2;11(1):63. doi: 10.1038/s41467-019-13710-4.


Roles of Two Major Alcohol Dehydrogenases, ADH1 (Class I) and ADH3 (Class III), in the Adaptive Enhancement of Alcohol Metabolism Induced by Chronic Alcohol Consumption in Mice.

Haseba T, Okuda T, Maruyama M, Akimoto T, Duester G, Ohno Y.

Alcohol Alcohol. 2019 Dec 11. pii: agz091. doi: 10.1093/alcalc/agz091. [Epub ahead of print]


Retinoic acid signaling pathways.

Ghyselinck NB, Duester G.

Development. 2019 Jul 4;146(13). pii: dev167502. doi: 10.1242/dev.167502. Review.


The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration.

Sala D, Cunningham TJ, Stec MJ, Etxaniz U, Nicoletti C, Dall'Agnese A, Puri PL, Duester G, Latella L, Sacco A.

Nat Commun. 2019 Apr 17;10(1):1796. doi: 10.1038/s41467-019-09746-1.


Knocking Out Enhancers to Enhance Epigenetic Research.

Duester G.

Trends Genet. 2019 Feb;35(2):89. doi: 10.1016/j.tig.2018.10.001. Epub 2018 Nov 19. No abstract available.


Mouse but not zebrafish requires retinoic acid for control of neuromesodermal progenitors and body axis extension.

Berenguer M, Lancman JJ, Cunningham TJ, Dong PDS, Duester G.

Dev Biol. 2018 Sep 1;441(1):127-131. doi: 10.1016/j.ydbio.2018.06.019. Epub 2018 Jun 28.


Genomic Knockout of Two Presumed Forelimb Tbx5 Enhancers Reveals They Are Nonessential for Limb Development.

Cunningham TJ, Lancman JJ, Berenguer M, Dong PDS, Duester G.

Cell Rep. 2018 Jun 12;23(11):3146-3151. doi: 10.1016/j.celrep.2018.05.052.


Publisher Correction: N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.

Wang Y, Li Y, Yue M, Wang J, Kumar S, Wechsler-Reya RJ, Zhang Z, Ogawa Y, Kellis M, Duester G, Zhao JC.

Nat Neurosci. 2018 Aug;21(8):1139. doi: 10.1038/s41593-018-0169-2.


N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.

Wang Y, Li Y, Yue M, Wang J, Kumar S, Wechsler-Reya RJ, Zhang Z, Ogawa Y, Kellis M, Duester G, Zhao JC.

Nat Neurosci. 2018 Feb;21(2):195-206. doi: 10.1038/s41593-017-0057-1. Epub 2018 Jan 15. Erratum in: Nat Neurosci. 2018 Aug;21(8):1139.


Retinoic acid's reproducible future.

Duester G.

Science. 2017 Dec 15;358(6369):1395. doi: 10.1126/science.aar6752. No abstract available.


Id genes are essential for early heart formation.

Cunningham TJ, Yu MS, McKeithan WL, Spiering S, Carrette F, Huang CT, Bushway PJ, Tierney M, Albini S, Giacca M, Mano M, Puri PL, Sacco A, Ruiz-Lozano P, Riou JF, Umbhauer M, Duester G, Mercola M, Colas AR.

Genes Dev. 2017 Jul 1;31(13):1325-1338. doi: 10.1101/gad.300400.117. Epub 2017 Aug 9.


Endogenous retinoic acid signaling is required for maintenance and regeneration of cornea.

Kumar S, Dollé P, Ghyselinck NB, Duester G.

Exp Eye Res. 2017 Jan;154:190-195. doi: 10.1016/j.exer.2016.11.009. Epub 2016 Nov 10. Review.


Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitors.

Cunningham TJ, Colas A, Duester G.

Biol Open. 2016 Dec 15;5(12):1821-1833. doi: 10.1242/bio.020891.


Nuclear receptor corepressors Ncor1 and Ncor2 (Smrt) are required for retinoic acid-dependent repression of Fgf8 during somitogenesis.

Kumar S, Cunningham TJ, Duester G.

Dev Biol. 2016 Oct 1;418(1):204-215. doi: 10.1016/j.ydbio.2016.08.005. Epub 2016 Aug 6.


Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis.

Cunningham TJ, Brade T, Sandell LL, Lewandoski M, Trainor PA, Colas A, Mercola M, Duester G.

PLoS One. 2015 Sep 14;10(9):e0137894. doi: 10.1371/journal.pone.0137894. eCollection 2015.


Retinoic acid-independent expression of Meis2 during autopod patterning in the developing bat and mouse limb.

Mason MK, Hockman D, Curry L, Cunningham TJ, Duester G, Logan M, Jacobs DS, Illing N.

Evodevo. 2015 Mar 14;6:6. doi: 10.1186/s13227-015-0001-y. eCollection 2015.


Wnt8a and Wnt3a cooperate in the axial stem cell niche to promote mammalian body axis extension.

Cunningham TJ, Kumar S, Yamaguchi TP, Duester G.

Dev Dyn. 2015 Jun;244(6):797-807. doi: 10.1002/dvdy.24275. Epub 2015 Apr 23.


Mechanisms of retinoic acid signalling and its roles in organ and limb development.

Cunningham TJ, Duester G.

Nat Rev Mol Cell Biol. 2015 Feb;16(2):110-23. doi: 10.1038/nrm3932. Epub 2015 Jan 5. Review.


A regulatory network controls nephrocan expression and midgut patterning.

Hou J, Wei W, Saund RS, Xiang P, Cunningham TJ, Yi Y, Alder O, Lu DY, Savory JG, Krentz NA, Montpetit R, Cullum R, Hofs N, Lohnes D, Humphries RK, Yamanaka Y, Duester G, Saijoh Y, Hoodless PA.

Development. 2014 Oct;141(19):3772-81. doi: 10.1242/dev.108274. Epub 2014 Sep 10.


Retinoic acid controls body axis extension by directly repressing Fgf8 transcription.

Kumar S, Duester G.

Development. 2014 Aug;141(15):2972-7. doi: 10.1242/dev.112367.


Alcohol dehydrogenase III exacerbates liver fibrosis by enhancing stellate cell activation and suppressing natural killer cells in mice.

Yi HS, Lee YS, Byun JS, Seo W, Jeong JM, Park O, Duester G, Haseba T, Kim SC, Park KG, Gao B, Jeong WI.

Hepatology. 2014 Sep;60(3):1044-53. doi: 10.1002/hep.27137. Epub 2014 May 9.


The Xenopus alcohol dehydrogenase gene family: characterization and comparative analysis incorporating amphibian and reptilian genomes.

Borràs E, Albalat R, Duester G, Parés X, Farrés J.

BMC Genomics. 2014 Mar 20;15:216. doi: 10.1186/1471-2164-15-216.


An evolutionarily conserved long noncoding RNA TUNA controls pluripotency and neural lineage commitment.

Lin N, Chang KY, Li Z, Gates K, Rana ZA, Dang J, Zhang D, Han T, Yang CS, Cunningham TJ, Head SR, Duester G, Dong PD, Rana TM.

Mol Cell. 2014 Mar 20;53(6):1005-19. doi: 10.1016/j.molcel.2014.01.021. Epub 2014 Feb 13. Erratum in: Mol Cell. 2014 Mar 20;53(6):1067.


Retinoid signaling in control of progenitor cell differentiation during mouse development.

Duester G.

Semin Cell Dev Biol. 2013 Dec;24(10-12):694-700. doi: 10.1016/j.semcdb.2013.08.001. Epub 2013 Aug 21. Review.


Resolving molecular events in the regulation of meiosis in male and female germ cells.

Kumar S, Cunningham TJ, Duester G.

Sci Signal. 2013 Aug 13;6(288):pe25. doi: 10.1126/scisignal.2004530.


Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function.

Wright-Jin EC, Grider JR, Duester G, Heuckeroth RO.

Dev Biol. 2013 Sep 1;381(1):28-37. doi: 10.1016/j.ydbio.2013.06.021. Epub 2013 Jun 24.


Investigation of retinoic acid function during embryonic brain development using retinaldehyde-rescued Rdh10 knockout mice.

Chatzi C, Cunningham TJ, Duester G.

Dev Dyn. 2013 Sep;242(9):1056-65. doi: 10.1002/dvdy.23999. Epub 2013 Jul 22.


Antagonism between retinoic acid and fibroblast growth factor signaling during limb development.

Cunningham TJ, Zhao X, Sandell LL, Evans SM, Trainor PA, Duester G.

Cell Rep. 2013 May 30;3(5):1503-11. doi: 10.1016/j.celrep.2013.03.036. Epub 2013 Apr 25.


Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis.

Colas AR, McKeithan WL, Cunningham TJ, Bushway PJ, Garmire LX, Duester G, Subramaniam S, Mercola M.

Genes Dev. 2012 Dec 1;26(23):2567-79. doi: 10.1101/gad.200758.112. Epub 2012 Nov 14.


Autocrine function of aldehyde dehydrogenase 1 as a determinant of diet- and sex-specific differences in visceral adiposity.

Yasmeen R, Reichert B, Deiuliis J, Yang F, Lynch A, Meyers J, Sharlach M, Shin S, Volz KS, Green KB, Lee K, Alder H, Duester G, Zechner R, Rajagopalan S, Ziouzenkova O.

Diabetes. 2013 Jan;62(1):124-36. doi: 10.2337/db11-1779. Epub 2012 Aug 28.


The prolonged survival of fibroblasts with forced lipid catabolism in visceral fat following encapsulation in alginate-poly-L-lysine.

Yang F, Zhang X, Maiseyeu A, Mihai G, Yasmeen R, DiSilvestro D, Maurya SK, Periasamy M, Bergdall KV, Duester G, Sen CK, Roy S, Lee LJ, Rajagopalan S, Ziouzenkova O.

Biomaterials. 2012 Aug;33(22):5638-49. doi: 10.1016/j.biomaterials.2012.04.035. Epub 2012 May 9.


Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism.

Kiefer FW, Orasanu G, Nallamshetty S, Brown JD, Wang H, Luger P, Qi NR, Burant CF, Duester G, Plutzky J.

Endocrinology. 2012 Jul;153(7):3089-99. doi: 10.1210/en.2011-2104. Epub 2012 May 3.


CD11b(+) Gr1(+) bone marrow cells ameliorate liver fibrosis by producing interleukin-10 in mice.

Suh YG, Kim JK, Byun JS, Yi HS, Lee YS, Eun HS, Kim SY, Han KH, Lee KS, Duester G, Friedman SL, Jeong WI.

Hepatology. 2012 Nov;56(5):1902-12. doi: 10.1002/hep.25817. Epub 2012 Oct 9.


Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development.

Gasparetto M, Sekulovic S, Brocker C, Tang P, Zakaryan A, Xiang P, Kuchenbauer F, Wen M, Kasaian K, Witty MF, Rosten P, Chen Y, Imren S, Duester G, Thompson DC, Humphries RK, Vasiliou V, Smith C.

Exp Hematol. 2012 Apr;40(4):318-29.e2. doi: 10.1016/j.exphem.2011.12.006. Epub 2011 Dec 20.


SnapShot: retinoic acid signaling.

Kumar S, Duester G.

Cell. 2011 Dec 9;147(6):1422-1422.e1. doi: 10.1016/j.cell.2011.11.034. No abstract available.


Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease.

Anvret A, Ran C, Westerlund M, Gellhaar S, Lindqvist E, Pernold K, Lundströmer K, Duester G, Felder MR, Galter D, Belin AC.

Behav Brain Res. 2012 Feb 1;227(1):252-7. doi: 10.1016/j.bbr.2011.10.040. Epub 2011 Nov 6.


Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex.

Crandall JE, Goodman T, McCarthy DM, Duester G, Bhide PG, Dräger UC, McCaffery P.

J Neurochem. 2011 Nov;119(4):723-35. doi: 10.1111/j.1471-4159.2011.07471.x. Epub 2011 Oct 11.


Functional significance of aldehyde dehydrogenase ALDH1A1 to the nigrostriatal dopamine system.

Anderson DW, Schray RC, Duester G, Schneider JS.

Brain Res. 2011 Aug 23;1408:81-7. doi: 10.1016/j.brainres.2011.06.051. Epub 2011 Jun 26.


Uncoupling of retinoic acid signaling from tailbud development before termination of body axis extension.

Cunningham TJ, Zhao X, Duester G.

Genesis. 2011 Oct;49(10):776-83. doi: 10.1002/dvg.20763. Epub 2011 Aug 24.


Retinoic acid functions as a key GABAergic differentiation signal in the basal ganglia.

Chatzi C, Brade T, Duester G.

PLoS Biol. 2011 Apr;9(4):e1000609. doi: 10.1371/journal.pbio.1000609. Epub 2011 Apr 12.


Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models.

Kumar S, Sandell LL, Trainor PA, Koentgen F, Duester G.

Biochim Biophys Acta. 2012 Jan;1821(1):198-205. doi: 10.1016/j.bbalip.2011.04.004. Epub 2011 Apr 15. Review.


Concerted action of aldehyde dehydrogenases influences depot-specific fat formation.

Reichert B, Yasmeen R, Jeyakumar SM, Yang F, Thomou T, Alder H, Duester G, Maiseyeu A, Mihai G, Harrison EH, Rajagopalan S, Kirkland JL, Ziouzenkova O.

Mol Endocrinol. 2011 May;25(5):799-809. doi: 10.1210/me.2010-0465. Epub 2011 Mar 24.


Rdh10 mutants deficient in limb field retinoic acid signaling exhibit normal limb patterning but display interdigital webbing.

Cunningham TJ, Chatzi C, Sandell LL, Trainor PA, Duester G.

Dev Dyn. 2011 May;240(5):1142-50. doi: 10.1002/dvdy.22583. Epub 2011 Feb 28.


Sex-specific timing of meiotic initiation is regulated by Cyp26b1 independent of retinoic acid signalling.

Kumar S, Chatzi C, Brade T, Cunningham TJ, Zhao X, Duester G.

Nat Commun. 2011 Jan 11;2:151.


Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2.

Brade T, Kumar S, Cunningham TJ, Chatzi C, Zhao X, Cavallero S, Li P, Sucov HM, Ruiz-Lozano P, Duester G.

Development. 2011 Jan;138(1):139-48. doi: 10.1242/dev.054239.


Modeling Parkinson's disease genetics: altered function of the dopamine system in Adh4 knockout mice.

Belin AC, Westerlund M, Anvret A, Lindqvist E, Pernold K, Ogren SO, Duester G, Galter D.

Behav Brain Res. 2011 Mar 1;217(2):439-45. doi: 10.1016/j.bbr.2010.11.023. Epub 2010 Nov 12.


Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling.

Urbán N, Martín-Ibáñez R, Herranz C, Esgleas M, Crespo E, Pardo M, Crespo-Enríquez I, Méndez-Gómez HR, Waclaw R, Chatzi C, Alvarez S, Alvarez R, Duester G, Campbell K, de Lera AR, Vicario-Abejón C, Martinez S, Alberch J, Canals JM.

Neural Dev. 2010 Aug 24;5:21. doi: 10.1186/1749-8104-5-21.


NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling.

Zhou H, Liu W, Su Y, Wei Z, Liu J, Kolluri SK, Wu H, Cao Y, Chen J, Wu Y, Yan T, Cao X, Gao W, Molotkov A, Jiang F, Li WG, Lin B, Zhang HP, Yu J, Luo SP, Zeng JZ, Duester G, Huang PQ, Zhang XK.

Cancer Cell. 2010 Jun 15;17(6):560-73. doi: 10.1016/j.ccr.2010.04.023.


Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma.

Mukhopadhyay B, Liu J, Osei-Hyiaman D, Godlewski G, Mukhopadhyay P, Wang L, Jeong WI, Gao B, Duester G, Mackie K, Kojima S, Kunos G.

J Biol Chem. 2010 Jun 18;285(25):19002-11. doi: 10.1074/jbc.M109.068460. Epub 2010 Apr 21.


Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2.

Kumar S, Duester G.

Dev Biol. 2010 Apr 1;340(1):67-74. doi: 10.1016/j.ydbio.2010.01.027. Epub 2010 Feb 1.

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