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Life-Saving Therapy versus Symptom Relief: Anti-Platelet Agents and Opioids in Coronary Intervention.

Duerschmied D, Bode C.

Thromb Haemost. 2018 Aug;118(8):1350-1351. doi: 10.1055/s-0038-1667173. Epub 2018 Jul 30. No abstract available.


Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease.

Benning L, Robinson S, Follo M, Heger LA, Stallmann D, Duerschmied D, Bode C, Ahrens I, Hortmann M.

J Vis Exp. 2018 Jul 3;(137). doi: 10.3791/57950.


Development and validation of a prognostic model for survival in patients treated with venoarterial extracorporeal membrane oxygenation: the PREDICT VA-ECMO score.

Wengenmayer T, Duerschmied D, Graf E, Chiabudini M, Benk C, Mühlschlegel S, Philipp A, Lubnow M, Bode C, Staudacher DL.

Eur Heart J Acute Cardiovasc Care. 2018 Jul 1:2048872618789052. doi: 10.1177/2048872618789052. [Epub ahead of print]


Expression of the oxygen-sensitive transcription factor subunit HIF-1α in patients suffering from secondary Raynaud syndrome.

Heger LA, Kerber M, Hortmann M, Robinson S, Mauler M, Stallmann D, Duerschmied D, Bode C, Hehrlein C, Ahrens I.

Acta Pharmacol Sin. 2018 Jul 10. doi: 10.1038/s41401-018-0055-1. [Epub ahead of print]


Autocrine and paracrine regulatory functions of platelet serotonin.

Mammadova-Bach E, Mauler M, Braun A, Duerschmied D.

Platelets. 2018 Jun 4:1-8. doi: 10.1080/09537104.2018.1478072. [Epub ahead of print]


A Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis.

Sauter RJ, Sauter M, Reis ES, Emschermann FN, Nording H, Ebenhöch S, Kraft P, Münzer P, Mauler M, Rheinlaender J, Madlung J, Edlich F, Schäffer TE, Meuth SG, Düerschmied D, Geisler T, Borst O, Gawaz M, Kleinschnitz C, Lambris JD, Langer HF.

Circulation. 2018 May 25. pii: CIRCULATIONAHA.118.034600. doi: 10.1161/CIRCULATIONAHA.118.034600. [Epub ahead of print]


Antithrombotic therapy in patients with non-valvular atrial fibrillation undergoing percutaneous coronary intervention: should we change our practice after the PIONEER AF-PCI and RE-DUAL PCI trials?

Duerschmied D, Brachmann J, Darius H, Frey N, Katus HA, Rottbauer W, Schäfer A, Thiele H, Bode C, Zeymer U.

Clin Res Cardiol. 2018 Jul;107(7):533-538. doi: 10.1007/s00392-018-1242-2. Epub 2018 Apr 20.


Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction.

Robinson S, Follo M, Haenel D, Mauler M, Stallmann D, Tewari M, Duerschmied D, Peter K, Bode C, Ahrens I, Hortmann M.

Int J Cardiol. 2018 Apr 15;257:247-254. doi: 10.1016/j.ijcard.2017.10.111.


Isoflurane or propofol sedation in patients with targeted temperature management after cardiopulmonary resuscitation: A single center study.

Staudacher DL, Hamilton SK, Duerschmied D, Biever PM, Zehender M, Bode C, Wengenmayer T.

J Crit Care. 2018 Jun;45:40-44. doi: 10.1016/j.jcrc.2018.01.014. Epub 2018 Feb 3.


A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense.

Wolf D, Anto-Michel N, Blankenbach H, Wiedemann A, Buscher K, Hohmann JD, Lim B, Bäuml M, Marki A, Mauler M, Duerschmied D, Fan Z, Winkels H, Sidler D, Diehl P, Zajonc DM, Hilgendorf I, Stachon P, Marchini T, Willecke F, Schell M, Sommer B, von Zur Muhlen C, Reinöhl J, Gerhardt T, Plow EF, Yakubenko V, Libby P, Bode C, Ley K, Peter K, Zirlik A.

Nat Commun. 2018 Feb 6;9(1):525. doi: 10.1038/s41467-018-02896-8.


Means for Transport in Patients After Remote Extracorporeal Membrane Oxygenation Implantation.

Supady A, Duerschmied D, Bode C, Staudacher DL.

Air Med J. 2018 Jan - Feb;37(1):5. doi: 10.1016/j.amj.2017.09.003. Epub 2017 Oct 16. No abstract available.


Dabigatran after Short Heparin Anticoagulation for Acute Intermediate-Risk Pulmonary Embolism: Rationale and Design of the Single-Arm PEITHO-2 Study.

Klok FA, Ageno W, Barco S, Binder H, Brenner B, Duerschmied D, Empen K, Faggiano P, Ficker JH, Galiè N, Ghuysen A, Held M, Heydenreich N, Huisman MV, Jiménez D, Kozak M, Lang IM, Lankeit M, Münzel T, Petris A, Pruszczyk P, Quitzau K, Schellong S, Schmidt KH, Stefanovic BS, Verschuren F, Wolf-Puetz A, Meyer G, Konstantinides SV; PEITHO-2 Investigators.

Thromb Haemost. 2017 Dec;117(12):2425-2434. doi: 10.1160/TH17-06-0434. Epub 2017 Dec 6.


Chip-based digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction patients.

Robinson S, Follo M, Haenel D, Mauler M, Stallmann D, Heger LA, Helbing T, Duerschmied D, Peter K, Bode C, Ahrens I, Hortmann M.

Acta Pharmacol Sin. 2018 Jul;39(7):1217-1227. doi: 10.1038/aps.2017.136. Epub 2017 Nov 30.


Circulating HtrA2 after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: A potential novel biomarker for mitochondrial induced cardiomyocyte apoptosis and ischemia-reperfusion injury.

Hortmann M, Robinson S, Mohr M, Haenel D, Mauler M, Laumann R, Stallmann D, Reinoehl J, Duerschmied D, Peter K, Bode C, Ahrens I.

Int J Cardiol. 2017 Dec 15;249:437. doi: 10.1016/j.ijcard.2017.08.022. No abstract available.


The Effects of Serotonin in Immune Cells.

Herr N, Bode C, Duerschmied D.

Front Cardiovasc Med. 2017 Jul 20;4:48. doi: 10.3389/fcvm.2017.00048. eCollection 2017. Review.


Influence of low-flow time on survival after extracorporeal cardiopulmonary resuscitation (eCPR).

Wengenmayer T, Rombach S, Ramshorn F, Biever P, Bode C, Duerschmied D, Staudacher DL.

Crit Care. 2017 Jun 22;21(1):157. doi: 10.1186/s13054-017-1744-8.


Resting limb muscle perfusion during inspiratory muscle loading in hypoxia and normoxia.

Klenze H, Köhler TC, Farquharson F, Walterspacher S, Duerschmied D, Roecker K, Kabitz HJ, Walker DJ.

Respir Physiol Neurobiol. 2017 Oct;244:1-9. doi: 10.1016/j.resp.2017.06.003. Epub 2017 Jun 15.


Circulating HtrA2 as a novel biomarker for mitochondrial induced cardiomyocyte apoptosis and ischemia-reperfusion injury in ST-segment elevation myocardial infarction.

Hortmann M, Robinson S, Mohr M, Haenel D, Mauler M, Stallmann D, Reinoehl J, Duerschmied D, Peter K, Bode C, Ahrens I.

Int J Cardiol. 2017 Sep 15;243:485-491. doi: 10.1016/j.ijcard.2017.05.088. Epub 2017 May 24.


The mitochondria-targeting peptide elamipretide diminishes circulating HtrA2 in ST-segment elevation myocardial infarction.

Hortmann M, Robinson S, Mohr M, Mauler M, Stallmann D, Reinöhl J, Duerschmied D, Peter K, Carr J, Gibson CM, Bode C, Ahrens I.

Eur Heart J Acute Cardiovasc Care. 2017 May 1:2048872617710789. doi: 10.1177/2048872617710789. [Epub ahead of print]


Impact of Thrombolytic Therapy on the Long-Term Outcome of Intermediate-Risk Pulmonary Embolism.

Konstantinides SV, Vicaut E, Danays T, Becattini C, Bertoletti L, Beyer-Westendorf J, Bouvaist H, Couturaud F, Dellas C, Duerschmied D, Empen K, Ferrari E, Galiè N, Jiménez D, Kostrubiec M, Kozak M, Kupatt C, Lang IM, Lankeit M, Meneveau N, Palazzini M, Pruszczyk P, Rugolotto M, Salvi A, Sanchez O, Schellong S, Sobkowicz B, Meyer G.

J Am Coll Cardiol. 2017 Mar 28;69(12):1536-1544. doi: 10.1016/j.jacc.2016.12.039.


Rescue of Cytokine Storm Due to HLH by Hemoadsorption in a CTLA4-Deficient Patient.

Greil C, Roether F, La Rosée P, Grimbacher B, Duerschmied D, Warnatz K.

J Clin Immunol. 2017 Apr;37(3):273-276. doi: 10.1007/s10875-017-0377-7. Epub 2017 Mar 6. No abstract available.


[Erratum to: Transcatheter aortic valve implantation and internal carotid artery stenting in a 74-year-old female patient].

Schmidt K, Pottgießer T, Meckel S, Duerschmied D, Bode C, Reinöhl J.

Internist (Berl). 2016 Dec;57(12):1253. doi: 10.1007/s00108-016-0134-7. German. No abstract available.


[Transcatheter aortic valve implantation and internal carotid artery stenting in a 74-year-old female patient].

Schmidt K, Pottgießer T, Meckel S, Duerschmied D, Bode C, Reinöhl J.

Internist (Berl). 2016 Dec;57(12):1235-1242. doi: 10.1007/s00108-016-0106-y. German. Erratum in: Internist (Berl). 2016 Dec;57(12 ):1253.


Acute exposure to air pollution particulate matter aggravates experimental myocardial infarction in mice by potentiating cytokine secretion from lung macrophages.

Marchini T, Wolf D, Michel NA, Mauler M, Dufner B, Hoppe N, Beckert J, Jäckel M, Magnani N, Duerschmied D, Tasat D, Alvarez S, Reinöhl J, von Zur Muhlen C, Idzko M, Bode C, Hilgendorf I, Evelson P, Zirlik A.

Basic Res Cardiol. 2016 Jul;111(4):44. doi: 10.1007/s00395-016-0562-5. Epub 2016 May 30.


Hsp70 preventing thrombosis: benefit without burden?

Duerschmied D, Bode C.

Cardiovasc Res. 2016 Jun 1;110(3):291-2. doi: 10.1093/cvr/cvw077. Epub 2016 Apr 20. No abstract available.


Home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban. Rationale and design of the HoT-PE Trial.

Barco S, Lankeit M, Binder H, Schellong S, Christ M, Beyer-Westendorf J, Duerschmied D, Bauersachs R, Empen K, Held M, Schwaiblmair M, Fonseca C, Jiménez D, Becattini C, Quitzau K, Konstantinides S.

Thromb Haemost. 2016 Jul 4;116(1):191-7. doi: 10.1160/TH16-01-0004. Epub 2016 Mar 24.


Diaphragmatic fatigue during inspiratory muscle loading in normoxia and hypoxia.

Walker DJ, Farquharson F, Klenze H, Walterspacher S, Storz L, Duerschmied D, Roecker K, Kabitz HJ.

Respir Physiol Neurobiol. 2016 Jun 15;227:1-8. doi: 10.1016/j.resp.2016.01.006. Epub 2016 Feb 1.


Platelet-neutrophil complex formation-a detailed in vitro analysis of murine and human blood samples.

Mauler M, Seyfert J, Haenel D, Seeba H, Guenther J, Stallmann D, Schoenichen C, Hilgendorf I, Bode C, Ahrens I, Duerschmied D.

J Leukoc Biol. 2016 May;99(5):781-9. doi: 10.1189/jlb.3TA0315-082R. Epub 2015 Nov 17.


Correction: Acute Fluoxetine Treatment Induces Slow Rolling of Leukocytes on Endothelium in Mice.

Herr N, Mauler M, Witsch T, Stallmann D, Schmitt S, Mezger J, Bode C, Duerschmied D.

PLoS One. 2015 Nov 6;10(11):e0142762. doi: 10.1371/journal.pone.0142762. eCollection 2015. No abstract available.


Clinical potential of vorapaxar in cardiovascular risk reduction in patients with atherosclerosis.

Diehl P, Bode C, Duerschmied D.

Ther Clin Risk Manag. 2015 Aug 3;11:1133-8. doi: 10.2147/TCRM.S55469. eCollection 2015. Review.


Intravital Microscopy of Leukocyte-endothelial and Platelet-leukocyte Interactions in Mesenterial Veins in Mice.

Herr N, Mauler M, Bode C, Duerschmied D.

J Vis Exp. 2015 Aug 13;(102):e53077. doi: 10.3791/53077.


HMGB1 binds to activated platelets via the receptor for advanced glycation end products and is present in platelet rich human coronary artery thrombi.

Ahrens I, Chen YC, Topcic D, Bode M, Haenel D, Hagemeyer CE, Seeba H, Duerschmied D, Bassler N, Jandeleit-Dahm KA, Sweet MJ, Agrotis A, Bobik A, Peter K.

Thromb Haemost. 2015 Nov;114(5):994-1003. doi: 10.1160/TH14-12-1073. Epub 2015 Jul 23.


Platelet serotonin modulates immune functions.

Mauler M, Bode C, Duerschmied D.

Hamostaseologie. 2016;36(1):11-6. doi: 10.5482/HAMO-14-11-0073. Epub 2015 Feb 19. Review.


Immune functions of platelets.

Duerschmied D, Bode C, Ahrens I.

Thromb Haemost. 2014 Oct;112(4):678-91. doi: 10.1160/TH14-02-0146. Epub 2014 Sep 11. Review.


Dual-contrast molecular imaging allows noninvasive characterization of myocardial ischemia/reperfusion injury after coronary vessel occlusion in mice by magnetic resonance imaging.

von Elverfeldt D, Maier A, Duerschmied D, Braig M, Witsch T, Wang X, Mauler M, Neudorfer I, Menza M, Idzko M, Zirlik A, Heidt T, Bronsert P, Bode C, Peter K, von Zur Muhlen C.

Circulation. 2014 Aug 19;130(8):676-87. doi: 10.1161/CIRCULATIONAHA.113.008157. Epub 2014 Jun 20.


Acute fluoxetine treatment induces slow rolling of leukocytes on endothelium in mice.

Herr N, Mauler M, Witsch T, Stallmann D, Schmitt S, Mezger J, Bode C, Duerschmied D.

PLoS One. 2014 Feb 10;9(2):e88316. doi: 10.1371/journal.pone.0088316. eCollection 2014. Erratum in: PLoS One. 2015;10(11):e0142762.


A novel hollow and perforated flexible wire allows the safe and effective local application of thrombolytic therapy in a mouse model of deep vein thrombosis.

Witsch T, Mauler M, Herr N, Stallmann D, Bode C, Hehrlein C, Duerschmied D.

J Thromb Thrombolysis. 2014 May;37(4):450-4. doi: 10.1007/s11239-013-1013-x.


[Prevention of recurrent thromboembolisms: WARFASA (aspirin for the prevention of recurrent venous thromboembolism - the Warfarin and Aspirin Study)].

Duerschmied D, Nitschmann S, Bode C.

Internist (Berl). 2013 Nov;54(11):1393-6. doi: 10.1007/s00108-013-3377-6. German. No abstract available.


Contrast ultrasound for the quantification of deep vein thrombosis in living mice: effects of enoxaparin and P2Y12 receptor inhibition.

Guenther F, Herr N, Mauler M, Witsch T, Roming F, Hein L, Boeynaems JM, Robaye B, Idzko M, Bode C, Von Zur Muhlen C, Duerschmied D.

J Thromb Haemost. 2013 Jun;11(6):1154-62. doi: 10.1111/jth.12206.


Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities.

Suidan GL, Duerschmied D, Dillon GM, Vanderhorst V, Hampton TG, Wong SL, Voorhees JR, Wagner DD.

PLoS One. 2013;8(3):e59032. doi: 10.1371/journal.pone.0059032. Epub 2013 Mar 14. Erratum in: PLoS One. 2013;8(8). doi:10.1371/annotation/49097405-57c1-4923-875a-9216de91d230.


Production of serotonin by tryptophan hydroxylase 1 and release via platelets contribute to allergic airway inflammation.

Dürk T, Duerschmied D, Müller T, Grimm M, Reuter S, Vieira RP, Ayata K, Cicko S, Sorichter S, Walther DJ, Virchow JC, Taube C, Idzko M.

Am J Respir Crit Care Med. 2013 Mar 1;187(5):476-85. doi: 10.1164/rccm.201208-1440OC. Epub 2013 Jan 17.


Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice.

Duerschmied D, Suidan GL, Demers M, Herr N, Carbo C, Brill A, Cifuni SM, Mauler M, Cicko S, Bader M, Idzko M, Bode C, Wagner DD.

Blood. 2013 Feb 7;121(6):1008-15. doi: 10.1182/blood-2012-06-437392. Epub 2012 Dec 12.


Vorapaxar expands antiplatelet options. Which patients may benefit from thrombin receptor antagonism?

Duerschmied D, Bode C.

Hamostaseologie. 2012;32(3):221-7. doi: 10.5482/HAMO-12-05-0006. Epub 2012 Jul 10.


Serotonin antagonism improves platelet inhibition in clopidogrel low-responders after coronary stent placement: an in vitro pilot study.

Duerschmied D, Ahrens I, Mauler M, Brandt C, Weidner S, Bode C, Moser M.

PLoS One. 2012;7(2):e32656. doi: 10.1371/journal.pone.0032656. Epub 2012 Feb 27.


ARC15105 is a potent antagonist of von Willebrand factor mediated platelet activation and adhesion.

Siller-Matula JM, Merhi Y, Tanguay JF, Duerschmied D, Wagner DD, McGinness KE, Pendergrast PS, Chung JK, Tian X, Schaub RG, Jilma B.

Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):902-9. doi: 10.1161/ATVBAHA.111.237529. Epub 2012 Jan 26.


Vorapaxar expands antiplatelet options.

Duerschmied D, Bode C.

Hamostaseologie. 2012;32(3):221-227. doi: 10.5482/HAMO-12-05-0006. Epub 2017 Dec 28.


Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice.

Wolf D, Hohmann JD, Wiedemann A, Bledzka K, Blankenbach H, Marchini T, Gutte K, Zeschky K, Bassler N, Hoppe N, Rodriguez AO, Herr N, Hilgendorf I, Stachon P, Willecke F, Duerschmied D, von zur Muhlen C, Soloviev DA, Zhang L, Bode C, Plow EF, Libby P, Peter K, Zirlik A.

Circ Res. 2011 Nov 11;109(11):1269-79. doi: 10.1161/CIRCRESAHA.111.247684. Epub 2011 Oct 13.


BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium.

Helbing T, Rothweiler R, Ketterer E, Goetz L, Heinke J, Grundmann S, Duerschmied D, Patterson C, Bode C, Moser M.

Blood. 2011 Nov 3;118(18):5040-9. doi: 10.1182/blood-2011-03-339762. Epub 2011 Sep 7.


Molecular magnetic resonance imaging allows the detection of activated platelets in a new mouse model of coronary artery thrombosis.

Duerschmied D, Meißner M, Peter K, Neudorfer I, Roming F, Zirlik A, Bode C, von Elverfeldt D, von Zur Muhlen C.

Invest Radiol. 2011 Oct;46(10):618-23. doi: 10.1097/RLI.0b013e31821e62fb.


Success of arterial revascularization determined by contrast ultrasound muscle perfusion imaging.

Duerschmied D, Maletzki P, Freund G, Olschewski M, Bode C, Hehrlein C.

J Vasc Surg. 2010 Dec;52(6):1531-6. doi: 10.1016/j.jvs.2010.07.010. Epub 2010 Sep 16.

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