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Items: 1 to 50 of 71


Cold parenting is associated with cellular aging in offspring: A retrospective study.

Knutsen R, Filippov V, Knutsen SF, Fraser GE, Lloren J, Juma D, Duerksen-Hughes P.

Biol Psychol. 2019 Jul;145:142-149. doi: 10.1016/j.biopsycho.2019.03.013. Epub 2019 Apr 20.


Approaches and Methods to Measure Oxidative Stress in Clinical Samples: Research Applications in the Cancer Field.

Katerji M, Filippova M, Duerksen-Hughes P.

Oxid Med Cell Longev. 2019 Mar 12;2019:1279250. doi: 10.1155/2019/1279250. eCollection 2019. Review.


Cancer stem cell self-renewal as a therapeutic target in human oral cancer.

Hu J, Mirshahidi S, Simental A, Lee SC, De Andrade Filho PA, Peterson NR, Duerksen-Hughes P, Yuan X.

Oncogene. 2019 Jul;38(27):5440-5456. doi: 10.1038/s41388-019-0800-z. Epub 2019 Apr 1.


Subpopulations of cancer stem cells found in papillary thyroid carcinoma.

Mirshahidi S, Simental A, Lee SC, De Andrade Filho PA, Peterson NR, Cao W, Necochea-Campion R, Yang H, Duerksen-Hughes P, Yuan X.

Exp Cell Res. 2018 Jan 15;362(2):515-524. doi: 10.1016/j.yexcr.2017.12.017. Epub 2017 Dec 21.


Overexpression of HPV16 E6* Alters β-Integrin and Mitochondrial Dysfunction Pathways in Cervical Cancer Cells.

Evans W, Filippova M, Filippov V, Bashkirova S, Zhang G, Reeves ME, Duerksen-Hughes P.

Cancer Genomics Proteomics. 2016 Jul-Aug;13(4):259-73.


Association between markers of glucose metabolism and risk of colorectal cancer.

Xu J, Ye Y, Wu H, Duerksen-Hughes P, Zhang H, Li P, Huang J, Yang J, Wu Y, Xia D.

BMJ Open. 2016 Jun 27;6(6):e011430. doi: 10.1136/bmjopen-2016-011430. Review.


Chronic oxidative stress increases the integration frequency of foreign DNA and human papillomavirus 16 in human keratinocytes.

Chen Wongworawat Y, Filippova M, Williams VM, Filippov V, Duerksen-Hughes PJ.

Am J Cancer Res. 2016 Mar 15;6(4):764-80. eCollection 2016.


Flavonol and imidazole derivatives block HPV16 E6 activities and reactivate apoptotic pathways in HPV⁺ cells.

Yuan CH, Filippova M, Krstenansky JL, Duerksen-Hughes PJ.

Cell Death Dis. 2016 Jan 21;7:2060. doi: 10.1038/cddis.2015.391.


Recent Progress in Therapeutic Treatments and Screening Strategies for the Prevention and Treatment of HPV-Associated Head and Neck Cancer.

Whang SN, Filippova M, Duerksen-Hughes P.

Viruses. 2015 Sep 17;7(9):5040-65. doi: 10.3390/v7092860. Review.


Selenium Attenuates HPV-18 Associated Apoptosis in Embryo-Derived Trophoblastic Cells but Not Inner Cell Mass In Vitro.

Tolen JA, Duerksen-Hughes P, Lau K, Chan PJ.

Int J Reprod Med. 2015;2015:562567. doi: 10.1155/2015/562567. Epub 2015 Aug 4.


Combined ultrasound-curcumin treatment of human cervical cancer cells.

Carr KR, Ioffe YJ, Filippova M, Duerksen-Hughes P, Chan PJ.

Eur J Obstet Gynecol Reprod Biol. 2015 Oct;193:96-101. doi: 10.1016/j.ejogrb.2015.07.011. Epub 2015 Aug 1.


Cellular levels of oxidative stress affect the response of cervical cancer cells to chemotherapeutic agents.

Filippova M, Filippov V, Williams VM, Zhang K, Kokoza A, Bashkirova S, Duerksen-Hughes P.

Biomed Res Int. 2014;2014:574659. doi: 10.1155/2014/574659. Epub 2014 Nov 16.


Viral carcinogenesis: factors inducing DNA damage and virus integration.

Chen Y, Williams V, Filippova M, Filippov V, Duerksen-Hughes P.

Cancers (Basel). 2014 Oct 22;6(4):2155-86. doi: 10.3390/cancers6042155. Review.


Paraspeckle protein 1 (PSPC1) is involved in the cisplatin induced DNA damage response--role in G1/S checkpoint.

Gao X, Kong L, Lu X, Zhang G, Chi L, Jiang Y, Wu Y, Yan C, Duerksen-Hughes P, Zhu X, Yang J.

PLoS One. 2014 May 12;9(5):e97174. doi: 10.1371/journal.pone.0097174. eCollection 2014.


Linifanib (ABT-869), enhances cytotoxicity with poly (ADP-ribose) polymerase inhibitor, veliparib (ABT-888), in head and neck carcinoma cells.

Hsu HW, de Necochea-Campion R, Williams V, Duerksen-Hughes PJ, Simental AA Jr, Ferris RL, Chen CS, Mirshahidi S.

Oral Oncol. 2014 Jul;50(7):662-9. doi: 10.1016/j.oraloncology.2014.03.006. Epub 2014 Apr 13.


Human papillomavirus type 16 E6* induces oxidative stress and DNA damage.

Williams VM, Filippova M, Filippov V, Payne KJ, Duerksen-Hughes P.

J Virol. 2014 Jun;88(12):6751-61. doi: 10.1128/JVI.03355-13. Epub 2014 Apr 2.


A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages.

Yu Y, Fuscoe JC, Zhao C, Guo C, Jia M, Qing T, Bannon DI, Lancashire L, Bao W, Du T, Luo H, Su Z, Jones WD, Moland CL, Branham WS, Qian F, Ning B, Li Y, Hong H, Guo L, Mei N, Shi T, Wang KY, Wolfinger RD, Nikolsky Y, Walker SJ, Duerksen-Hughes P, Mason CE, Tong W, Thierry-Mieg J, Thierry-Mieg D, Shi L, Wang C.

Nat Commun. 2014;5:3230. doi: 10.1038/ncomms4230.


The small splice variant of HPV16 E6, E6, reduces tumor formation in cervical carcinoma xenografts.

Filippova M, Evans W, Aragon R, Filippov V, Williams VM, Hong L, Reeves ME, Duerksen-Hughes P.

Virology. 2014 Feb;450-451:153-164. doi: 10.1016/j.virol.2013.12.011. Epub 2014 Jan 1.


Proteomic analysis of cellular response induced by multi-walled carbon nanotubes exposure in A549 cells.

Ju L, Zhang G, Zhang X, Jia Z, Gao X, Jiang Y, Yan C, Duerksen-Hughes PJ, Chen FF, Li H, Zhu X, Yang J.

PLoS One. 2014 Jan 14;9(1):e84974. doi: 10.1371/journal.pone.0084974. eCollection 2014.


Quantum dot-related genotoxicity perturbation can be attenuated by PEG encapsulation.

Ju L, Zhang G, Zhang C, Sun L, Jiang Y, Yan C, Duerksen-Hughes PJ, Zhang X, Zhu X, Chen FF, Yang J.

Mutat Res. 2013 Apr 30;753(1):54-64. doi: 10.1016/j.mrgentox.2013.01.006. Epub 2013 Feb 13.


Modulation of apoptotic pathways by human papillomaviruses (HPV): mechanisms and implications for therapy.

Yuan CH, Filippova M, Duerksen-Hughes P.

Viruses. 2012 Dec 18;4(12):3831-50. doi: 10.3390/v4123831. Review.


Effects of benzo(a)pyrene on the contractile function of the thoracic aorta of Sprague-Dawley rats.

Gan TE, Xiao SP, Jiang Y, Hu H, Wu YH, Duerksen-Hughes PJ, Sheng JZ, Yang J.

Biomed Environ Sci. 2012 Oct;25(5):549-56. doi: 10.3967/0895-3988.2012.05.008.


Methyl methanesulfonate induces apoptosis in p53-deficient H1299 and Hep3B cells through a caspase 2- and mitochondria-associated pathway.

Jiang Y, Zhang XY, Sun L, Zhang GL, Duerksen-Hughes P, Zhu XQ, Yang J.

Environ Toxicol Pharmacol. 2012 Nov;34(3):694-704. doi: 10.1016/j.etap.2012.09.019. Epub 2012 Oct 8.


Interleukin 24: mechanisms and therapeutic potential of an anti-cancer gene.

Whitaker EL, Filippov VA, Duerksen-Hughes PJ.

Cytokine Growth Factor Rev. 2012 Dec;23(6):323-31. doi: 10.1016/j.cytogfr.2012.08.004. Epub 2012 Sep 14. Review.


Cisplatin treatment leads to changes in nuclear protein and microRNA expression.

Zhang G, Sun L, Lu X, Chen Z, Duerksen-Hughes PJ, Hu H, Zhu X, Yang J.

Mutat Res. 2012 Jul 4;746(1):66-77. doi: 10.1016/j.mrgentox.2012.03.004. Epub 2012 Mar 28.


DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells.

Haynes TA, Filippov V, Filippova M, Yang J, Zhang K, Duerksen-Hughes PJ.

Biochim Biophys Acta. 2012 Jul;1821(7):943-53. doi: 10.1016/j.bbalip.2012.02.002. Epub 2012 Feb 11.


Small molecule inhibitors of the HPV16-E6 interaction with caspase 8.

Yuan CH, Filippova M, Tungteakkhun SS, Duerksen-Hughes PJ, Krstenansky JL.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):2125-9. doi: 10.1016/j.bmcl.2011.12.145. Epub 2012 Jan 10.


Increased ceramide in brains with Alzheimer's and other neurodegenerative diseases.

Filippov V, Song MA, Zhang K, Vinters HV, Tung S, Kirsch WM, Yang J, Duerksen-Hughes PJ.

J Alzheimers Dis. 2012;29(3):537-47. doi: 10.3233/JAD-2011-111202.


Nuclear proteome analysis of benzo(a)pyrene-treated HeLa cells.

Yan C, Chen Z, Li H, Zhang G, Li F, Duerksen-Hughes PJ, Zhu X, Yang J.

Mutat Res. 2012 Mar 1;731(1-2):75-84. doi: 10.1016/j.mrfmmm.2011.11.007. Epub 2011 Nov 25.


Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells.

Whitaker EL, Filippov V, Filippova M, Guerrero-Juarez CF, Duerksen-Hughes PJ.

Cytokine. 2011 Nov;56(2):272-81. doi: 10.1016/j.cyto.2011.07.020. Epub 2011 Aug 16.


Mass spectrometric studies on epigenetic interaction networks in cell differentiation.

Xiong L, Darwanto A, Sharma S, Herring J, Hu S, Filippova M, Filippov V, Wang Y, Chen CS, Duerksen-Hughes PJ, Sowers LC, Zhang K.

J Biol Chem. 2011 Apr 15;286(15):13657-68. doi: 10.1074/jbc.M110.204800. Epub 2011 Feb 18.


HPV-DNA integration and carcinogenesis: putative roles for inflammation and oxidative stress.

Williams VM, Filippova M, Soto U, Duerksen-Hughes PJ.

Future Virol. 2011 Jan 1;6(1):45-57.


Long-term, progressive, aerobic training increases adiponectin in middle-aged, overweight, untrained males and females.

Mujumdar PP, Duerksen-Hughes PJ, Firek AF, Hessinger DA.

Scand J Clin Lab Invest. 2011 Apr;71(2):101-7. doi: 10.3109/00365513.2011.554995. Epub 2011 Jan 27.


Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK.

Yan C, Lu J, Zhang G, Gan T, Zeng Q, Shao Z, Duerksen-Hughes PJ, Yang J.

Toxicol In Vitro. 2011 Feb;25(1):91-9. doi: 10.1016/j.tiv.2010.09.012. Epub 2010 Oct 1.


Nuclear proteome analysis of cisplatin-treated HeLa cells.

Wu W, Yan C, Gan T, Chen Z, Lu X, Duerksen-Hughes PJ, Zhu X, Yang J.

Mutat Res. 2010 Sep 10;691(1-2):1-8. doi: 10.1016/j.mrfmmm.2010.06.002. Epub 2010 Jun 9.


Benzo[a]pyrene treatment leads to changes in nuclear protein expression and alternative splicing.

Yan C, Wu W, Li H, Zhang G, Duerksen-Hughes PJ, Zhu X, Yang J.

Mutat Res. 2010 Apr 1;686(1-2):47-56. doi: 10.1016/j.mrfmmm.2010.01.015. Epub 2010 Jan 25.


The full-length isoform of human papillomavirus 16 E6 and its splice variant E6* bind to different sites on the procaspase 8 death effector domain.

Tungteakkhun SS, Filippova M, Fodor N, Duerksen-Hughes PJ.

J Virol. 2010 Feb;84(3):1453-63. doi: 10.1128/JVI.01331-09. Epub 2009 Nov 11.


Complexes of human papillomavirus type 16 E6 proteins form pseudo-death-inducing signaling complex structures during tumor necrosis factor-mediated apoptosis.

Filippova M, Filippov VA, Kagoda M, Garnett T, Fodor N, Duerksen-Hughes PJ.

J Virol. 2009 Jan;83(1):210-27. doi: 10.1128/JVI.01365-08. Epub 2008 Oct 8.


The interaction between human papillomavirus type 16 and FADD is mediated by a novel E6 binding domain.

Tungteakkhun SS, Filippova M, Neidigh JW, Fodor N, Duerksen-Hughes PJ.

J Virol. 2008 Oct;82(19):9600-14. doi: 10.1128/JVI.00538-08. Epub 2008 Jul 16.


Splicing and splice factor SRp55 participate in the response to DNA damage by changing isoform ratios of target genes.

Filippov V, Schmidt EL, Filippova M, Duerksen-Hughes PJ.

Gene. 2008 Aug 15;420(1):34-41. doi: 10.1016/j.gene.2008.05.008. Epub 2008 May 23.


C18 ceramide analysis in mammalian cells employing reversed-phase high-performance liquid chromatography tandem mass spectrometry.

Haynes TA, Duerksen-Hughes PJ, Filippova M, Filippov V, Zhang K.

Anal Biochem. 2008 Jul 1;378(1):80-6. doi: 10.1016/j.ab.2008.03.045. Epub 2008 Mar 29.


Cellular binding partners of the human papillomavirus E6 protein.

Tungteakkhun SS, Duerksen-Hughes PJ.

Arch Virol. 2008;153(3):397-408. doi: 10.1007/s00705-007-0022-5. Epub 2008 Jan 3. Review.


Bid is cleaved upstream of caspase-8 activation during TRAIL-mediated apoptosis in human osteosarcoma cells.

Garnett TO, Filippova M, Duerksen-Hughes PJ.

Apoptosis. 2007 Jul;12(7):1299-315.


The large and small isoforms of human papillomavirus type 16 E6 bind to and differentially affect procaspase 8 stability and activity.

Filippova M, Johnson MM, Bautista M, Filippov V, Fodor N, Tungteakkhun SS, Williams K, Duerksen-Hughes PJ.

J Virol. 2007 Apr;81(8):4116-29. Epub 2007 Jan 31.


Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.

Garnett TO, Duerksen-Hughes PJ.

Arch Virol. 2006 Dec;151(12):2321-35. Epub 2006 Jul 27. Review.


Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis.

Garnett TO, Filippova M, Duerksen-Hughes PJ.

Cell Death Differ. 2006 Nov;13(11):1915-26. Epub 2006 Mar 10.


The human papillomavirus 16 E6 protein can either protect or further sensitize cells to TNF: effect of dose.

Filippova M, Brown-Bryan TA, Casiano CA, Duerksen-Hughes PJ.

Cell Death Differ. 2005 Dec;12(12):1622-35. Epub 2005 Jun 3.


Ceramide and other sphingolipids in cellular responses.

Yang J, Yu Y, Sun S, Duerksen-Hughes PJ.

Cell Biochem Biophys. 2004;40(3):323-50. Review.


The human papillomavirus 16 E6 protein binds to Fas-associated death domain and protects cells from Fas-triggered apoptosis.

Filippova M, Parkhurst L, Duerksen-Hughes PJ.

J Biol Chem. 2004 Jun 11;279(24):25729-44. Epub 2004 Apr 8.

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