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Items: 31


Sfp1 links TORC1 and cell growth regulation to the yeast SAGA-complex component Tra1 in response to polyQ proteotoxicity.

Jiang Y, Berg MD, Genereaux J, Ahmed K, Duennwald ML, Brandl CJ, Lajoie P.

Traffic. 2019 Apr;20(4):267-283. doi: 10.1111/tra.12637.


A subset of calcium-binding S100 proteins show preferential heterodimerization.

Spratt DE, Barber KR, Marlatt NM, Ngo V, Macklin JA, Xiao Y, Konermann L, Duennwald ML, Shaw GS.

FEBS J. 2019 May;286(10):1859-1876. doi: 10.1111/febs.14775. Epub 2019 Feb 21.


RNA surveillance by uridylation-dependent RNA decay in Schizosaccharomyces pombe.

Chung CZ, Jaramillo JE, Ellis MJ, Bour DYN, Seidl LE, Jo DHS, Turk MA, Mann MR, Bi Y, Haniford DB, Duennwald ML, Heinemann IU.

Nucleic Acids Res. 2019 Apr 8;47(6):3045-3057. doi: 10.1093/nar/gkz043.


Effect of Fluorescent Proteins on Fusion Partners Using Polyglutamine Toxicity Assays in Yeast.

Jiang Y, Di Gregorio S, Albakri MB, Duennwald ML, Lajoie P.

J Vis Exp. 2018 Nov 28;(141). doi: 10.3791/58748.


ALS Yeast Models-Past Success Stories and New Opportunities.

Di Gregorio SE, Duennwald ML.

Front Mol Neurosci. 2018 Oct 30;11:394. doi: 10.3389/fnmol.2018.00394. eCollection 2018. Review.


Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species.

Zhao Y, Zurawel AA, Jenkins NP, Duennwald ML, Cheng C, Kettenbach AN, Supattapone S.

Sci Rep. 2018 Jun 22;8(1):9554. doi: 10.1038/s41598-018-27900-5.


Yeast as a model to study protein misfolding in aged cells.

Di Gregorio SE, Duennwald ML.

FEMS Yeast Res. 2018 Sep 1;18(6). doi: 10.1093/femsyr/foy054. Review.


Visualizing tRNA-dependent mistranslation in human cells.

Lant JT, Berg MD, Sze DHW, Hoffman KS, Akinpelu IC, Turk MA, Heinemann IU, Duennwald ML, Brandl CJ, O'Donoghue P.

RNA Biol. 2018;15(4-5):567-575. doi: 10.1080/15476286.2017.1379645. Epub 2017 Nov 9.


The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases.

Lackie RE, Maciejewski A, Ostapchenko VG, Marques-Lopes J, Choy WY, Duennwald ML, Prado VF, Prado MAM.

Front Neurosci. 2017 May 16;11:254. doi: 10.3389/fnins.2017.00254. eCollection 2017. Review.


Candida albicans Is Resistant to Polyglutamine Aggregation and Toxicity.

Leach MD, Kim T, DiGregorio SE, Collins C, Zhang Z, Duennwald ML, Cowen LE.

G3 (Bethesda). 2017 Jan 5;7(1):95-108. doi: 10.1534/g3.116.035675.


Polyglutamine toxicity in yeast uncovers phenotypic variations between different fluorescent protein fusions.

Jiang Y, Di Gregorio SE, Duennwald ML, Lajoie P.

Traffic. 2017 Jan;18(1):58-70. doi: 10.1111/tra.12453. Epub 2016 Nov 1.


CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine Proteins.

Zurawel AA, Kabeche R, DiGregorio SE, Deng L, Menon KM, Opalko H, Duennwald ML, Moseley JB, Supattapone S.

MBio. 2016 Sep 27;7(5). pii: e01367-16. doi: 10.1128/mBio.01367-16.


Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response.

Hoffman KS, Duennwald ML, Karagiannis J, Genereaux J, McCarton AS, Brandl CJ.

G3 (Bethesda). 2016 Jun 1;6(6):1649-59. doi: 10.1534/g3.116.029520.


A Toolbox for Rapid Quantitative Assessment of Chronological Lifespan and Survival in Saccharomyces cerevisiae.

Chadwick SR, Pananos AD, Di Gregorio SE, Park AE, Etedali-Zadeh P, Duennwald ML, Lajoie P.

Traffic. 2016 Jun;17(6):689-703. doi: 10.1111/tra.12391. Epub 2016 Apr 1.


Cellular stress responses in protein misfolding diseases.

Duennwald ML.

Future Sci OA. 2015 Sep 1;1(2):FSO42. doi: 10.4155/fso.15.42. eCollection 2015 Sep. Review.


Yeast as a platform to explore polyglutamine toxicity and aggregation.

Duennwald ML.

Methods Mol Biol. 2013;1017:153-61. doi: 10.1007/978-1-62703-438-8_11. Review.


Poly-glutamine expanded huntingtin dramatically alters the genome wide binding of HSF1.

Riva L, Koeva M, Yildirim F, Pirhaji L, Dinesh D, Mazor T, Duennwald ML, Fraenkel E.

J Huntingtons Dis. 2012;1(1):33-45.


Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans.

Duennwald ML, Echeverria A, Shorter J.

PLoS Biol. 2012;10(6):e1001346. doi: 10.1371/journal.pbio.1001346. Epub 2012 Jun 19.


Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation.

Chafekar SM, Wisén S, Thompson AD, Echeverria A, Walter GM, Evans CG, Makley LN, Gestwicki JE, Duennwald ML.

ACS Chem Biol. 2012 Sep 21;7(9):1556-64. Epub 2012 Jun 22.


Impaired heat shock response in cells expressing full-length polyglutamine-expanded huntingtin.

Chafekar SM, Duennwald ML.

PLoS One. 2012;7(5):e37929. doi: 10.1371/journal.pone.0037929. Epub 2012 May 23.


Growth assays to assess polyglutamine toxicity in yeast.

Duennwald ML.

J Vis Exp. 2012 Mar 5;(61):e3461. doi: 10.3791/3461.


Polyglutamine misfolding in yeast: toxic and protective aggregation.

Duennwald ML.

Prion. 2011 Oct-Dec;5(4):285-90. doi: 10.4161/pri.18071. Epub 2011 Oct 1. Review.


Ordered assembly of heat shock proteins, Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revealed by chemical probes.

Walter GM, Smith MC, Wisén S, Basrur V, Elenitoba-Johnson KS, Duennwald ML, Kumar A, Gestwicki JE.

J Biol Chem. 2011 Nov 25;286(47):40486-93. doi: 10.1074/jbc.M111.284448. Epub 2011 Oct 3.


Monitoring polyglutamine toxicity in yeast.

Duennwald ML.

Methods. 2011 Mar;53(3):232-7. doi: 10.1016/j.ymeth.2010.12.001. Epub 2010 Dec 6.


Countering amyloid polymorphism and drug resistance with minimal drug cocktails.

Duennwald ML, Shorter J.

Prion. 2010 Oct-Dec;4(4):244-51. Epub 2010 Oct 12.


A synergistic small-molecule combination directly eradicates diverse prion strain structures.

Roberts BE, Duennwald ML, Wang H, Chung C, Lopreiato NP, Sweeny EA, Knight MN, Shorter J.

Nat Chem Biol. 2009 Dec;5(12):936-46. doi: 10.1038/nchembio.246. Epub 2009 Nov 1.


Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity.

Duennwald ML, Lindquist S.

Genes Dev. 2008 Dec 1;22(23):3308-19. doi: 10.1101/gad.1673408. Epub 2008 Nov 17.


Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs.

Wang H, Duennwald ML, Roberts BE, Rozeboom LM, Zhang YL, Steele AD, Krishnan R, Su LJ, Griffin D, Mukhopadhyay S, Hennessy EJ, Weigele P, Blanchard BJ, King J, Deniz AA, Buchwald SL, Ingram VM, Lindquist S, Shorter J.

Proc Natl Acad Sci U S A. 2008 May 20;105(20):7159-64. doi: 10.1073/pnas.0801934105. Epub 2008 May 14.


Chaperone-dependent amyloid assembly protects cells from prion toxicity.

Douglas PM, Treusch S, Ren HY, Halfmann R, Duennwald ML, Lindquist S, Cyr DM.

Proc Natl Acad Sci U S A. 2008 May 20;105(20):7206-11. doi: 10.1073/pnas.0802593105. Epub 2008 May 14.


Flanking sequences profoundly alter polyglutamine toxicity in yeast.

Duennwald ML, Jagadish S, Muchowski PJ, Lindquist S.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):11045-50. Epub 2006 Jul 10.


A network of protein interactions determines polyglutamine toxicity.

Duennwald ML, Jagadish S, Giorgini F, Muchowski PJ, Lindquist S.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):11051-6. Epub 2006 Jul 10.

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