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Items: 1 to 50 of 127

1.

Isolevuglandin scavenger attenuates pressure overload-induced cardiac oxidative stress, cardiac hypertrophy, heart failure and lung remodeling.

Shang L, Weng X, Wang D, Yue W, Mernaugh R, Amarnath V, Weir EK, Dudley SC, Xu Y, Hou M, Chen Y.

Free Radic Biol Med. 2019 Sep;141:291-298. doi: 10.1016/j.freeradbiomed.2019.06.029. Epub 2019 Jun 26.

PMID:
31254620
2.

Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy.

Yue W, Tong L, Liu X, Weng X, Chen X, Wang D, Dudley SC, Weir EK, Ding W, Lu Z, Xu Y, Chen Y.

Redox Biol. 2019 Apr;22:101161. doi: 10.1016/j.redox.2019.101161. Epub 2019 Mar 6.

3.

Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function.

Liu M, Jeong EM, Liu H, Xie A, So EY, Shi G, Jeong GE, Zhou A, Dudley SC Jr.

JCI Insight. 2019 Jan 10;4(1). pii: 123182. doi: 10.1172/jci.insight.123182. [Epub ahead of print]

4.

The role of the unfolded protein response in arrhythmias.

Liu M, Dudley SC Jr.

Channels (Austin). 2018;12(1):335-345. doi: 10.1080/19336950.2018.1516985. Review.

PMID:
30165782
5.

Functional cardiac Na+ channels are expressed in human melanoma cells.

Xie A, Gallant B, Guo H, Gonzalez A, Clark M, Madigan A, Feng F, Chen HD, Cui Y, Dudley SC Jr, Wan Y.

Oncol Lett. 2018 Aug;16(2):1689-1695. doi: 10.3892/ol.2018.8865. Epub 2018 May 31.

6.

Mitochondrial Ca2+ flux modulates spontaneous electrical activity in ventricular cardiomyocytes.

Xie A, Zhou A, Liu H, Shi G, Liu M, Boheler KR, Dudley SC Jr.

PLoS One. 2018 Jul 12;13(7):e0200448. doi: 10.1371/journal.pone.0200448. eCollection 2018.

7.

Multi-ethnic genome-wide association study for atrial fibrillation.

Roselli C, Chaffin MD, Weng LC, Aeschbacher S, Ahlberg G, Albert CM, Almgren P, Alonso A, Anderson CD, Aragam KG, Arking DE, Barnard J, Bartz TM, Benjamin EJ, Bihlmeyer NA, Bis JC, Bloom HL, Boerwinkle E, Bottinger EB, Brody JA, Calkins H, Campbell A, Cappola TP, Carlquist J, Chasman DI, Chen LY, Chen YI, Choi EK, Choi SH, Christophersen IE, Chung MK, Cole JW, Conen D, Cook J, Crijns HJ, Cutler MJ, Damrauer SM, Daniels BR, Darbar D, Delgado G, Denny JC, Dichgans M, Dörr M, Dudink EA, Dudley SC, Esa N, Esko T, Eskola M, Fatkin D, Felix SB, Ford I, Franco OH, Geelhoed B, Grewal RP, Gudnason V, Guo X, Gupta N, Gustafsson S, Gutmann R, Hamsten A, Harris TB, Hayward C, Heckbert SR, Hernesniemi J, Hocking LJ, Hofman A, Horimoto ARVR, Huang J, Huang PL, Huffman J, Ingelsson E, Ipek EG, Ito K, Jimenez-Conde J, Johnson R, Jukema JW, Kääb S, Kähönen M, Kamatani Y, Kane JP, Kastrati A, Kathiresan S, Katschnig-Winter P, Kavousi M, Kessler T, Kietselaer BL, Kirchhof P, Kleber ME, Knight S, Krieger JE, Kubo M, Launer LJ, Laurikka J, Lehtimäki T, Leineweber K, Lemaitre RN, Li M, Lim HE, Lin HJ, Lin H, Lind L, Lindgren CM, Lokki ML, London B, Loos RJF, Low SK, Lu Y, Lyytikäinen LP, Macfarlane PW, Magnusson PK, Mahajan A, Malik R, Mansur AJ, Marcus GM, Margolin L, Margulies KB, März W, McManus DD, Melander O, Mohanty S, Montgomery JA, Morley MP, Morris AP, Müller-Nurasyid M, Natale A, Nazarian S, Neumann B, Newton-Cheh C, Niemeijer MN, Nikus K, Nilsson P, Noordam R, Oellers H, Olesen MS, Orho-Melander M, Padmanabhan S, Pak HN, Paré G, Pedersen NL, Pera J, Pereira A, Porteous D, Psaty BM, Pulit SL, Pullinger CR, Rader DJ, Refsgaard L, Ribasés M, Ridker PM, Rienstra M, Risch L, Roden DM, Rosand J, Rosenberg MA, Rost N, Rotter JI, Saba S, Sandhu RK, Schnabel RB, Schramm K, Schunkert H, Schurman C, Scott SA, Seppälä I, Shaffer C, Shah S, Shalaby AA, Shim J, Shoemaker MB, Siland JE, Sinisalo J, Sinner MF, Slowik A, Smith AV, Smith BH, Smith JG, Smith JD, Smith NL, Soliman EZ, Sotoodehnia N, Stricker BH, Sun A, Sun H, Svendsen JH, Tanaka T, Tanriverdi K, Taylor KD, Teder-Laving M, Teumer A, Thériault S, Trompet S, Tucker NR, Tveit A, Uitterlinden AG, Van Der Harst P, Van Gelder IC, Van Wagoner DR, Verweij N, Vlachopoulou E, Völker U, Wang B, Weeke PE, Weijs B, Weiss R, Weiss S, Wells QS, Wiggins KL, Wong JA, Woo D, Worrall BB, Yang PS, Yao J, Yoneda ZT, Zeller T, Zeng L, Lubitz SA, Lunetta KL, Ellinor PT.

Nat Genet. 2018 Jun 11;50(9):1225-1233. doi: 10.1038/s41588-018-0133-9.

8.

RNA Binding Protein, HuR, Regulates SCN5A Expression Through Stabilizing MEF2C transcription factor mRNA.

Zhou A, Shi G, Kang GJ, Xie A, Liu H, Jiang N, Liu M, Jeong EM, Dudley SC Jr.

J Am Heart Assoc. 2018 Apr 20;7(9). pii: e007802. doi: 10.1161/JAHA.117.007802.

9.

Mitochondrial Ca2+ Influx Contributes to Arrhythmic Risk in Nonischemic Cardiomyopathy.

Xie A, Song Z, Liu H, Zhou A, Shi G, Wang Q, Gu L, Liu M, Xie LH, Qu Z, Dudley SC Jr.

J Am Heart Assoc. 2018 Apr 7;7(8). pii: e007805. doi: 10.1161/JAHA.117.007805.

10.

Activation of the unfolded protein response downregulates cardiac ion channels in human induced pluripotent stem cell-derived cardiomyocytes.

Liu M, Shi G, Zhou A, Rupert CE, Coulombe KLK, Dudley SC Jr.

J Mol Cell Cardiol. 2018 Apr;117:62-71. doi: 10.1016/j.yjmcc.2018.02.011. Epub 2018 Feb 21.

11.

A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality.

Zhang X, Yoon JY, Morley M, McLendon JM, Mapuskar KA, Gutmann R, Mehdi H, Bloom HL, Dudley SC, Ellinor PT, Shalaby AA, Weiss R, Tang WHW, Moravec CS, Singh M, Taylor AL, Yancy CW, Feldman AM, McNamara DM, Irani K, Spitz DR, Breheny P, Margulies KB, London B, Boudreau RL.

J Clin Invest. 2018 Mar 1;128(3):1154-1163. doi: 10.1172/JCI95710. Epub 2018 Feb 19.

12.

HuR-mediated SCN5A messenger RNA stability reduces arrhythmic risk in heart failure.

Zhou A, Xie A, Kim TY, Liu H, Shi G, Kang GJ, Jiang N, Liu M, Jeong EM, Choi BR, Dudley SC Jr.

Heart Rhythm. 2018 Jul;15(7):1072-1080. doi: 10.1016/j.hrthm.2018.02.018. Epub 2018 Feb 16.

13.

Abnormal sodium channel mRNA splicing in hypertrophic cardiomyopathy.

Noyes AM, Zhou A, Gao G, Gu L, Day S, Andrew Wasserstrom J, Dudley SC.

Int J Cardiol. 2017 Dec 15;249:282-286. doi: 10.1016/j.ijcard.2017.08.071. Epub 2017 Sep 7.

14.

Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.

Vang A, Clements RT, Chichger H, Kue N, Allawzi A, O'Connell K, Jeong EM, Dudley SC Jr, Sakhatskyy P, Lu Q, Zhang P, Rounds S, Choudhary G.

Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L748-L759. doi: 10.1152/ajplung.00393.2016. Epub 2017 Mar 3.

15.

SK channel enhancers attenuate Ca2+-dependent arrhythmia in hypertrophic hearts by regulating mito-ROS-dependent oxidation and activity of RyR.

Kim TY, Terentyeva R, Roder KH, Li W, Liu M, Greener I, Hamilton S, Polina I, Murphy KR, Clements RT, Dudley SC Jr, Koren G, Choi BR, Terentyev D.

Cardiovasc Res. 2017 Mar 1;113(3):343-353. doi: 10.1093/cvr/cvx005.

16.

Role of protein kinase C in metabolic regulation of the cardiac Na+ channel.

Liu M, Shi G, Yang KC, Gu L, Kanthasamy AG, Anantharam V, Dudley SC Jr.

Heart Rhythm. 2017 Mar;14(3):440-447. doi: 10.1016/j.hrthm.2016.12.026. Epub 2016 Dec 15.

17.

Associations of Prolonged QTc in Sickle Cell Disease.

Indik JH, Nair V, Rafikov R, Nyotowidjojo IS, Bisla J, Kansal M, Parikh DS, Robinson M, Desai A, Oberoi M, Gupta A, Abbasi T, Khalpey Z, Patel AR, Lang RM, Dudley SC, Choi BR, Garcia JG, Machado RF, Desai AA.

PLoS One. 2016 Oct 13;11(10):e0164526. doi: 10.1371/journal.pone.0164526. eCollection 2016.

18.

Cardiac Sodium Channel Mutations: Why so Many Phenotypes?

Liu M, Yang KC, Dudley SC Jr.

Curr Top Membr. 2016;78:513-59. doi: 10.1016/bs.ctm.2015.12.004. Epub 2016 Mar 14.

PMID:
27586294
19.

Obstructive Sleep Apnea and Circulating Potassium Channel Levels.

Jiang N, Zhou A, Prasad B, Zhou L, Doumit J, Shi G, Imran H, Kaseer B, Millman R, Dudley SC Jr.

J Am Heart Assoc. 2016 Aug 19;5(8). pii: e003666. doi: 10.1161/JAHA.116.003666.

20.

Role of Mitochondrial Oxidative Stress in Glucose Tolerance, Insulin Resistance, and Cardiac Diastolic Dysfunction.

Jeong EM, Chung J, Liu H, Go Y, Gladstein S, Farzaneh-Far A, Lewandowski ED, Dudley SC Jr.

J Am Heart Assoc. 2016 May 5;5(5). pii: e003046. doi: 10.1161/JAHA.115.003046.

21.

Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias.

Liu M, Dudley SC Jr.

Int J Mol Sci. 2015 Dec 31;17(1). pii: E52. doi: 10.3390/ijms17010052. Review.

22.

Renin-Angiotensin Activation and Oxidative Stress in Early Heart Failure with Preserved Ejection Fraction.

Negi SI, Jeong EM, Shukrullah I, Veleder E, Jones DP, Fan TH, Varadarajan S, Danilov SM, Fukai T, Dudley SC Jr.

Biomed Res Int. 2015;2015:825027. doi: 10.1155/2015/825027. Epub 2015 Oct 4.

23.

Serum amine-based metabolites and their association with outcomes in primary prevention implantable cardioverter-defibrillator patients.

Zhang Y, Blasco-Colmenares E, Harms AC, London B, Halder I, Singh M, Dudley SC, Gutmann R, Guallar E, Hankemeier T, Tomaselli GF, Cheng A.

Europace. 2016 Sep;18(9):1383-90. doi: 10.1093/europace/euv342. Epub 2015 Oct 25.

24.

Left Ventricular Dilatation Increases the Risk of Ventricular Arrhythmias in Patients With Reduced Systolic Function.

Aleong RG, Mulvahill MJ, Halder I, Carlson NE, Singh M, Bloom HL, Dudley SC, Ellinor PT, Shalaby A, Weiss R, Gutmann R, Sauer WH, Narayanan K, Chugh SS, Saba S, London B.

J Am Heart Assoc. 2015 Jul 31;4(8):e001566. doi: 10.1161/JAHA.114.001566.

25.

Mechanisms of sudden cardiac death: oxidants and metabolism.

Yang KC, Kyle JW, Makielski JC, Dudley SC Jr.

Circ Res. 2015 Jun 5;116(12):1937-55. doi: 10.1161/CIRCRESAHA.116.304691. Review.

26.

Diastolic dysfunction.

Jeong EM, Dudley SC Jr.

Circ J. 2015;79(3):470-7. doi: 10.1253/circj.CJ-15-0064. Epub 2015 Feb 5. Review.

27.
28.

Effect of angiotensin-converting enzyme inhibitors and receptor blockers on appropriate implantable cardiac defibrillator shock in patients with severe systolic heart failure (from the GRADE Multicenter Study).

AlJaroudi WA, Refaat MM, Habib RH, Al-Shaar L, Singh M, Gutmann R, Bloom HL, Dudley SC, Ellinor PT, Saba SF, Shalaby AA, Weiss R, McNamara DM, Halder I, London B; Genetic Risk Assessment of Defibrillator Events Investigators.

Am J Cardiol. 2015 Apr 1;115(7):924-31. doi: 10.1016/j.amjcard.2015.01.020. Epub 2015 Jan 15.

29.

Nitroglycerin tolerance in caveolin-1 deficient mice.

Mao M, Varadarajan S, Fukai T, Bakhshi FR, Chernaya O, Dudley SC Jr, Minshall RD, Bonini MG.

PLoS One. 2014 Aug 26;9(8):e104101. doi: 10.1371/journal.pone.0104101. eCollection 2014.

30.

Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase.

Yang KC, Rutledge CA, Mao M, Bakhshi FR, Xie A, Liu H, Bonini MG, Patel HH, Minshall RD, Dudley SC Jr.

Circ Arrhythm Electrophysiol. 2014 Aug;7(4):701-10. doi: 10.1161/CIRCEP.113.001394. Epub 2014 Jul 13.

31.

Cardiac sodium channel mutations: why so many phenotypes?

Liu M, Yang KC, Dudley SC Jr.

Nat Rev Cardiol. 2014 Oct;11(10):607-15. doi: 10.1038/nrcardio.2014.85. Epub 2014 Jun 24. Review.

32.

Targeting the unfolded protein response in heart diseases.

Liu M, Dudley SC Jr.

Expert Opin Ther Targets. 2014 Jul;18(7):719-23. doi: 10.1517/14728222.2014.918605. Epub 2014 May 28.

33.

Mitochondria and arrhythmias.

Yang KC, Bonini MG, Dudley SC Jr.

Free Radic Biol Med. 2014 Jun;71:351-61. doi: 10.1016/j.freeradbiomed.2014.03.033. Epub 2014 Apr 5. Review.

34.

Enhanced risk profiling of implanted defibrillator shocks with circulating SCN5A mRNA splicing variants: a pilot trial.

Gao G, Brahmanandam V, Raicu M, Gu L, Zhou L, Kasturirangan S, Shah A, Negi SI, Wood MR, Desai AA, Tatooles A, Schwartz A, Dudley SC Jr.

J Am Coll Cardiol. 2014 Jun 3;63(21):2261-9. doi: 10.1016/j.jacc.2014.02.588. Epub 2014 Apr 2.

35.

New diagnostic and therapeutic possibilities for diastolic heart failure.

Jeong EM, Dudley SC Jr.

R I Med J (2013). 2014 Feb 3;97(2):35-7.

36.

c-Src kinase inhibition reduces arrhythmia inducibility and connexin43 dysregulation after myocardial infarction.

Rutledge CA, Ng FS, Sulkin MS, Greener ID, Sergeyenko AM, Liu H, Gemel J, Beyer EC, Sovari AA, Efimov IR, Dudley SC.

J Am Coll Cardiol. 2014 Mar 11;63(9):928-34. doi: 10.1016/j.jacc.2013.10.081. Epub 2014 Jan 8.

37.

Unfolded protein response regulates cardiac sodium current in systolic human heart failure.

Gao G, Xie A, Zhang J, Herman AM, Jeong EM, Gu L, Liu M, Yang KC, Kamp TJ, Dudley SC.

Circ Arrhythm Electrophysiol. 2013 Oct;6(5):1018-24. doi: 10.1161/CIRCEP.113.000274. Epub 2013 Sep 13.

38.

Oxidative stress and atrial fibrillation: finding a missing piece to the puzzle.

Yang KC, Dudley SC Jr.

Circulation. 2013 Oct 15;128(16):1724-6. doi: 10.1161/CIRCULATIONAHA.113.005837. Epub 2013 Sep 12. No abstract available.

39.

Mitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death.

Sovari AA, Rutledge CA, Jeong EM, Dolmatova E, Arasu D, Liu H, Vahdani N, Gu L, Zandieh S, Xiao L, Bonini MG, Duffy HS, Dudley SC Jr.

Circ Arrhythm Electrophysiol. 2013 Jun;6(3):623-31. doi: 10.1161/CIRCEP.112.976787. Epub 2013 Apr 4.

40.

SCN5A splicing variants and the possibility of predicting heart failure-associated arrhythmia.

Gao G, Dudley SC Jr.

Expert Rev Cardiovasc Ther. 2013 Feb;11(2):117-9. doi: 10.1586/erc.12.180. No abstract available.

41.

Tetrahydrobiopterin improves diastolic dysfunction by reversing changes in myofilament properties.

Jeong EM, Monasky MM, Gu L, Taglieri DM, Patel BG, Liu H, Wang Q, Greener I, Dudley SC Jr, Solaro RJ.

J Mol Cell Cardiol. 2013 Mar;56:44-54. doi: 10.1016/j.yjmcc.2012.12.003. Epub 2012 Dec 14.

42.

Mitochondrial dysfunction causing cardiac sodium channel downregulation in cardiomyopathy.

Liu M, Gu L, Sulkin MS, Liu H, Jeong EM, Greener I, Xie A, Efimov IR, Dudley SC Jr.

J Mol Cell Cardiol. 2013 Jan;54:25-34. doi: 10.1016/j.yjmcc.2012.10.011. Epub 2012 Nov 1.

43.

RBM25/LUC7L3 function in cardiac sodium channel splicing regulation of human heart failure.

Gao G, Dudley SC Jr.

Trends Cardiovasc Med. 2013 Jan;23(1):5-8. doi: 10.1016/j.tcm.2012.08.003. Epub 2012 Aug 31.

44.

Angiotensin receptor type 1 single nucleotide polymorphism 1166A/C is associated with malignant arrhythmias and altered circulating miR-155 levels in patients with chronic heart failure.

Blanco RR, Austin H, Vest RN 3rd, Valadri R, Li W, Lassegue B, Song Q, London B, Dudley SC, Bloom HL, Searles CD, Zafari AM.

J Card Fail. 2012 Sep;18(9):717-23. doi: 10.1016/j.cardfail.2012.06.531. Epub 2012 Aug 9.

45.

Reactive oxygen species-targeted therapeutic interventions for atrial fibrillation.

Sovari AA, Dudley SC Jr.

Front Physiol. 2012 Aug 6;3:311. doi: 10.3389/fphys.2012.00311. eCollection 2012.

46.

Antioxidant therapy for atrial fibrillation: lost in translation?

Sovari AA, Dudley SC.

Heart. 2012 Nov;98(22):1615-6. doi: 10.1136/heartjnl-2012-302328. Epub 2012 Aug 15. No abstract available.

47.

Gene and cell therapies for the failing heart to prevent sudden arrhythmic death.

Sovari AA, Dudley SC Jr.

Minerva Cardioangiol. 2012 Aug;60(4):363-73. Review.

48.

Association of low plasma adiponectin with early diastolic dysfunction.

Negi SI, Jeong EM, Shukrullah I, Raicu M, Dudley SC Jr.

Congest Heart Fail. 2012 Jul-Aug;18(4):187-91. doi: 10.1111/j.1751-7133.2011.00276.x. Epub 2012 Jan 9.

49.

Varicella-zoster virus (VZV) and alpha 1 antitrypsin: a fatal outcome in a patient affected by endemic pemphigus foliaceus.

Abreu Velez AM, Smoller BR, Gao W, Grossniklaus HE, Jiao Z, Arias LF, Dudley SC Jr, Howard MS.

Int J Dermatol. 2012 Jul;51(7):809-16. doi: 10.1111/j.1365-4632.2011.05296.x.

PMID:
22715825
50.

Determination of ebselen-sensitive reactive oxygen metabolites (ebROM) in human serum based upon N,N'-diethyl-1,4-phenylenediamine oxidation.

Liang Y, Roede JR, Dikalov S, Miller NG, Dudley SC Jr, Quyyumi A, Jones DP.

Clin Chim Acta. 2012 Dec 24;414:1-6. doi: 10.1016/j.cca.2012.06.003. Epub 2012 Jun 8.

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