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Items: 46

1.

Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells.

Trinidad AG, Whalley N, Rowlinson R, Delpuech O, Dudley P, Rooney C, Critchlow SE.

Oncogene. 2017 Nov 2;36(44):6164-6176. doi: 10.1038/onc.2017.224. Epub 2017 Jul 10.

2.

Intermittent High-Dose Scheduling of AZD8835, a Novel Selective Inhibitor of PI3Kα and PI3Kδ, Demonstrates Treatment Strategies for PIK3CA-Dependent Breast Cancers.

Hudson K, Hancox UJ, Trigwell C, McEwen R, Polanska UM, Nikolaou M, Morentin Gutierrez P, Avivar-Valderas A, Delpuech O, Dudley P, Hanson L, Ellston R, Jones A, Cumberbatch M, Cosulich SC, Ward L, Cruzalegui F, Green S.

Mol Cancer Ther. 2016 May;15(5):877-89. doi: 10.1158/1535-7163.MCT-15-0687. Epub 2016 Feb 2.

3.

Tumors with AKT1E17K Mutations Are Rational Targets for Single Agent or Combination Therapy with AKT Inhibitors.

Davies BR, Guan N, Logie A, Crafter C, Hanson L, Jacobs V, James N, Dudley P, Jacques K, Ladd B, D'Cruz CM, Zinda M, Lindemann J, Kodaira M, Tamura K, Jenkins EL.

Mol Cancer Ther. 2015 Nov;14(11):2441-51. doi: 10.1158/1535-7163.MCT-15-0230. Epub 2015 Sep 8.

4.

Combining AZD8931, a novel EGFR/HER2/HER3 signalling inhibitor, with AZD5363 limits AKT inhibitor induced feedback and enhances antitumour efficacy in HER2-amplified breast cancer models.

Crafter C, Vincent JP, Tang E, Dudley P, James NH, Klinowska T, Davies BR.

Int J Oncol. 2015 Aug;47(2):446-54. doi: 10.3892/ijo.2015.3062. Epub 2015 Jun 22.

5.

Validation of a predictive modeling approach to demonstrate the relative efficacy of three different schedules of the AKT inhibitor AZD5363.

Yates JW, Dudley P, Cheng J, D'Cruz C, Davies BR.

Cancer Chemother Pharmacol. 2015 Aug;76(2):343-56. doi: 10.1007/s00280-015-2795-7. Epub 2015 Jun 20.

PMID:
26092323
6.

Leatherbacks swimming in silico: modeling and verifying their momentum and heat balance using computational fluid dynamics.

Dudley PN, Bonazza R, Jones TT, Wyneken J, Porter WP.

PLoS One. 2014 Oct 29;9(10):e110701. doi: 10.1371/journal.pone.0110701. eCollection 2014.

7.

Sleep duration, quality, or stability and obesity in an urban family medicine center.

Logue EE, Scott ED, Palmieri PA, Dudley P.

J Clin Sleep Med. 2014 Feb 15;10(2):177-82. doi: 10.5664/jcsm.3448.

8.

Consider a non-spherical elephant: computational fluid dynamics simulations of heat transfer coefficients and drag verified using wind tunnel experiments.

Dudley PN, Bonazza R, Porter WP.

J Exp Zool A Ecol Genet Physiol. 2013 Jul;319(6):319-27. doi: 10.1002/jez.1796. Epub 2013 Apr 23.

PMID:
23613217
9.

Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases.

Addie M, Ballard P, Buttar D, Crafter C, Currie G, Davies BR, Debreczeni J, Dry H, Dudley P, Greenwood R, Johnson PD, Kettle JG, Lane C, Lamont G, Leach A, Luke RW, Morris J, Ogilvie D, Page K, Pass M, Pearson S, Ruston L.

J Med Chem. 2013 Mar 14;56(5):2059-73. doi: 10.1021/jm301762v. Epub 2013 Feb 26.

PMID:
23394218
10.

2-Deoxy-2-[18F]fluoro-D-glucose positron emission tomography demonstrates target inhibition with the potential to predict anti-tumour activity following treatment with the AKT inhibitor AZD5363.

Maynard J, Ricketts SA, Gendrin C, Dudley P, Davies BR.

Mol Imaging Biol. 2013 Aug;15(4):476-85. doi: 10.1007/s11307-013-0613-3.

PMID:
23344784
11.

The better weight-better sleep study: a pilot intervention in primary care.

Logue EE, Bourguet CC, Palmieri PA, Scott ED, Matthews BA, Dudley P, Chipman KJ.

Am J Health Behav. 2012 Mar;36(3):319-34. doi: 10.5993/AJHB.36.3.4.

PMID:
22370434
12.

Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background.

Davies BR, Greenwood H, Dudley P, Crafter C, Yu DH, Zhang J, Li J, Gao B, Ji Q, Maynard J, Ricketts SA, Cross D, Cosulich S, Chresta CC, Page K, Yates J, Lane C, Watson R, Luke R, Ogilvie D, Pass M.

Mol Cancer Ther. 2012 Apr;11(4):873-87. doi: 10.1158/1535-7163.MCT-11-0824-T. Epub 2012 Jan 31.

13.

Diverse heterocyclic scaffolds as allosteric inhibitors of AKT.

Kettle JG, Brown S, Crafter C, Davies BR, Dudley P, Fairley G, Faulder P, Fillery S, Greenwood H, Hawkins J, James M, Johnson K, Lane CD, Pass M, Pink JH, Plant H, Cosulich SC.

J Med Chem. 2012 Feb 9;55(3):1261-73. doi: 10.1021/jm201394e. Epub 2012 Jan 27.

PMID:
22248236
14.

Assessing the activity of cediranib, a VEGFR-2/3 tyrosine kinase inhibitor, against VEGFR-1 and members of the structurally related PDGFR family.

Brave SR, Ratcliffe K, Wilson Z, James NH, Ashton S, Wainwright A, Kendrew J, Dudley P, Broadbent N, Sproat G, Taylor S, Barnes C, Silva JC, Farnsworth CL, Hennequin L, Ogilvie DJ, Jürgensmeier JM, Shibuya M, Wedge SR, Barry ST.

Mol Cancer Ther. 2011 May;10(5):861-73. doi: 10.1158/1535-7163.MCT-10-0976. Epub 2011 Mar 25.

15.

An opt-out influenza vaccination policy improves immunization rates in primary care.

Logue E, Dudley P, Imhoff T, Smucker W, Stapin J, DiSabato J, Schueller C.

J Health Care Poor Underserved. 2011 Feb;22(1):232-42. doi: 10.1353/hpu.2011.0009.

PMID:
21317518
16.

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.

Chresta CM, Davies BR, Hickson I, Harding T, Cosulich S, Critchlow SE, Vincent JP, Ellston R, Jones D, Sini P, James D, Howard Z, Dudley P, Hughes G, Smith L, Maguire S, Hummersone M, Malagu K, Menear K, Jenkins R, Jacobsen M, Smith GC, Guichard S, Pass M.

Cancer Res. 2010 Jan 1;70(1):288-98. doi: 10.1158/0008-5472.CAN-09-1751. Epub 2009 Dec 22.

17.

A molecular-genetic study of the Arabidopsis Toc75 gene family.

Baldwin A, Wardle A, Patel R, Dudley P, Park SK, Twell D, Inoue K, Jarvis P.

Plant Physiol. 2005 Jun;138(2):715-33. Epub 2005 May 20.

18.

In vivo studies on the roles of Tic110, Tic40 and Hsp93 during chloroplast protein import.

Kovacheva S, Bédard J, Patel R, Dudley P, Twell D, Ríos G, Koncz C, Jarvis P.

Plant J. 2005 Feb;41(3):412-28.

19.

Characterizing ectopic pregnancies that rupture despite treatment with methotrexate.

Dudley PS, Heard MJ, Sangi-Haghpeykar H, Carson SA, Buster JE.

Fertil Steril. 2004 Nov;82(5):1374-8.

PMID:
15533363
20.

Timing of ICAM-I Expression in a Canine Model of Post-Haemorrhagic Cerebral Vasospasm.

Abruzzo T, Shengelaia GG, Cloft HJ, Thaxton G, Dudley P, Tong F, Dion JE.

Interv Neuroradiol. 2000 Jun 30;6(2):95-106. Epub 2001 May 15.

22.
23.

Developmental regulation of respiratory activity and protein import in plant mitochondria.

Wood CK, Dudley P, Albury MS, Affourtit C, Leach GR, Pratt JR, Whitehouse DG, Moore AL.

Biochem Soc Trans. 1996 Aug;24(3):746-9. Review. No abstract available.

PMID:
8878839
24.
25.

Computer-aided self-instruction training with hearing-impaired impulsive students.

Campbell DS, Neill J, Dudley P.

Am Ann Deaf. 1989 Jul;134(3):227-31.

PMID:
2683685
26.

Laxative abuse in eating disorders.

Willard SG, Winstead DK, Anding R, Dudley P.

Psychiatr Med. 1989;7(3):75-87. No abstract available.

PMID:
2554370
27.
28.

Relationship between untreated and insulin-treated diabetes and vascular relaxation.

Pfaffman MA, Dudley P, Prater A.

Arch Int Pharmacodyn Ther. 1983 Nov;266(1):131-43.

PMID:
6230063
29.

Nonpolar lipid methylation-identification of nonpolar methylated products synthesized by rat basophilic leukemia cells, retina and parotid.

Kloog Y, Zatz M, Rivnay B, Dudley PA, Markey SP.

Biochem Pharmacol. 1982 Mar 1;31(5):753-9.

PMID:
7082343
30.
31.

Phospholipid transfer protein from bovine retina with high activity towards retinal rod disc membranes.

Dudley PA, Anderson RE.

FEBS Lett. 1978 Nov 1;95(1):57-60. No abstract available.

32.

Essential fatty acid deficiency and renewal of rod outer segments in the albino rat.

Anderson RE, Landis DJ, Dudley PA.

Invest Ophthalmol. 1976 Mar;15(3):232-6.

PMID:
1254413
33.

Further studies on the chemistry of photoreceptor membranes of rats fed an essential fatty acid deficient diet.

Dudley PA, Landis DJ, Anderson RE.

Exp Eye Res. 1975 Dec;21(6):523-30. No abstract available.

PMID:
1204681
34.

Proceedings: Polyunsaturated fatty acids of photoreceptor membranes.

Anderson RE, Benolken RM, Dudley PA, Landis DJ, Wheeler TG.

Exp Eye Res. 1974 Mar;18(3):205-13. No abstract available.

PMID:
4833763
35.

Alteration of disc formation in photoreceptors of rat retina.

Landis DJ, Dudley PA, Anderson RE.

Science. 1973 Dec 14;182(4117):1144-6.

PMID:
4750611
36.

Morphological stages of regeneration in the planarian Dugesia tigrina: A light and electron microscopic study.

Spiegelman M, Dudley PL.

J Morphol. 1973 Feb;139(2):155-183. doi: 10.1002/jmor.1051390203.

PMID:
30336649
37.
38.

Penrose conference on fracture mechanics and earthquake source mechanisms.

Dudley PP, Riecker RE.

Science. 1972 Jul 7;177(4043):87-8. No abstract available.

PMID:
17756319
39.

Ultramicroscopic filaments in the ascidian Botryllus schlosseri (Pallas) and their possible role in ampullar contractions.

De Santo RS, Dudley PL.

J Ultrastruct Res. 1969 Aug;28(3):259-74. No abstract available.

PMID:
4898419
40.

The fine structure and development of the nauplius eye of the copepod. Doropygus seclusus Illg.

Dudley PL.

Cellule. 1969;68(1):5-42. No abstract available.

PMID:
5387154
41.

Further experience with the round window ultrasonic technique.

Kossoff G, Wadsworth JH, Dudley PF.

Arch Otolaryngol. 1968 Sep;88(3):254-7. No abstract available.

PMID:
5663383
43.

The round window ultrasonic technique for treatment of Ménière's disease.

Kossoff G, Wadsworth JR, Dudley PF.

Arch Otolaryngol. 1967 Nov;86(5):535-42. Review. No abstract available.

PMID:
4952841
44.

Partial hepatectomy for primary hepatoma.

Dudley P.

Nurs Mirror Midwives J. 1966 Apr 29;122(5):7-8. No abstract available.

PMID:
4286129
45.

Partial hepatectomy for primary hepatoma.

Dudley P.

UNA Nurs J. 1966 Jan;64:19-21. No abstract available.

PMID:
4286131
46.

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