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Items: 1 to 50 of 70

1.

HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome.

Illing PT, Pymm P, Croft NP, Hilton HG, Jojic V, Han AS, Mendoza JL, Mifsud NA, Dudek NL, McCluskey J, Parham P, Rossjohn J, Vivian JP, Purcell AW.

Nat Commun. 2018 Nov 8;9(1):4693. doi: 10.1038/s41467-018-07109-w.

2.

Gait differences between K3 and K4 persons with transfemoral amputation across level and non-level walking conditions.

Sturk JA, Lemaire ED, Sinitski E, Dudek NL, Besemann M, Hebert JS, Baddour N.

Prosthet Orthot Int. 2018 Dec;42(6):626-635. doi: 10.1177/0309364618785724. Epub 2018 Jul 25.

PMID:
30044178
3.

Maintaining stable transfemoral amputee gait on level, sloped and simulated uneven conditions in a virtual environment.

Sturk JA, Lemaire ED, Sinitski EH, Dudek NL, Besemann M, Hebert JS, Baddour N.

Disabil Rehabil Assist Technol. 2019 Apr;14(3):226-235. doi: 10.1080/17483107.2017.1420250. Epub 2017 Dec 24.

PMID:
29276850
4.

Supervisor-trainee continuity and the quality of work-based assessments.

Cheung WJ, Dudek NL, Wood TJ, Frank JR.

Med Educ. 2017 Dec;51(12):1260-1268. doi: 10.1111/medu.13415. Epub 2017 Oct 3.

PMID:
28971502
5.

The molecular basis for peptide repertoire selection in the human leucocyte antigen (HLA) C*06:02 molecule.

Mobbs JI, Illing PT, Dudek NL, Brooks AG, Baker DG, Purcell AW, Rossjohn J, Vivian JP.

J Biol Chem. 2017 Oct 20;292(42):17203-17215. doi: 10.1074/jbc.M117.806976. Epub 2017 Aug 30.

6.

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

Ooi JD, Petersen J, Tan YH, Huynh M, Willett ZJ, Ramarathinam SH, Eggenhuizen PJ, Loh KL, Watson KA, Gan PY, Alikhan MA, Dudek NL, Handel A, Hudson BG, Fugger L, Power DA, Holt SG, Coates PT, Gregersen JW, Purcell AW, Holdsworth SR, La Gruta NL, Reid HH, Rossjohn J, Kitching AR.

Nature. 2017 May 11;545(7653):243-247. doi: 10.1038/nature22329. Epub 2017 May 3.

7.

Characterization of the Antigen Processing Machinery and Endogenous Peptide Presentation of a Bat MHC Class I Molecule.

Wynne JW, Woon AP, Dudek NL, Croft NP, Ng JH, Baker ML, Wang LF, Purcell AW.

J Immunol. 2016 Jun 1;196(11):4468-76. doi: 10.4049/jimmunol.1502062. Epub 2016 Apr 27.

8.

Feedback to Supervisors: Is Anonymity Really So Important?

Dudek NL, Dojeiji S, Day K, Varpio L.

Acad Med. 2016 Sep;91(9):1305-12. doi: 10.1097/ACM.0000000000001170.

PMID:
27028033
9.

A prominent role of PDIA6 in processing of misfolded proinsulin.

Gorasia DG, Dudek NL, Safavi-Hemami H, Perez RA, Schittenhelm RB, Saunders PM, Wee S, Mangum JE, Hubbard MJ, Purcell AW.

Biochim Biophys Acta. 2016 Jun;1864(6):715-723. doi: 10.1016/j.bbapap.2016.03.002. Epub 2016 Mar 3.

PMID:
26947243
10.

Continued Validation of the O-SCORE (Ottawa Surgical Competency Operating Room Evaluation): Use in the Simulated Environment.

MacEwan MJ, Dudek NL, Wood TJ, Gofton WT.

Teach Learn Med. 2016;28(1):72-9. doi: 10.1080/10401334.2015.1107483.

PMID:
26787087
11.

A Systems Approach to Understand Antigen Presentation and the Immune Response.

Dudek NL, Croft NP, Schittenhelm RB, Ramarathinam SH, Purcell AW.

Methods Mol Biol. 2016;1394:189-209. doi: 10.1007/978-1-4939-3341-9_14.

PMID:
26700050
12.

Changes to transtibial amputee gait with a weighted backpack on multiple surfaces.

Doyle SS, Lemaire ED, Besemann M, Dudek NL.

Clin Biomech (Bristol, Avon). 2015 Dec;30(10):1119-24. doi: 10.1016/j.clinbiomech.2015.08.015. Epub 2015 Sep 2.

PMID:
26476601
13.

Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells.

Ternette N, Yang H, Partridge T, Llano A, Cedeño S, Fischer R, Charles PD, Dudek NL, Mothe B, Crespo M, Fischer WM, Korber BT, Nielsen M, Borrow P, Purcell AW, Brander C, Dorrell L, Kessler BM, Hanke T.

Eur J Immunol. 2016 Jan;46(1):60-9. doi: 10.1002/eji.201545890. Epub 2015 Nov 4.

14.

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex.

Beringer DX, Kleijwegt FS, Wiede F, van der Slik AR, Loh KL, Petersen J, Dudek NL, Duinkerken G, Laban S, Joosten A, Vivian JP, Chen Z, Uldrich AP, Godfrey DI, McCluskey J, Price DA, Radford KJ, Purcell AW, Nikolic T, Reid HH, Tiganis T, Roep BO, Rossjohn J.

Nat Immunol. 2015 Nov;16(11):1153-61. doi: 10.1038/ni.3271. Epub 2015 Oct 5.

PMID:
26437244
15.

Center of pressure and total force analyses for amputees walking with a backpack load over four surfaces.

Sinitski EH, Herbert-Copley AG, Lemaire ED, Doyle SS, Besemann M, Dudek NL.

Appl Ergon. 2016 Jan;52:169-76. doi: 10.1016/j.apergo.2015.07.014. Epub 2015 Jul 31.

PMID:
26360208
16.

Going Paperless? Issues in Converting a Surgical Assessment Tool to an Electronic Version.

Dudek NL, Papp S, Gofton WT.

Teach Learn Med. 2015;27(3):274-9. doi: 10.1080/10401334.2015.1044661.

PMID:
26158329
17.

Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients.

Benham H, Nel HJ, Law SC, Mehdi AM, Street S, Ramnoruth N, Pahau H, Lee BT, Ng J, Brunck ME, Hyde C, Trouw LA, Dudek NL, Purcell AW, O'Sullivan BJ, Connolly JE, Paul SK, Lê Cao KA, Thomas R.

Sci Transl Med. 2015 Jun 3;7(290):290ra87. doi: 10.1126/scitranslmed.aaa9301.

PMID:
26041704
18.

A comprehensive analysis of peptides presented by HLA-A1.

Giam K, Ayala-Perez R, Illing PT, Schittenhelm RB, Croft NP, Purcell AW, Dudek NL.

Tissue Antigens. 2015 Jun;85(6):492-6. doi: 10.1111/tan.12565. Epub 2015 Apr 16.

PMID:
25880248
19.

Fixed and self-paced treadmill walking for able-bodied and transtibial amputees in a multi-terrain virtual environment.

Sinitski EH, Lemaire ED, Baddour N, Besemann M, Dudek NL, Hebert JS.

Gait Posture. 2015 Feb;41(2):568-73. doi: 10.1016/j.gaitpost.2014.12.016. Epub 2014 Dec 29.

PMID:
25661003
20.

Ingestion of oats and barley in patients with celiac disease mobilizes cross-reactive T cells activated by avenin peptides and immuno-dominant hordein peptides.

Hardy MY, Tye-Din JA, Stewart JA, Schmitz F, Dudek NL, Hanchapola I, Purcell AW, Anderson RP.

J Autoimmun. 2015 Jan;56:56-65. doi: 10.1016/j.jaut.2014.10.003. Epub 2014 Nov 1.

PMID:
25457306
21.

Revisiting the arthritogenic peptide theory: quantitative not qualitative changes in the peptide repertoire of HLA-B27 allotypes.

Schittenhelm RB, Sian TC, Wilmann PG, Dudek NL, Purcell AW.

Arthritis Rheumatol. 2015 Mar;67(3):702-13. doi: 10.1002/art.38963.

22.

Pancreatic beta cells are highly susceptible to oxidative and ER stresses during the development of diabetes.

Gorasia DG, Dudek NL, Veith PD, Shankar R, Safavi-Hemami H, Williamson NA, Reynolds EC, Hubbard MJ, Purcell AW.

J Proteome Res. 2015 Feb 6;14(2):688-99. doi: 10.1021/pr500643h. Epub 2014 Dec 8.

PMID:
25412008
23.

Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes.

Pathiraja V, Kuehlich JP, Campbell PD, Krishnamurthy B, Loudovaris T, Coates PT, Brodnicki TC, O'Connell PJ, Kedzierska K, Rodda C, Bergman P, Hill E, Purcell AW, Dudek NL, Thomas HE, Kay TW, Mannering SI.

Diabetes. 2015 Jan;64(1):172-82. doi: 10.2337/db14-0858. Epub 2014 Aug 25.

24.

The cellular redox environment alters antigen presentation.

Trujillo JA, Croft NP, Dudek NL, Channappanavar R, Theodossis A, Webb AI, Dunstone MA, Illing PT, Butler NS, Fett C, Tscharke DC, Rossjohn J, Perlman S, Purcell AW.

J Biol Chem. 2014 Oct 3;289(40):27979-91. doi: 10.1074/jbc.M114.573402. Epub 2014 Aug 18.

25.

In-training evaluations: developing an automated screening tool to measure report quality.

Bismil R, Dudek NL, Wood TJ.

Med Educ. 2014 Jul;48(7):724-32. doi: 10.1111/medu.12490.

PMID:
24909534
26.

The beta cell immunopeptidome.

Dudek NL, Purcell AW.

Vitam Horm. 2014;95:115-44. doi: 10.1016/B978-0-12-800174-5.00005-3. Review.

PMID:
24559916
27.

A comprehensive analysis of constitutive naturally processed and presented HLA-C*04:01 (Cw4)-specific peptides.

Schittenhelm RB, Dudek NL, Croft NP, Ramarathinam SH, Purcell AW.

Tissue Antigens. 2014 Mar;83(3):174-9. doi: 10.1111/tan.12282. Epub 2014 Jan 7.

PMID:
24397554
28.

Changes to level ground transtibial amputee gait with a weighted backpack.

Doyle SS, Lemaire ED, Besemann M, Dudek NL.

Clin Biomech (Bristol, Avon). 2014 Feb;29(2):149-54. doi: 10.1016/j.clinbiomech.2013.11.019. Epub 2013 Dec 4.

PMID:
24355702
29.

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis.

Scally SW, Petersen J, Law SC, Dudek NL, Nel HJ, Loh KL, Wijeyewickrema LC, Eckle SB, van Heemst J, Pike RN, McCluskey J, Toes RE, La Gruta NL, Purcell AW, Reid HH, Thomas R, Rossjohn J.

J Exp Med. 2013 Nov 18;210(12):2569-82. doi: 10.1084/jem.20131241. Epub 2013 Nov 4.

30.

Quality in-training evaluation reports--does feedback drive faculty performance?

Dudek NL, Marks MB, Bandiera G, White J, Wood TJ.

Acad Med. 2013 Aug;88(8):1129-34. doi: 10.1097/ACM.0b013e318299394c.

PMID:
23807095
31.

Kinetics of antigen expression and epitope presentation during virus infection.

Croft NP, Smith SA, Wong YC, Tan CT, Dudek NL, Flesch IE, Lin LC, Tscharke DC, Purcell AW.

PLoS Pathog. 2013 Jan;9(1):e1003129. doi: 10.1371/journal.ppat.1003129. Epub 2013 Jan 31.

32.

Quality evaluation reports: Can a faculty development program make a difference?

Dudek NL, Marks MB, Wood TJ, Dojeiji S, Bandiera G, Hatala R, Cooke L, Sadownik L.

Med Teach. 2012;34(11):e725-31. doi: 10.3109/0142159X.2012.689444.

PMID:
23140304
33.

MR1 presents microbial vitamin B metabolites to MAIT cells.

Kjer-Nielsen L, Patel O, Corbett AJ, Le Nours J, Meehan B, Liu L, Bhati M, Chen Z, Kostenko L, Reantragoon R, Williamson NA, Purcell AW, Dudek NL, McConville MJ, O'Hair RA, Khairallah GN, Godfrey DI, Fairlie DP, Rossjohn J, McCluskey J.

Nature. 2012 Nov 29;491(7426):717-23. doi: 10.1038/nature11605. Epub 2012 Oct 10.

PMID:
23051753
34.

The Ottawa Surgical Competency Operating Room Evaluation (O-SCORE): a tool to assess surgical competence.

Gofton WT, Dudek NL, Wood TJ, Balaa F, Hamstra SJ.

Acad Med. 2012 Oct;87(10):1401-7.

PMID:
22914526
35.

Constitutive and inflammatory immunopeptidome of pancreatic β-cells.

Dudek NL, Tan CT, Gorasia DG, Croft NP, Illing PT, Purcell AW.

Diabetes. 2012 Nov;61(11):3018-25. doi: 10.2337/db11-1333. Epub 2012 Aug 7.

36.

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire.

Illing PT, Vivian JP, Dudek NL, Kostenko L, Chen Z, Bharadwaj M, Miles JJ, Kjer-Nielsen L, Gras S, Williamson NA, Burrows SR, Purcell AW, Rossjohn J, McCluskey J.

Nature. 2012 Jun 28;486(7404):554-8. doi: 10.1038/nature11147.

PMID:
22722860
37.

Secreted HLA recapitulates the immunopeptidome and allows in-depth coverage of HLA A*02:01 ligands.

Scull KE, Dudek NL, Corbett AJ, Ramarathinam SH, Gorasia DG, Williamson NA, Purcell AW.

Mol Immunol. 2012 Jun;51(2):136-42. doi: 10.1016/j.molimm.2012.02.117. Epub 2012 Mar 17.

PMID:
22424782
38.

A qualitative study of factors influencing the decision to have an elective amputation.

Quon DL, Dudek NL, Marks M, Boutet M, Varpio L.

J Bone Joint Surg Am. 2011 Nov 16;93(22):2087-92. doi: 10.2106/JBJS.J.01998.

PMID:
22262380
39.

Direct quantitation of MHC-bound peptide epitopes by selected reaction monitoring.

Tan CT, Croft NP, Dudek NL, Williamson NA, Purcell AW.

Proteomics. 2011 Jun;11(11):2336-40. doi: 10.1002/pmic.201000531. Epub 2011 May 20.

PMID:
21598389
40.

Phospholipase C, Ca2+, and calmodulin signaling are required for 5-HT2A receptor-mediated transamidation of Rac1 by transglutaminase.

Dai Y, Dudek NL, Li Q, Muma NA.

Psychopharmacology (Berl). 2011 Feb;213(2-3):403-12. doi: 10.1007/s00213-010-1984-7. Epub 2010 Aug 18.

41.

Epitope discovery and their use in peptide based vaccines.

Dudek NL, Perlmutter P, Aguilar MI, Croft NP, Purcell AW.

Curr Pharm Des. 2010;16(28):3149-57. Review.

PMID:
20687873
42.

Indicators of dynamic stability in transtibial prosthesis users.

Kendell C, Lemaire ED, Dudek NL, Kofman J.

Gait Posture. 2010 Mar;31(3):375-9. doi: 10.1016/j.gaitpost.2010.01.003.

PMID:
20138523
43.

Reactivity with dichotomous determinants of Ro 60 stratifies autoantibody responses in lupus and primary Sjögren's syndrome.

Reed JH, Dudek NL, Osborne SE, Kaufman KM, Jackson MW, Purcell AW, Gordon TP.

Arthritis Rheum. 2010 May;62(5):1448-56. doi: 10.1002/art.27370.

44.

Striatal expression of a calmodulin fragment improved motor function, weight loss, and neuropathology in the R6/2 mouse model of Huntington's disease.

Dai Y, Dudek NL, Li Q, Fowler SC, Muma NA.

J Neurosci. 2009 Sep 16;29(37):11550-9. doi: 10.1523/JNEUROSCI.3307-09.2009.

45.

SOCS1 negatively regulates the production of Foxp3+ CD4+ T cells in the thymus.

Zhan Y, Davey GM, Graham KL, Kiu H, Dudek NL, Kay T, Lew AM.

Immunol Cell Biol. 2009 Aug-Sep;87(6):473-80. doi: 10.1038/icb.2009.23. Epub 2009 Apr 21.

PMID:
19381159
46.

Neuroprotective effects of calmodulin peptide 76-121aa: disruption of calmodulin binding to mutant huntingtin.

Dudek NL, Dai Y, Muma NA.

Brain Pathol. 2010 Jan;20(1):176-89. doi: 10.1111/j.1750-3639.2008.00258.x. Epub 2009 Mar 10.

47.

Interferon signalling in pancreatic beta cells.

Thomas HE, Graham KL, Angstetra E, McKenzie MD, Dudek NL, Kay TW.

Front Biosci (Landmark Ed). 2009 Jan 1;14:644-56. Review.

PMID:
19273092
48.

Cytotoxic T cell mechanisms of beta cell destruction in non-obese diabetic mice.

Kay TW, Dudek NL, Graham K, Estella E, Angstetra E, McKenzie MD, Allison J, Thomas HE.

Novartis Found Symp. 2008;292:68-78; discussion 78-84, 122-9, 202-3.

PMID:
19203093
49.

In vivo effects of cytokines on pancreatic beta-cells in models of type I diabetes dependent on CD4(+) T lymphocytes.

Angstetra E, Graham KL, Emmett S, Dudek NL, Darwiche R, Ayala-Perez R, Allison J, Santamaria P, Kay TW, Thomas HE.

Immunol Cell Biol. 2009 Feb;87(2):178-85. doi: 10.1038/icb.2008.81. Epub 2008 Nov 18.

PMID:
19015667
50.

Ambulation monitoring of transtibial amputation subjects with patient activity monitor versus pedometer.

Dudek NL, Khan OD, Lemaire ED, Marks MB, Saville L.

J Rehabil Res Dev. 2008;45(4):577-85.

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