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Items: 1 to 50 of 83

1.

Specific Inhibition of Hepatic Lactate Dehydrogenase Reduces Oxalate Production in Mouse Models of Primary Hyperoxaluria.

Lai C, Pursell N, Gierut J, Saxena U, Zhou W, Dills M, Diwanji R, Dutta C, Koser M, Nazef N, Storr R, Kim B, Martin-Higueras C, Salido E, Wang W, Abrams M, Dudek H, Brown BD.

Mol Ther. 2018 Jun 15. pii: S1525-0016(18)30219-3. doi: 10.1016/j.ymthe.2018.05.016. [Epub ahead of print]

2.

Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases.

Pursell N, Gierut J, Zhou W, Dills M, Diwanji R, Gjorgjieva M, Saxena U, Yang JS, Shah A, Venkat N, Storr R, Kim B, Wang W, Abrams M, Raffin M, Mithieux G, Rajas F, Dudek H, Brown BD, Lai C.

Mol Ther. 2018 Jul 5;26(7):1771-1782. doi: 10.1016/j.ymthe.2018.04.023. Epub 2018 Apr 27.

3.

β-Catenin mRNA Silencing and MEK Inhibition Display Synergistic Efficacy in Preclinical Tumor Models.

Ganesh S, Shui X, Craig KP, Koser ML, Chopda GR, Cyr WA, Lai C, Dudek H, Wang W, Brown BD, Abrams MT.

Mol Cancer Ther. 2018 Feb;17(2):544-553. doi: 10.1158/1535-7163.MCT-17-0605. Epub 2017 Dec 27.

PMID:
29282298
4.

Metal Dependence of the Xylose Isomerase from Piromyces sp. E2 Explored by Activity Profiling and Protein Crystallography.

Lee M, Rozeboom HJ, de Waal PP, de Jong RM, Dudek HM, Janssen DB.

Biochemistry. 2017 Nov 14;56(45):5991-6005. doi: 10.1021/acs.biochem.7b00777. Epub 2017 Nov 2.

5.

Polycyclic Ketone Monooxygenase from the Thermophilic Fungus Thermothelomyces thermophila: A Structurally Distinct Biocatalyst for Bulky Substrates.

Fürst MJ, Savino S, Dudek HM, Gómez Castellanos JR, Gutiérrez de Souza C, Rovida S, Fraaije MW, Mattevi A.

J Am Chem Soc. 2017 Jan 18;139(2):627-630. doi: 10.1021/jacs.6b12246. Epub 2017 Jan 3.

PMID:
28010060
6.

Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin.

Ganesh S, Koser ML, Cyr WA, Chopda GR, Tao J, Shui X, Ying B, Chen D, Pandya P, Chipumuro E, Siddiquee Z, Craig K, Lai C, Dudek H, Monga SP, Wang W, Brown BD, Abrams MT.

Mol Cancer Ther. 2016 Sep;15(9):2143-54. doi: 10.1158/1535-7163.MCT-16-0309. Epub 2016 Jul 7.

7.

Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1.

Dutta C, Avitahl-Curtis N, Pursell N, Larsson Cohen M, Holmes B, Diwanji R, Zhou W, Apponi L, Koser M, Ying B, Chen D, Shui X, Saxena U, Cyr WA, Shah A, Nazef N, Wang W, Abrams M, Dudek H, Salido E, Brown BD, Lai C.

Mol Ther. 2016 Apr;24(4):770-8. doi: 10.1038/mt.2016.4. Epub 2016 Jan 13.

8.

Erratum: Cloning, overexpression and biocatalytic exploration of a novel Baeyer-Villiger monooxygenase from Aspergillus fumigatus Af293.

Mascotti ML, Ayub MJ, Dudek H, Sanz MK, Fraaije MW.

AMB Express. 2014 Dec;4(1):62. doi: 10.1186/s13568-014-0062-7. Epub 2014 Sep 20. No abstract available.

9.

Finding the switch: turning a baeyer-villiger monooxygenase into a NADPH oxidase.

Brondani PB, Dudek HM, Martinoli C, Mattevi A, Fraaije MW.

J Am Chem Soc. 2014 Dec 10;136(49):16966-9. doi: 10.1021/ja508265b. Epub 2014 Dec 1.

PMID:
25423359
10.

Beyond the Protein Matrix: Probing Cofactor Variants in a Baeyer-Villiger Oxygenation Reaction.

Martinoli C, Dudek HM, Orru R, Edmondson DE, Fraaije MW, Mattevi A.

ACS Catal. 2013;3(12):3058-3062.

11.

Extending the substrate scope of a Baeyer-Villiger monooxygenase by multiple-site mutagenesis.

Dudek HM, Fink MJ, Shivange AV, Dennig A, Mihovilovic MD, Schwaneberg U, Fraaije MW.

Appl Microbiol Biotechnol. 2014 May;98(9):4009-20. doi: 10.1007/s00253-013-5364-1. Epub 2013 Nov 19.

PMID:
24247989
12.

Knockdown of β-catenin with dicer-substrate siRNAs reduces liver tumor burden in vivo.

Dudek H, Wong DH, Arvan R, Shah A, Wortham K, Ying B, Diwanji R, Zhou W, Holmes B, Yang H, Cyr WA, Zhou Y, Shah A, Farkiwala R, Lee M, Li Y, Rettig GR, Collingwood MA, Basu SK, Behlke MA, Brown BD.

Mol Ther. 2014 Jan;22(1):92-101. doi: 10.1038/mt.2013.233. Epub 2013 Oct 3.

13.

Cloning, overexpression and biocatalytic exploration of a novel Baeyer-Villiger monooxygenase from Aspergillus fumigatus Af293.

Mascotti ML, Juri Ayub M, Dudek H, Sanz MK, Fraaije MW.

AMB Express. 2013 Jun 14;3(1):33. doi: 10.1186/2191-0855-3-33.

14.

A generic, whole-cell-based screening method for Baeyer-Villiger monooxygenases.

Dudek HM, Popken P, van Bloois E, Duetz WA, Fraaije MW.

J Biomol Screen. 2013 Jul;18(6):678-87. doi: 10.1177/1087057113480390. Epub 2013 Mar 27.

PMID:
23536548
15.

A stepwise approach for the reproducible optimization of PAMO expression in Escherichia coli for whole-cell biocatalysis.

van Bloois E, Dudek HM, Duetz WA, Fraaije MW.

BMC Biotechnol. 2012 Jun 21;12:31. doi: 10.1186/1472-6750-12-31.

16.

Expanding the set of rhodococcal Baeyer-Villiger monooxygenases by high-throughput cloning, expression and substrate screening.

Riebel A, Dudek HM, de Gonzalo G, Stepniak P, Rychlewski L, Fraaije MW.

Appl Microbiol Biotechnol. 2012 Sep;95(6):1479-89. doi: 10.1007/s00253-011-3823-0. Epub 2012 Jan 5.

17.

Mapping the substrate binding site of phenylacetone monooxygenase from Thermobifida fusca by mutational analysis.

Dudek HM, de Gonzalo G, Pazmiño DE, Stepniak P, Wyrwicz LS, Rychlewski L, Fraaije MW.

Appl Environ Microbiol. 2011 Aug 15;77(16):5730-8. doi: 10.1128/AEM.00687-11. Epub 2011 Jul 1.

18.

Snapshots of enzymatic Baeyer-Villiger catalysis: oxygen activation and intermediate stabilization.

Orru R, Dudek HM, Martinoli C, Torres Pazmiño DE, Royant A, Weik M, Fraaije MW, Mattevi A.

J Biol Chem. 2011 Aug 19;286(33):29284-91. doi: 10.1074/jbc.M111.255075. Epub 2011 Jun 22.

19.

Investigating the coenzyme specificity of phenylacetone monooxygenase from Thermobifida fusca.

Dudek HM, Torres Pazmiño DE, Rodríguez C, de Gonzalo G, Gotor V, Fraaije MW.

Appl Microbiol Biotechnol. 2010 Nov;88(5):1135-43. doi: 10.1007/s00253-010-2769-y. Epub 2010 Aug 12.

20.

Baeyer-Villiger monooxygenases: recent advances and future challenges.

Torres Pazmiño DE, Dudek HM, Fraaije MW.

Curr Opin Chem Biol. 2010 Apr;14(2):138-44. doi: 10.1016/j.cbpa.2009.11.017. Epub 2009 Dec 16. Review.

PMID:
20015679
21.

Liposomal packaging generates Wnt protein with in vivo biological activity.

Morrell NT, Leucht P, Zhao L, Kim JB, ten Berge D, Ponnusamy K, Carre AL, Dudek H, Zachlederova M, McElhaney M, Brunton S, Gunzner J, Callow M, Polakis P, Costa M, Zhang XM, Helms JA, Nusse R.

PLoS One. 2008 Aug 13;3(8):e2930. doi: 10.1371/journal.pone.0002930.

22.

Calcium phosphate transfection of DNA into neurons in primary culture.

Dudek H, Ghosh A, Greenberg ME.

Curr Protoc Neurosci. 2001 May;Chapter 3:Unit 3.11. doi: 10.1002/0471142301.ns0311s03.

PMID:
18428460
23.

[Concentration of glutathione (GSH), ascorbic acid (vitamin C) and substances reacting with thiobarbituric acid (TBA-rs) in single human brain metastases].

Dudek H, Farbiszewski R, Rydzewska M, Michno T, Kozłowski A.

Wiad Lek. 2005;58(7-8):379-81. Polish.

PMID:
16425787
24.

Evaluation of antioxidant enzymes activity and concentration of non-enzymatic antioxidants in human brain tumours.

Dudek H, Farbiszewski R, Rydzewska M, Michno T, Kozłowski A.

Wiad Lek. 2004;57(1-2):16-9.

PMID:
15181743
25.

Sonic hedgehog is a neuromodulator in the adult subthalamic nucleus.

Bezard E, Baufreton J, Owens G, Crossman AR, Dudek H, Taupignon A, Brotchie JM.

FASEB J. 2003 Dec;17(15):2337-8. Epub 2003 Oct 2.

PMID:
14525941
26.

Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.

Machold R, Hayashi S, Rutlin M, Muzumdar MD, Nery S, Corbin JG, Gritli-Linde A, Dellovade T, Porter JA, Rubin LL, Dudek H, McMahon AP, Fishell G.

Neuron. 2003 Sep 11;39(6):937-50. Erratum in: Neuron. 2003 Sep 25;40(1):189.

27.

Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy.

Calcutt NA, Allendoerfer KL, Mizisin AP, Middlemas A, Freshwater JD, Burgers M, Ranciato R, Delcroix JD, Taylor FR, Shapiro R, Strauch K, Dudek H, Engber TM, Galdes A, Rubin LL, Tomlinson DR.

J Clin Invest. 2003 Feb;111(4):507-14.

28.

The decrease in antioxidant potential in human brain tumours.

Dudek H, Farbiszewski R, Michno T, Witek A, Kozłowski A, Rydzewska M.

Rocz Akad Med Bialymst. 2002;47:113-22.

PMID:
12533953
29.

Translation of developmental biology into therapeutics: the hedgehog signaling pathway and neurodegenerative diseases.

Allendoerfer KL, Dudek H.

Curr Opin Investig Drugs. 2002 Dec;3(12):1742-4. Review. No abstract available.

PMID:
12528310
30.

[Standards for the measuring check of eye tonometers--comparative measurements with 50 test apparatuses].

Dudek H, Schwenteck T, Thiemich HJ.

Klin Monbl Augenheilkd. 2002 Oct;219(10):703-9. German.

PMID:
12447714
31.

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.

Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA.

J Biol. 2002 Nov 6;1(2):10.

32.

[The role of platelet activating factor (PAF) in physiology and pathology of the central nervous system].

Farbiszewski R, Dudek H, Skrzydlewska E, Lewko J.

Neurol Neurochir Pol. 2002 Jul-Aug;36(4):801-8. Review. Polish.

PMID:
12418143
33.
34.

[Evaluation of surgical treatment results in extreme lateral lumbar disc prolapsed after 12 months of follow-up].

Dudek H, Michno T, Kozłowski A.

Neurol Neurochir Pol. 2002 Mar-Apr;36(2):285-92. Polish.

PMID:
12046505
35.

[Concentration of glutathione (GSH), ascorbic acid (Vit. C), and thiobarbiturate acid reacting components (MDA) in brain neoplasms].

Dudek H, Farbiszewski R, Łebkowski WJ, Michno T, Kozłowski A.

Wiad Lek. 2001;54(11-12):615-20. Polish.

PMID:
11928548
36.

[Evaluation of results of surgical treatment of epidural canal lipomatosis with 3 years of follow-up of a case].

Dudek H, Michno T, Kozłowski A.

Neurol Neurochir Pol. 2001 Sep-Oct;35(5):877-81. Polish.

PMID:
11873600
37.

[Activity of glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-R) and superoxide dismutase in the brain tumors].

Dudek H, Farbiszewski R, Michno T, Łebkowski WJ, Kozłowski A.

Przegl Lek. 2001;58(6):504-6. Polish.

PMID:
11816741
38.

[Giant intradural disk herniation].

Łebkowski WJ, Dudek H, Drapało L.

Chir Narzadow Ruchu Ortop Pol. 2001;66(4):413-5. Polish.

PMID:
11761764
39.

[Long-term results of surgical treatment of lumbar disk herniation in adults].

Dudek H, Michno T, Łebkowski WJ, Kozłowski A.

Chir Narzadow Ruchu Ortop Pol. 2001;66(4):351-6. Polish.

PMID:
11761755
40.

Neoplasms of the central nervous system of lipoid origin.

Łebkowski WJ, Dudek H, Łebkowska U, Dziecioł J.

Pol J Pathol. 2000;51(3):159-63.

PMID:
11247399
41.

[Early results of surgical treatment of herniated nucleus pulposus in the lumbar spine in adults patients].

Dudek H, Michno T, Michalski J.

Chir Narzadow Ruchu Ortop Pol. 2000;65(5):477-82. Polish.

PMID:
11235076
42.

[Lateral lumbar disk herniation].

Dudek H, Michno T, Michalski J.

Chir Narzadow Ruchu Ortop Pol. 2000;65(1):65-70. Polish.

PMID:
10838771
43.

[Anamnestic and anthropometric assessment of patients with herniated lumbar intervertebral disc].

Dudek H, Michno T, Michalski J.

Chir Narzadow Ruchu Ortop Pol. 1999;64(6):619-25. Polish.

PMID:
10765478
44.

Late posttraumatic epilepsy in patients with an alcoholic problem treated surgically for posttraumatic chronic subdural hematomas.

Dudek H, Michno T, Michalski J, Kaczmarek M, Drapało L.

Rocz Akad Med Bialymst. 1999;44:119-27.

PMID:
10697426
45.

[Lipoma of the corpus callosum].

Dudek H, Polityńska B, Michno T, Michalski J.

Neurol Neurochir Pol. 1999 Jan-Feb;33(1):203-9. Polish.

PMID:
10399737
46.

[Long-term results of surgical treatment of lumbar discopathy in children and adolescents].

Dudek H, Michno T, Michalski J.

Chir Narzadow Ruchu Ortop Pol. 1998;63(5):469-73. Polish.

PMID:
10093392
47.

[Immediate and short-term results of surgical treatment for lumbar disc protrusion in children and adolescents].

Dudek H, Michno T, Michalski J.

Chir Narzadow Ruchu Ortop Pol. 1998;63(2):109-15. Polish.

PMID:
9684493
48.

[Idiopathic epidural lipomatosis of the vertebral canal].

Dudek H, Michno T, Michalski J.

Neurol Neurochir Pol. 1998 Jan-Feb;32(1):185-9. Polish.

PMID:
9631390
49.

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.

Cell. 1997 Oct 17;91(2):231-41.

50.

Regulation of neuronal survival by the serine-threonine protein kinase Akt.

Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME.

Science. 1997 Jan 31;275(5300):661-5.

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