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Items: 1 to 50 of 115

1.

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.

Manousaki D, Dudding T, Haworth S, Hsu YH, Liu CT, Medina-Gómez C, Voortman T, van der Velde N, Melhus H, Robinson-Cohen C, Cousminer DL, Nethander M, Vandenput L, Noordam R, Forgetta V, Greenwood CMT, Biggs ML, Psaty BM, Rotter JI, Zemel BS, Mitchell JA, Taylor B, Lorentzon M, Karlsson M, Jaddoe VVW, Tiemeier H, Campos-Obando N, Franco OH, Utterlinden AG, Broer L, van Schoor NM, Ham AC, Ikram MA, Karasik D, de Mutsert R, Rosendaal FR, den Heijer M, Wang TJ, Lind L, Orwoll ES, Mook-Kanamori DO, Michaëlsson K, Kestenbaum B, Ohlsson C, Mellström D, de Groot LCPGM, Grant SFA, Kiel DP, Zillikens MC, Rivadeneira F, Sawcer S, Timpson NJ, Richards JB.

Am J Hum Genet. 2018 Dec 6;103(6):1053. doi: 10.1016/j.ajhg.2018.11.010. No abstract available.

PMID:
30526863
2.

Cyclopropenium Enhanced Thiourea Catalysis.

Smajlagic I, Durán R, Pilkington M, Dudding T.

J Org Chem. 2018 Nov 16;83(22):13973-13980. doi: 10.1021/acs.joc.8b02321. Epub 2018 Oct 30.

PMID:
30352160
3.

Author Correction: Amine hemilability enables boron to mechanistically resemble either hydride or proton.

Lee CF, Diaz DB, Holownia A, Kaldas SJ, Liew SK, Garrett GE, Dudding T, Yudin AK.

Nat Chem. 2018 Oct;10(10):1071. doi: 10.1038/s41557-018-0151-3.

PMID:
30202105
4.

Synthesis of α-Borylated Ketones by Regioselective Wacker Oxidation of Alkenylboronates.

Corless VB, Holownia A, Foy H, Mendoza-Sanchez R, Adachi S, Dudding T, Yudin AK.

Org Lett. 2018 Sep 7;20(17):5300-5303. doi: 10.1021/acs.orglett.8b02234. Epub 2018 Aug 21.

PMID:
30129366
5.

Reassessing the Association between Circulating Vitamin D and IGFBP-3: Observational and Mendelian Randomization Estimates from Independent Sources.

Tan VY, Biernacka KM, Dudding T, Bonilla C, Gilbert R, Kaplan RC, Qibin Q, Teumer A, Martin RM, Perks CM, Timpson NJ, Holly JMP; PRACTICAL consortium.

Cancer Epidemiol Biomarkers Prev. 2018 Dec;27(12):1462-1471. doi: 10.1158/1055-9965.EPI-18-0113. Epub 2018 Aug 2.

PMID:
30072546
6.

Amine hemilability enables boron to mechanistically resemble either hydride or proton.

Lee CF, Diaz DB, Holownia A, Kaldas SJ, Liew SK, Garrett GE, Dudding T, Yudin AK.

Nat Chem. 2018 Oct;10(10):1062-1070. doi: 10.1038/s41557-018-0097-5. Epub 2018 Jul 30. Erratum in: Nat Chem. 2018 Sep 10;:.

PMID:
30061615
7.

Bilateral versus unilateral botulinum toxin injections for chronic anal fissure: a randomised trial.

Pilkington SA, Bhome R, Welch RE, Ku F, Warden C, Harris S, Hicks J, Richardson C, Dudding TC, Knight JS, King AT, Mirnezami AH, Beck NE, Nichols PH, Nugent KP.

Tech Coloproctol. 2018 Jul;22(7):545-551. doi: 10.1007/s10151-018-1821-2. Epub 2018 Jul 18.

8.

A Mechanistic Model for the Aziridine Aldehyde-Driven Macrocyclization of Peptides.

Belding L, Zaretsky S, Yudin AK, Dudding T.

J Org Chem. 2018 Aug 17;83(16):9119-9124. doi: 10.1021/acs.joc.8b01198. Epub 2018 Jul 19.

PMID:
29966423
9.

Efficacy and mechanism of sub-sensory sacral (optimised) neuromodulation in adults with faecal incontinence: study protocol for a randomised controlled trial.

McAlees E, Vollebregt PF, Stevens N, Dudding TC, Emmanuel AV, Furlong PL, Hamdy S, Hooper RL, Jones JFX, Norton C, O'Connell PR, Scott SM, Knowles CH.

Trials. 2018 Jun 26;19(1):336. doi: 10.1186/s13063-018-2689-1.

10.

Consortium-based genome-wide meta-analysis for childhood dental caries traits.

Haworth S, Shungin D, van der Tas JT, Vucic S, Medina-Gomez C, Yakimov V, Feenstra B, Shaffer JR, Lee MK, Standl M, Thiering E, Wang C, Bønnelykke K, Waage J, Jessen LE, Nørrisgaard PE, Joro R, Seppälä I, Raitakari O, Dudding T, Grgic O, Ongkosuwito E, Vierola A, Eloranta AM, West NX, Thomas SJ, McNeil DW, Levy SM, Slayton R, Nohr EA, Lehtimäki T, Lakka T, Bisgaard H, Pennell C, Kühnisch J, Marazita ML, Melbye M, Geller F, Rivadeneira F, Wolvius EB, Franks PW, Johansson I, Timpson NJ.

Hum Mol Genet. 2018 Sep 1;27(17):3113-3127. doi: 10.1093/hmg/ddy237.

11.

Age 23 years + oral health questionnaire in Avon Longitudinal Study of Parents and Children.

Dudding T, Haworth S, Sandy J, Timpson NJ.

Wellcome Open Res. 2018 Mar 26;3:34. doi: 10.12688/wellcomeopenres.14159.2. eCollection 2018.

12.

Fluorescence of Cyclopropenium Ion Derivatives.

Belding L, Guest M, Le Sueur R, Dudding T.

J Org Chem. 2018 Jun 15;83(12):6489-6497. doi: 10.1021/acs.joc.8b00770. Epub 2018 May 31.

PMID:
29790751
13.

Bis(amino)cyclopropenium Trifluoroborates: Synthesis, Hydrolytic Stability Studies, and DFT Insights.

Mir R, Dudding T.

J Org Chem. 2018 Apr 20;83(8):4384-4388. doi: 10.1021/acs.joc.8b00060. Epub 2018 Apr 10.

PMID:
29620888
14.

Assessing the causal association between 25-hydroxyvitamin D and the risk of oral and oropharyngeal cancer using Mendelian randomization.

Dudding T, Johansson M, Thomas SJ, Brennan P, Martin RM, Timpson NJ.

Int J Cancer. 2018 Sep 1;143(5):1029-1036. doi: 10.1002/ijc.31377.

15.

Differential regulation of two FLNA transcripts explains some of the phenotypic heterogeneity in the loss-of-function filaminopathies.

Jenkins ZA, Macharg A, Chang CY, van Kogelenberg M, Morgan T, Frentz S, Wei W, Pilch J, Hannibal M, Foulds N, McGillivray G, Leventer RJ, García-Miñaúr S, Sugito S, Nightingale S, Markie DM, Dudding T, Kapur RP, Robertson SP.

Hum Mutat. 2018 Jan;39(1):103-113. doi: 10.1002/humu.23355. Epub 2017 Nov 2.

PMID:
29024177
16.

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.

Manousaki D, Dudding T, Haworth S, Hsu YH, Liu CT, Medina-Gómez C, Voortman T, van der Velde N, Melhus H, Robinson-Cohen C, Cousminer DL, Nethander M, Vandenput L, Noordam R, Forgetta V, Greenwood CMT, Biggs ML, Psaty BM, Rotter JI, Zemel BS, Mitchell JA, Taylor B, Lorentzon M, Karlsson M, Jaddoe VVW, Tiemeier H, Campos-Obando N, Franco OH, Utterlinden AG, Broer L, van Schoor NM, Ham AC, Ikram MA, Karasik D, de Mutsert R, Rosendaal FR, den Heijer M, Wang TJ, Lind L, Orwoll ES, Mook-Kanamori DO, Michaëlsson K, Kestenbaum B, Ohlsson C, Mellström D, de Groot LCPGM, Grant SFA, Kiel DP, Zillikens MC, Rivadeneira F, Sawcer S, Timpson NJ, Richards JB.

Am J Hum Genet. 2017 Aug 3;101(2):227-238. doi: 10.1016/j.ajhg.2017.06.014. Epub 2017 Jul 27. Erratum in: Am J Hum Genet. 2018 Dec 6;103(6):1053.

17.

Ten years on: Is dental general anaesthesia in childhood a risk factor for caries and anxiety?

Haworth S, Dudding T, Waylen A, Thomas SJ, Timpson NJ.

Br Dent J. 2017 Feb 24;222(4):299-304. doi: 10.1038/sj.bdj.2017.175.

18.

Erratum: Hwang Y.T. et al. Molecular Inconsistencies in a Fragile X Male with Early Onset Ataxia. Genes 2016, 7, 68.

Hwang YT, Dudding T, Aliaga SM, Arpone M, Francis D, Li X, Slater HR, Rogers C, Bretherton L, du Sart D, Heard R, Godler DE.

Genes (Basel). 2017 Jan 24;8(2). pii: E47. doi: 10.3390/genes8020047.

19.

Phase-Transfer Catalyzed O-Silyl Ether Deprotection Mediated by a Cyclopropenium Cation.

Mir R, Dudding T.

J Org Chem. 2017 Jan 6;82(1):709-714. doi: 10.1021/acs.joc.6b02733. Epub 2016 Dec 21.

PMID:
27935706
20.

Microbiological assessment of aerosol generated during debond of fixed orthodontic appliances.

Dawson M, Soro V, Dymock D, Price R, Griffiths H, Dudding T, Sandy JR, Ireland AJ.

Am J Orthod Dentofacial Orthop. 2016 Nov;150(5):831-838. doi: 10.1016/j.ajodo.2016.04.022.

PMID:
27871710
21.

Molecular Inconsistencies in a Fragile X Male with Early Onset Ataxia.

Hwang YT, Dudding T, Aliaga SM, Arpone M, Francis D, Li X, Slater HR, Rogers C, Bretherton L, du Sart D, Heard R, Godler DE.

Genes (Basel). 2016 Sep 21;7(9). pii: E68. doi: 10.3390/genes7090068.

22.

Somatic-gonadal mosaicism causing Sotos syndrome.

Kamien B, Dadd T, Buckman M, Ronan A, Dudding T, Meldrum C, Scott R, Mina K.

Am J Med Genet A. 2016 Dec;170(12):3360-3362. doi: 10.1002/ajmg.a.37867. Epub 2016 Sep 8. No abstract available.

PMID:
27604501
23.

Unique molecular geometries of reduced 4- and 5-coordinate zinc complexes stabilised by diiminopyridine ligand.

Chu T, Belding L, Poddutoori PK, van der Est A, Dudding T, Korobkov I, Nikonov GI.

Dalton Trans. 2016 Sep 14;45(34):13440-8. doi: 10.1039/c6dt02001a. Epub 2016 Aug 4.

PMID:
27488247
24.

Synthesis of Chiral Piperazinones Using Amphoteric Aziridine Aldehyde Dimers and Functionalized Isocyanides.

Heine NB, Kaldas SJ, Belding L, Shmatova O, Dudding T, Nenajdenko VG, Studer A, Yudin AK.

J Org Chem. 2016 Jun 17;81(12):5209-16. doi: 10.1021/acs.joc.6b00471. Epub 2016 Jun 1.

PMID:
27156711
25.

An Evolving Insight into Chiral H-Bond Catalyzed Aza-Henry Reactions: A Cooperative Role for Noncovalent Attractive Interactions Unveiled by Density Functional Theory.

Taimoory SM, Dudding T.

J Org Chem. 2016 Apr 15;81(8):3286-95. doi: 10.1021/acs.joc.6b00248. Epub 2016 Apr 4.

PMID:
27008440
26.

A Au(I)-Precatalyst with a Cyclopropenium Counterion: An Unusual Ion Pair.

Mir R, Dudding T.

J Org Chem. 2016 Mar 18;81(6):2675-9. doi: 10.1021/acs.joc.6b00241. Epub 2016 Feb 25.

PMID:
26889777
27.

Re-Examining the Association between Vitamin D and Childhood Caries.

Dudding T, Thomas SJ, Duncan K, Lawlor DA, Timpson NJ.

PLoS One. 2015 Dec 21;10(12):e0143769. doi: 10.1371/journal.pone.0143769. eCollection 2015.

28.

Phase-Transfer Catalysis via a Proton Sponge: A Bifunctional Role for Biscyclopropenimine.

Belding L, Stoyanov P, Dudding T.

J Org Chem. 2016 Jan 15;81(2):553-8. doi: 10.1021/acs.joc.5b02395. Epub 2015 Dec 22.

PMID:
26649566
29.

Cost-Utility Analysis of Sacral Nerve Stimulation for The Treatment of Fecal Incontinence Refractory to Conservative Treatment: Looking for Optimal Treatment Path.

Pochopien M, Plisko R, Drzal R, Baran M, Sekiewicz B, Dudding T, Knowles C, Grifi M, Valyi A.

Value Health. 2015 Nov;18(7):A359. doi: 10.1016/j.jval.2015.09.687. Epub 2015 Oct 20. No abstract available.

30.

Synthesis, Theoretical Analysis, and Experimental pKa Determination of a Fluorescent, Nonsymmetric, In-Out Proton Sponge.

Belding L, Stoyanov P, Dudding T.

J Org Chem. 2016 Jan 4;81(1):6-13. doi: 10.1021/acs.joc.5b01743. Epub 2015 Oct 16.

PMID:
26440446
31.

Recognizable cerebellar dysplasia associated with mutations in multiple tubulin genes.

Oegema R, Cushion TD, Phelps IG, Chung SK, Dempsey JC, Collins S, Mullins JG, Dudding T, Gill H, Green AJ, Dobyns WB, Ishak GE, Rees MI, Doherty D.

Hum Mol Genet. 2015 Sep 15;24(18):5313-25. doi: 10.1093/hmg/ddv250. Epub 2015 Jun 30.

32.

A double-blinded randomized multicentre study to investigate the effect of changes in stimulation parameters on sacral nerve stimulation for constipation.

Thomas GP, Duelund-Jakobsen J, Dudding TC, Bradshaw E, Nicholls RJ, Alam A, Emmanuel A, Thin N, Knowles CH, Laurberg S, Vaizey CJ.

Colorectal Dis. 2015 Nov;17(11):990-5. doi: 10.1111/codi.12982.

PMID:
25916959
33.

Expanding the forefront of strong organic Brønsted acids: proton-catalyzed hydroamination of unactivated alkenes and activation of Au(I) for alkyne hydroamination.

Mirabdolbaghi R, Dudding T.

Org Lett. 2015 Apr 17;17(8):1930-3. doi: 10.1021/acs.orglett.5b00617. Epub 2015 Apr 8.

PMID:
25853739
34.

Diverse phenotypic consequences of mutations affecting the C-terminus of FLNA.

van Kogelenberg M, Clark AR, Jenkins Z, Morgan T, Anandan A, Sawyer GM, Edwards M, Dudding T, Homfray T, Castle B, Tolmie J, Stewart F, Kivuva E, Pilz DT, Gabbett M, Sutherland-Smith AJ, Robertson SP.

J Mol Med (Berl). 2015 Jul;93(7):773-82. doi: 10.1007/s00109-015-1261-7. Epub 2015 Feb 18.

PMID:
25686753
35.

Shifting the energy landscape of multicomponent reactions using aziridine aldehyde dimers: a mechanistic study.

Belding L, Zaretsky S, Rotstein BH, Yudin AK, Dudding T.

J Org Chem. 2014 Oct 17;79(20):9465-71. doi: 10.1021/jo501242r. Epub 2014 Sep 29.

PMID:
25264960
36.

Hydroxyproline-derived pseudoenantiomeric [2.2.1] bicyclic phosphines: asymmetric synthesis of (+)- and (-)-pyrrolines.

Henry CE, Xu Q, Fan YC, Martin TJ, Belding L, Dudding T, Kwon O.

J Am Chem Soc. 2014 Aug 27;136(34):11890-3. doi: 10.1021/ja505592h. Epub 2014 Aug 14.

37.

A pilot study of chronic pudendal nerve stimulation for faecal incontinence for those who have failed sacral nerve stimulation.

Thomas GP, George AT, Dudding TC, Nicholls RJ, Vaizey CJ.

Tech Coloproctol. 2014 Aug;18(8):731-7. doi: 10.1007/s10151-014-1174-4. Epub 2014 Jun 22.

PMID:
24952733
38.

A class of phase-transfer catalyst with interionic strain: insight into the bonding of disubstituted N- vs carbene-stabilized N(I)-centered cations.

Mirabdolbaghi R, Dudding T, Stamatatos T.

Org Lett. 2014 Jun 6;16(11):2790-3. doi: 10.1021/ol501068f. Epub 2014 May 23.

PMID:
24857779
39.

A coordination compound of Ge(0) stabilized by a diiminopyridine ligand.

Chu T, Belding L, van der Est A, Dudding T, Korobkov I, Nikonov GI.

Angew Chem Int Ed Engl. 2014 Mar 3;53(10):2711-5. doi: 10.1002/anie.201309421. Epub 2014 Feb 2.

PMID:
24488623
40.

Synthesis and theoretical investigation of a 1,8-bis(bis(diisopropylamino)cyclopropeniminyl)naphthalene proton sponge derivative.

Belding L, Dudding T.

Chemistry. 2014 Jan 20;20(4):1032-7. doi: 10.1002/chem.201302959. Epub 2013 Dec 16.

PMID:
24357468
41.

Carbimazole/methimazole embryopathy in siblings: a possible genetic susceptibility.

Goel H, Dudding T.

Birth Defects Res A Clin Mol Teratol. 2013 Nov;97(11):755-8. doi: 10.1002/bdra.23200. Epub 2013 Nov 6.

PMID:
24265129
42.

A pilot study to compare daily with twice weekly transcutaneous posterior tibial nerve stimulation for faecal incontinence.

Thomas GP, Dudding TC, Bradshaw E, Nicholls RJ, Vaizey CJ.

Colorectal Dis. 2013 Dec;15(12):1504-9. doi: 10.1111/codi.12428.

PMID:
24118972
43.

A computational study of the copper(II)-catalyzed enantioselective intramolecular aminooxygenation of alkenes.

Belding L, Chemler SR, Dudding T.

J Org Chem. 2013 Oct 18;78(20):10288-97. doi: 10.1021/jo401665n. Epub 2013 Oct 1.

44.

Bilateral transcutaneous posterior tibial nerve stimulation for the treatment of fecal incontinence.

Thomas GP, Dudding TC, Nicholls RJ, Vaizey CJ.

Dis Colon Rectum. 2013 Sep;56(9):1075-9. doi: 10.1097/DCR.0b013e31829bf940.

PMID:
23929017
45.

Sacral nerve stimulation: an effective treatment for chronic functional anal pain?

Dudding TC, Thomas GP, Hollingshead JR, George AT, Stern J, Vaizey CJ.

Colorectal Dis. 2013 Sep;15(9):1140-4. doi: 10.1111/codi.12277.

PMID:
23692279
46.

Pudendal nerve stimulation for bowel dysfunction in complete cauda equina syndrome.

George AT, Dudding TC, Gurmany S, Kamm MA, Nicholls RJ, Vaizey CJ.

Ann Surg. 2014 Mar;259(3):502-7. doi: 10.1097/SLA.0b013e31828e7602.

PMID:
23579581
47.

A detailed NMR- and DFT-based study of the Sakurai-Hosomi-Yamamoto asymmetric allylation reaction.

Hurem D, Moiseev AG, Simionescu R, Dudding T.

J Org Chem. 2013 May 3;78(9):4440-5. doi: 10.1021/jo400451u. Epub 2013 Apr 22.

PMID:
23570439
48.

Randomized controlled trial of percutaneous versus transcutaneous posterior tibial nerve stimulation in faecal incontinence.

George AT, Kalmar K, Sala S, Kopanakis K, Panarese A, Dudding TC, Hollingshead JR, Nicholls RJ, Vaizey CJ.

Br J Surg. 2013 Feb;100(3):330-8. doi: 10.1002/bjs.9000.

PMID:
23300071
49.

A review of posterior tibial nerve stimulation for faecal incontinence.

Thomas GP, Dudding TC, Rahbour G, Nicholls RJ, Vaizey CJ.

Colorectal Dis. 2013 May;15(5):519-26. doi: 10.1111/codi.12093. Review.

PMID:
23216902
50.

Sacral nerve stimulation for constipation.

Thomas GP, Dudding TC, Rahbour G, Nicholls RJ, Vaizey CJ.

Br J Surg. 2013 Jan;100(2):174-81. doi: 10.1002/bjs.8944. Epub 2012 Nov 2. Review.

PMID:
23124687

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