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Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function.

Löffler J, Sass FA, Filter S, Rose A, Ellinghaus A, Duda GN, Dienelt A.

Front Immunol. 2019 Oct 18;10:2443. doi: 10.3389/fimmu.2019.02443. eCollection 2019.


Towards multi-dynamic mechano-biological optimization of 3D-printed scaffolds to foster bone regeneration.

Metz C, Duda GN, Checa S.

Acta Biomater. 2019 Oct 24. pii: S1742-7061(19)30708-1. doi: 10.1016/j.actbio.2019.10.029. [Epub ahead of print]


Oxidized alginate beads for tunable release of osteogenically potent mesenchymal stromal cells.

Xiang G, Lippens E, Hafeez S, Duda GN, Geissler S, Qazi TH.

Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109911. doi: 10.1016/j.msec.2019.109911. Epub 2019 Jun 22.


Individual Effector/Regulator T Cell Ratios Impact Bone Regeneration.

Schlundt C, Reinke S, Geissler S, Bucher CH, Giannini C, Märdian S, Dahne M, Kleber C, Samans B, Baron U, Duda GN, Volk HD, Schmidt-Bleek K.

Front Immunol. 2019 Aug 16;10:1954. doi: 10.3389/fimmu.2019.01954. eCollection 2019.


Locking plate constructs benefit from interfragmentary lag screw fixation with decreased shear movements and more predictable fracture gap motion in simple fracture patterns.

Märdian S, Schmölz W, Schaser KD, Duda GN, Heyland M.

Clin Biomech (Bristol, Avon). 2019 Aug 16;70:89-96. doi: 10.1016/j.clinbiomech.2019.08.008. [Epub ahead of print]


Baseline structural tissue pathology is not strongly associated with longitudinal change in transverse relaxation time (T2) in knees without osteoarthritis.

Roemer FW, Eckstein F, Duda GN, Guermazi A, Maschek S, Wirth W.

Eur J Radiol. 2019 Sep;118:161-168. doi: 10.1016/j.ejrad.2019.07.013. Epub 2019 Jul 20.


Integrated additive design and manufacturing approach for the bioengineering of bone scaffolds for favorable mechanical and biological properties.

Valainis D, Dondl P, Foehr P, Burgkart R, Kalkhof S, Duda GN, van Griensven M, Poh PSP.

Biomed Mater. 2019 Sep 9;14(6):065002. doi: 10.1088/1748-605X/ab38c6.


Load-induced osteogenic differentiation of mesenchymal stromal cells is caused by mechano-regulated autocrine signaling.

Schreivogel S, Kuchibhotla V, Knaus P, Duda GN, Petersen A.

J Tissue Eng Regen Med. 2019 Jul 30. doi: 10.1002/term.2948. [Epub ahead of print]


T1 and T2* mapping of the human quadriceps and patellar tendons using ultra-short echo-time (UTE) imaging and bivariate relaxation parameter-based volumetric visualization.

Krämer M, Maggioni MB, Brisson NM, Zachow S, Teichgräber U, Duda GN, Reichenbach JR.

Magn Reson Imaging. 2019 Jul 24;63:29-36. doi: 10.1016/j.mri.2019.07.015. [Epub ahead of print]


From macroscopic mechanics to cell-effective stiffness within highly aligned macroporous collagen scaffolds.

Herrera A, Hellwig J, Leemhuis H, von Klitzing R, Heschel I, Duda GN, Petersen A.

Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109760. doi: 10.1016/j.msec.2019.109760. Epub 2019 May 16.


Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxation time than those with normal contralateral knees: a model of early OA? - data from the Osteoarthritis Initiative (OAI).

Wirth W, Maschek S, Roemer FW, Sharma L, Duda GN, Eckstein F.

Osteoarthritis Cartilage. 2019 Nov;27(11):1663-1668. doi: 10.1016/j.joca.2019.06.013. Epub 2019 Jul 10.


Enzymatically-degradable alginate hydrogels promote cell spreading and in vivo tissue infiltration.

Lueckgen A, Garske DS, Ellinghaus A, Mooney DJ, Duda GN, Cipitria A.

Biomaterials. 2019 Oct;217:119294. doi: 10.1016/j.biomaterials.2019.119294. Epub 2019 Jun 20.


Weight Bearing Activities change the Pivot Position after Total Knee Arthroplasty.

Moewis P, Hommel H, Trepczynski A, Krahl L, von Roth P, Duda GN.

Sci Rep. 2019 Jun 24;9(1):9148. doi: 10.1038/s41598-019-45694-y.


Dynamics of postural control in individuals with ankle instability: Effect of visual input and orthotic use.

Raffalt PC, Chrysanthou M, Duda GN, Agres AN.

Comput Biol Med. 2019 Jul;110:120-126. doi: 10.1016/j.compbiomed.2019.05.018. Epub 2019 May 24.


Age-Related Changes in the Mechanical Regulation of Bone Healing Are Explained by Altered Cellular Mechanoresponse.

Borgiani E, Figge C, Kruck B, Willie BM, Duda GN, Checa S.

J Bone Miner Res. 2019 Oct;34(10):1923-1937. doi: 10.1002/jbmr.3801. Epub 2019 Jul 29.


Collagen Fibrils Mechanically Contribute to Tissue Contraction in an In Vitro Wound Healing Scenario.

Brauer E, Lippens E, Klein O, Nebrich G, Schreivogel S, Korus G, Duda GN, Petersen A.

Adv Sci (Weinh). 2019 Mar 14;6(9):1801780. doi: 10.1002/advs.201801780. eCollection 2019 May 3.


Association between changes in molecular biomarkers of cartilage matrix turnover and changes in knee articular cartilage: a longitudinal pilot study.

Boeth H, Raffalt PC, MacMahon A, Poole AR, Eckstein F, Wirth W, Buttgereit F, Önnerfjord P, Lorenzo P, Klint C, Pramhed A, Duda GN.

J Exp Orthop. 2019 May 3;6(1):19. doi: 10.1186/s40634-019-0179-3.


Experience in the Adaptive Immunity Impacts Bone Homeostasis, Remodeling, and Healing.

Bucher CH, Schlundt C, Wulsten D, Sass FA, Wendler S, Ellinghaus A, Thiele T, Seemann R, Willie BM, Volk HD, Duda GN, Schmidt-Bleek K.

Front Immunol. 2019 Apr 12;10:797. doi: 10.3389/fimmu.2019.00797. eCollection 2019.


ESB Clinical Biomechanics Award 2018: Muscle atrophy-related increased joint loading after total hip arthroplasty and their postoperative change from 3 to 50 months.

Damm P, Brackertz S, Streitparth F, Perka C, Bergmann G, Duda GN, Winkler T.

Clin Biomech (Bristol, Avon). 2019 May;65:105-109. doi: 10.1016/j.clinbiomech.2019.04.008. Epub 2019 Apr 13.


Immune Modulation to Enhance Bone Healing-A New Concept to Induce Bone Using Prostacyclin to Locally Modulate Immunity.

Wendler S, Schlundt C, Bucher CH, Birkigt J, Schipp CJ, Volk HD, Duda GN, Schmidt-Bleek K.

Front Immunol. 2019 Apr 5;10:713. doi: 10.3389/fimmu.2019.00713. eCollection 2019.


Impact of Gentamicin-Loaded Bone Graft on Defect Healing in a Sheep Model.

Beuttel E, Bormann N, Pobloth AM, Duda GN, Wildemann B.

Materials (Basel). 2019 Apr 4;12(7). pii: E1116. doi: 10.3390/ma12071116.


Author Correction: Tibio-Femoral Contact Force Distribution is Not the Only Factor Governing Pivot Location after Total Knee Arthroplasty.

Trepczynski A, Kutzner I, Schütz P, Dymke J, List R, von Roth P, Moewis P, Bergmann G, Taylor WR, Duda GN.

Sci Rep. 2019 Apr 11;9(1):6188. doi: 10.1038/s41598-019-41668-2.


Treatment of osteochondral defects: chondrointegration of metal implants improves after hydroxyapatite coating.

Schell H, Zimpfer E, Schmidt-Bleek K, Jung T, Duda GN, Ryd L.

Knee Surg Sports Traumatol Arthrosc. 2019 Nov;27(11):3575-3582. doi: 10.1007/s00167-019-05484-5. Epub 2019 Mar 16.


Cell therapy to improve regeneration of skeletal muscle injuries.

Qazi TH, Duda GN, Ort MJ, Perka C, Geissler S, Winkler T.

J Cachexia Sarcopenia Muscle. 2019 Jun;10(3):501-516. doi: 10.1002/jcsm.12416. Epub 2019 Mar 6. Review.


Anatomic grooved stem mitigates strain shielding compared to established total hip arthroplasty stem designs in finite-element models.

Heyland M, Checa S, Kendoff D, Duda GN.

Sci Rep. 2019 Jan 24;9(1):482. doi: 10.1038/s41598-018-36503-z.


Tibio-Femoral Contact Force Distribution is Not the Only Factor Governing Pivot Location after Total Knee Arthroplasty.

Trepczynski A, Kutzner I, Schütz P, Dymke J, List R, von Roth P, Moewis P, Bergmann G, Taylor WR, Duda GN.

Sci Rep. 2019 Jan 17;9(1):182. doi: 10.1038/s41598-018-37189-z. Erratum in: Sci Rep. 2019 Apr 11;9(1):6188.


Collagen I-based scaffolds negatively impact fracture healing in a mouse-osteotomy-model although used routinely in research and clinical application.

Lang A, Kirchner M, Stefanowski J, Durst M, Weber MC, Pfeiffenberger M, Damerau A, Hauser AE, Hoff P, Duda GN, Buttgereit F, Schmidt-Bleek K, Gaber T.

Acta Biomater. 2019 Mar 1;86:171-184. doi: 10.1016/j.actbio.2018.12.043. Epub 2019 Jan 5.


Normal trabecular vertebral bone is formed via rapid transformation of mineralized spicules: A high-resolution 3D ex-vivo murine study.

Zenzes M, Bortel EL, Fratzl P, Mundlos S, Schuetz M, Schmidt H, Duda GN, Witte F, Zaslansky P.

Acta Biomater. 2019 Mar 1;86:429-440. doi: 10.1016/j.actbio.2018.12.050. Epub 2018 Dec 31.


Loading of the hip and knee joints during whole body vibration training.

Bergmann G, Kutzner I, Bender A, Dymke J, Trepczynski A, Duda GN, Felsenberg D, Damm P.

PLoS One. 2018 Dec 12;13(12):e0207014. doi: 10.1371/journal.pone.0207014. eCollection 2018.


Impact of antagonistic muscle co-contraction on in vivo knee contact forces.

Trepczynski A, Kutzner I, Schwachmeyer V, Heller MO, Pfitzner T, Duda GN.

J Neuroeng Rehabil. 2018 Nov 8;15(1):101. doi: 10.1186/s12984-018-0434-3.


Cartilage loss in radiographically normal knees depends on radiographic status of the contralateral knee - data from the Osteoarthritis Initiative.

Eckstein F, Maschek S, Roemer FW, Duda GN, Sharma L, Wirth W.

Osteoarthritis Cartilage. 2019 Feb;27(2):273-277. doi: 10.1016/j.joca.2018.10.006. Epub 2018 Oct 28.


A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects.

Petersen A, Princ A, Korus G, Ellinghaus A, Leemhuis H, Herrera A, Klaumünzer A, Schreivogel S, Woloszyk A, Schmidt-Bleek K, Geissler S, Heschel I, Duda GN.

Nat Commun. 2018 Oct 25;9(1):4430. doi: 10.1038/s41467-018-06504-7.


Alterations in structure of the muscle-tendon unit and gait pattern after percutaneous repair of Achilles tendon rupture with the Dresden instrument.

Manegold S, Tsitsilonis S, Gehlen T, Kopf S, Duda GN, Agres AN.

Foot Ankle Surg. 2019 Aug;25(4):529-533. doi: 10.1016/j.fas.2018.04.004. Epub 2018 Apr 14.


The Interaction of BMP2-Induced Defect Healing in Rat and Fixator Stiffness Modulates Matrix Alignment and Contraction.

Schwarz C, Ott CE, Wulsten D, Brauer E, Schreivogel S, Petersen A, Hassanein K, Roewer L, Schmidt T, Willie BM, Duda GN.

JBMR Plus. 2018 Apr 17;2(3):174-186. doi: 10.1002/jbm4.10031. eCollection 2018 May.


Evaluation of the accuracy of musculoskeletal simulation during squats by means of instrumented knee prostheses.

Schellenberg F, Taylor WR, Trepczynski A, List R, Kutzner I, Schütz P, Duda GN, Lorenzetti S.

Med Eng Phys. 2018 Nov;61:95-99. doi: 10.1016/j.medengphy.2018.09.004. Epub 2018 Sep 30.


Dosage and composition of bioactive glasses differentially regulate angiogenic and osteogenic response of human MSCs.

Qazi TH, Berkmann JC, Schoon J, Geißler S, Duda GN, Boccaccini AR, Lippens E.

J Biomed Mater Res A. 2018 Nov;106(11):2827-2837. doi: 10.1002/jbm.a.36470. Epub 2018 Oct 3.


Physical Activities That Cause High Friction Moments at the Cup in Hip Implants.

Bergmann G, Bender A, Dymke J, Duda GN, Damm P.

J Bone Joint Surg Am. 2018 Oct 3;100(19):1637-1644. doi: 10.2106/JBJS.17.01298.


Immunomodulatory placental-expanded, mesenchymal stromal cells improve muscle function following hip arthroplasty.

Winkler T, Perka C, von Roth P, Agres AN, Plage H, Preininger B, Pumberger M, Geissler S, Hagai EL, Ofir R, Pinzur L, Eyal E, Stoltenburg-Didinger G, Meisel C, Consentius C, Streitz M, Reinke P, Duda GN, Volk HD.

J Cachexia Sarcopenia Muscle. 2018 Oct;9(5):880-897. doi: 10.1002/jcsm.12316. Epub 2018 Sep 19.


Optimization of cell-laden bioinks for 3D bioprinting and efficient infection with influenza A virus.

Berg J, Hiller T, Kissner MS, Qazi TH, Duda GN, Hocke AC, Hippenstiel S, Elomaa L, Weinhart M, Fahrenson C, Kurreck J.

Sci Rep. 2018 Sep 17;8(1):13877. doi: 10.1038/s41598-018-31880-x.


Unraveling local tissue changes within severely injured skeletal muscles in response to MSC-based intervention using MALDI Imaging mass spectrometry.

Klein O, Strohschein K, Nebrich G, Fuchs M, Thiele H, Giavalisco P, Duda GN, Winkler T, Kobarg JH, Trede D, Geissler S.

Sci Rep. 2018 Aug 23;8(1):12677. doi: 10.1038/s41598-018-30990-w.


Hydrolytically-degradable click-crosslinked alginate hydrogels.

Lueckgen A, Garske DS, Ellinghaus A, Desai RM, Stafford AG, Mooney DJ, Duda GN, Cipitria A.

Biomaterials. 2018 Oct;181:189-198. doi: 10.1016/j.biomaterials.2018.07.031. Epub 2018 Jul 24.


A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering: The unsolved challenge.

Winkler T, Sass FA, Duda GN, Schmidt-Bleek K.

Bone Joint Res. 2018 May 5;7(3):232-243. doi: 10.1302/2046-3758.73.BJR-2017-0270.R1. eCollection 2018 Mar.


Sclerostin Neutralizing Antibody Treatment Enhances Bone Formation but Does Not Rescue Mechanically Induced Delayed Healing.

Kruck B, Zimmermann EA, Damerow S, Figge C, Julien C, Wulsten D, Thiele T, Martin M, Hamdy R, Reumann MK, Duda GN, Checa S, Willie BM.

J Bone Miner Res. 2018 Sep;33(9):1686-1697. doi: 10.1002/jbmr.3454. Epub 2018 May 23.


Sost deficiency leads to reduced mechanical strains at the tibia midshaft in strain-matched in vivo loading experiments in mice.

Albiol L, Cilla M, Pflanz D, Kramer I, Kneissel M, Duda GN, Willie BM, Checa S.

J R Soc Interface. 2018 Apr;15(141). pii: 20180012. doi: 10.1098/rsif.2018.0012.


Loss of the Hematopoietic Stem Cell Factor GATA2 in the Osteogenic Lineage Impairs Trabecularization and Mechanical Strength of Bone.

Tolkachov A, Fischer C, Ambrosi TH, Bothe M, Han CT, Muenzner M, Mathia S, Salminen M, Seifert G, Thiele M, Duda GN, Meijsing SH, Sauer S, Schulz TJ, Schupp M.

Mol Cell Biol. 2018 May 29;38(12). pii: e00599-17. doi: 10.1128/MCB.00599-17. Print 2018 Jun 15.


Short-term functional assessment of gait, plantarflexor strength, and tendon properties after Achilles tendon rupture.

Agres AN, Gehlen TJ, Arampatzis A, Taylor WR, Duda GN, Manegold S.

Gait Posture. 2018 May;62:179-185. doi: 10.1016/j.gaitpost.2018.03.007. Epub 2018 Mar 5.


Clinical and Research Approaches to Treat Non-union Fracture.

Schlundt C, Bucher CH, Tsitsilonis S, Schell H, Duda GN, Schmidt-Bleek K.

Curr Osteoporos Rep. 2018 Apr;16(2):155-168. doi: 10.1007/s11914-018-0432-1. Review.


Immunology Guides Skeletal Muscle Regeneration.

Sass FA, Fuchs M, Pumberger M, Geissler S, Duda GN, Perka C, Schmidt-Bleek K.

Int J Mol Sci. 2018 Mar 13;19(3). pii: E835. doi: 10.3390/ijms19030835. Review.


Physiological joint line total knee arthroplasty designs are especially sensitive to rotational placement - A finite element analysis.

Moewis P, Checa S, Kutzner I, Hommel H, Duda GN.

PLoS One. 2018 Feb 5;13(2):e0192225. doi: 10.1371/journal.pone.0192225. eCollection 2018.


Mechanobiologically optimized 3D titanium-mesh scaffolds enhance bone regeneration in critical segmental defects in sheep.

Pobloth AM, Checa S, Razi H, Petersen A, Weaver JC, Schmidt-Bleek K, Windolf M, Tatai AÁ, Roth CP, Schaser KD, Duda GN, Schwabe P.

Sci Transl Med. 2018 Jan 10;10(423). pii: eaam8828. doi: 10.1126/scitranslmed.aam8828.


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