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Measure and characterization of the forces exerted by growing multicellular spheroids using microdevice arrays.

Aoun L, Larnier S, Weiss P, Cazales M, Herbulot A, Ducommun B, Vieu C, Lobjois V.

PLoS One. 2019 May 23;14(5):e0217227. doi: 10.1371/journal.pone.0217227. eCollection 2019.


Characterization of the physical properties of tumor-derived spheroids reveals critical insights for pre-clinical studies.

Guillaume L, Rigal L, Fehrenbach J, Severac C, Ducommun B, Lobjois V.

Sci Rep. 2019 Apr 29;9(1):6597. doi: 10.1038/s41598-019-43090-0.


A checkpoint-oriented cell cycle simulation model.

Bernard D, Mondesert O, Gomes A, Duthen Y, Lobjois V, Cussat-Blanc S, Ducommun B.

Cell Cycle. 2019 Apr;18(8):795-808. doi: 10.1080/15384101.2019.1591125. Epub 2019 Apr 4.


Impact of physical confinement on nuclei geometry and cell division dynamics in 3D spheroids.

Desmaison A, Guillaume L, Triclin S, Weiss P, Ducommun B, Lobjois V.

Sci Rep. 2018 Jun 8;8(1):8785. doi: 10.1038/s41598-018-27060-6.


Gap junctions contribute to anchorage-independent clustering of breast cancer cells.

Gava F, Rigal L, Mondesert O, Pesce E, Ducommun B, Lobjois V.

BMC Cancer. 2018 Feb 27;18(1):221. doi: 10.1186/s12885-018-4148-5.


Reversible growth arrest of 3D tumor spheroids stored in oxygen absorber-induced anoxia.

Gomes A, Defaux M, Lemee RM, Lobjois V, Ducommun B.

Oncol Lett. 2018 Feb;15(2):2006-2009. doi: 10.3892/ol.2017.7465. Epub 2017 Nov 21.


Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?

Leroy-Lerêtre M, Dimarco G, Cazales M, Boizeau ML, Ducommun B, Lobjois V, Degond P.

Bull Math Biol. 2017 Oct;79(10):2356-2393. doi: 10.1007/s11538-017-0333-y. Epub 2017 Aug 29.


Evaluation by quantitative image analysis of anticancer drug activity on multicellular spheroids grown in 3D matrices.

Gomes A, Russo A, Vidal G, Demange E, Pannetier P, Souguir Z, Lagarde JM, Ducommun B, Lobjois V.

Oncol Lett. 2016 Dec;12(6):4371-4376. doi: 10.3892/ol.2016.5221. Epub 2016 Oct 4.


Oxygen Partial Pressure Is a Rate-Limiting Parameter for Cell Proliferation in 3D Spheroids Grown in Physioxic Culture Condition.

Gomes A, Guillaume L, Grimes DR, Fehrenbach J, Lobjois V, Ducommun B.

PLoS One. 2016 Aug 30;11(8):e0161239. doi: 10.1371/journal.pone.0161239. eCollection 2016.


Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells.

Jullien D, Vignard J, Fedor Y, Béry N, Olichon A, Crozatier M, Erard M, Cassard H, Ducommun B, Salles B, Mirey G.

J Cell Sci. 2016 Jul 1;129(13):2673-83. doi: 10.1242/jcs.183103. Epub 2016 May 20.


Short and long time effects of low temperature Plasma Activated Media on 3D multicellular tumor spheroids.

Judée F, Fongia C, Ducommun B, Yousfi M, Lobjois V, Merbahi N.

Sci Rep. 2016 Feb 22;6:21421. doi: 10.1038/srep21421.


High-resolution in-depth imaging of optically cleared thick samples using an adaptive SPIM.

Masson A, Escande P, Frongia C, Clouvel G, Ducommun B, Lorenzo C.

Sci Rep. 2015 Nov 18;5:16898. doi: 10.1038/srep16898.


Structure Tensor Based Analysis of Cells and Nuclei Organization in Tissues.

Zhang W, Fehrenbach J, Desmaison A, Lobjois V, Ducommun B, Weiss P.

IEEE Trans Med Imaging. 2016 Jan;35(1):294-306. doi: 10.1109/TMI.2015.2470093. Epub 2015 Aug 19.


Monitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid Model.

Mondesert O, Frongia C, Clayton O, Boizeau ML, Lobjois V, Ducommun B.

PLoS One. 2015 Jul 30;10(7):e0134411. doi: 10.1371/journal.pone.0134411. eCollection 2015.


3D print customized sample holders for live light sheet microscopy.

Jeandupeux E, Lobjois V, Ducommun B.

Biochem Biophys Res Commun. 2015 Aug 7;463(4):1141-3. doi: 10.1016/j.bbrc.2015.06.072. Epub 2015 Jun 18.


Cell-Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation.

Saias L, Gomes A, Cazales M, Ducommun B, Lobjois V.

Cancer Res. 2015 Jun 15;75(12):2426-33. doi: 10.1158/0008-5472.CAN-14-3534. Epub 2015 Apr 8.


Microdevice arrays of high aspect ratio poly(dimethylsiloxane) pillars for the investigation of multicellular tumour spheroid mechanical properties.

Aoun L, Weiss P, Laborde A, Ducommun B, Lobjois V, Vieu C.

Lab Chip. 2014 Jul 7;14(13):2344-53. doi: 10.1039/c4lc00197d.


Mechanical stress impairs mitosis progression in multi-cellular tumor spheroids.

Desmaison A, Frongia C, Grenier K, Ducommun B, Lobjois V.

PLoS One. 2013 Dec 3;8(12):e80447. doi: 10.1371/journal.pone.0080447. eCollection 2013.


CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar foci.

Boutros R, Mondesert O, Lorenzo C, Astuti P, McArthur G, Chircop M, Ducommun B, Gabrielli B.

PLoS One. 2013 Jul 1;8(7):e67822. doi: 10.1371/journal.pone.0067822. Print 2013.


A versatile sample holder for single plane illumination microscopy.

Desmaison A, Lorenzo C, Rouquette J, Ducommun B, Lobjois V.

J Microsc. 2013 Aug;251(2):128-32. doi: 10.1111/jmi.12051. Epub 2013 May 20.


Multicellular tumor spheroid models to explore cell cycle checkpoints in 3D.

Laurent J, Frongia C, Cazales M, Mondesert O, Ducommun B, Lobjois V.

BMC Cancer. 2013 Feb 8;13:73. doi: 10.1186/1471-2407-13-73.


Doxorubicin promotes transcriptional upregulation of Cdc25B in cancer cells by releasing Sp1 from the promoter.

Dalvai M, Mondesert O, Bugler B, Manenti S, Ducommun B, Dozier C.

Oncogene. 2013 Oct 17;32(42):5123-8. doi: 10.1038/onc.2012.524. Epub 2012 Nov 19.


Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide.

Deslandes S, Lamoral-Theys D, Frongia C, Chassaing S, Bruyère C, Lozach O, Meijer L, Ducommun B, Kiss R, Delfourne E.

Eur J Med Chem. 2012 Aug;54:626-36. doi: 10.1016/j.ejmech.2012.06.012. Epub 2012 Jun 21.


Deep and clear optical imaging of thick inhomogeneous samples.

Jorand R, Le Corre G, Andilla J, Maandhui A, Frongia C, Lobjois V, Ducommun B, Lorenzo C.

PLoS One. 2012;7(4):e35795. doi: 10.1371/journal.pone.0035795. Epub 2012 Apr 25.


Characterization of the antiproliferative activity of Xylopia aethiopica.

Choumessi AT, Danel M, Chassaing S, Truchet I, Penlap VB, Pieme AC, Asonganyi T, Ducommun B, Valette A.

Cell Div. 2012 Mar 12;7(1):8. doi: 10.1186/1747-1028-7-8.


The CDC25B phosphatase shortens the G2 phase of neural progenitors and promotes efficient neuron production.

Peco E, Escude T, Agius E, Sabado V, Medevielle F, Ducommun B, Pituello F.

Development. 2012 Mar;139(6):1095-104. doi: 10.1242/dev.068569. Epub 2012 Feb 8.


Evaluation of checkpoint kinase targeting therapy in acute myeloid leukemia with complex karyotype.

Didier C, Demur C, Grimal F, Jullien D, Manenti S, Ducommun B.

Cancer Biol Ther. 2012 Mar;13(5):307-13. doi: 10.4161/cbt.19074. Epub 2012 Mar 1.


Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer.

Dufau I, Frongia C, Sicard F, Dedieu L, Cordelier P, Ausseil F, Ducommun B, Valette A.

BMC Cancer. 2012 Jan 13;12:15. doi: 10.1186/1471-2407-12-15.


Live cell division dynamics monitoring in 3D large spheroid tumor models using light sheet microscopy.

Lorenzo C, Frongia C, Jorand R, Fehrenbach J, Weiss P, Maandhui A, Gay G, Ducommun B, Lobjois V.

Cell Div. 2011 Dec 12;6:22. doi: 10.1186/1747-1028-6-22.


The cell cycle regulator CDC25A is a target for JAK2V617F oncogene.

Gautier EF, Picard M, Laurent C, Marty C, Villeval JL, Demur C, Delhommeau F, Hexner E, Giraudier S, Bonnevialle N, Ducommun B, Récher C, Laurent G, Manenti S, Mansat-De Mas V.

Blood. 2012 Feb 2;119(5):1190-9. doi: 10.1182/blood-2011-01-327742. Epub 2011 Nov 7.


Study of the docking-dependent PLK1 phosphorylation of the CDC25B phosphatase.

Lobjois V, Froment C, Braud E, Grimal F, Burlet-Schiltz O, Ducommun B, Bouche JP.

Biochem Biophys Res Commun. 2011 Jun 24;410(1):87-90. doi: 10.1016/j.bbrc.2011.05.110. Epub 2011 May 27.


Identification of N-terminally truncated stable nuclear isoforms of CDC25B that are specifically involved in G2/M checkpoint recovery.

Jullien D, Bugler B, Dozier C, Cazales M, Ducommun B.

Cancer Res. 2011 Mar 1;71(5):1968-77. doi: 10.1158/0008-5472.CAN-10-2453.


Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors.

Dalvai M, Mondesert O, Bourdon JC, Ducommun B, Dozier C.

Oncogene. 2011 May 12;30(19):2282-8. doi: 10.1038/onc.2010.588. Epub 2011 Jan 17.


CDC25B associates with a centrin 2-containing complex and is involved in maintaining centrosome integrity.

Boutros R, Lorenzo C, Mondesert O, Jauneau A, Oakes V, Dozier C, Gabrielli B, Ducommun B.

Biol Cell. 2011 Feb;103(2):55-68. doi: 10.1042/BC20100111.


A screen for deubiquitinating enzymes involved in the G₂/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability.

Aressy B, Jullien D, Cazales M, Marcellin M, Bugler B, Burlet-Schiltz O, Ducommun B.

Cell Cycle. 2010 Sep 15;9(18):3815-22. doi: 10.4161/cc.9.18.13133. Epub 2010 Sep 25.


Mitotic phosphorylation of Cdc25B Ser321 disrupts 14-3-3 binding to the high affinity Ser323 site.

Astuti P, Boutros R, Ducommun B, Gabrielli B.

J Biol Chem. 2010 Nov 5;285(45):34364-70. doi: 10.1074/jbc.M110.138412. Epub 2010 Aug 27.


UV-induced downregulation of the CDC25B protein in human cells.

Lemaire M, Ducommun B, Nebreda AR.

FEBS Lett. 2010 Mar 19;584(6):1199-204. doi: 10.1016/j.febslet.2010.02.043. Epub 2010 Feb 19.


Unscheduled expression of CDC25B in S-phase leads to replicative stress and DNA damage.

Bugler B, Schmitt E, Aressy B, Ducommun B.

Mol Cancer. 2010 Feb 4;9:29. doi: 10.1186/1476-4598-9-29.


5-Substituted [1]pyrindine derivatives with antiproliferative activity.

Kolb S, Goddard ML, Loukaci A, Mondésert O, Ducommun B, Braud E, Garbay C.

Eur J Med Chem. 2010 Mar;45(3):896-901. doi: 10.1016/j.ejmech.2009.11.028. Epub 2009 Dec 6.


Constitutive activation of the DNA damage signaling pathway in acute myeloid leukemia with complex karyotype: potential importance for checkpoint targeting therapy.

Cavelier C, Didier C, Prade N, Mansat-De Mas V, Manenti S, Recher C, Demur C, Ducommun B.

Cancer Res. 2009 Nov 15;69(22):8652-61. doi: 10.1158/0008-5472.CAN-09-0939. Epub 2009 Oct 20.


3D imaging of the response to CDC25 inhibition in multicellular spheroids.

Frongia C, Lorenzo C, Gianni F, Prevost GP, Ducommun B, Lobjois V.

Cancer Biol Ther. 2009 Dec;8(23):2230-36. Epub 2009 Dec 3.


Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1.

Tibelius A, Marhold J, Zentgraf H, Heilig CE, Neitzel H, Ducommun B, Rauch A, Ho AD, Bartek J, Krämer A.

J Cell Biol. 2009 Jun 29;185(7):1149-57. doi: 10.1083/jcb.200810159. Epub 2009 Jun 22.


Pharmacological inhibition of aurora-A but not aurora-B impairs interphase microtubule dynamics.

Lorenzo C, Liao Q, Hardwicke MA, Ducommun B.

Cell Cycle. 2009 Jun 1;8(11):1733-7. Epub 2009 Jun 2.


OPA1 functions in mitochondria and dysfunctions in optic nerve.

Lenaers G, Reynier P, Elachouri G, Soukkarieh C, Olichon A, Belenguer P, Baricault L, Ducommun B, Hamel C, Delettre C.

Int J Biochem Cell Biol. 2009 Oct;41(10):1866-74. doi: 10.1016/j.biocel.2009.04.013. Epub 2009 Apr 21. Review.


Development of novel thiazolopyrimidines as CDC25B phosphatase inhibitors.

Kolb S, Mondésert O, Goddard ML, Jullien D, Villoutreix BO, Ducommun B, Garbay C, Braud E.

ChemMedChem. 2009 Apr;4(4):633-48. doi: 10.1002/cmdc.200800415.


The polo-like kinase 1 regulates CDC25B-dependent mitosis entry.

Lobjois V, Jullien D, Bouché JP, Ducommun B.

Biochim Biophys Acta. 2009 Mar;1793(3):462-8. doi: 10.1016/j.bbamcr.2008.12.015. Epub 2009 Jan 2.


Cell cycle control by the CDC25 phosphatases.

Aressy B, Ducommun B.

Anticancer Agents Med Chem. 2008 Dec;8(8):818-24. Review.


IRC-083864, a novel bis quinone inhibitor of CDC25 phosphatases active against human cancer cells.

Brezak MC, Valette A, Quaranta M, Contour-Galcera MO, Jullien D, Lavergne O, Frongia C, Bigg D, Kasprzyk PG, Prevost GP, Ducommun B.

Int J Cancer. 2009 Mar 15;124(6):1449-56. doi: 10.1002/ijc.24080.


A caspase-dependent cleavage of CDC25A generates an active fragment activating cyclin-dependent kinase 2 during apoptosis.

Mazars A, Fernandez-Vidal A, Mondesert O, Lorenzo C, Prévost G, Ducommun B, Payrastre B, Racaud-Sultan C, Manenti S.

Cell Death Differ. 2009 Feb;16(2):208-18. doi: 10.1038/cdd.2008.142. Epub 2008 Oct 17.


Decreased motivational properties of morphine in mouse models of cancerous- or inflammatory-chronic pain: implication of supraspinal neuropeptide FF(2) receptors.

Betourne A, Familiades J, Lacassagne L, Halley H, Cazales M, Ducommun B, Lassalle JM, Zajac JM, Frances B.

Neuroscience. 2008 Nov 11;157(1):12-21. doi: 10.1016/j.neuroscience.2008.08.045. Epub 2008 Aug 29.


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