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Items: 36


βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1.

Nieto A, Hara MR, Quereda V, Grant W, Saunders V, Xiao K, McDonald PH, Duckett DR.

Cell Death Differ. 2019 Sep 10. doi: 10.1038/s41418-019-0406-6. [Epub ahead of print]


In Silico HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors.

Wood SD, Grant W, Adrados I, Choi JY, Alburger JM, Duckett DR, Roush WR.

ACS Med Chem Lett. 2017 Nov 22;8(12):1258-1263. doi: 10.1021/acsmedchemlett.7b00344. eCollection 2017 Dec 14.


CK1δ: an exploitable vulnerability in breast cancer.

Rosenberg LH, Cleveland JL, Roush WR, Duckett DR.

Ann Transl Med. 2016 Dec;4(23):474. doi: 10.21037/atm.2016.12.15. No abstract available.


Design of a small molecule against an oncogenic noncoding RNA.

Velagapudi SP, Cameron MD, Haga CL, Rosenberg LH, Lafitte M, Duckett DR, Phinney DG, Disney MD.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):5898-903. doi: 10.1073/pnas.1523975113. Epub 2016 May 11.


Therapeutic targeting of casein kinase 1δ in breast cancer.

Rosenberg LH, Lafitte M, Quereda V, Grant W, Chen W, Bibian M, Noguchi Y, Fallahi M, Yang C, Chang JC, Roush WR, Cleveland JL, Duckett DR.

Sci Transl Med. 2015 Dec 16;7(318):318ra202. doi: 10.1126/scitranslmed.aac8773.


Identification of an EGFRvIII-JNK2-HGF/c-Met-Signaling Axis Required for Intercellular Crosstalk and Glioblastoma Multiforme Cell Invasion.

Saunders VC, Lafitte M, Adrados I, Quereda V, Feurstein D, Ling Y, Fallahi M, Rosenberg LH, Duckett DR.

Mol Pharmacol. 2015 Dec;88(6):962-9. doi: 10.1124/mol.115.097774. Epub 2015 Oct 9.


Development of an HTS-Compatible Assay for the Discovery of Ulk1 Inhibitors.

Rosenberg LH, Lafitte M, Grant W, Chen W, Cleveland JL, Duckett DR.

J Biomol Screen. 2015 Aug;20(7):913-20. doi: 10.1177/1087057115579391. Epub 2015 Apr 7.


Antiproliferation activity of a small molecule repressor of liver receptor homolog 1.

Corzo CA, Mari Y, Chang MR, Khan T, Kuruvilla D, Nuhant P, Kumar N, West GM, Duckett DR, Roush WR, Griffin PR.

Mol Pharmacol. 2015 Feb;87(2):296-304. doi: 10.1124/mol.114.095554. Epub 2014 Dec 3.


Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties.

Bibian M, Rahaim RJ, Choi JY, Noguchi Y, Schürer S, Chen W, Nakanishi S, Licht K, Rosenberg LH, Li L, Feng Y, Cameron MD, Duckett DR, Cleveland JL, Roush WR.

Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80. doi: 10.1016/j.bmcl.2013.05.075. Epub 2013 May 31.


Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors.

Jiang R, Frackowiak B, Shin Y, Song X, Chen W, Lin L, Cameron MD, Duckett DR, Kamenecka TM.

Bioorg Med Chem Lett. 2013 May 1;23(9):2683-7. doi: 10.1016/j.bmcl.2013.02.082. Epub 2013 Feb 27.


Synthesis and SAR of 2-phenoxypyridines as novel c-Jun N-terminal kinase inhibitors.

Song X, Chen W, Lin L, Ruiz CH, Cameron MD, Duckett DR, Kamenecka TM.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7072-5. doi: 10.1016/j.bmcl.2011.09.090. Epub 2011 Sep 29.


A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.

Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ.

Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368.


Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors.

Noël R, Shin Y, Song X, He Y, Koenig M, Chen W, Ling YY, Lin L, Ruiz CH, LoGrasso P, Cameron MD, Duckett DR, Kamenecka TM.

Bioorg Med Chem Lett. 2011 May 1;21(9):2732-5. doi: 10.1016/j.bmcl.2010.11.104. Epub 2010 Dec 1.


Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist.

Kumar N, Kojetin DJ, Solt LA, Kumar KG, Nuhant P, Duckett DR, Cameron MD, Butler AA, Roush WR, Griffin PR, Burris TP.

ACS Chem Biol. 2011 Mar 18;6(3):218-22. doi: 10.1021/cb1002762. Epub 2010 Dec 6.


Metabolism considerations for kinase inhibitors in cancer treatment.

Duckett DR, Cameron MD.

Expert Opin Drug Metab Toxicol. 2010 Oct;6(10):1175-93. doi: 10.1517/17425255.2010.506873. Review.


Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.

Heerding DA, Rhodes N, Leber JD, Clark TJ, Keenan RM, Lafrance LV, Li M, Safonov IG, Takata DT, Venslavsky JW, Yamashita DS, Choudhry AE, Copeland RA, Lai Z, Schaber MD, Tummino PJ, Strum SL, Wood ER, Duckett DR, Eberwein D, Knick VB, Lansing TJ, McConnell RT, Zhang S, Minthorn EA, Concha NO, Warren GL, Kumar R.

J Med Chem. 2008 Sep 25;51(18):5663-79. doi: 10.1021/jm8004527.


Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity.

Rhodes N, Heerding DA, Duckett DR, Eberwein DJ, Knick VB, Lansing TJ, McConnell RT, Gilmer TM, Zhang SY, Robell K, Kahana JA, Geske RS, Kleymenova EV, Choudhry AE, Lai Z, Leber JD, Minthorn EA, Strum SL, Wood ER, Huang PS, Copeland RA, Kumar R.

Cancer Res. 2008 Apr 1;68(7):2366-74. doi: 10.1158/0008-5472.CAN-07-5783.


In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1.

Lansing TJ, McConnell RT, Duckett DR, Spehar GM, Knick VB, Hassler DF, Noro N, Furuta M, Emmitte KA, Gilmer TM, Mook RA Jr, Cheung M.

Mol Cancer Ther. 2007 Feb;6(2):450-9. Epub 2007 Jan 31.


Nucleic acid structure and recognition.

Duckett DR, Murchie AI, Clegg RM, Bassi GS, Giraud-Panis MJ, Lilley DM.

Biophys Chem. 1997 Oct;68(1-3):53-62.


hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage.

Duckett DR, Bronstein SM, Taya Y, Modrich P.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12384-8.


Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems.

Mu D, Tursun M, Duckett DR, Drummond JT, Modrich P, Sancar A.

Mol Cell Biol. 1997 Feb;17(2):760-9.


Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.

Duckett DR, Drummond JT, Murchie AI, Reardon JT, Sancar A, Lilley DM, Modrich P.

Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6443-7.


The global folding of four-way helical junctions in RNA, including that in U1 snRNA.

Duckett DR, Murchie AI, Lilley DM.

Cell. 1995 Dec 15;83(6):1027-36.


The modular character of a DNA junction-resolving enzyme: a zinc-binding motif in bacteriophage T4 endonuclease VII.

Giraud-Panis MJ, Duckett DR, Lilley DM.

J Mol Biol. 1995 Oct 6;252(5):596-610.


Structure of the four-way DNA junction and its interaction with proteins.

Duckett DR, Murchie AI, Giraud-Panis MJ, Pöhler JR, Lilley DM.

Philos Trans R Soc Lond B Biol Sci. 1995 Jan 30;347(1319):27-36. Review.


Structure of four-way DNA junctions containing a nick in one strand.

Pöhler JR, Duckett DR, Lilley DM.

J Mol Biol. 1994 Apr 22;238(1):62-74.


Structures of bulged three-way DNA junctions.

Welch JB, Duckett DR, Lilley DM.

Nucleic Acids Res. 1993 Sep 25;21(19):4548-55.


Gel electrophoretic analysis of the structure of nucleic acids.

Lilley DM, Bhattacharyya A, McAteer SP, Duckett DR.

Biochem Soc Trans. 1993 Feb;21(1):111-6. Review. No abstract available.


The structure of DNA junctions and their interaction with enzymes.

Duckett DR, Murchie AI, Bhattacharyya A, Clegg RM, Diekmann S, von Kitzing E, Lilley DM.

Eur J Biochem. 1993 Jan 15;211(1-2):285-95. Review. No abstract available.


Effects of base mismatches on the structure of the four-way DNA junction.

Duckett DR, Lilley DM.

J Mol Biol. 1991 Sep 5;221(1):147-61.


The role of metal ions in the conformation of the four-way DNA junction.

Duckett DR, Murchie AI, Lilley DM.

EMBO J. 1990 Feb;9(2):583-90.


Fluorescence energy transfer shows that the four-way DNA junction is a right-handed cross of antiparallel molecules.

Murchie AI, Clegg RM, von Kitzing E, Duckett DR, Diekmann S, Lilley DM.

Nature. 1989 Oct 26;341(6244):763-6.


The structure of the Holliday junction, and its resolution.

Duckett DR, Murchie AI, Diekmann S, von Kitzing E, Kemper B, Lilley DM.

Cell. 1988 Oct 7;55(1):79-89.


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