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Items: 16

1.

Design and Synthesis of New 1,3,5-Trisubstituted Triazines for the Treatment of Cancer and Inflammation.

Zacharie B, Abbott SD, Duceppe JS, Gagnon L, Grouix B, Geerts L, Gervais L, Sarra-Bournet F, Perron V, Wilb N, Penney CL, Laurin P.

ChemistryOpen. 2018 Sep 21;7(9):737-749. doi: 10.1002/open.201800136. eCollection 2018 Sep.

2.

A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84.

Gagnon L, Leduc M, Thibodeau JF, Zhang MZ, Grouix B, Sarra-Bournet F, Gagnon W, Hince K, Tremblay M, Geerts L, Kennedy CRJ, Hébert RL, Gutsol A, Holterman CE, Kamto E, Gervais L, Ouboudinar J, Richard J, Felton A, Laverdure A, Simard JC, Létourneau S, Cloutier MP, Leblond FA, Abbott SD, Penney C, Duceppe JS, Zacharie B, Dupuis J, Calderone A, Nguyen QT, Harris RC, Laurin P.

Am J Pathol. 2018 May;188(5):1132-1148. doi: 10.1016/j.ajpath.2018.01.009. Epub 2018 Feb 16.

3.

2,4,6-trisubstituted triazines as protein a mimetics for the treatment of autoimmune diseases.

Zacharie B, Abbott SD, Bienvenu JF, Cameron AD, Cloutier J, Duceppe JS, Ezzitouni A, Fortin D, Houde K, Lauzon C, Moreau N, Perron V, Wilb N, Asselin M, Doucet A, Fafard ME, Gaudreau D, Grouix B, Sarra-Bournet F, St-Amant N, Gagnon L, Penney CL.

J Med Chem. 2010 Feb 11;53(3):1138-45. doi: 10.1021/jm901403r.

PMID:
20047277
4.

Dimethylthiazolidine carboxylic acid as a rigid p3 unit in inhibitors of serine proteases: application to two targets.

Kawai SH, Aubry N, Duceppe JS, Llinàs-Brunet M, LaPlante SR.

Chem Biol Drug Des. 2009 Nov;74(5):517-22. doi: 10.1111/j.1747-0285.2009.00870.x. Epub 2009 Sep 22.

PMID:
19780760
5.

Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds.

Beaulieu PL, Gillard J, Bykowski D, Brochu C, Dansereau N, Duceppe JS, Haché B, Jakalian A, Lagacé L, LaPlante S, McKercher G, Moreau E, Perreault S, Stammers T, Thauvette L, Warrington J, Kukolj G.

Bioorg Med Chem Lett. 2006 Oct 1;16(19):4987-93.

PMID:
16908138
6.

Synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid vinyl-ACCA) derivatives: key intermediates for the preparation of inhibitors of the hepatitis C virus NS3 protease.

Beaulieu PL, Gillard J, Bailey MD, Boucher C, Duceppe JS, Simoneau B, Wang XJ, Zhang L, Grozinger K, Houpis I, Farina V, Heimroth H, Krueger T, Schnaubelt J.

J Org Chem. 2005 Jul 22;70(15):5869-79.

PMID:
16018680
7.

Potent inhibitors of the hepatitis C virus NS3 protease: design and synthesis of macrocyclic substrate-based beta-strand mimics.

Goudreau N, Brochu C, Cameron DR, Duceppe JS, Faucher AM, Ferland JM, Grand-Maître C, Poirier M, Simoneau B, Tsantrizos YS.

J Org Chem. 2004 Sep 17;69(19):6185-201.

PMID:
15357576
8.

Synthesis of BILN 2061, an HCV NS3 protease inhibitor with proven antiviral effect in humans.

Faucher AM, Bailey MD, Beaulieu PL, Brochu C, Duceppe JS, Ferland JM, Ghiro E, Gorys V, Halmos T, Kawai SH, Poirier M, Simoneau B, Tsantrizos YS, Llinàs-Brunet M.

Org Lett. 2004 Aug 19;6(17):2901-4.

PMID:
15330643
9.

Practical Synthesis of BILA 2157 BS, a Potent and Orally Active Renin Inhibitor: Use of an Enzyme-Catalyzed Hydrolysis for the Preparation of Homochiral Succinic Acid Derivatives.

Beaulieu PL, Gillard J, Bailey M, Beaulieu C, Duceppe JS, Lavallée P, Wernic D.

J Org Chem. 1999 Sep 3;64(18):6622-6634.

PMID:
11674665
10.

Peptidomimetic inhibitors of the human cytomegalovirus protease.

Ogilvie W, Bailey M, Poupart MA, Abraham A, Bhavsar A, Bonneau P, Bordeleau J, Bousquet Y, Chabot C, Duceppe JS, Fazal G, Goulet S, Grand-Maître C, Guse I, Halmos T, Lavallée P, Leach M, Malenfant E, O'Meara J, Plante R, Plouffe C, Poirier M, Soucy F, Yoakim C, Déziel R.

J Med Chem. 1997 Dec 5;40(25):4113-35.

PMID:
9406601
11.

Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase with improved in vivo antiviral activity.

Moss N, Beaulieu P, Duceppe JS, Ferland JM, Garneau M, Gauthier J, Ghiro E, Goulet S, Guse I, Jaramillo J, Llinas-Brunet M, Malenfant E, Plante R, Poirier M, Soucy F, Wernic D, Yoakim C, Déziel R.

J Med Chem. 1996 Oct 11;39(21):4173-80.

PMID:
8863795
12.

Ureido-based peptidomimetic inhibitor of herpes simplex virus ribonucleotide reductase: an investigation of inhibitor bioactive conformation.

Moss N, Beaulieu P, Duceppe JS, Ferland JM, Gauthier J, Ghiro E, Goulet S, Guse I, Llinàs-Brunet M, Plante R, Plamondon L, Wernic D, Déziel R.

J Med Chem. 1996 May 24;39(11):2178-87.

PMID:
8667361
13.

A Practical and Diastereoselective Synthesis of Ketomethylene Dipeptide Isosteres of the Type AAPsi[COCH(2)]Asp.

Déziel R, Plante R, Caron V, Grenier L, Llinas-Brunet M, Duceppe JS, Malenfant E, Moss N.

J Org Chem. 1996 Apr 19;61(8):2901-2903. No abstract available.

PMID:
11667134
14.

Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase: a new class of antiviral agents.

Moss N, Beaulieu P, Duceppe JS, Ferland JM, Gauthier J, Ghiro E, Goulet S, Grenier L, Llinas-Brunet M, Plante R, et al.

J Med Chem. 1995 Sep 1;38(18):3617-23.

PMID:
7658449
15.

Inhibition of herpes simplex virus type 1 ribonucleotide reductase by substituted tetrapeptide derivatives.

Moss N, Déziel R, Adams J, Aubry N, Bailey M, Baillet M, Beaulieu P, DiMaio J, Duceppe JS, Ferland JM, et al.

J Med Chem. 1993 Oct 1;36(20):3005-9.

PMID:
8411018
16.

Specific inhibition of ribonucleotide reductases by peptides corresponding to the C-terminal of their second subunit.

Cosentino G, Lavallée P, Rakhit S, Plante R, Gaudette Y, Lawetz C, Whitehead PW, Duceppe JS, Lépine-Frenette C, Dansereau N, et al.

Biochem Cell Biol. 1991 Jan;69(1):79-83.

PMID:
2043345

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