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Items: 1 to 50 of 147

1.

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor.

Yang J, Liu Z, Wang C, Yang R, Rathkey JK, Pinkard OW, Shi W, Chen Y, Dubyak GR, Abbott DW, Xiao TS.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6792-6797. doi: 10.1073/pnas.1800562115. Epub 2018 Jun 11.

PMID:
29891674
2.

Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition.

Liu Z, Wang C, Rathkey JK, Yang J, Dubyak GR, Abbott DW, Xiao TS.

Structure. 2018 May 1;26(5):778-784.e3. doi: 10.1016/j.str.2018.03.002. Epub 2018 Mar 22.

PMID:
29576317
3.

Factor XII and uPAR upregulate neutrophil functions to influence wound healing.

Stavrou EX, Fang C, Bane KL, Long AT, Naudin C, Kucukal E, Gandhi A, Brett-Morris A, Mumaw MM, Izadmehr S, Merkulova A, Reynolds CC, Alhalabi O, Nayak L, Yu WM, Qu CK, Meyerson HJ, Dubyak GR, Gurkan UA, Nieman MT, Sen Gupta A, Renné T, Schmaier AH.

J Clin Invest. 2018 Mar 1;128(3):944-959. doi: 10.1172/JCI92880. Epub 2018 Jan 29.

4.

Live-cell visualization of gasdermin D-driven pyroptotic cell death.

Rathkey JK, Benson BL, Chirieleison SM, Yang J, Xiao TS, Dubyak GR, Huang AY, Abbott DW.

J Biol Chem. 2017 Sep 1;292(35):14649-14658. doi: 10.1074/jbc.M117.797217. Epub 2017 Jul 18.

PMID:
28726636
6.

Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease.

Chirieleison SM, Marsh RA, Kumar P, Rathkey JK, Dubyak GR, Abbott DW.

J Biol Chem. 2017 Jun 9;292(23):9666-9679. doi: 10.1074/jbc.M117.781500. Epub 2017 Apr 12.

7.

Ligation of CD40 in Human Müller Cells Induces P2X7 Receptor-Dependent Death of Retinal Endothelial Cells.

Portillo JC, Lopez Corcino Y, Dubyak GR, Kern TS, Matsuyama S, Subauste CS.

Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6278-6286. doi: 10.1167/iovs.16-20301.

8.

CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy.

Portillo JC, Lopez Corcino Y, Miao Y, Tang J, Sheibani N, Kern TS, Dubyak GR, Subauste CS.

Diabetes. 2017 Feb;66(2):483-493. doi: 10.2337/db16-0051. Epub 2016 Jul 29.

9.

Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides.

Russo HM, Rathkey J, Boyd-Tressler A, Katsnelson MA, Abbott DW, Dubyak GR.

J Immunol. 2016 Aug 15;197(4):1353-67. doi: 10.4049/jimmunol.1600699. Epub 2016 Jul 6.

10.

NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx.

Katsnelson MA, Lozada-Soto KM, Russo HM, Miller BA, Dubyak GR.

Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C83-C100. doi: 10.1152/ajpcell.00298.2015. Epub 2016 May 11.

11.

T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.

Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X.

Nat Immunol. 2016 May;17(5):583-92. doi: 10.1038/ni.3389. Epub 2016 Mar 21.

12.

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP.

Karmakar M, Katsnelson MA, Dubyak GR, Pearlman E.

Nat Commun. 2016 Feb 15;7:10555. doi: 10.1038/ncomms10555.

13.

Purinergic Receptors: Key Mediators of HIV-1 Infection and Inflammation.

Swartz TH, Dubyak GR, Chen BK.

Front Immunol. 2015 Nov 26;6:585. doi: 10.3389/fimmu.2015.00585. eCollection 2015. Review.

14.

Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans.

Yuan Y, Hakimi P, Kao C, Kao A, Liu R, Janocha A, Boyd-Tressler A, Hang X, Alhoraibi H, Slater E, Xia K, Cao P, Shue Q, Ching TT, Hsu AL, Erzurum SC, Dubyak GR, Berger NA, Hanson RW, Feng Z.

J Biol Chem. 2016 Jan 15;291(3):1307-19. doi: 10.1074/jbc.M115.691766. Epub 2015 Dec 2.

15.

Human β Defensin-3 Increases CD86 Expression on Monocytes by Activating the ATP-Gated Channel P2X7.

Lioi AB, Ferrari BM, Dubyak GR, Weinberg A, Sieg SF.

J Immunol. 2015 Nov 1;195(9):4438-45. doi: 10.4049/jimmunol.1401319. Epub 2015 Sep 28.

16.

Modification of β-Defensin-2 by Dicarbonyls Methylglyoxal and Glyoxal Inhibits Antibacterial and Chemotactic Function In Vitro.

Kiselar JG, Wang X, Dubyak GR, El Sanadi C, Ghosh SK, Lundberg K, Williams WM.

PLoS One. 2015 Aug 5;10(8):e0130533. doi: 10.1371/journal.pone.0130533. eCollection 2015.

17.

Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling.

Antonopoulos C, Russo HM, El Sanadi C, Martin BN, Li X, Kaiser WJ, Mocarski ES, Dubyak GR.

J Biol Chem. 2015 Aug 14;290(33):20167-84. doi: 10.1074/jbc.M115.652321. Epub 2015 Jun 22.

18.

Stealth filaments: Polymer chain length and conformation affect the in vivo fate of PEGylated potato virus X.

Lee KL, Shukla S, Wu M, Ayat NR, El Sanadi CE, Wen AM, Edelbrock JF, Pokorski JK, Commandeur U, Dubyak GR, Steinmetz NF.

Acta Biomater. 2015 Jun;19:166-79. doi: 10.1016/j.actbio.2015.03.001. Epub 2015 Mar 10.

19.

K+ efflux agonists induce NLRP3 inflammasome activation independently of Ca2+ signaling.

Katsnelson MA, Rucker LG, Russo HM, Dubyak GR.

J Immunol. 2015 Apr 15;194(8):3937-52. doi: 10.4049/jimmunol.1402658. Epub 2015 Mar 11.

20.

Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux.

Karmakar M, Katsnelson M, Malak HA, Greene NG, Howell SJ, Hise AG, Camilli A, Kadioglu A, Dubyak GR, Pearlman E.

J Immunol. 2015 Feb 15;194(4):1763-75. doi: 10.4049/jimmunol.1401624. Epub 2015 Jan 21.

21.

Chemotherapeutic drugs induce ATP release via caspase-gated pannexin-1 channels and a caspase/pannexin-1-independent mechanism.

Boyd-Tressler A, Penuela S, Laird DW, Dubyak GR.

J Biol Chem. 2014 Sep 26;289(39):27246-63. doi: 10.1074/jbc.M114.590240. Epub 2014 Aug 11.

22.

Chemotherapy engages multiple pathways leading to IL-1β production by myeloid leukocytes.

Antonopoulos C, Dubyak GR.

Oncoimmunology. 2014 Jan 1;3(1):e27499. Epub 2014 Jan 3.

23.

The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes.

Rosenthal AK, Gohr CM, Mitton-Fitzgerald E, Lutz MK, Dubyak GR, Ryan LM.

Arthritis Res Ther. 2013 Oct 17;15(5):R154. doi: 10.1186/ar4337.

24.

Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1β via caspase-8 in dendritic cells.

Antonopoulos C, El Sanadi C, Kaiser WJ, Mocarski ES, Dubyak GR.

J Immunol. 2013 Nov 1;191(9):4789-803. doi: 10.4049/jimmunol.1300645. Epub 2013 Sep 27.

25.

Human β-defensin-3 structure motifs that are important in CXCR4 antagonism.

Feng Z, Dubyak GR, Jia X, Lubkowski JT, Weinberg A.

FEBS J. 2013 Jul;280(14):3365-75. doi: 10.1111/febs.12328. Epub 2013 Jun 7.

26.

Dueling nucleosides: cross-regulation of extracellular adenosine by guanosine. Focus on "Extracellular guanosine regulates extracellular adenosine levels".

Dubyak GR.

Am J Physiol Cell Physiol. 2013 Mar 1;304(5):C403-5. doi: 10.1152/ajpcell.00012.2013. Epub 2013 Jan 16. No abstract available.

27.
28.

P2X7 receptor regulation of non-classical secretion from immune effector cells.

Dubyak GR.

Cell Microbiol. 2012 Nov;14(11):1697-706. doi: 10.1111/cmi.12001. Epub 2012 Aug 24. Review.

29.

Purinergic regulation of high-glucose-induced caspase-1 activation in the rat retinal Müller cell line rMC-1.

Trueblood KE, Mohr S, Dubyak GR.

Am J Physiol Cell Physiol. 2011 Nov;301(5):C1213-23. doi: 10.1152/ajpcell.00265.2011. Epub 2011 Aug 10.

30.

Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation.

Qu Y, Misaghi S, Newton K, Gilmour LL, Louie S, Cupp JE, Dubyak GR, Hackos D, Dixit VM.

J Immunol. 2011 Jun 1;186(11):6553-61. doi: 10.4049/jimmunol.1100478. Epub 2011 Apr 20.

31.

Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle.

Villa-Bellosta R, Wang X, Millán JL, Dubyak GR, O'Neill WC.

Am J Physiol Heart Circ Physiol. 2011 Jul;301(1):H61-8. doi: 10.1152/ajpheart.01020.2010. Epub 2011 Apr 13.

32.

Charge of the mito brigade. Focus on "Changes in mitochondrial surface charge mediate recruitment of signaling molecules during apoptosis".

Dubyak GR.

Am J Physiol Cell Physiol. 2011 Jan;300(1):C11-3. doi: 10.1152/ajpcell.00454.2010. Epub 2010 Nov 10. No abstract available.

33.

Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing major histocompatibility complex class II molecules capable of antigen presentation.

Ramachandra L, Qu Y, Wang Y, Lewis CJ, Cobb BA, Takatsu K, Boom WH, Dubyak GR, Harding CV.

Infect Immun. 2010 Dec;78(12):5116-25. doi: 10.1128/IAI.01089-09. Epub 2010 Sep 13.

34.

Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone.

Franchi L, Chen G, Marina-Garcia N, Abe A, Qu Y, Bao S, Shayman JA, Turk J, Dubyak GR, Núñez G.

J Innate Immun. 2009;1(6):607-17. doi: 10.1159/000227263.

35.

Regulation of vascular smooth muscle cell calcification by extracellular pyrophosphate homeostasis: synergistic modulation by cyclic AMP and hyperphosphatemia.

Prosdocimo DA, Wyler SC, Romani AM, O'Neill WC, Dubyak GR.

Am J Physiol Cell Physiol. 2010 Mar;298(3):C702-13. doi: 10.1152/ajpcell.00419.2009. Epub 2009 Dec 16.

36.

Extracellular osmolarity modulates G protein-coupled receptor-dependent ATP release from 1321N1 astrocytoma cells.

Blum AE, Walsh BC, Dubyak GR.

Am J Physiol Cell Physiol. 2010 Feb;298(2):C386-96. doi: 10.1152/ajpcell.00430.2009. Epub 2009 Nov 11.

37.

Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells.

Hong S, Schwarz N, Brass A, Seman M, Haag F, Koch-Nolte F, Schilling WP, Dubyak GR.

J Immunol. 2009 Jul 1;183(1):578-92. doi: 10.4049/jimmunol.0900120.

38.

Basal and inducible expression of the thiol-sensitive ART2.1 ecto-ADP-ribosyltransferase in myeloid and lymphoid leukocytes.

Hong S, Brass A, Seman M, Haag F, Koch-Nolte F, Dubyak GR.

Purinergic Signal. 2009 Sep;5(3):369-83. doi: 10.1007/s11302-009-9162-2. Epub 2009 Apr 30.

39.

P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1.

Qu Y, Ramachandra L, Mohr S, Franchi L, Harding CV, Nunez G, Dubyak GR.

J Immunol. 2009 Apr 15;182(8):5052-62. doi: 10.4049/jimmunol.0802968.

40.

Autocrine ATP release coupled to extracellular pyrophosphate accumulation in vascular smooth muscle cells.

Prosdocimo DA, Douglas DC, Romani AM, O'Neill WC, Dubyak GR.

Am J Physiol Cell Physiol. 2009 Apr;296(4):C828-39. doi: 10.1152/ajpcell.00619.2008. Epub 2009 Feb 4.

41.

P2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathways.

Qu Y, Dubyak GR.

Purinergic Signal. 2009 Jun;5(2):163-73. doi: 10.1007/s11302-009-9132-8. Epub 2009 Feb 3.

42.
43.

Rho-family GTPases modulate Ca(2+) -dependent ATP release from astrocytes.

Blum AE, Joseph SM, Przybylski RJ, Dubyak GR.

Am J Physiol Cell Physiol. 2008 Jul;295(1):C231-41. doi: 10.1152/ajpcell.00175.2008. Epub 2008 May 21.

44.

The inflammatory effects of UDP-glucose in N9 microglia are not mediated by P2Y14 receptor activation.

Brautigam VM, Dubyak GR, Crain JM, Watters JJ.

Purinergic Signal. 2008 Mar;4(1):73-8. doi: 10.1007/s11302-008-9095-1. Epub 2008 Feb 8.

45.

Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells.

Strainic MG, Liu J, Huang D, An F, Lalli PN, Muqim N, Shapiro VS, Dubyak GR, Heeger PS, Medof ME.

Immunity. 2008 Mar;28(3):425-35. doi: 10.1016/j.immuni.2008.02.001. Epub 2008 Mar 6.

46.
47.

Go it alone no more--P2X7 joins the society of heteromeric ATP-gated receptor channels.

Dubyak GR.

Mol Pharmacol. 2007 Dec;72(6):1402-5. Epub 2007 Sep 25. Review.

49.

Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria.

Franchi L, Kanneganti TD, Dubyak GR, Núñez G.

J Biol Chem. 2007 Jun 29;282(26):18810-8. Epub 2007 May 9.

50.

Sulfated signal from ASJ sensory neurons modulates stomatin-dependent coordination in Caenorhabditis elegans.

Carroll BT, Dubyak GR, Sedensky MM, Morgan PG.

J Biol Chem. 2006 Nov 24;281(47):35989-96. Epub 2006 Sep 13.

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