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Items: 1 to 50 of 147

1.

The Hippo Kinase LATS2 Controls Helicobacter pylori-Induced Epithelial-Mesenchymal Transition and Intestinal Metaplasia in Gastric Mucosa.

Molina Castro SE, Tiffon C, Giraud J, Boeuf H, Sifre E, Giese A, Belleannée G, Lehours P, Bessède E, Mégraud F, Dubus P, Staedel C, Varon C.

Cell Mol Gastroenterol Hepatol. 2019 Oct 24. pii: S2352-345X(19)30143-2. doi: 10.1016/j.jcmgh.2019.10.007. [Epub ahead of print]

2.

Cytolethal distending toxin induces the formation of transient messenger-rich ribonucleoprotein nuclear invaginations in surviving cells.

Azzi-Martin L, He W, Péré-Védrenne C, Korolik V, Alix C, Prochazkova-Carlotti M, Morel JL, Le Roux-Goglin E, Lehours P, Djavaheri-Mergny M, Grosset CF, Varon C, Dubus P, Ménard A.

PLoS Pathog. 2019 Sep 30;15(9):e1007921. doi: 10.1371/journal.ppat.1007921. eCollection 2019 Sep.

3.

Verteporfin targeting YAP1/TAZ-TEAD transcriptional activity inhibits the tumorigenic properties of gastric cancer stem cells.

Giraud J, Molina-Castro S, Seeneevassen L, Sifré E, Izotte J, Tiffon C, Staedel C, Boeuf H, Fernandez S, Barthelemy P, Megraud F, Lehours P, Dubus P, Varon C.

Int J Cancer. 2019 Sep 6. doi: 10.1002/ijc.32667. [Epub ahead of print]

PMID:
31489619
4.

Targeted gene therapy in human-induced pluripotent stem cells from a patient with primary hyperoxaluria type 1 using CRISPR/Cas9 technology.

Estève J, Blouin JM, Lalanne M, Azzi-Martin L, Dubus P, Bidet A, Harambat J, Llanas B, Moranvillier I, Bedel A, Moreau-Gaudry F, Richard E.

Biochem Biophys Res Commun. 2019 Oct 1;517(4):677-683. doi: 10.1016/j.bbrc.2019.07.109. Epub 2019 Aug 8.

PMID:
31402115
5.

Generation of induced pluripotent stem cells-derived hepatocyte-like cells for ex vivo gene therapy of primary hyperoxaluria type 1.

Estève J, Blouin JM, Lalanne M, Azzi-Martin L, Dubus P, Bidet A, Harambat J, Llanas B, Moranvillier I, Bedel A, Moreau-Gaudry F, Richard E.

Stem Cell Res. 2019 Jul;38:101467. doi: 10.1016/j.scr.2019.101467. Epub 2019 May 21.

6.

Orthotopic Patient-Derived Xenografts of Gastric Cancer to Decipher Drugs Effects on Cancer Stem Cells and Metastatic Dissemination.

Giraud J, Bouriez D, Seeneevassen L, Rousseau B, Sifré E, Giese A, Mégraud F, Lehours P, Dubus P, Gronnier C, Varon C.

Cancers (Basel). 2019 Apr 19;11(4). pii: E560. doi: 10.3390/cancers11040560.

7.

Hematopoietic niche drives FLT3-ITD acute myeloid leukemia resistance to quizartinib via STAT5-and hypoxia-dependent upregulation of AXL.

Dumas PY, Naudin C, Martin-Lannerée S, Izac B, Casetti L, Mansier O, Rousseau B, Artus A, Dufossée M, Giese A, Dubus P, Pigneux A, Praloran V, Bidet A, Villacreces A, Guitart A, Milpied N, Kosmider O, Vigon I, Desplat V, Dusanter-Fourt I, Pasquet JM.

Haematologica. 2019 Oct;104(10):2017-2027. doi: 10.3324/haematol.2018.205385. Epub 2019 Mar 28.

8.

[Indolent T-lymphoblastic proliferation in association with localized Castleman disease: A case report].

Chauveau B, Le Loarer F, Bacci J, Baylac F, Dubus P, Ling C, Parrens M.

Ann Pathol. 2019 Feb;39(1):29-35. doi: 10.1016/j.annpat.2018.09.003. Epub 2018 Dec 13. French.

PMID:
30554835
9.

Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria.

Urquiza P, Laín A, Sanz-Parra A, Moreno J, Bernardo-Seisdedos G, Dubus P, González E, Gutiérrez-de-Juan V, García S, Eraña H, San Juan I, Macías I, Ben Bdira F, Pluta P, Ortega G, Oyarzábal J, González-Muñiz R, Rodríguez-Cuesta J, Anguita J, Díez E, Blouin JM, de Verneuil H, Mato JM, Richard E, Falcón-Pérez JM, Castilla J, Millet O.

Sci Transl Med. 2018 Sep 19;10(459). pii: eaat7467. doi: 10.1126/scitranslmed.aat7467.

PMID:
30232228
10.

Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling.

Javary J, Allain-Courtois N, Saucisse N, Costet P, Heraud C, Benhamed F, Pierre R, Bure C, Pallares-Lupon N, Do Cruzeiro M, Postic C, Cota D, Dubus P, Rosenbaum J, Benhamouche-Trouillet S.

Gut. 2018 Dec;67(12):2192-2203. doi: 10.1136/gutjnl-2017-314208. Epub 2017 Oct 26.

PMID:
29074727
11.

Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRASG12D-driven Pancreatic Tumorigenesis.

Chuvin N, Vincent DF, Pommier RM, Alcaraz LB, Gout J, Caligaris C, Yacoub K, Cardot V, Roger E, Kaniewski B, Martel S, Cintas C, Goddard-Léon S, Colombe A, Valantin J, Gadot N, Servoz E, Morton J, Goddard I, Couvelard A, Rebours V, Guillermet J, Sansom OJ, Treilleux I, Valcourt U, Sentis S, Dubus P, Bartholin L.

Cell Mol Gastroenterol Hepatol. 2017 May 31;4(2):263-282. doi: 10.1016/j.jcmgh.2017.05.005. eCollection 2017 Sep.

12.

Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer.

Salvador F, Martin A, López-Menéndez C, Moreno-Bueno G, Santos V, Vázquez-Naharro A, Santamaria PG, Morales S, Dubus PR, Muinelo-Romay L, López-López R, Tung JC, Weaver VM, Portillo F, Cano A.

Cancer Res. 2017 Nov 1;77(21):5846-5859. doi: 10.1158/0008-5472.CAN-16-3152. Epub 2017 Jul 18.

13.

The Cytolethal Distending Toxin Subunit CdtB of Helicobacter hepaticus Promotes Senescence and Endoreplication in Xenograft Mouse Models of Hepatic and Intestinal Cell Lines.

Péré-Védrenne C, Prochazkova-Carlotti M, Rousseau B, He W, Chambonnier L, Sifré E, Buissonnière A, Dubus P, Mégraud F, Varon C, Ménard A.

Front Cell Infect Microbiol. 2017 Jun 30;7:268. doi: 10.3389/fcimb.2017.00268. eCollection 2017.

14.

Deregulation of MicroRNAs in Gastric Lymphomagenesis Induced in the d3Tx Mouse Model of Helicobacter pylori Infection.

Floch P, Capdevielle C, Staedel C, Izotte J, Sifré E, Laur AM, Giese A, Korolik V, Dubus P, Mégraud F, Lehours P.

Front Cell Infect Microbiol. 2017 May 16;7:185. doi: 10.3389/fcimb.2017.00185. eCollection 2017.

15.

A New Animal Model of Gastric Lymphomagenesis: APRIL Transgenic Mice Infected by Helicobacter Species.

Floch P, Izotte J, Guillemaud J, Sifré E, Costet P, Rousseau B, Laur AM, Giese A, Korolik V, Mégraud F, Dubus P, Hahne M, Lehours P.

Am J Pathol. 2017 Jul;187(7):1473-1484. doi: 10.1016/j.ajpath.2017.03.004. Epub 2017 Apr 29.

PMID:
28460208
16.

Unr defines a novel class of nucleoplasmic reticulum involved in mRNA translation.

Saltel F, Giese A, Azzi L, Elatmani H, Costet P, Ezzoukhry Z, Dugot-Senant N, Miquerol L, Boussadia O, Wodrich H, Dubus P, Jacquemin-Sablon H.

J Cell Sci. 2017 May 15;130(10):1796-1808. doi: 10.1242/jcs.198697. Epub 2017 Apr 6.

17.

Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis.

Roussel-Gervais A, Naciri I, Kirsh O, Kasprzyk L, Velasco G, Grillo G, Dubus P, Defossez PA.

Cancer Res. 2017 Jan 1;77(1):62-73. doi: 10.1158/0008-5472.CAN-16-1181. Epub 2016 Nov 4.

18.

All-trans retinoic acid targets gastric cancer stem cells and inhibits patient-derived gastric carcinoma tumor growth.

Nguyen PH, Giraud J, Staedel C, Chambonnier L, Dubus P, Chevret E, Bœuf H, Gauthereau X, Rousseau B, Fevre M, Soubeyran I, Belleannée G, Evrard S, Collet D, Mégraud F, Varon C.

Oncogene. 2016 Oct 27;35(43):5619-5628. doi: 10.1038/onc.2016.87. Epub 2016 May 9.

PMID:
27157616
19.

Deletion of IQGAP1 promotes Helicobacter pylori-induced gastric dysplasia in mice and acquisition of cancer stem cell properties in vitro.

Bessède E, Molina S, Acuña-Amador L, Dubus P, Staedel C, Chambonnier L, Buissonnière A, Sifré E, Giese A, Bénéjat L, Rousseau B, Costet P, Sacks DB, Mégraud F, Varon C.

Oncotarget. 2016 Dec 6;7(49):80688-80699. doi: 10.18632/oncotarget.12486.

20.

Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma.

Nguyen PH, Giraud J, Chambonnier L, Dubus P, Wittkop L, Belleannée G, Collet D, Soubeyran I, Evrard S, Rousseau B, Senant-Dugot N, Mégraud F, Mazurier F, Varon C.

Clin Cancer Res. 2017 Mar 15;23(6):1586-1597. doi: 10.1158/1078-0432.CCR-15-2157. Epub 2016 Sep 12.

21.

Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution.

Le Calvé B, Griveau A, Vindrieux D, Maréchal R, Wiel C, Svrcek M, Gout J, Azzi L, Payen L, Cros J, de la Fouchardière C, Dubus P, Guitton J, Bartholin L, Bachet JB, Bernard D.

Oncotarget. 2016 May 31;7(22):32100-12. doi: 10.18632/oncotarget.8527.

22.

REG3β Plays a Key Role in IL17RA Protumoral Effect-Response.

Loncle C, Bonjoch L, Folch-Puy E, Lopez-Millan MB, Lac S, Molejon MI, Chuluyan E, Cordelier P, Dubus P, Lomberk G, Urrutia R, Closa D, Iovanna JL.

Cancer Res. 2016 Apr 1;76(7):2051. doi: 10.1158/0008-5472.CAN-15-3355. Epub 2016 Mar 18. No abstract available.

23.

CDK4 is an essential insulin effector in adipocytes.

Lagarrigue S, Lopez-Mejia IC, Denechaud PD, Escoté X, Castillo-Armengol J, Jimenez V, Chavey C, Giralt A, Lai Q, Zhang L, Martinez-Carreres L, Delacuisine B, Annicotte JS, Blanchet E, Huré S, Abella A, Tinahones FJ, Vendrell J, Dubus P, Bosch F, Kahn CR, Fajas L.

J Clin Invest. 2016 Jan;126(1):335-48. doi: 10.1172/JCI81480. Epub 2015 Dec 14.

24.

Regulatory T cells may participate in Helicobacter pylori persistence in gastric MALT lymphoma: lessons from an animal model.

Laur AM, Floch P, Chambonnier L, Benejat L, Korolik V, Giese A, Dubus P, Mégraud F, Bandeira A, Lehours P.

Oncotarget. 2016 Jan 19;7(3):3394-402. doi: 10.18632/oncotarget.6492.

25.

Synergistic cooperation between ABT-263 and MEK1/2 inhibitor: effect on apoptosis and proliferation of acute myeloid leukemia cells.

Airiau K, Prouzet-Mauléon V, Rousseau B, Pigneux A, Jeanneteau M, Giraudon M, Allou K, Dubus P, Belloc F, Mahon FX.

Oncotarget. 2016 Jan 5;7(1):845-59. doi: 10.18632/oncotarget.6417.

26.

Characterisation of inflammatory processes in Helicobacter pylori-induced gastric lymphomagenesis in a mouse model.

Floch P, Laur AM, Korolik V, Chrisment D, Cappellen D, Idrissi Y, Dubus P, Mégraud F, Lehours P.

Oncotarget. 2015 Oct 27;6(33):34525-36. doi: 10.18632/oncotarget.5948.

27.

IL17 Functions through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer.

Loncle C, Bonjoch L, Folch-Puy E, Lopez-Millan MB, Lac S, Molejon MI, Chuluyan E, Cordelier P, Dubus P, Lomberk G, Urrutia R, Closa D, Iovanna JL.

Cancer Res. 2015 Nov 15;75(22):4852-62. doi: 10.1158/0008-5472.CAN-15-0896. Epub 2015 Sep 24.

28.

An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress.

Quereda V, Porlan E, Cañamero M, Dubus P, Malumbres M.

Cell Death Differ. 2016 Mar;23(3):430-41. doi: 10.1038/cdd.2015.112. Epub 2015 Aug 21.

29.

Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.

Martin A, Salvador F, Moreno-Bueno G, Floristán A, Ruiz-Herguido C, Cuevas EP, Morales S, Santos V, Csiszar K, Dubus P, Haigh JJ, Bigas A, Portillo F, Cano A.

EMBO J. 2015 Apr 15;34(8):1090-109. doi: 10.15252/embj.201489975. Epub 2015 Mar 10.

30.

γδ T cells confer protection against murine cytomegalovirus (MCMV).

Khairallah C, Netzer S, Villacreces A, Juzan M, Rousseau B, Dulanto S, Giese A, Costet P, Praloran V, Moreau JF, Dubus P, Vermijlen D, Déchanet-Merville J, Capone M.

PLoS Pathog. 2015 Mar 6;11(3):e1004702. doi: 10.1371/journal.ppat.1004702. eCollection 2015 Mar.

31.

An Eighteen-Month Helicobacter Infection Does Not Induce Amyloid Plaques or Neuroinflammation in Brains of Wild Type C57BL/6J Mice.

Baudron CR, Chambonnier L, Buissionnière A, Giese A, Macrez N, Cho Y, Fénelon V, Blaszczyk L, Dubus P, Lehours P, Mégraud F, Salles N, Varon C.

J Alzheimers Dis. 2015;45(4):1045-50.

PMID:
25697698
32.

[KHSV/EBV associated germinotropic lymphoproliferative disorder: a rare entity, case report and review of the literature].

Taris M, de Mascarel A, Riols M, Delwail V, Milpied N, Dubus P, Parrens M.

Ann Pathol. 2014 Oct;34(5):373-7. doi: 10.1016/j.annpat.2014.06.013. Epub 2014 Sep 26. Review. French.

PMID:
25439990
33.

Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis.

Rodríguez-Díez E, Quereda V, Bellutti F, Prchal-Murphy M, Partida D, Eguren M, Kollmann K, Gómez de Cedrón M, Dubus P, Cañamero M, Martínez D, Sexl V, Malumbres M.

Blood. 2014 Oct 9;124(15):2380-90. doi: 10.1182/blood-2014-02-555292. Epub 2014 Aug 25.

PMID:
25157181
34.

Helicobacter pylori infection and stem cells at the origin of gastric cancer.

Bessède E, Dubus P, Mégraud F, Varon C.

Oncogene. 2015 May 14;34(20):2547-55. doi: 10.1038/onc.2014.187. Epub 2014 Jul 21. Review.

PMID:
25043305
35.

Heterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder.

Segura-Puimedon M, Sahún I, Velot E, Dubus P, Borralleras C, Rodrigues AJ, Valero MC, Valverde O, Sousa N, Herault Y, Dierssen M, Pérez-Jurado LA, Campuzano V.

Hum Mol Genet. 2014 Dec 15;23(24):6481-94. doi: 10.1093/hmg/ddu368. Epub 2014 Jul 15.

PMID:
25027326
36.

Neonatal thymectomy favors Helicobacter pylori-promoted gastric mucosa-associated lymphoid tissue lymphoma lesions in BALB/c mice.

Chrisment D, Dubus P, Chambonnier L, Hocès de la Guardia A, Sifré E, Giese A, Capone M, Khairallah C, Costet P, Rousseau B, Hubert C, Burlen-Defranoux O, Varon C, Bandeira A, Mégraud F, Lehours P.

Am J Pathol. 2014 Aug;184(8):2174-84. doi: 10.1016/j.ajpath.2014.04.008. Epub 2014 Jun 6.

37.

Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors.

Cerqueira A, Martín A, Symonds CE, Odajima J, Dubus P, Barbacid M, Santamaría D.

Mol Cell Biol. 2014 Apr;34(8):1452-9. doi: 10.1128/MCB.01163-13. Epub 2014 Feb 10.

38.

Telomerase functions beyond telomere maintenance in primary cutaneous T-cell lymphoma.

Chevret E, Andrique L, Prochazkova-Carlotti M, Ferrer J, Cappellen D, Laharanne E, Idrissi Y, Boettiger A, Sahraoui W, Ruiz F, Pham-Ledard A, Vergier B, Belloc F, Dubus P, Beylot-Barry M, Merlio JP.

Blood. 2014 Mar 20;123(12):1850-9. doi: 10.1182/blood-2013-05-500686. Epub 2014 Jan 27.

PMID:
24470590
39.

Outcome-based determination of optimal pyrosequencing assay for MGMT methylation detection in glioblastoma patients.

Quillien V, Lavenu A, Sanson M, Legrain M, Dubus P, Karayan-Tapon L, Mosser J, Ichimura K, Figarella-Branger D.

J Neurooncol. 2014 Feb;116(3):487-96. doi: 10.1007/s11060-013-1332-y. Epub 2014 Jan 14.

40.

Variable behavior of iPSCs derived from CML patients for response to TKI and hematopoietic differentiation.

Bedel A, Pasquet JM, Lippert E, Taillepierre M, Lagarde V, Dabernat S, Dubus P, Charaf L, Beliveau F, de Verneuil H, Richard E, Mahon FX, Moreau-Gaudry F.

PLoS One. 2013 Aug 23;8(8):e71596. doi: 10.1371/journal.pone.0071596. eCollection 2013.

41.

FGFR3 has tumor suppressor properties in cells with epithelial phenotype.

Lafitte M, Moranvillier I, Garcia S, Peuchant E, Iovanna J, Rousseau B, Dubus P, Guyonnet-Dupérat V, Belleannée G, Ramos J, Bedel A, de Verneuil H, Moreau-Gaudry F, Dabernat S.

Mol Cancer. 2013 Jul 31;12:83. doi: 10.1186/1476-4598-12-83.

42.

Hypereosinophilic syndrome - lymphocytic variant transforming into peripheral T-cell lymphoma with severe oral manifestations.

d'Elbée JM, Parrens M, Mercié P, Longy Boursier M, Dieval C, de Mascarel A, Duffau P, Dubus P, Fricain JC.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Sep;116(3):e185-90. doi: 10.1016/j.oooo.2013.03.017. Epub 2013 May 10.

PMID:
23669204
43.

[The mouse as preclinical models of lung cancer].

Francoz S, Mathiaux J, Dubus P.

Bull Cancer. 2012 Nov;99(11):1017-27. doi: 10.1684/bdc.2012.1657. Review. French.

44.

In vivo gene transfer targeting in pancreatic adenocarcinoma with cell surface antigens.

Lafitte M, Rousseau B, Moranvillier I, Taillepierre M, Peuchant E, Guyonnet-Dupérat V, Bedel A, Dubus P, de Verneuil H, Moreau-Gaudry F, Dabernat S.

Mol Cancer. 2012 Oct 22;11:81. doi: 10.1186/1476-4598-11-81.

45.

Hepatic lesions observed in hepatitis C virus transgenic mice infected by Helicobacter hepaticus.

Le Roux-Goglin E, Dubus P, Asencio C, Jutand MA, Rosenbaum J, Mégraud F.

Helicobacter. 2013 Feb;18(1):33-40. doi: 10.1111/j.1523-5378.2012.00995.x. Epub 2012 Oct 3.

PMID:
23067369
46.

Metabolic correction of congenital erythropoietic porphyria with iPSCs free of reprogramming factors.

Bedel A, Taillepierre M, Guyonnet-Duperat V, Lippert E, Dubus P, Dabernat S, Mautuit T, Cardinaud B, Pain C, Rousseau B, Lalanne M, Ged C, Duchartre Y, Richard E, de Verneuil H, Moreau-Gaudry F.

Am J Hum Genet. 2012 Jul 13;91(1):109-21. doi: 10.1016/j.ajhg.2012.05.026.

47.

Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53+/- mice and c-myc-3'RR/Cdk4R24C mice: differential oncogenic mechanisms but similar cellular origin.

Rouaud P, Fiancette R, Vincent-Fabert C, Magnone V, Cogné M, Dubus P, Denizot Y.

Oncotarget. 2012 May;3(5):586-93.

48.

Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway.

Vincent DF, Gout J, Chuvin N, Arfi V, Pommier RM, Bertolino P, Jonckheere N, Ripoche D, Kaniewski B, Martel S, Langlois JB, Goddard-Léon S, Colombe A, Janier M, Van Seuningen I, Losson R, Valcourt U, Treilleux I, Dubus P, Bardeesy N, Bartholin L.

Am J Pathol. 2012 Jun;180(6):2214-21. doi: 10.1016/j.ajpath.2012.02.006. Epub 2012 Mar 31.

49.

A defect of the INK4-Cdk4 checkpoint and Myc collaborate in blastoid mantle cell lymphoma-like lymphoma formation in mice.

Vincent-Fabert C, Fiancette R, Rouaud P, Baudet C, Truffinet V, Magnone V, Guillaudeau A, Cogné M, Dubus P, Denizot Y.

Am J Pathol. 2012 Apr;180(4):1688-701. doi: 10.1016/j.ajpath.2012.01.004. Epub 2012 Feb 9.

PMID:
22326754
50.

Loss of epidermal hypoxia-inducible factor-1α accelerates epidermal aging and affects re-epithelialization in human and mouse.

Rezvani HR, Ali N, Serrano-Sanchez M, Dubus P, Varon C, Ged C, Pain C, Cario-André M, Seneschal J, Taïeb A, de Verneuil H, Mazurier F.

J Cell Sci. 2011 Dec 15;124(Pt 24):4172-83. doi: 10.1242/jcs.082370. Epub 2011 Dec 22.

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