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Contribution of the Gut Microbiota in P28GST-Mediated Anti-Inflammatory Effects: Experimental and Clinical Insights.

Foligné B, Plé C, Titécat M, Dendooven A, Pagny A, Daniel C, Singer E, Pottier M, Bertin B, Neut C, Deplanque D, Dubuquoy L, Desreumaux P, Capron M, Standaert A.

Cells. 2019 Jun 12;8(6). pii: E577. doi: 10.3390/cells8060577.


Nucleotide-binding oligomerization domain 1 (NOD1) modulates liver ischemia reperfusion through the expression adhesion molecules.

Lassailly G, Bou Saleh M, Leleu-Chavain N, Ningarhari M, Gantier E, Carpentier R, Artru F, Gnemmi V, Bertin B, Maboudou P, Betbeder D, Gheeraert C, Maggiotto F, Dharancy S, Mathurin P, Louvet A, Dubuquoy L.

J Hepatol. 2019 Jun;70(6):1159-1169. doi: 10.1016/j.jhep.2019.01.019. Epub 2019 Jan 25.


Treatment with P28GST, a schistosome-derived enzyme, after acute colitis induction in mice: Decrease of intestinal inflammation associated with a down regulation of Th1/Th17 responses.

Sarazin A, Dendooven A, Delbeke M, Gatault S, Pagny A, Standaert A, Rousseaux C, Desreumaux P, Dubuquoy L, Capron M.

PLoS One. 2018 Dec 28;13(12):e0209681. doi: 10.1371/journal.pone.0209681. eCollection 2018.


Ductular Reaction Cells Display an Inflammatory Profile and Recruit Neutrophils in Alcoholic Hepatitis.

Aguilar-Bravo B, Rodrigo-Torres D, Ariño S, Coll M, Pose E, Blaya D, Graupera I, Perea L, Vallverdú J, Rubio-Tomás T, Dubuquoy L, Armengol C, Lo Nigro A, Stärkel P, Mathurin P, Bataller R, Caballería J, José Lozano J, Ginès P, Sancho-Bru P.

Hepatology. 2019 May;69(5):2180-2195. doi: 10.1002/hep.30472. Epub 2019 Mar 12.


High carriage of adherent invasive E. coli in wildlife and healthy individuals.

Rahmouni O, Vignal C, Titécat M, Foligné B, Pariente B, Dubuquoy L, Desreumaux P, Neut C.

Gut Pathog. 2018 Jun 14;10:23. doi: 10.1186/s13099-018-0248-7. eCollection 2018.


β-Hydroxybutyrate protects from alcohol-induced liver injury via a Hcar2-cAMP dependent pathway.

Chen Y, Ouyang X, Hoque R, Garcia-Martinez I, Yousaf MN, Tonack S, Offermanns S, Dubuquoy L, Louvet A, Mathurin P, Massey V, Schnabl B, Bataller RA, Mehal WZ.

J Hepatol. 2018 Sep;69(3):687-696. doi: 10.1016/j.jhep.2018.04.004. Epub 2018 Apr 27.


Cross regulation between mTOR signaling and O-GlcNAcylation.

Very N, Steenackers A, Dubuquoy C, Vermuse J, Dubuquoy L, Lefebvre T, El Yazidi-Belkoura I.

J Bioenerg Biomembr. 2018 Jun;50(3):213-222. doi: 10.1007/s10863-018-9747-y. Epub 2018 Mar 9.


Cholesterol-enriched membrane microdomains are needed for insulin signaling and proliferation in hepatic cells.

Fonseca MC, França A, Florentino RM, Fonseca RC, Lima Filho ACM, Vidigal PTV, Oliveira AG, Dubuquoy L, Nathanson MH, Leite MF.

Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G80-G94. doi: 10.1152/ajpgi.00008.2018. Epub 2018 Feb 22.


Neoboutonia melleri var velutina Prain: in vitro and in vivo hepatoprotective effects of the aqueous stem bark extract on acute hepatitis models.

Endougou Effa AM, Gantier E, Hennebelle T, Roumy V, Rivière C, Dimo T, Kamtchouing P, Desreumaux P, Dubuquoy L.

BMC Complement Altern Med. 2018 Jan 22;18(1):24. doi: 10.1186/s12906-018-2091-2.


One- or Two-Step Synthesis of C-8 and N-9 Substituted Purines.

Bollier M, Klupsch F, Six P, Dubuquoy L, Azaroual N, Millet R, Leleu-Chavain N.

J Org Chem. 2018 Jan 5;83(1):422-430. doi: 10.1021/acs.joc.7b02269. Epub 2017 Dec 14.


Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis.

Darnaud M, Dos Santos A, Gonzalez P, Augui S, Lacoste C, Desterke C, De Hertogh G, Valentino E, Braun E, Zheng J, Boisgard R, Neut C, Dubuquoy L, Chiappini F, Samuel D, Lepage P, Guerrieri F, Doré J, Bréchot C, Moniaux N, Faivre J.

Gastroenterology. 2018 Mar;154(4):1009-1023.e14. doi: 10.1053/j.gastro.2017.11.003. Epub 2017 Nov 11.


Peroxisome proliferator-activated receptor gamma (PPARγ) regulates lactase expression and activity in the gut.

Fumery M, Speca S, Langlois A, Davila AM, Dubuquoy C, Grauso M, Martin Mena A, Figeac M, Metzger D, Rousseaux C, Colombel JF, Dubuquoy L, Desreumaux P, Bertin B.

EMBO Mol Med. 2017 Nov;9(11):1471-1481. doi: 10.15252/emmm.201707795.


The Expression of the Short Isoform of Thymic Stromal Lymphopoietin in the Colon Is Regulated by the Nuclear Receptor Peroxisome Proliferator Activated Receptor-Gamma and Is Impaired during Ulcerative Colitis.

Martin Mena A, Langlois A, Speca S, Schneider L, Desreumaux P, Dubuquoy L, Bertin B.

Front Immunol. 2017 Sep 4;8:1052. doi: 10.3389/fimmu.2017.01052. eCollection 2017.


Role of TLR1, TLR2 and TLR6 in the modulation of intestinal inflammation and Candida albicans elimination.

Choteau L, Vancraeyneste H, Le Roy D, Dubuquoy L, Romani L, Jouault T, Poulain D, Sendid B, Calandra T, Roger T, Jawhara S.

Gut Pathog. 2017 Feb 15;9:9. doi: 10.1186/s13099-017-0158-0. eCollection 2017.


Chronic bowel inflammation and inflammatory joint disease: Pathophysiology.

Speca S, Dubuquoy L.

Joint Bone Spine. 2017 Jul;84(4):417-420. doi: 10.1016/j.jbspin.2016.12.016. Epub 2017 Jan 3. Review.


[Enteric microflora in inflammatory bowel disease patients].

Rahmouni O, Dubuquoy L, Desreumaux P, Neut C.

Med Sci (Paris). 2016 Nov;32(11):968-973. doi: 10.1051/medsci/20163211012. Epub 2016 Dec 23. Review. French.


Lymphoid Aggregates Remodel Lymphatic Collecting Vessels that Serve Mesenteric Lymph Nodes in Crohn Disease.

Randolph GJ, Bala S, Rahier JF, Johnson MW, Wang PL, Nalbantoglu I, Dubuquoy L, Chau A, Pariente B, Kartheuser A, Zinselmeyer BH, Colombel JF.

Am J Pathol. 2016 Dec;186(12):3066-3073. doi: 10.1016/j.ajpath.2016.07.026. Epub 2016 Oct 13.


Periodontal manifestations of inflammatory bowel disease: emerging epidemiologic and biologic evidence.

Agossa K, Dendooven A, Dubuquoy L, Gower-Rousseau C, Delcourt-Debruyne E, Capron M.

J Periodontal Res. 2017 Jun;52(3):313-324. doi: 10.1111/jre.12422. Epub 2016 Sep 24. Review.


Corrigendum: Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn's Disease Patients.

Choteau L, Vasseur F, Lepretre F, Figeac M, Gower-Rousseau C, Dubuquoy L, Poulain D, Colombel JF, Sendid B, Jawhara S.

Sci Rep. 2016 Sep 16;6:33426. doi: 10.1038/srep33426. No abstract available.


Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn's Disease Patients.

Choteau L, Vasseur F, Lepretre F, Figeac M, Gower-Rousseau C, Dubuquoy L, Poulain D, Colombel JF, Sendid B, Jawhara S.

Sci Rep. 2016 Jul 12;6:29636. doi: 10.1038/srep29636. Erratum in: Sci Rep. 2016 Sep 16;6:33426.


Short fungal fractions of β-1,3 glucans affect platelet activation.

Vancraeyneste H, Charlet R, Guerardel Y, Choteau L, Bauters A, Tardivel M, François N, Dubuquoy L, Soloviev D, Poulain D, Sendid B, Jawhara S.

Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H725-34. doi: 10.1152/ajpheart.00907.2015. Epub 2016 Jun 10.


MicroRNA in alcoholic hepatitis: implications for pathophysiology and treatment.

Stickel F, Dubuquoy L.

Gut. 2016 Sep;65(9):1400-1. doi: 10.1136/gutjnl-2016-312101. Epub 2016 Jun 1. No abstract available.


Lipocalin 2 highlights the complex role of neutrophils in alcoholic liver disease.

Dubuquoy L.

J Hepatol. 2016 Apr;64(4):770-2. doi: 10.1016/j.jhep.2016.01.020. Epub 2016 Jan 23. No abstract available.


Novel PPARγ Modulator GED-0507-34 Levo Ameliorates Inflammation-driven Intestinal Fibrosis.

Speca S, Rousseaux C, Dubuquoy C, Rieder F, Vetuschi A, Sferra R, Giusti I, Bertin B, Dubuquoy L, Gaudio E, Desreumaux P, Latella G.

Inflamm Bowel Dis. 2016 Feb;22(2):279-92. doi: 10.1097/MIB.0000000000000618.


Role of mannose-binding lectin in intestinal homeostasis and fungal elimination.

Choteau L, Parny M, François N, Bertin B, Fumery M, Dubuquoy L, Takahashi K, Colombel JF, Jouault T, Poulain D, Sendid B, Jawhara S.

Mucosal Immunol. 2016 May;9(3):767-76. doi: 10.1038/mi.2015.100. Epub 2015 Oct 7.


Controlled delivery of a new broad spectrum antibacterial agent against colitis: In vitro and in vivo performance.

Nieto-Bobadilla MS, Siepmann F, Djouina M, Dubuquoy L, Tesse N, Willart JF, Dubreuil L, Siepmann J, Neut C.

Eur J Pharm Biopharm. 2015 Oct;96:152-61. doi: 10.1016/j.ejpb.2015.07.012. Epub 2015 Jul 21.


The schistosome glutathione S-transferase P28GST, a unique helminth protein, prevents intestinal inflammation in experimental colitis through a Th2-type response with mucosal eosinophils.

Driss V, El Nady M, Delbeke M, Rousseaux C, Dubuquoy C, Sarazin A, Gatault S, Dendooven A, Riveau G, Colombel JF, Desreumaux P, Dubuquoy L, Capron M.

Mucosal Immunol. 2016 Mar;9(2):322-35. doi: 10.1038/mi.2015.62. Epub 2015 Jul 15.


Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier.

Gouyer V, Dubuquoy L, Robbe-Masselot C, Neut C, Singer E, Plet S, Geboes K, Desreumaux P, Gottrand F, Desseyn JL.

Sci Rep. 2015 May 14;5:9577. doi: 10.1038/srep09577.


Escherichia coli LF82 differentially regulates ROS production and mucin expression in intestinal epithelial T84 cells: implication of NOX1.

Elatrech I, Marzaioli V, Boukemara H, Bournier O, Neut C, Darfeuille-Michaud A, Luis J, Dubuquoy L, El-Benna J, My-Chan Dang P, Marie JC.

Inflamm Bowel Dis. 2015 May;21(5):1018-26. doi: 10.1097/MIB.0000000000000365.


Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitis.

Dubuquoy L, Louvet A, Lassailly G, Truant S, Boleslawski E, Artru F, Maggiotto F, Gantier E, Buob D, Leteurtre E, Cannesson A, Dharancy S, Moreno C, Pruvot FR, Bataller R, Mathurin P.

Gut. 2015 Dec;64(12):1949-60. doi: 10.1136/gutjnl-2014-308410. Epub 2015 Mar 2.


Intestinal steroidogenesis.

Bouguen G, Dubuquoy L, Desreumaux P, Brunner T, Bertin B.

Steroids. 2015 Nov;103:64-71. doi: 10.1016/j.steroids.2014.12.022. Epub 2015 Jan 2. Review.


In vivo efficacy of microbiota-sensitive coatings for colon targeting: a promising tool for IBD therapy.

Karrout Y, Dubuquoy L, Piveteau C, Siepmann F, Moussa E, Wils D, Beghyn T, Neut C, Flament MP, Guerin-Deremaux L, Dubreuil L, Deprez B, Desreumaux P, Siepmann J.

J Control Release. 2015 Jan 10;197:121-30. doi: 10.1016/j.jconrel.2014.11.006. Epub 2014 Nov 10.


Peroxisome proliferator-activated receptor gamma in the colon: inflammation and innate antimicrobial immunity.

Speca S, Dubuquoy L, Desreumaux P.

J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S23-7. doi: 10.1097/MCG.0000000000000253. Review.


Intestinal steroidogenesis controls PPARγ expression in the colon and is impaired during ulcerative colitis.

Bouguen G, Langlois A, Djouina M, Branche J, Koriche D, Dewaeles E, Mongy A, Auwerx J, Colombel JF, Desreumaux P, Dubuquoy L, Bertin B.

Gut. 2015 Jun;64(6):901-10. doi: 10.1136/gutjnl-2014-307618. Epub 2014 Jul 22.


Glugacon-like peptide-2: broad receptor expression, limited therapeutic effect on intestinal inflammation and novel role in liver regeneration.

El-Jamal N, Erdual E, Neunlist M, Koriche D, Dubuquoy C, Maggiotto F, Chevalier J, Berrebi D, Dubuquoy L, Boulanger E, Cortot A, Desreumaux P.

Am J Physiol Gastrointest Liver Physiol. 2014 Aug 1;307(3):G274-85. doi: 10.1152/ajpgi.00389.2012. Epub 2014 May 29.


Functional polymorphisms in the regulatory regions of the VNN1 gene are associated with susceptibility to inflammatory bowel diseases.

Gensollen T, Bourges C, Rihet P, Rostan A, Millet V, Noguchi T, Bourdon V, Sobol H, Dubuquoy L, Bertin B, Fumery M, Desreumaux P, Colombel JF, Chamaillard M, Hebuterne X, Hofman P, Naquet P, Galland F.

Inflamm Bowel Dis. 2013 Oct;19(11):2315-25. doi: 10.1097/MIB.0b013e3182a32b03. Erratum in: Inflamm Bowel Dis. 2014 Aug;20(8):1457. Chamaillard, Mathias [added].


Decreased lymphatic vessel density is associated with postoperative endoscopic recurrence in Crohn's disease.

Rahier JF, Dubuquoy L, Colombel JF, Jouret-Mourin A, Delos M, Ferrante M, Sokol H, Hertogh GD, Salleron J, Geboes K, Desreumaux P.

Inflamm Bowel Dis. 2013 Sep;19(10):2084-90. doi: 10.1097/MIB.0b013e3182971cec.


The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ.

Rousseaux C, El-Jamal N, Fumery M, Dubuquoy C, Romano O, Chatelain D, Langlois A, Bertin B, Buob D, Colombel JF, Cortot A, Desreumaux P, Dubuquoy L.

Carcinogenesis. 2013 Nov;34(11):2580-6. doi: 10.1093/carcin/bgt245. Epub 2013 Jul 10.


ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading.

Fernandez A, Matias N, Fucho R, Ribas V, Von Montfort C, Nuño N, Baulies A, Martinez L, Tarrats N, Mari M, Colell A, Morales A, Dubuquoy L, Mathurin P, Bataller R, Caballeria J, Elena M, Balsinde J, Kaplowitz N, Garcia-Ruiz C, Fernandez-Checa JC.

J Hepatol. 2013 Oct;59(4):805-13. doi: 10.1016/j.jhep.2013.05.023. Epub 2013 May 23.


PPAR-gamma in ulcerative colitis: a novel target for intervention.

Bertin B, Dubuquoy L, Colombel JF, Desreumaux P.

Curr Drug Targets. 2013 Nov;14(12):1501-7. Review.


Colonic inflammation in mice is improved by cigarette smoke through iNKT cells recruitment.

Montbarbon M, Pichavant M, Langlois A, Erdual E, Maggiotto F, Neut C, Mallevaey T, Dharancy S, Dubuquoy L, Trottein F, Cortot A, Desreumaux P, Gosset P, Bertin B.

PLoS One. 2013 Apr 25;8(4):e62208. doi: 10.1371/journal.pone.0062208. Print 2013.


In vivo imaging reveals selective PPAR activity in the skin of peroxisome proliferator-activated receptor responsive element-luciferase reporter mice.

El-Jamal N, Dubuquoy L, Auwerx J, Bertin B, Desreumaux P.

Exp Dermatol. 2013 Feb;22(2):137-40. doi: 10.1111/exd.12082.


Modulation of intestinal inflammation by yeasts and cell wall extracts: strain dependence and unexpected anti-inflammatory role of glucan fractions.

Jawhara S, Habib K, Maggiotto F, Pignede G, Vandekerckove P, Maes E, Dubuquoy L, Fontaine T, Guerardel Y, Poulain D.

PLoS One. 2012;7(7):e40648. doi: 10.1371/journal.pone.0040648. Epub 2012 Jul 27.


Murine model of dextran sulfate sodium-induced colitis reveals Candida glabrata virulence and contribution of β-mannosyltransferases.

Jawhara S, Mogensen E, Maggiotto F, Fradin C, Sarazin A, Dubuquoy L, Maes E, Guérardel Y, Janbon G, Poulain D.

J Biol Chem. 2012 Mar 30;287(14):11313-24. doi: 10.1074/jbc.M111.329300. Epub 2012 Jan 30.


Visceral fat and gut inflammation.

Drouet M, Dubuquoy L, Desreumaux P, Bertin B.

Nutrition. 2012 Feb;28(2):113-7. doi: 10.1016/j.nut.2011.09.009. Review.


Mesenteric fat as a source of C reactive protein and as a target for bacterial translocation in Crohn's disease.

Peyrin-Biroulet L, Gonzalez F, Dubuquoy L, Rousseaux C, Dubuquoy C, Decourcelle C, Saudemont A, Tachon M, Béclin E, Odou MF, Neut C, Colombel JF, Desreumaux P.

Gut. 2012 Jan;61(1):78-85. doi: 10.1136/gutjnl-2011-300370. Epub 2011 Sep 21.


Variants of NOD1 and NOD2 genes display opposite associations with familial risk of Crohn's disease and anti-saccharomyces cerevisiae antibody levels.

Vasseur F, Sendid B, Jouault T, Standaert-Vitse A, Dubuquoy L, Francois N, Gower-Rousseau C, Desreumaux P, Broly F, Vermeire S, Colombel JF, Poulain D.

Inflamm Bowel Dis. 2012 Mar;18(3):430-8. doi: 10.1002/ibd.21817. Epub 2011 Jul 7.


Increased lymphatic vessel density and lymphangiogenesis in inflammatory bowel disease.

Rahier JF, De Beauce S, Dubuquoy L, Erdual E, Colombel JF, Jouret-Mourin A, Geboes K, Desreumaux P.

Aliment Pharmacol Ther. 2011 Sep;34(5):533-43. doi: 10.1111/j.1365-2036.2011.04759.x. Epub 2011 Jul 7.


Obesity, visceral fat and Crohn's disease.

Bertin B, Desreumaux P, Dubuquoy L.

Curr Opin Clin Nutr Metab Care. 2010 Sep;13(5):574-80. doi: 10.1097/MCO.0b013e32833cf0f4. Review.


Neutrophil migration during liver injury is under nucleotide-binding oligomerization domain 1 control.

Dharancy S, Body-Malapel M, Louvet A, Berrebi D, Gantier E, Gosset P, Viala J, Hollebecque A, Moreno C, Philpott DJ, Girardin SE, Sansonetti PJ, Desreumaux P, Mathurin P, Dubuquoy L.

Gastroenterology. 2010 Apr;138(4):1546-56, 1556.e1-5. doi: 10.1053/j.gastro.2009.12.008. Epub 2009 Dec 21.


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