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Items: 30


E2F1 binds to the peptide-binding groove within the BIR3 domain of cIAP1 and requires cIAP1 for chromatin binding.

Allègre J, Cartier J, Glorian V, Droin N, Dumetier B, Kayaci C, Berthelet J, Gemble S, Vuillier C, Maillet L, Garrido C, Dubrez L.

PLoS One. 2018 Oct 25;13(10):e0206253. doi: 10.1371/journal.pone.0206253. eCollection 2018.


Correction: DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues.

Glorian V, Allègre J, Berthelet J, Dumetier B, Boutanquoi PM, Droin N, Kayaci C, Cartier J, Gemble S, Marcion G, Gonzalez D, Boidot R, Garrido C, Micheau O, Solary E, Dubrez L.

Cell Death Dis. 2018 Jul 16;9(8):785. doi: 10.1038/s41419-018-0822-4.


E2F1 interacts with BCL-xL and regulates its subcellular localization dynamics to trigger cell death.

Vuillier C, Lohard S, Fétiveau A, Allègre J, Kayaci C, King LE, Braun F, Barillé-Nion S, Gautier F, Dubrez L, Gilmore AP, Juin PP, Maillet L.

EMBO Rep. 2018 Feb;19(2):234-243. doi: 10.15252/embr.201744046. Epub 2017 Dec 12.


Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation.

Dubrez L.

Int J Mol Sci. 2017 Oct 19;18(10). pii: E2188. doi: 10.3390/ijms18102188. Review.


DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues.

Glorian V, Allègre J, Berthelet J, Dumetier B, Boutanquoi PM, Droin N, Kayaci C, Cartier J, Gemble S, Marcion G, Gonzalez D, Boidot R, Garrido C, Michaud O, Solary E, Dubrez L.

Cell Death Dis. 2017 May 25;8(5):e2816. doi: 10.1038/cddis.2017.222. Erratum in: Cell Death Dis. 2018 Jul 16;9(8):785.


IAPs: Mediators of Oncogenesis and Targets for Anticancer Therapy.

Bouaouiche S, Dubrez L, Bettaieb A, Plenchette S.

Crit Rev Oncog. 2016;21(5-6):399-411. doi: 10.1615/CritRevOncog.2017021084.


IAPs and cell migration.

Dubrez L, Rajalingam K.

Semin Cell Dev Biol. 2015 Mar;39:124-31. doi: 10.1016/j.semcdb.2015.02.015. Epub 2015 Mar 10. Review.


Towards the elaboration of new gold-based optical theranostics.

Doulain PE, Decréau R, Racoeur C, Goncalves V, Dubrez L, Bettaieb A, Le Gendre P, Denat F, Paul C, Goze C, Bodio E.

Dalton Trans. 2015 Mar 21;44(11):4874-83. doi: 10.1039/c4dt02977a.


[IAP and Rho finally connected].

Dubrez L, Marivin A, Berthelet J.

Med Sci (Paris). 2014 Mar;30(3):231-3. doi: 10.1051/medsci/20143003003. Epub 2014 Mar 31. French. No abstract available.


cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation.

Marivin A, Berthelet J, Cartier J, Paul C, Gemble S, Morizot A, Boireau W, Saleh M, Bertoglio J, Solary E, Dubrez L.

Oncogene. 2014 Nov 27;33(48):5534-45. doi: 10.1038/onc.2013.499. Epub 2013 Nov 25.


IAP proteins as targets for drug development in oncology.

Dubrez L, Berthelet J, Glorian V.

Onco Targets Ther. 2013 Sep 16;9:1285-304. doi: 10.2147/OTT.S33375. Review.


Regulation of Apoptosis by Inhibitors of Apoptosis (IAPs).

Berthelet J, Dubrez L.

Cells. 2013 Mar 14;2(1):163-87. doi: 10.3390/cells2010163.


[IAPs: a central element in the NF-κB activating signaling pathway].

Cartier J, Marivin A, Berthelet J, Dubrez L.

Med Sci (Paris). 2012 Jan;28(1):69-75. doi: 10.1051/medsci/2012281019. Epub 2012 Jan 27. Review. French.


The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress.

Marivin A, Berthelet J, Plenchette S, Dubrez L.

Cells. 2012 Oct 10;1(4):711-37. doi: 10.3390/cells1040711.


Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription.

Cartier J, Berthelet J, Marivin A, Gemble S, Edmond V, Plenchette S, Lagrange B, Hammann A, Dupoux A, Delva L, Eymin B, Solary E, Dubrez L.

J Biol Chem. 2011 Jul 29;286(30):26406-17. doi: 10.1074/jbc.M110.191239. Epub 2011 Jun 8.


Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines.

Hurbin A, Dubrez L, Coll JL, Favrot MC.

J Biol Chem. 2002 Dec 20;277(51):49127-33. Epub 2002 Sep 27.


Cell cycle arrest is sufficient for p53-mediated tumor regression.

Dubrez L, Coll JL, Hurbin A, de Fraipont F, Lantejoul S, Favrot MC.

Gene Ther. 2001 Nov;8(22):1705-12.


BCR-ABL fails to inhibit apoptosis in U937 myelomonocytic cells expressing a carboxyl-terminal truncated STAT5.

Ahmed M, Dusanter-Fourt I, Dugray A, Dubrez L, Novault S, Bonnet ML, Gisselbrecht S, Varet B, Solary E, Vainchenker W, Turhan AG.

Leuk Lymphoma. 2001 Jul;42(3):445-55.


Caffeine sensitizes human H358 cell line to p53-mediated apoptosis by inducing mitochondrial translocation and conformational change of BAX protein.

Dubrez L, Coll JL, Hurbin A, Solary E, Favrot MC.

J Biol Chem. 2001 Oct 19;276(42):38980-7. Epub 2001 Aug 6.


Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis.

Griffiths GJ, Dubrez L, Morgan CP, Jones NA, Whitehouse J, Corfe BM, Dive C, Hickman JA.

J Cell Biol. 1999 Mar 8;144(5):903-14.


Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis.

Droin N, Dubrez L, Eymin B, Renvoizé C, Bréard J, Dimanche-Boitrel MT, Solary E.

Oncogene. 1998 Jun 4;16(22):2885-94.


BCR-ABL delays apoptosis upstream of procaspase-3 activation.

Dubrez L, Eymin B, Sordet O, Droin N, Turhan AG, Solary E.

Blood. 1998 Apr 1;91(7):2415-22.


Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways.

Dubrez L, Savoy I, Hamman A, Solary E.

EMBO J. 1996 Oct 15;15(20):5504-12.


The role of apoptosis in the pathogenesis and treatment of diseases.

Solary E, Dubrez L, Eymin B.

Eur Respir J. 1996 Jun;9(6):1293-305. Review.


Induction of apoptosis in endothelial cells treated with cholesterol oxides.

Lizard G, Deckert V, Dubrez L, Moisant M, Gambert P, Lagrost L.

Am J Pathol. 1996 May;148(5):1625-38.


[Apoptosis of human leukemic cells induced by topoisomerase I and II inhibitors].

Solary E, Dubrez L, Eymin B, Bertrand R, Pommier Y.

Bull Cancer. 1996 Mar;83(3):205-12. French.


Cellular pharmacology of azatoxins (topoisomerase-II and tubulin inhibitors) in P-glycoprotein-positive and -negative cell lines.

Eymin B, Solary E, Chevillard S, Dubrez L, Goldwasser F, Duchamp O, Genne P, Leteurtre F, Pommier Y.

Int J Cancer. 1995 Oct 9;63(2):268-75.


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