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Items: 1 to 50 of 55

1.

Glioblastoma Therapy in the Age of Molecular Medicine.

Geraldo LHM, Garcia C, da Fonseca ACC, Dubois LGF, de Sampaio E Spohr TCL, Matias D, de Camargo Magalhães ES, do Amaral RF, da Rosa BG, Grimaldi I, Leser FS, Janeiro JM, Macharia L, Wanjiru C, Pereira CM, Moura-Neto V, Freitas C, Lima FRS.

Trends Cancer. 2019 Jan;5(1):46-65. doi: 10.1016/j.trecan.2018.11.002. Epub 2018 Dec 7. Review.

PMID:
30616755
2.

Correlation of monocular grating acuity at age 12 months with recognition acuity at age 4.5 years: findings from the Infant Aphakia Treatment Study.

Hartmann EE, Drews-Botsch C, DuBois LG, Cotsonis G, Lambert SR; Infant Aphakia Treatment Study Group.

J AAPOS. 2018 Aug;22(4):299-303.e2. doi: 10.1016/j.jaapos.2018.03.011. Epub 2018 Jul 20.

PMID:
30031874
3.

GBM-Derived Wnt3a Induces M2-Like Phenotype in Microglial Cells Through Wnt/β-Catenin Signaling.

Matias D, Dubois LG, Pontes B, Rosário L, Ferrer VP, Balça-Silva J, Fonseca ACC, Macharia LW, Romão L, E Spohr TCLS, Chimelli L, Filho PN, Lopes MC, Abreu JG, Lima FRS, Moura-Neto V.

Mol Neurobiol. 2019 Feb;56(2):1517-1530. doi: 10.1007/s12035-018-1150-5. Epub 2018 Jun 14.

PMID:
29948952
4.

p53 expression and subcellular survivin localization improve the diagnosis and prognosis of patients with diffuse astrocytic tumors.

Faccion RS, Bernardo PS, de Lopes GPF, Bastos LS, Teixeira CL, de Oliveira JA, Fernandes PV, Dubois LG, Chimelli L, Maia RC.

Cell Oncol (Dordr). 2018 Apr;41(2):141-157. doi: 10.1007/s13402-017-0361-5. Epub 2018 Jan 26.

PMID:
29374392
5.

Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness.

Bogeas A, Morvan-Dubois G, El-Habr EA, Lejeune FX, Defrance M, Narayanan A, Kuranda K, Burel-Vandenbos F, Sayd S, Delaunay V, Dubois LG, Parrinello H, Rialle S, Fabrega S, Idbaih A, Haiech J, Bièche I, Virolle T, Goodhardt M, Chneiweiss H, Junier MP.

Acta Neuropathol. 2018 Feb;135(2):267-283. doi: 10.1007/s00401-017-1783-x. Epub 2017 Nov 17.

6.

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells.

Baek AE, Yu YA, He S, Wardell SE, Chang CY, Kwon S, Pillai RV, McDowell HB, Thompson JW, Dubois LG, Sullivan PM, Kemper JK, Gunn MD, McDonnell DP, Nelson ER.

Nat Commun. 2017 Oct 11;8(1):864. doi: 10.1038/s41467-017-00910-z.

7.

Glioblastoma entities express subtle differences in molecular composition and response to treatment.

Balça-Silva J, Matias D, Do Carmo A, Dubois LG, Gonçalves AC, Girão H, Canedo NHS, Correia AH, De Souza JM, Sarmento-Ribeiro AB, Lopes MC, Moura-Neto V.

Oncol Rep. 2017 Sep;38(3):1341-1352. doi: 10.3892/or.2017.5799. Epub 2017 Jul 7.

8.

The Expression of Connexins and SOX2 Reflects the Plasticity of Glioma Stem-Like Cells.

Balça-Silva J, Matias D, Dubois LG, Carneiro B, do Carmo A, Girão H, Ferreira F, Ferrer VP, Chimelli L, Filho PN, Tão H, Rebelo O, Barbosa M, Sarmento-Ribeiro AB, Lopes MC, Moura-Neto V.

Transl Oncol. 2017 Aug;10(4):555-569. doi: 10.1016/j.tranon.2017.04.005. Epub 2017 Jun 24.

9.

Dual treatment with shikonin and temozolomide reduces glioblastoma tumor growth, migration and glial-to-mesenchymal transition.

Matias D, Balça-Silva J, Dubois LG, Pontes B, Ferrer VP, Rosário L, do Carmo A, Echevarria-Lima J, Sarmento-Ribeiro AB, Lopes MC, Moura-Neto V.

Cell Oncol (Dordr). 2017 Jun;40(3):247-261. doi: 10.1007/s13402-017-0320-1. Epub 2017 Apr 11.

PMID:
28401486
10.

A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.

Wagner GR, Bhatt DP, O'Connell TM, Thompson JW, Dubois LG, Backos DS, Yang H, Mitchell GA, Ilkayeva OR, Stevens RD, Grimsrud PA, Hirschey MD.

Cell Metab. 2017 Apr 4;25(4):823-837.e8. doi: 10.1016/j.cmet.2017.03.006.

11.

Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis.

Wang L, Ko ER, Gilchrist JJ, Pittman KJ, Rautanen A, Pirinen M, Thompson JW, Dubois LG, Langley RJ, Jaslow SL, Salinas RE, Rouse DC, Moseley MA, Mwarumba S, Njuguna P, Mturi N; Wellcome Trust Case Control Consortium 2; Kenyan Bacteraemia Study Group, Williams TN, Scott JA, Hill AV, Woods CW, Ginsburg GS, Tsalik EL, Ko DC.

Sci Adv. 2017 Mar 8;3(3):e1602096. doi: 10.1126/sciadv.1602096. eCollection 2017 Mar.

12.

CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer.

Alfaqih MA, Nelson ER, Liu W, Safi R, Jasper JS, Macias E, Geradts J, Thompson JW, Dubois LG, Freeman MR, Chang CY, Chi JT, McDonnell DP, Freedland SJ.

Cancer Res. 2017 Apr 1;77(7):1662-1673. doi: 10.1158/0008-5472.CAN-16-2738. Epub 2017 Jan 27.

13.

Bisacodyl and its cytotoxic activity on human glioblastoma stem-like cells. Implication of inositol 1,4,5-triphosphate receptor dependent calcium signaling.

Dong J, Aulestia FJ, Assad Kahn S, Zeniou M, Dubois LG, El-Habr EA, Daubeuf F, Tounsi N, Cheshier SH, Frossard N, Junier MP, Chneiweiss H, Néant I, Moreau M, Leclerc C, Haiech J, Kilhoffer MC.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):1018-1027. doi: 10.1016/j.bbamcr.2017.01.010. Epub 2017 Jan 18.

14.

Erratum: Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage.

Lei B, James ML, Liu J, Zhou G, Venkatraman TN, Lascola CD, Acheson SK, Dubois LG, Laskowitz DT, Wang H.

Sci Rep. 2017 Jan 5;7:39580. doi: 10.1038/srep39580. No abstract available.

15.

A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma.

El-Habr EA, Dubois LG, Burel-Vandenbos F, Bogeas A, Lipecka J, Turchi L, Lejeune FX, Coehlo PL, Yamaki T, Wittmann BM, Fareh M, Mahfoudhi E, Janin M, Narayanan A, Morvan-Dubois G, Schmitt C, Verreault M, Oliver L, Sharif A, Pallud J, Devaux B, Puget S, Korkolopoulou P, Varlet P, Ottolenghi C, Plo I, Moura-Neto V, Virolle T, Chneiweiss H, Junier MP.

Acta Neuropathol. 2017 Apr;133(4):645-660. doi: 10.1007/s00401-016-1659-5. Epub 2016 Dec 28.

16.

Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage.

Lei B, James ML, Liu J, Zhou G, Venkatraman TN, Lascola CD, Acheson SK, Dubois LG, Laskowitz DT, Wang H.

Sci Rep. 2016 Oct 7;6:34834. doi: 10.1038/srep34834. Erratum in: Sci Rep. 2017 Jan 05;7:39580.

17.

Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection.

Feger BJ, Thompson JW, Dubois LG, Kommaddi RP, Foster MW, Mishra R, Shenoy SK, Shibata Y, Kidane YH, Moseley MA, Carnell LS, Bowles DE.

Sci Rep. 2016 Sep 27;6:34091. doi: 10.1038/srep34091.

18.

The availability of the embryonic TGF-β protein Nodal is dynamically regulated during glioblastoma multiforme tumorigenesis.

Oliveira-Nunes MC, Assad Kahn S, de Oliveira Barbeitas AL, E Spohr TC, Dubois LG, Ventura Matioszek GM, Querido W, Campanati L, de Brito Neto JM, Lima FR, Moura-Neto V, Carneiro K.

Cancer Cell Int. 2016 Jun 17;16:46. doi: 10.1186/s12935-016-0324-3. eCollection 2016.

19.

Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer.

Alwarawrah Y, Hughes P, Loiselle D, Carlson DA, Darr DB, Jordan JL, Xiong J, Hunter LM, Dubois LG, Thompson JW, Kulkarni MM, Ratcliff AN, Kwiek JJ, Haystead TA.

Cell Chem Biol. 2016 Jun 23;23(6):678-88. doi: 10.1016/j.chembiol.2016.04.011. Epub 2016 Jun 2.

20.

The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.

Assad Kahn S, Costa SL, Gholamin S, Nitta RT, Dubois LG, Fève M, Zeniou M, Coelho PL, El-Habr E, Cadusseau J, Varlet P, Mitra SS, Devaux B, Kilhoffer MC, Cheshier SH, Moura-Neto V, Haiech J, Junier MP, Chneiweiss H.

EMBO Mol Med. 2016 May 2;8(5):511-26. doi: 10.15252/emmm.201505421. Print 2016 May.

21.

The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.

Davies MN, Kjalarsdottir L, Thompson JW, Dubois LG, Stevens RD, Ilkayeva OR, Brosnan MJ, Rolph TP, Grimsrud PA, Muoio DM.

Cell Rep. 2016 Jan 12;14(2):243-54. doi: 10.1016/j.celrep.2015.12.030. Epub 2015 Dec 31.

22.

Comprehensive Proteomic and Metabolomic Signatures of Nontypeable Haemophilus influenzae-Induced Acute Otitis Media Reveal Bacterial Aerobic Respiration in an Immunosuppressed Environment.

Harrison A, Dubois LG, St John-Williams L, Moseley MA, Hardison RL, Heimlich DR, Stoddard A, Kerschner JE, Justice SS, Thompson JW, Mason KM.

Mol Cell Proteomics. 2016 Mar;15(3):1117-38. doi: 10.1074/mcp.M115.052498. Epub 2015 Dec 28.

23.

Connective-Tissue Growth Factor (CTGF/CCN2) Induces Astrogenesis and Fibronectin Expression of Embryonic Neural Cells In Vitro.

Mendes FA, Coelho Aguiar JM, Kahn SA, Reis AH, Dubois LG, Romão LF, Ferreira LS, Chneiweiss H, Moura Neto V, Abreu JG.

PLoS One. 2015 Aug 4;10(8):e0133689. doi: 10.1371/journal.pone.0133689. eCollection 2015.

24.

Motor skills of children with unilateral visual impairment in the Infant Aphakia Treatment Study.

Celano M, Hartmann EE, DuBois LG, Drews-Botsch C; Infant Aphakia Treatment Study Group.

Dev Med Child Neurol. 2016 Feb;58(2):154-9. doi: 10.1111/dmcn.12832. Epub 2015 Jun 17.

25.

Chlamydia trachomatis Infection Leads to Defined Alterations to the Lipid Droplet Proteome in Epithelial Cells.

Saka HA, Thompson JW, Chen YS, Dubois LG, Haas JT, Moseley A, Valdivia RH.

PLoS One. 2015 Apr 24;10(4):e0124630. doi: 10.1371/journal.pone.0124630. eCollection 2015.

26.

An assessment of human gastric fluid composition as a function of PPI usage.

Foltz E, Azad S, Everett ML, Holzknecht ZE, Sanders NL, Thompson JW, Dubois LG, Parker W, Keshavjee S, Palmer SM, Davis RD, Lin SS.

Physiol Rep. 2015 Jan 27;3(1). pii: e12269. doi: 10.14814/phy2.12269. Print 2015 Jan 1.

27.

Gliomas and the vascular fragility of the blood brain barrier.

Dubois LG, Campanati L, Righy C, D'Andrea-Meira I, Spohr TC, Porto-Carreiro I, Pereira CM, Balça-Silva J, Kahn SA, DosSantos MF, Oliveira Mde A, Ximenes-da-Silva A, Lopes MC, Faveret E, Gasparetto EL, Moura-Neto V.

Front Cell Neurosci. 2014 Dec 12;8:418. doi: 10.3389/fncel.2014.00418. eCollection 2014. Review.

28.

Optimizing Urine Processing Protocols for Protein and Metabolite Detection.

Siddiqui NY, DuBois LG, St John-Williams L, Will TJ, Grenier C, Burke E, Fraser MO, Amundsen CL, Murphy SK.

J Proteomics Bioinform. 2015;2015(Suppl 14). pii: 003. Epub 2015 Dec 21.

29.

The orthotopic xenotransplant of human glioblastoma successfully recapitulates glioblastoma-microenvironment interactions in a non-immunosuppressed mouse model.

Garcia C, Dubois LG, Xavier AL, Geraldo LH, da Fonseca AC, Correia AH, Meirelles F, Ventura G, Romão L, Canedo NH, de Souza JM, de Menezes JR, Moura-Neto V, Tovar-Moll F, Lima FR.

BMC Cancer. 2014 Dec 8;14:923. doi: 10.1186/1471-2407-14-923.

30.

Identification and Quantitation of Coding Variants and Isoforms of Pulmonary Surfactant Protein A.

Foster MW, Thompson JW, Ledford JG, Dubois LG, Hollingsworth JW, Francisco D, Tanyaratsrisakul S, Voelker DR, Kraft M, Moseley MA, Foster WM.

J Proteome Res. 2014 Aug 1;13(8):3722-32. doi: 10.1021/pr500307f. Epub 2014 Jul 15.

31.

Proteomic differences between male and female anterior cruciate ligament and patellar tendon.

Little D, Thompson JW, Dubois LG, Ruch DS, Moseley MA, Guilak F.

PLoS One. 2014 May 12;9(5):e96526. doi: 10.1371/journal.pone.0096526. eCollection 2014.

32.

Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia.

Iwabuchi M, Sheng H, Thompson JW, Wang L, Dubois LG, Gooden D, Moseley M, Paschen W, Yang W.

J Cereb Blood Flow Metab. 2014 Mar;34(3):425-32. doi: 10.1038/jcbfm.2013.210. Epub 2013 Dec 4.

33.

Sirtuin-2 activity is required for glioma stem cell proliferation arrest but not necrosis induced by resveratrol.

Sayd S, Thirant C, El-Habr EA, Lipecka J, Dubois LG, Bogeas A, Tahiri-Jouti N, Chneiweiss H, Junier MP.

Stem Cell Rev. 2014 Feb;10(1):103-13. doi: 10.1007/s12015-013-9465-0.

PMID:
23955573
34.

Proteomic analysis of ERK1/2-mediated human sickle red blood cell membrane protein phosphorylation.

Soderblom EJ, Thompson JW, Schwartz EA, Chiou E, Dubois LG, Moseley MA, Zennadi R.

Clin Proteomics. 2013 Jan 3;10(1):1. doi: 10.1186/1559-0275-10-1.

35.

NADPH:quinone oxidoreductase 1 regulates host susceptibility to ozone via isoprostane generation.

Kummarapurugu AB, Fischer BM, Zheng S, Milne GL, Ghio AJ, Potts-Kant EN, Foster WM, Soderblom EJ, Dubois LG, Moseley MA, Thompson JW, Voynow JA.

J Biol Chem. 2013 Feb 15;288(7):4681-91. doi: 10.1074/jbc.M112.438440. Epub 2012 Dec 28.

36.

Proteomic analysis of an unculturable bacterial endosymbiont (Blochmannia) reveals high abundance of chaperonins and biosynthetic enzymes.

Fan Y, Thompson JW, Dubois LG, Moseley MA, Wernegreen JJ.

J Proteome Res. 2013 Feb 1;12(2):704-18. doi: 10.1021/pr3007842. Epub 2012 Dec 27.

37.

Axial elongation following cataract surgery during the first year of life in the infant Aphakia Treatment Study.

Lambert SR, Lynn MJ, DuBois LG, Cotsonis GA, Hartmann EE, Wilson ME; Infant Aphakia Treatment Study Groups.

Invest Ophthalmol Vis Sci. 2012 Nov 7;53(12):7539-45. doi: 10.1167/iovs.12-10285.

38.

Cost of intraocular lens versus contact lens treatment after unilateral congenital cataract surgery: retrospective analysis at age 1 year.

Carrigan AK, DuBois LG, Becker ER, Lambert SR; Infant Aphakia Treatment Study Group.

Ophthalmology. 2013 Jan;120(1):14-9. doi: 10.1016/j.ophtha.2012.07.049. Epub 2012 Oct 6.

39.

Metaprotein expression modeling for label-free quantitative proteomics.

Lucas JE, Thompson JW, Dubois LG, McCarthy J, Tillmann H, Thompson A, Shire N, Hendrickson R, Dieguez F, Goldman P, Schwarz K, Patel K, McHutchison J, Moseley MA.

BMC Bioinformatics. 2012 May 4;13:74. doi: 10.1186/1471-2105-13-74.

40.

Predictability of intraocular lens calculation and early refractive status: the Infant Aphakia Treatment Study.

VanderVeen DK, Nizam A, Lynn MJ, Bothun ED, McClatchey SK, Weakley DR, DuBois LG, Lambert SR; Infant Aphakia Treatment Study Group.

Arch Ophthalmol. 2012 Mar;130(3):293-9. doi: 10.1001/archophthalmol.2011.358.

41.

Differential proteomic analysis of human glioblastoma and neural stem cells reveals HDGF as a novel angiogenic secreted factor.

Thirant C, Galan-Moya EM, Dubois LG, Pinte S, Chafey P, Broussard C, Varlet P, Devaux B, Soncin F, Gavard J, Junier MP, Chneiweiss H.

Stem Cells. 2012 May;30(5):845-53. doi: 10.1002/stem.1062.

42.

Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium.

Zennadi R, Whalen EJ, Soderblom EJ, Alexander SC, Thompson JW, Dubois LG, Moseley MA, Telen MJ.

Blood. 2012 Feb 2;119(5):1217-27. doi: 10.1182/blood-2011-03-344440. Epub 2011 Dec 6.

43.

Quantitative proteomics reveals metabolic and pathogenic properties of Chlamydia trachomatis developmental forms.

Saka HA, Thompson JW, Chen YS, Kumar Y, Dubois LG, Moseley MA, Valdivia RH.

Mol Microbiol. 2011 Dec;82(5):1185-203. doi: 10.1111/j.1365-2958.2011.07877.x. Epub 2011 Nov 7.

44.

Staphylococcus aureus sortase A contributes to the Trojan horse mechanism of immune defense evasion with its intrinsic resistance to Cys184 oxidation.

Melvin JA, Murphy CF, Dubois LG, Thompson JW, Moseley MA, McCafferty DG.

Biochemistry. 2011 Sep 6;50(35):7591-9. doi: 10.1021/bi200844h. Epub 2011 Aug 10.

45.

Tenascin-C in the extracellular matrix promotes the selection of highly proliferative and tubulogenesis-defective endothelial cells.

Alves TR, da Fonseca AC, Nunes SS, da Silva AO, Dubois LG, Faria J, Kahn SA, Viana NB, Marcondes J, Legrand C, Moura-Neto V, Morandi V.

Exp Cell Res. 2011 Sep 10;317(15):2073-85. doi: 10.1016/j.yexcr.2011.06.006. Epub 2011 Jun 25.

PMID:
21740900
46.

Glioblastoma cells: a heterogeneous and fatal tumor interacting with the parenchyma.

Alves TR, Lima FR, Kahn SA, Lobo D, Dubois LG, Soletti R, Borges H, Neto VM.

Life Sci. 2011 Oct 10;89(15-16):532-9. doi: 10.1016/j.lfs.2011.04.022. Epub 2011 May 18. Review.

47.

High predictive accuracy of an unbiased proteomic profile for sustained virologic response in chronic hepatitis C patients.

Patel K, Lucas JE, Thompson JW, Dubois LG, Tillmann HL, Thompson AJ, Uzarski D, Califf RM, Moseley MA, Ginsburg GS, McHutchison JG, McCarthy JJ; MURDOCK Horizon 1 Study Team.

Hepatology. 2011 Jun;53(6):1809-18. doi: 10.1002/hep.24284. Epub 2011 May 14.

PMID:
21381069
48.

Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90.

Fadden P, Huang KH, Veal JM, Steed PM, Barabasz AF, Foley B, Hu M, Partridge JM, Rice J, Scott A, Dubois LG, Freed TA, Silinski MA, Barta TE, Hughes PF, Ommen A, Ma W, Smith ED, Spangenberg AW, Eaves J, Hanson GJ, Hinkley L, Jenks M, Lewis M, Otto J, Pronk GJ, Verleysen K, Haystead TA, Hall SE.

Chem Biol. 2010 Jul 30;17(7):686-94. doi: 10.1016/j.chembiol.2010.04.015.

49.

Mass spectrometry-based thermal shift assay for protein-ligand binding analysis.

West GM, Thompson JW, Soderblom EJ, Dubois LG, Dearmond PD, Moseley MA, Fitzgerald MC.

Anal Chem. 2010 Jul 1;82(13):5573-81. doi: 10.1021/ac100465a.

PMID:
20527820
50.

Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.

Huang KH, Veal JM, Fadden RP, Rice JW, Eaves J, Strachan JP, Barabasz AF, Foley BE, Barta TE, Ma W, Silinski MA, Hu M, Partridge JM, Scott A, DuBois LG, Freed T, Steed PM, Ommen AJ, Smith ED, Hughes PF, Woodward AR, Hanson GJ, McCall WS, Markworth CJ, Hinkley L, Jenks M, Geng L, Lewis M, Otto J, Pronk B, Verleysen K, Hall SE.

J Med Chem. 2009 Jul 23;52(14):4288-305. doi: 10.1021/jm900230j.

PMID:
19552433

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